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iopamidol
Black Box Warnings .
Risk with Inadvertent Intrathecal Administration
inadvertent intrathecal administration may cause death, convulsions, seizures, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, rhabdomyolysis, hyperthermia, and brain edema; for oral use only
Adult Dosing .
Dosage forms: SOLUTION: 9 mg per mL
Special Note
- [strength clarification]
- Info: strength expressed as iodine concentration
computed tomography, abdomen or pelvis
- [500-1000 mL PO x1]
- Start: 60min before procedure; Info: may dilute solution to 6 mg per mL, see pkg insert
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: SOLUTION: 9 mg per mL
Special Note
- [strength clarification]
- Info: strength expressed as iodine concentration
computed tomography, abdomen or pelvis
- [<3 yo]
- Dose: 50-300 mL PO x1; Start: 60min before procedure; Info: may dilute solution to 6 mg per mL, see pkg insert
- [3-5 yo]
- Dose: 300-360 mL PO x1; Start: 60min before procedure; Info: may dilute solution to 6 mg per mL, see pkg insert
- [6-11 yo]
- Dose: 360-500 mL PO x1; Start: 60min before procedure; Info: may dilute solution to 6 mg per mL, see pkg insert
- [12 yo and older]
- Dose: 500-1000 mL PO x1; Start: 60min before procedure; Info: may dilute solution to 6 mg per mL, see pkg insert
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- intrathecal use
- intravascular use
- caution: hypersensitivity to other iodinated contrast media
- caution: asthma
- caution: allergies, known
- caution: patients <3 yo
Drug Interactions .
Overview
iopamidol
contrast agent
- lowers seizure threshold
- nephrotoxicity
- thrombogenic effects
- avoid radioactive iodine during and up to 6wk after iopamidol tx; iopamidol may decr. thyroid uptake of radioactive iodine, efficacy
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
Common Reactions
- nausea
- vomiting
- diarrhea
- esophageal pain
- oral paresthesia
- lip swelling
- urticaria
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at 1.4x and 2.7x recommended human dose
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on minimal drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for iopamidol: none; CYP450: none; Info: minimal systemic absorption
Excretion: for iopamidol: feces primarily; Half-life: unknown
Subclass: Contrast Agents
Mechanism of Action
for iopamidol: attenuates X-ray beams and opacifies vessels and anatomical structures, enhancing visualization of normal and pathological tissue (nonionic iodine-based contrast medium)
Formulary .
No Formulary Selected
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