codeine/ guaifenesin

Overview

codeine

opioid

• CYP2D6 substrate
• CYP3A4 substrate
• antidiuretic hormone effects
• CNS depression
• decreases gastrointestinal motility
• hyponatremia
• hypotensive effects
• lowers seizure threshold
• opioid agonist
• potentiates neuromuscular blockade
• serotonergic effects
• urinary retention

• consider prescribing naloxone, esp. w/ concomitant CNS depressant use
• add MAO inhibitor to Interaction Check if recent (14 days) use

guaifenesin

expectorant

None

Contraindicated

• isocarboxazid
codeine/ guaifenesin (generic)

+

isocarboxazid

1 interaction

Contraindicated

codeine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• isoniazid
codeine/ guaifenesin (generic)

+

isoniazid

1 interaction

Contraindicated

codeine + isoniazid

contraindicated w/in 14 days of isoniazid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects, isoniazid inhibits monoamine oxidase)

• linezolid
codeine/ guaifenesin (generic)

+

linezolid

1 interaction

Contraindicated

codeine + linezolid

contraindicated w/in 14 days of linezolid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome (additive effects, linezolid reversibly inhibits monoamine oxidase)

• methylene blue injection
codeine/ guaifenesin (generic)

+

methylene blue injection

1 interaction

Contraindicated

codeine + methylene blue injection

contraindicated w/in 14 days of methylene blue use; hold codeine if emergency use; monitor resp. rate, BP, serotonin syndrome sx up to 4h after last methylene blue dose; may resume codeine 72h after last methylene blue dose: combo may incr. risk of resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylene blue oral
codeine/ guaifenesin (generic)

+

methylene blue oral

1 interaction

Contraindicated

codeine + methylene blue oral

contraindicated w/in 14 days of methylene blue use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• naltrexone
codeine/ guaifenesin (generic)

+

naltrexone

1 interaction

Contraindicated

codeine + naltrexone

contraindicated; D/C codeine at least 7-10 days before naltrexone start: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent pts (antagonistic effects)

• phenelzine
codeine/ guaifenesin (generic)

+

phenelzine

1 interaction

Contraindicated

codeine + phenelzine

contraindicated w/in 14 days of phenelzine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• potassium chloride
codeine/ guaifenesin (generic)

+

potassium chloride

1 interaction

Contraindicated

codeine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
codeine/ guaifenesin (generic)

+

potassium citrate

1 interaction

Contraindicated

codeine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• procarbazine
codeine/ guaifenesin (generic)

+

procarbazine

1 interaction

Contraindicated

codeine + procarbazine

contraindicated w/in 14 days of procarbazine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, procarbazine inhibits monoamine oxidase)

• rasagiline
codeine/ guaifenesin (generic)

+

rasagiline

1 interaction

Contraindicated

codeine + rasagiline

contraindicated w/in 14 days of rasagiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• safinamide
codeine/ guaifenesin (generic)

+

safinamide

1 interaction

Contraindicated

codeine + safinamide

contraindicated w/in 14 days of safinamide use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• samidorphan
codeine/ guaifenesin (generic)

+

samidorphan

1 interaction

Contraindicated

codeine + samidorphan

contraindicated; D/C codeine at least 7 days before samidorphan start; D/C samidorphan at least 5 days before non-urgent codeine use: combo may decr. codeine efficacy, precipitate severe withdrawal in opioid dependent pts (antagonistic effects)

• selegiline
codeine/ guaifenesin (generic)

+

selegiline

1 interaction

Contraindicated

codeine + selegiline

contraindicated w/in 14 days of selegiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• selegiline transdermal
codeine/ guaifenesin (generic)

+

selegiline transdermal

1 interaction

Contraindicated

codeine + selegiline transdermal

contraindicated w/in 14 days of selegiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• tranylcypromine
codeine/ guaifenesin (generic)

+

tranylcypromine

1 interaction

Contraindicated

codeine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• yohimbe
codeine/ guaifenesin (generic)

+

yohimbe

1 interaction

Contraindicated

codeine + yohimbe

contraindicated w/in 14 days of yohimbe use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, yohimbe inhibits monoamine oxidase)

Avoid/Use Alternative

• 5-HTP
codeine/ guaifenesin (generic)

+

5-HTP

1 interaction

Avoid/Use Alternative

codeine + 5-HTP

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• abiraterone acetate
codeine/ guaifenesin (generic)

+

abiraterone acetate

1 interaction

Avoid/Use Alternative

codeine + abiraterone acetate

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• adagrasib
codeine/ guaifenesin (generic)

+

adagrasib

1 interaction

Avoid/Use Alternative

codeine + adagrasib

consider alternative: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• aldesleukin
codeine/ guaifenesin (generic)

+

aldesleukin

1 interaction

Avoid/Use Alternative

codeine + aldesleukin

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis, syncope), seizures (additive effects)

• alfentanil
codeine/ guaifenesin (generic)

+

alfentanil

1 interaction

Avoid/Use Alternative

codeine + alfentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (additive effects)

• allopurinol
codeine/ guaifenesin (generic)

+

allopurinol

1 interaction

Avoid/Use Alternative

codeine + allopurinol

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• almotriptan
codeine/ guaifenesin (generic)

+

almotriptan

1 interaction

Avoid/Use Alternative

codeine + almotriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment (additive effects)

• alprazolam
codeine/ guaifenesin (generic)

+

alprazolam

1 interaction

Avoid/Use Alternative

codeine + alprazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• amantadine
codeine/ guaifenesin (generic)

+

amantadine

1 interaction

Avoid/Use Alternative

codeine + amantadine

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• amifampridine
codeine/ guaifenesin (generic)

+

amifampridine

1 interaction

Avoid/Use Alternative

codeine + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amiodarone
codeine/ guaifenesin (generic)

+

amiodarone

1 interaction

Avoid/Use Alternative

codeine + amiodarone

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• amitriptyline
codeine/ guaifenesin (generic)

+

amitriptyline

1 interaction

Avoid/Use Alternative

codeine + amitriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• amlodipine
codeine/ guaifenesin (generic)

+

amlodipine

1 interaction

Avoid/Use Alternative

codeine + amlodipine

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• amoxapine
codeine/ guaifenesin (generic)

+

amoxapine

1 interaction

Avoid/Use Alternative

codeine + amoxapine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• amphetamine
codeine/ guaifenesin (generic)

+

amphetamine

1 interaction

Avoid/Use Alternative

codeine + amphetamine

use alternative or decr. amphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• apalutamide
codeine/ guaifenesin (generic)

+

apalutamide

1 interaction

Avoid/Use Alternative

codeine + apalutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• apomorphine
codeine/ guaifenesin (generic)

+

apomorphine

1 interaction

Avoid/Use Alternative

codeine + apomorphine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
codeine/ guaifenesin (generic)

+

apraclonidine ophthalmic

1 interaction

Avoid/Use Alternative

codeine + apraclonidine ophthalmic

avoid combo if antitussive use; otherwise, monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aprepitant
codeine/ guaifenesin (generic)

+

aprepitant

1 interaction

Avoid/Use Alternative

codeine + aprepitant

if aprepitant 3-day regimen, use alternative or monitor resp. rate; consider decr. codeine dose; aprepitant single dose-regimen OK: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• aripiprazole bimonthly injection
codeine/ guaifenesin (generic)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

codeine + aripiprazole bimonthly injection

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole lauroxil
codeine/ guaifenesin (generic)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

codeine + aripiprazole lauroxil

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole monthly injection
codeine/ guaifenesin (generic)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

codeine + aripiprazole monthly injection

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole oral
codeine/ guaifenesin (generic)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

codeine + aripiprazole oral

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• armodafinil
codeine/ guaifenesin (generic)

+

armodafinil

1 interaction

Avoid/Use Alternative

codeine + armodafinil

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• artemether/lumefantrine
codeine/ guaifenesin (generic)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

codeine + artemether/ lumefantrine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. or decr. codeine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy; may decr. active metabolite morphine levels, efficacy (hepatic metab. altered, decr. conversion to morphine)

• asciminib
codeine/ guaifenesin (generic)

+

asciminib

1 interaction

Avoid/Use Alternative

codeine + asciminib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• asenapine
codeine/ guaifenesin (generic)

+

asenapine

1 interaction

Avoid/Use Alternative

codeine + asenapine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• atazanavir
codeine/ guaifenesin (generic)

+

atazanavir

1 interaction

Avoid/Use Alternative

codeine + atazanavir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• atorvastatin
codeine/ guaifenesin (generic)

+

atorvastatin

1 interaction

Avoid/Use Alternative

codeine + atorvastatin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• avacopan
codeine/ guaifenesin (generic)

+

avacopan

1 interaction

Avoid/Use Alternative

codeine + avacopan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• baclofen
codeine/ guaifenesin (generic)

+

baclofen

1 interaction

Avoid/Use Alternative

codeine + baclofen

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• baclofen intrathecal
codeine/ guaifenesin (generic)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

codeine + baclofen intrathecal

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• belumosudil
codeine/ guaifenesin (generic)

+

belumosudil

1 interaction

Avoid/Use Alternative

codeine + belumosudil

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• belzutifan
codeine/ guaifenesin (generic)

+

belzutifan

1 interaction

Avoid/Use Alternative

codeine + belzutifan

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• berberine
codeine/ guaifenesin (generic)

+

berberine

1 interaction

Avoid/Use Alternative

codeine + berberine

use alternative or monitor resp. rate, BP, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• berotralstat
codeine/ guaifenesin (generic)

+

berotralstat

1 interaction

Avoid/Use Alternative

codeine + berotralstat

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, conversion to morphine altered)

• bexarotene
codeine/ guaifenesin (generic)

+

bexarotene

1 interaction

Avoid/Use Alternative

codeine + bexarotene

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• bicalutamide
codeine/ guaifenesin (generic)

+

bicalutamide

1 interaction

Avoid/Use Alternative

codeine + bicalutamide

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• bosentan
codeine/ guaifenesin (generic)

+

bosentan

1 interaction

Avoid/Use Alternative

codeine + bosentan

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• brexpiprazole
codeine/ guaifenesin (generic)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

codeine + brexpiprazole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brigatinib
codeine/ guaifenesin (generic)

+

brigatinib

1 interaction

Avoid/Use Alternative

codeine + brigatinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• brimonidine ophthalmic
codeine/ guaifenesin (generic)

+

brimonidine ophthalmic

1 interaction

Avoid/Use Alternative

codeine + brimonidine ophthalmic

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine topical
codeine/ guaifenesin (generic)

+

brimonidine topical

1 interaction

Avoid/Use Alternative

codeine + brimonidine topical

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brivaracetam
codeine/ guaifenesin (generic)

+

brivaracetam

1 interaction

Avoid/Use Alternative

codeine + brivaracetam

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• bromocriptine
codeine/ guaifenesin (generic)

+

bromocriptine

1 interaction

Avoid/Use Alternative

codeine + bromocriptine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• brompheniramine
codeine/ guaifenesin (generic)

+

brompheniramine

1 interaction

Avoid/Use Alternative

codeine + brompheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• buprenorphine
codeine/ guaifenesin (generic)

+

buprenorphine

1 interaction

Avoid/Use Alternative

codeine + buprenorphine

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent pts; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (antagonistic effects; additive effects)

• bupropion
codeine/ guaifenesin (generic)

+

bupropion

1 interaction

Avoid/Use Alternative

codeine + bupropion

use alternative or monitor resp. rate, withdrawal sx; consider lower bupropion doses: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• buspirone
codeine/ guaifenesin (generic)

+

buspirone

1 interaction

Avoid/Use Alternative

codeine + buspirone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• butalbital
codeine/ guaifenesin (generic)

+

butalbital

1 interaction

Avoid/Use Alternative

codeine + butalbital

avoid combo: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• butorphanol
codeine/ guaifenesin (generic)

+

butorphanol

1 interaction

Avoid/Use Alternative

codeine + butorphanol

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent pts; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• cannabidiol
codeine/ guaifenesin (generic)

+

cannabidiol

1 interaction

Avoid/Use Alternative

codeine + cannabidiol

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• cannabis
codeine/ guaifenesin (generic)

+

cannabis

1 interaction

Avoid/Use Alternative

codeine + cannabis

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• capivasertib
codeine/ guaifenesin (generic)

+

capivasertib

1 interaction

Avoid/Use Alternative

codeine + capivasertib

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may incr. or decr. active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may incr. or decr. production of active metabolite morphine)

• carbamazepine
codeine/ guaifenesin (generic)

+

carbamazepine

1 interaction

Avoid/Use Alternative

codeine + carbamazepine

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension (incl. syncope), serotonin syndrome; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• carbinoxamine
codeine/ guaifenesin (generic)

+

carbinoxamine

1 interaction

Avoid/Use Alternative

codeine + carbinoxamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• cariprazine
codeine/ guaifenesin (generic)

+

cariprazine

1 interaction

Avoid/Use Alternative

codeine + cariprazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• carisoprodol
codeine/ guaifenesin (generic)

+

carisoprodol

1 interaction

Avoid/Use Alternative

codeine + carisoprodol

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• celecoxib
codeine/ guaifenesin (generic)

+

celecoxib

1 interaction

Avoid/Use Alternative

codeine + celecoxib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• cenobamate
codeine/ guaifenesin (generic)

+

cenobamate

1 interaction

Avoid/Use Alternative

codeine + cenobamate

avoid combo if antitussive use, otherwise use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• ceritinib
codeine/ guaifenesin (generic)

+

ceritinib

1 interaction

Avoid/Use Alternative

codeine + ceritinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cetirizine
codeine/ guaifenesin (generic)

+

cetirizine

1 interaction

Avoid/Use Alternative

codeine + cetirizine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chamomile, German
codeine/ guaifenesin (generic)

+

chamomile, German

1 interaction

Avoid/Use Alternative

codeine + chamomile, German

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlophedianol
codeine/ guaifenesin (generic)

+

chlophedianol

1 interaction

Avoid/Use Alternative

codeine + chlophedianol

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• chloramphenicol
codeine/ guaifenesin (generic)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

codeine + chloramphenicol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• chlordiazepoxide
codeine/ guaifenesin (generic)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

codeine + chlordiazepoxide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• chlorpheniramine
codeine/ guaifenesin (generic)

+

chlorpheniramine

1 interaction

Avoid/Use Alternative

codeine + chlorpheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• chlorpromazine
codeine/ guaifenesin (generic)

+

chlorpromazine

1 interaction

Avoid/Use Alternative

codeine + chlorpromazine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. codeine conversion to morphine; additive effects)

• chlorzoxazone
codeine/ guaifenesin (generic)

+

chlorzoxazone

1 interaction

Avoid/Use Alternative

codeine + chlorzoxazone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• cilostazol
codeine/ guaifenesin (generic)

+

cilostazol

1 interaction

Avoid/Use Alternative

codeine + cilostazol

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• cimetidine
codeine/ guaifenesin (generic)

+

cimetidine

1 interaction

Avoid/Use Alternative

codeine + cimetidine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• cinacalcet
codeine/ guaifenesin (generic)

+

cinacalcet

1 interaction

Avoid/Use Alternative

codeine + cinacalcet

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ciprofloxacin
codeine/ guaifenesin (generic)

+

ciprofloxacin

1 interaction

Avoid/Use Alternative

codeine + ciprofloxacin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• citalopram
codeine/ guaifenesin (generic)

+

citalopram

1 interaction

Avoid/Use Alternative

codeine + citalopram

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• clarithromycin
codeine/ guaifenesin (generic)

+

clarithromycin

1 interaction

Avoid/Use Alternative

codeine + clarithromycin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• clemastine
codeine/ guaifenesin (generic)

+

clemastine

1 interaction

Avoid/Use Alternative

codeine + clemastine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• clobazam
codeine/ guaifenesin (generic)

+

clobazam

1 interaction

Avoid/Use Alternative

codeine + clobazam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, BP; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may alter codeine or decr. active metabolite morphine levels, incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy; may alter seizure control (hepatic metab. altered, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clofazimine
codeine/ guaifenesin (generic)

+

clofazimine

1 interaction

Avoid/Use Alternative

codeine + clofazimine

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• clomipramine
codeine/ guaifenesin (generic)

+

clomipramine

1 interaction

Avoid/Use Alternative

codeine + clomipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• clonazepam
codeine/ guaifenesin (generic)

+

clonazepam

1 interaction

Avoid/Use Alternative

codeine + clonazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clonidine
codeine/ guaifenesin (generic)

+

clonidine

1 interaction

Avoid/Use Alternative

codeine + clonidine

avoid combo if ADHD or antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• clopidogrel
codeine/ guaifenesin (generic)

+

clopidogrel

1 interaction

Avoid/Use Alternative

codeine + clopidogrel

consider alternative parenteral antiplatelet agent for acute tx of ACS; otherwise, caution advised: combo may decr. clopidogrel and active metabolite levels, efficacy (absorption of clopidogrel possibly affected by delayed gastric emptying)

• clorazepate
codeine/ guaifenesin (generic)

+

clorazepate

1 interaction

Avoid/Use Alternative

codeine + clorazepate

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clotrimazole oropharyngeal
codeine/ guaifenesin (generic)

+

clotrimazole oropharyngeal

1 interaction

Avoid/Use Alternative

codeine + clotrimazole oropharyngeal

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• clozapine
codeine/ guaifenesin (generic)

+

clozapine

1 interaction

Avoid/Use Alternative

codeine + clozapine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, HR, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. possibly inhibited, decr. conversion to morphine, additive effects)

• cobicistat
codeine/ guaifenesin (generic)

+

cobicistat

1 interaction

Avoid/Use Alternative

codeine + cobicistat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• cocaine
codeine/ guaifenesin (generic)

+

cocaine

1 interaction

Avoid/Use Alternative

codeine + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
codeine/ guaifenesin (generic)

+

codeine

1 interaction

Avoid/Use Alternative

codeine + codeine

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, other adverse effects (additive effects, duplicate tx)

• conivaptan
codeine/ guaifenesin (generic)

+

conivaptan

1 interaction

Avoid/Use Alternative

codeine + conivaptan

use alternative or monitor resp. rate; consider decr. codeine dose during and x7 days after conivaptan tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cranberry
codeine/ guaifenesin (generic)

+

cranberry

1 interaction

Avoid/Use Alternative

codeine + cranberry

use alternative or monitor resp. rate, consider decr. codeine dose, especially w/ large amounts of cranberry: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• crizotinib
codeine/ guaifenesin (generic)

+

crizotinib

1 interaction

Avoid/Use Alternative

codeine + crizotinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cyclobenzaprine
codeine/ guaifenesin (generic)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

codeine + cyclobenzaprine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe constipation/paralytic ileus, other adverse effects (additive effects)

• cyclosporine
codeine/ guaifenesin (generic)

+

cyclosporine

1 interaction

Avoid/Use Alternative

codeine + cyclosporine

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cyproheptadine
codeine/ guaifenesin (generic)

+

cyproheptadine

1 interaction

Avoid/Use Alternative

codeine + cyproheptadine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dabrafenib
codeine/ guaifenesin (generic)

+

dabrafenib

1 interaction

Avoid/Use Alternative

codeine + dabrafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dacomitinib
codeine/ guaifenesin (generic)

+

dacomitinib

1 interaction

Avoid/Use Alternative

codeine + dacomitinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• danazol
codeine/ guaifenesin (generic)

+

danazol

1 interaction

Avoid/Use Alternative

codeine + danazol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• danshen
codeine/ guaifenesin (generic)

+

danshen

1 interaction

Avoid/Use Alternative

codeine + danshen

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dantrolene
codeine/ guaifenesin (generic)

+

dantrolene

1 interaction

Avoid/Use Alternative

codeine + dantrolene

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• daridorexant
codeine/ guaifenesin (generic)

+

daridorexant

1 interaction

Avoid/Use Alternative

codeine + daridorexant

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• darifenacin
codeine/ guaifenesin (generic)

+

darifenacin

1 interaction

Avoid/Use Alternative

codeine + darifenacin

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• darolutamide
codeine/ guaifenesin (generic)

+

darolutamide

1 interaction

Avoid/Use Alternative

codeine + darolutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• darunavir
codeine/ guaifenesin (generic)

+

darunavir

1 interaction

Avoid/Use Alternative

codeine + darunavir

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, conversion to morphine altered)

• desflurane
codeine/ guaifenesin (generic)

+

desflurane

1 interaction

Avoid/Use Alternative

codeine + desflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• desipramine
codeine/ guaifenesin (generic)

+

desipramine

1 interaction

Avoid/Use Alternative

codeine + desipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• desvenlafaxine
codeine/ guaifenesin (generic)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

codeine + desvenlafaxine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• deutetrabenazine
codeine/ guaifenesin (generic)

+

deutetrabenazine

1 interaction

Avoid/Use Alternative

codeine + deutetrabenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dexamethasone
codeine/ guaifenesin (generic)

+

dexamethasone

1 interaction

Avoid/Use Alternative

codeine + dexamethasone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dexbrompheniramine
codeine/ guaifenesin (generic)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

codeine + dexbrompheniramine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• dexchlorpheniramine
codeine/ guaifenesin (generic)

+

dexchlorpheniramine

1 interaction

Avoid/Use Alternative

codeine + dexchlorpheniramine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• dexmedetomidine
codeine/ guaifenesin (generic)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

codeine + dexmedetomidine

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• dexmedetomidine injection
codeine/ guaifenesin (generic)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

codeine + dexmedetomidine injection

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis, syncope), bradycardia, AV block (additive effects)

• dexmethylphenidate
codeine/ guaifenesin (generic)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

codeine + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
codeine/ guaifenesin (generic)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

codeine + dextroamphetamine

use alternative or decr. dextroamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
codeine/ guaifenesin (generic)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

codeine + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diazepam
codeine/ guaifenesin (generic)

+

diazepam

1 interaction

Avoid/Use Alternative

codeine + diazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• dichlorphenamide
codeine/ guaifenesin (generic)

+

dichlorphenamide

1 interaction

Avoid/Use Alternative

codeine + dichlorphenamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dicloxacillin
codeine/ guaifenesin (generic)

+

dicloxacillin

1 interaction

Avoid/Use Alternative

codeine + dicloxacillin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• difelikefalin
codeine/ guaifenesin (generic)

+

difelikefalin

1 interaction

Avoid/Use Alternative

codeine + difelikefalin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• difenoxin
codeine/ guaifenesin (generic)

+

difenoxin

1 interaction

Avoid/Use Alternative

codeine + difenoxin

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• dihydrocodeine
codeine/ guaifenesin (generic)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

codeine + dihydrocodeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• dihydroergotamine
codeine/ guaifenesin (generic)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

codeine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diltiazem
codeine/ guaifenesin (generic)

+

diltiazem

1 interaction

Avoid/Use Alternative

codeine + diltiazem

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• dimenhydrinate
codeine/ guaifenesin (generic)

+

dimenhydrinate

1 interaction

Avoid/Use Alternative

codeine + dimenhydrinate

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• diosmin
codeine/ guaifenesin (generic)

+

diosmin

1 interaction

Avoid/Use Alternative

codeine + diosmin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• diphenhydramine
codeine/ guaifenesin (generic)

+

diphenhydramine

1 interaction

Avoid/Use Alternative

codeine + diphenhydramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. codeine conversion to morphine; additive effects)

• diphenoxylate
codeine/ guaifenesin (generic)

+

diphenoxylate

1 interaction

Avoid/Use Alternative

codeine + diphenoxylate

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• domperidone
codeine/ guaifenesin (generic)

+

domperidone

1 interaction

Avoid/Use Alternative

codeine + domperidone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• doxepin
codeine/ guaifenesin (generic)

+

doxepin

1 interaction

Avoid/Use Alternative

codeine + doxepin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• doxepin topical
codeine/ guaifenesin (generic)

+

doxepin topical

1 interaction

Avoid/Use Alternative

codeine + doxepin topical

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• doxylamine
codeine/ guaifenesin (generic)

+

doxylamine

1 interaction

Avoid/Use Alternative

codeine + doxylamine

avoid combo if antitussive use or doxylamine use for pregnancy-related nausea/vomiting; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dronabinol
codeine/ guaifenesin (generic)

+

dronabinol

1 interaction

Avoid/Use Alternative

codeine + dronabinol

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• dronedarone
codeine/ guaifenesin (generic)

+

dronedarone

1 interaction

Avoid/Use Alternative

codeine + dronedarone

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• droperidol
codeine/ guaifenesin (generic)

+

droperidol

1 interaction

Avoid/Use Alternative

codeine + droperidol

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• duloxetine
codeine/ guaifenesin (generic)

+

duloxetine

1 interaction

Avoid/Use Alternative

codeine + duloxetine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• duvelisib
codeine/ guaifenesin (generic)

+

duvelisib

1 interaction

Avoid/Use Alternative

codeine + duvelisib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• echinacea
codeine/ guaifenesin (generic)

+

echinacea

1 interaction

Avoid/Use Alternative

codeine + echinacea

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• efavirenz
codeine/ guaifenesin (generic)

+

efavirenz

1 interaction

Avoid/Use Alternative

codeine + efavirenz

avoid combo if antitussive use; otherwise monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• elafibranor
codeine/ guaifenesin (generic)

+

elafibranor

1 interaction

Avoid/Use Alternative

codeine + elafibranor

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• elagolix
codeine/ guaifenesin (generic)

+

elagolix

1 interaction

Avoid/Use Alternative

codeine + elagolix

use alternative or monitor withdrawal sx: combo may decr. codeine levels, efficacy (hepatic metab. induced)

• eletriptan
codeine/ guaifenesin (generic)

+

eletriptan

1 interaction

Avoid/Use Alternative

codeine + eletriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• eliglustat
codeine/ guaifenesin (generic)

+

eliglustat

1 interaction

Avoid/Use Alternative

codeine + eliglustat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• eluxadoline
codeine/ guaifenesin (generic)

+

eluxadoline

1 interaction

Avoid/Use Alternative

codeine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• enasidenib
codeine/ guaifenesin (generic)

+

enasidenib

1 interaction

Avoid/Use Alternative

codeine + enasidenib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered, decr. conversion to morphine)

• encorafenib
codeine/ guaifenesin (generic)

+

encorafenib

1 interaction

Avoid/Use Alternative

codeine + encorafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• entacapone
codeine/ guaifenesin (generic)

+

entacapone

1 interaction

Avoid/Use Alternative

codeine + entacapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• entrectinib
codeine/ guaifenesin (generic)

+

entrectinib

1 interaction

Avoid/Use Alternative

codeine + entrectinib

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• enzalutamide
codeine/ guaifenesin (generic)

+

enzalutamide

1 interaction

Avoid/Use Alternative

codeine + enzalutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• ergotamine
codeine/ guaifenesin (generic)

+

ergotamine

1 interaction

Avoid/Use Alternative

codeine + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• erythromycin
codeine/ guaifenesin (generic)

+

erythromycin

1 interaction

Avoid/Use Alternative

codeine + erythromycin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. erythromycin efficacy when used for GI promotility (hepatic metab. inhibited, may incr. production of active metabolite morphine; antagonistic effects)

• escitalopram
codeine/ guaifenesin (generic)

+

escitalopram

1 interaction

Avoid/Use Alternative

codeine + escitalopram

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• esketamine
codeine/ guaifenesin (generic)

+

esketamine

1 interaction

Avoid/Use Alternative

codeine + esketamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
codeine/ guaifenesin (generic)

+

eslicarbazepine acetate

1 interaction

Avoid/Use Alternative

codeine + eslicarbazepine acetate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• estazolam
codeine/ guaifenesin (generic)

+

estazolam

1 interaction

Avoid/Use Alternative

codeine + estazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• eszopiclone
codeine/ guaifenesin (generic)

+

eszopiclone

1 interaction

Avoid/Use Alternative

codeine + eszopiclone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethanol
codeine/ guaifenesin (generic)

+

ethanol

1 interaction

Avoid/Use Alternative

codeine + ethanol

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ethanol (in some formulations)
codeine/ guaifenesin (generic)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

codeine + ethanol (in some formulations)

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
codeine/ guaifenesin (generic)

+

ethinyl estradiol (contraceptive)

1 interaction

Avoid/Use Alternative

codeine + ethinyl estradiol (contraceptive)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• ethosuximide
codeine/ guaifenesin (generic)

+

ethosuximide

1 interaction

Avoid/Use Alternative

codeine + ethosuximide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• etomidate
codeine/ guaifenesin (generic)

+

etomidate

1 interaction

Avoid/Use Alternative

codeine + etomidate

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension (additive effects)

• etravirine
codeine/ guaifenesin (generic)

+

etravirine

1 interaction

Avoid/Use Alternative

codeine + etravirine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• everolimus
codeine/ guaifenesin (generic)

+

everolimus

1 interaction

Avoid/Use Alternative

codeine + everolimus

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• fedratinib
codeine/ guaifenesin (generic)

+

fedratinib

1 interaction

Avoid/Use Alternative

codeine + fedratinib

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, conversion to morphine altered)

• felbamate
codeine/ guaifenesin (generic)

+

felbamate

1 interaction

Avoid/Use Alternative

codeine + felbamate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• felodipine
codeine/ guaifenesin (generic)

+

felodipine

1 interaction

Avoid/Use Alternative

codeine + felodipine

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• fenfluramine
codeine/ guaifenesin (generic)

+

fenfluramine

1 interaction

Avoid/Use Alternative

codeine + fenfluramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• fentanyl
codeine/ guaifenesin (generic)

+

fentanyl

1 interaction

Avoid/Use Alternative

codeine + fentanyl

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• fesoterodine
codeine/ guaifenesin (generic)

+

fesoterodine

1 interaction

Avoid/Use Alternative

codeine + fesoterodine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• fexinidazole
codeine/ guaifenesin (generic)

+

fexinidazole

1 interaction

Avoid/Use Alternative

codeine + fexinidazole

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• finerenone
codeine/ guaifenesin (generic)

+

finerenone

1 interaction

Avoid/Use Alternative

codeine + finerenone

use alternative or monitor resp. rate if on finerenone 40 mg/day; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• flibanserin
codeine/ guaifenesin (generic)

+

flibanserin

1 interaction

Avoid/Use Alternative

codeine + flibanserin

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• fluconazole
codeine/ guaifenesin (generic)

+

fluconazole

1 interaction

Avoid/Use Alternative

codeine + fluconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• fluoxetine
codeine/ guaifenesin (generic)

+

fluoxetine

1 interaction

Avoid/Use Alternative

codeine + fluoxetine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• fluphenazine
codeine/ guaifenesin (generic)

+

fluphenazine

1 interaction

Avoid/Use Alternative

codeine + fluphenazine

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• flurazepam
codeine/ guaifenesin (generic)

+

flurazepam

1 interaction

Avoid/Use Alternative

codeine + flurazepam

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fluvoxamine
codeine/ guaifenesin (generic)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

codeine + fluvoxamine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• fosamprenavir
codeine/ guaifenesin (generic)

+

fosamprenavir

1 interaction

Avoid/Use Alternative

codeine + fosamprenavir

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• fosaprepitant
codeine/ guaifenesin (generic)

+

fosaprepitant

1 interaction

Avoid/Use Alternative

codeine + fosaprepitant

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may alter production of active metabolite morphine)

• foslevodopa
codeine/ guaifenesin (generic)

+

foslevodopa

1 interaction

Avoid/Use Alternative

codeine + foslevodopa

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fosphenytoin
codeine/ guaifenesin (generic)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

codeine + fosphenytoin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• fostamatinib
codeine/ guaifenesin (generic)

+

fostamatinib

1 interaction

Avoid/Use Alternative

codeine + fostamatinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• frovatriptan
codeine/ guaifenesin (generic)

+

frovatriptan

1 interaction

Avoid/Use Alternative

codeine + frovatriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• gabapentin
codeine/ guaifenesin (generic)

+

gabapentin

1 interaction

Avoid/Use Alternative

codeine + gabapentin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• gabapentin enacarbil
codeine/ guaifenesin (generic)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

codeine + gabapentin enacarbil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ganaxolone
codeine/ guaifenesin (generic)

+

ganaxolone

1 interaction

Avoid/Use Alternative

codeine + ganaxolone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• garlic
codeine/ guaifenesin (generic)

+

garlic

1 interaction

Avoid/Use Alternative

codeine + garlic

use alternative or monitor withdrawal sx, BP w/ supplemental garlic; dietary intake OK: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• gefitinib
codeine/ guaifenesin (generic)

+

gefitinib

1 interaction

Avoid/Use Alternative

codeine + gefitinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• gepirone
codeine/ guaifenesin (generic)

+

gepirone

1 interaction

Avoid/Use Alternative

codeine + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• gepotidacin
codeine/ guaifenesin (generic)

+

gepotidacin

1 interaction

Avoid/Use Alternative

codeine + gepotidacin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ginkgo
codeine/ guaifenesin (generic)

+

ginkgo

1 interaction

Avoid/Use Alternative

codeine + ginkgo

avoid combo: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• ginseng, Asian
codeine/ guaifenesin (generic)

+

ginseng, Asian

1 interaction

Avoid/Use Alternative

codeine + ginseng, Asian

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• givinostat
codeine/ guaifenesin (generic)

+

givinostat

1 interaction

Avoid/Use Alternative

codeine + givinostat

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• givosiran
codeine/ guaifenesin (generic)

+

givosiran

1 interaction

Avoid/Use Alternative

codeine + givosiran

use alternative or monitor resp. rate, withdrawal sx, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may incr. or decr. conversion to active metabolite morphine; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glecaprevir
codeine/ guaifenesin (generic)

+

glecaprevir

1 interaction

Avoid/Use Alternative

codeine + glecaprevir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• glofitamab
codeine/ guaifenesin (generic)

+

glofitamab

1 interaction

Avoid/Use Alternative

codeine + glofitamab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• glycerol phenylbutyrate
codeine/ guaifenesin (generic)

+

glycerol phenylbutyrate

1 interaction

Avoid/Use Alternative

codeine + glycerol phenylbutyrate

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• glycopyrrolate
codeine/ guaifenesin (generic)

+

glycopyrrolate

1 interaction

Avoid/Use Alternative

codeine + glycopyrrolate

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• goldenseal
codeine/ guaifenesin (generic)

+

goldenseal

1 interaction

Avoid/Use Alternative

codeine + goldenseal

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• granisetron
codeine/ guaifenesin (generic)

+

granisetron

1 interaction

Avoid/Use Alternative

codeine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• grapefruit
codeine/ guaifenesin (generic)

+

grapefruit

1 interaction

Avoid/Use Alternative

codeine + grapefruit

avoid grapefruit juice: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• grazoprevir
codeine/ guaifenesin (generic)

+

grazoprevir

1 interaction

Avoid/Use Alternative

codeine + grazoprevir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• griseofulvin
codeine/ guaifenesin (generic)

+

griseofulvin

1 interaction

Avoid/Use Alternative

codeine + griseofulvin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• guanfacine
codeine/ guaifenesin (generic)

+

guanfacine

1 interaction

Avoid/Use Alternative

codeine + guanfacine

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• haloperidol
codeine/ guaifenesin (generic)

+

haloperidol

1 interaction

Avoid/Use Alternative

codeine + haloperidol

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydralazine
codeine/ guaifenesin (generic)

+

hydralazine

1 interaction

Avoid/Use Alternative

codeine + hydralazine

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• hydrocodone
codeine/ guaifenesin (generic)

+

hydrocodone

1 interaction

Avoid/Use Alternative

codeine + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydromorphone
codeine/ guaifenesin (generic)

+

hydromorphone

1 interaction

Avoid/Use Alternative

codeine + hydromorphone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus (additive effects)

• hydroxychloroquine
codeine/ guaifenesin (generic)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

codeine + hydroxychloroquine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy; may incr. risk of seizures (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• hydroxyzine
codeine/ guaifenesin (generic)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

codeine + hydroxyzine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hyoscyamine
codeine/ guaifenesin (generic)

+

hyoscyamine

1 interaction

Avoid/Use Alternative

codeine + hyoscyamine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• idelalisib
codeine/ guaifenesin (generic)

+

idelalisib

1 interaction

Avoid/Use Alternative

codeine + idelalisib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ifosfamide
codeine/ guaifenesin (generic)

+

ifosfamide

1 interaction

Avoid/Use Alternative

codeine + ifosfamide

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• iloperidone
codeine/ guaifenesin (generic)

+

iloperidone

1 interaction

Avoid/Use Alternative

codeine + iloperidone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• imatinib
codeine/ guaifenesin (generic)

+

imatinib

1 interaction

Avoid/Use Alternative

codeine + imatinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• imipramine
codeine/ guaifenesin (generic)

+

imipramine

1 interaction

Avoid/Use Alternative

codeine + imipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• iohexol
codeine/ guaifenesin (generic)

+

iohexol

1 interaction

Avoid/Use Alternative

codeine + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isavuconazonium
codeine/ guaifenesin (generic)

+

isavuconazonium

1 interaction

Avoid/Use Alternative

codeine + isavuconazonium

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• isoflurane
codeine/ guaifenesin (generic)

+

isoflurane

1 interaction

Avoid/Use Alternative

codeine + isoflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• istradefylline
codeine/ guaifenesin (generic)

+

istradefylline

1 interaction

Avoid/Use Alternative

codeine + istradefylline

use alternative or monitor resp. rate, consider decr. codeine dose, especially w/ istradefylline 40 mg dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• itraconazole
codeine/ guaifenesin (generic)

+

itraconazole

1 interaction

Avoid/Use Alternative

codeine + itraconazole

use alternative or monitor resp. rate; consider decr. codeine dose during and x2wk after itraconazole tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ivacaftor
codeine/ guaifenesin (generic)

+

ivacaftor

1 interaction

Avoid/Use Alternative

codeine + ivacaftor

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ivosidenib
codeine/ guaifenesin (generic)

+

ivosidenib

1 interaction

Avoid/Use Alternative

codeine + ivosidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• kava
codeine/ guaifenesin (generic)

+

kava

1 interaction

Avoid/Use Alternative

codeine + kava

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ketamine
codeine/ guaifenesin (generic)

+

ketamine

1 interaction

Avoid/Use Alternative

codeine + ketamine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment, delayed recovery from anesthesia (additive effects)

• ketoconazole
codeine/ guaifenesin (generic)

+

ketoconazole

1 interaction

Avoid/Use Alternative

codeine + ketoconazole

use alternative or monitor resp. rate; consider decr. codeine dose during and up to 1wk after ketoconazole tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• kratom
codeine/ guaifenesin (generic)

+

kratom

1 interaction

Avoid/Use Alternative

codeine + kratom

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine, additive effects)

• labetalol
codeine/ guaifenesin (generic)

+

labetalol

1 interaction

Avoid/Use Alternative

codeine + labetalol

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• lacosamide
codeine/ guaifenesin (generic)

+

lacosamide

1 interaction

Avoid/Use Alternative

codeine + lacosamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lamotrigine
codeine/ guaifenesin (generic)

+

lamotrigine

1 interaction

Avoid/Use Alternative

codeine + lamotrigine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lapatinib
codeine/ guaifenesin (generic)

+

lapatinib

1 interaction

Avoid/Use Alternative

codeine + lapatinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• larotrectinib
codeine/ guaifenesin (generic)

+

larotrectinib

1 interaction

Avoid/Use Alternative

codeine + larotrectinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lasmiditan
codeine/ guaifenesin (generic)

+

lasmiditan

1 interaction

Avoid/Use Alternative

codeine + lasmiditan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• lazertinib
codeine/ guaifenesin (generic)

+

lazertinib

1 interaction

Avoid/Use Alternative

codeine + lazertinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lefamulin
codeine/ guaifenesin (generic)

+

lefamulin

1 interaction

Avoid/Use Alternative

codeine + lefamulin

ORAL LEFAMULIN: use alternative or monitor resp. rate, consider decr. codeine dose; IV lefamulin use OK: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lemborexant
codeine/ guaifenesin (generic)

+

lemborexant

1 interaction

Avoid/Use Alternative

codeine + lemborexant

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lenacapavir
codeine/ guaifenesin (generic)

+

lenacapavir

1 interaction

Avoid/Use Alternative

codeine + lenacapavir

use alternative or monitor resp. rate, consider decr. codeine dose during and x9mo after lenacapavir tx: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• letermovir
codeine/ guaifenesin (generic)

+

letermovir

1 interaction

Avoid/Use Alternative

codeine + letermovir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• levetiracetam
codeine/ guaifenesin (generic)

+

levetiracetam

1 interaction

Avoid/Use Alternative

codeine + levetiracetam

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• levocetirizine
codeine/ guaifenesin (generic)

+

levocetirizine

1 interaction

Avoid/Use Alternative

codeine + levocetirizine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levodopa
codeine/ guaifenesin (generic)

+

levodopa

1 interaction

Avoid/Use Alternative

codeine + levodopa

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• levoketoconazole
codeine/ guaifenesin (generic)

+

levoketoconazole

1 interaction

Avoid/Use Alternative

codeine + levoketoconazole

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• levomilnacipran
codeine/ guaifenesin (generic)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

codeine + levomilnacipran

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• levorphanol
codeine/ guaifenesin (generic)

+

levorphanol

1 interaction

Avoid/Use Alternative

codeine + levorphanol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. levorphanol start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• linvoseltamab
codeine/ guaifenesin (generic)

+

linvoseltamab

1 interaction

Avoid/Use Alternative

codeine + linvoseltamab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lisdexamfetamine
codeine/ guaifenesin (generic)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

codeine + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
codeine/ guaifenesin (generic)

+

lithium

1 interaction

Avoid/Use Alternative

codeine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lofexidine
codeine/ guaifenesin (generic)

+

lofexidine

1 interaction

Avoid/Use Alternative

codeine + lofexidine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lomitapide
codeine/ guaifenesin (generic)

+

lomitapide

1 interaction

Avoid/Use Alternative

codeine + lomitapide

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lonafarnib
codeine/ guaifenesin (generic)

+

lonafarnib

1 interaction

Avoid/Use Alternative

codeine + lonafarnib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lopinavir/ritonavir
codeine/ guaifenesin (generic)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

codeine + lopinavir/ ritonavir

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• lorazepam
codeine/ guaifenesin (generic)

+

lorazepam

1 interaction

Avoid/Use Alternative

codeine + lorazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lorlatinib
codeine/ guaifenesin (generic)

+

lorlatinib

1 interaction

Avoid/Use Alternative

codeine + lorlatinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• lovastatin
codeine/ guaifenesin (generic)

+

lovastatin

1 interaction

Avoid/Use Alternative

codeine + lovastatin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• loxapine
codeine/ guaifenesin (generic)

+

loxapine

1 interaction

Avoid/Use Alternative

codeine + loxapine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• lumacaftor/ivacaftor
codeine/ guaifenesin (generic)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

codeine + lumacaftor/ ivacaftor

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• lumateperone
codeine/ guaifenesin (generic)

+

lumateperone

1 interaction

Avoid/Use Alternative

codeine + lumateperone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
codeine/ guaifenesin (generic)

+

lurasidone

1 interaction

Avoid/Use Alternative

codeine + lurasidone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• maribavir
codeine/ guaifenesin (generic)

+

maribavir

1 interaction

Avoid/Use Alternative

codeine + maribavir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• mavacamten
codeine/ guaifenesin (generic)

+

mavacamten

1 interaction

Avoid/Use Alternative

codeine + mavacamten

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• mavorixafor
codeine/ guaifenesin (generic)

+

mavorixafor

1 interaction

Avoid/Use Alternative

codeine + mavorixafor

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• meclizine
codeine/ guaifenesin (generic)

+

meclizine

1 interaction

Avoid/Use Alternative

codeine + meclizine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• melatonin
codeine/ guaifenesin (generic)

+

melatonin

1 interaction

Avoid/Use Alternative

codeine + melatonin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meperidine
codeine/ guaifenesin (generic)

+

meperidine

1 interaction

Avoid/Use Alternative

codeine + meperidine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. meperidine dose 25-50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• meprobamate
codeine/ guaifenesin (generic)

+

meprobamate

1 interaction

Avoid/Use Alternative

codeine + meprobamate

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meropenem
codeine/ guaifenesin (generic)

+

meropenem

1 interaction

Avoid/Use Alternative

codeine + meropenem

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• metaxalone
codeine/ guaifenesin (generic)

+

metaxalone

1 interaction

Avoid/Use Alternative

codeine + metaxalone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
codeine/ guaifenesin (generic)

+

methadone

1 interaction

Avoid/Use Alternative

codeine + methadone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• methamphetamine
codeine/ guaifenesin (generic)

+

methamphetamine

1 interaction

Avoid/Use Alternative

codeine + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methocarbamol
codeine/ guaifenesin (generic)

+

methocarbamol

1 interaction

Avoid/Use Alternative

codeine + methocarbamol

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methohexital
codeine/ guaifenesin (generic)

+

methohexital

1 interaction

Avoid/Use Alternative

codeine + methohexital

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• methsuximide
codeine/ guaifenesin (generic)

+

methsuximide

1 interaction

Avoid/Use Alternative

codeine + methsuximide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• methyldopa
codeine/ guaifenesin (generic)

+

methyldopa

1 interaction

Avoid/Use Alternative

codeine + methyldopa

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• methylergonovine
codeine/ guaifenesin (generic)

+

methylergonovine

1 interaction

Avoid/Use Alternative

codeine + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
codeine/ guaifenesin (generic)

+

methylphenidate

1 interaction

Avoid/Use Alternative

codeine + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
codeine/ guaifenesin (generic)

+

metoclopramide

1 interaction

Avoid/Use Alternative

codeine + metoclopramide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• metyrapone
codeine/ guaifenesin (generic)

+

metyrapone

1 interaction

Avoid/Use Alternative

codeine + metyrapone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• metyrosine
codeine/ guaifenesin (generic)

+

metyrosine

1 interaction

Avoid/Use Alternative

codeine + metyrosine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• midazolam
codeine/ guaifenesin (generic)

+

midazolam

1 interaction

Avoid/Use Alternative

codeine + midazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• mifepristone
codeine/ guaifenesin (generic)

+

mifepristone

1 interaction

Avoid/Use Alternative

codeine + mifepristone

use alternative or monitor resp. rate; consider decr. codeine dose during and x14 days after daily mifepristone use; caution advised if pregnancy termination use: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• milnacipran
codeine/ guaifenesin (generic)

+

milnacipran

1 interaction

Avoid/Use Alternative

codeine + milnacipran

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• mirabegron
codeine/ guaifenesin (generic)

+

mirabegron

1 interaction

Avoid/Use Alternative

codeine + mirabegron

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• mirtazapine
codeine/ guaifenesin (generic)

+

mirtazapine

1 interaction

Avoid/Use Alternative

codeine + mirtazapine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• mitapivat
codeine/ guaifenesin (generic)

+

mitapivat

1 interaction

Avoid/Use Alternative

codeine + mitapivat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• mitotane
codeine/ guaifenesin (generic)

+

mitotane

1 interaction

Avoid/Use Alternative

codeine + mitotane

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• mobocertinib
codeine/ guaifenesin (generic)

+

mobocertinib

1 interaction

Avoid/Use Alternative

codeine + mobocertinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• modafinil
codeine/ guaifenesin (generic)

+

modafinil

1 interaction

Avoid/Use Alternative

codeine + modafinil

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• molindone
codeine/ guaifenesin (generic)

+

molindone

1 interaction

Avoid/Use Alternative

codeine + molindone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• morphine
codeine/ guaifenesin (generic)

+

morphine

1 interaction

Avoid/Use Alternative

codeine + morphine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• mosunetuzumab
codeine/ guaifenesin (generic)

+

mosunetuzumab

1 interaction

Avoid/Use Alternative

codeine + mosunetuzumab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
codeine/ guaifenesin (generic)

+

mycophenolate mofetil

1 interaction

Avoid/Use Alternative

codeine + mycophenolate mofetil

avoid combo if antitussive use; otherwise monitor resp. rate, decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• nafcillin
codeine/ guaifenesin (generic)

+

nafcillin

1 interaction

Avoid/Use Alternative

codeine + nafcillin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• nalbuphine
codeine/ guaifenesin (generic)

+

nalbuphine

1 interaction

Avoid/Use Alternative

codeine + nalbuphine

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent pts; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• naratriptan
codeine/ guaifenesin (generic)

+

naratriptan

1 interaction

Avoid/Use Alternative

codeine + naratriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• nefazodone
codeine/ guaifenesin (generic)

+

nefazodone

1 interaction

Avoid/Use Alternative

codeine + nefazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• nelarabine
codeine/ guaifenesin (generic)

+

nelarabine

1 interaction

Avoid/Use Alternative

codeine + nelarabine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx; withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• nelfinavir
codeine/ guaifenesin (generic)

+

nelfinavir

1 interaction

Avoid/Use Alternative

codeine + nelfinavir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• netupitant
codeine/ guaifenesin (generic)

+

netupitant

1 interaction

Avoid/Use Alternative

codeine + netupitant

use alternative or monitor resp. rate, consider decr. codeine dose during and x1wk after (fos)netupitant tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nevirapine
codeine/ guaifenesin (generic)

+

nevirapine

1 interaction

Avoid/Use Alternative

codeine + nevirapine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• nicardipine
codeine/ guaifenesin (generic)

+

nicardipine

1 interaction

Avoid/Use Alternative

codeine + nicardipine

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• nilotinib
codeine/ guaifenesin (generic)

+

nilotinib

1 interaction

Avoid/Use Alternative

codeine + nilotinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nirogacestat
codeine/ guaifenesin (generic)

+

nirogacestat

1 interaction

Avoid/Use Alternative

codeine + nirogacestat

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nortriptyline
codeine/ guaifenesin (generic)

+

nortriptyline

1 interaction

Avoid/Use Alternative

codeine + nortriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• odevixibat
codeine/ guaifenesin (generic)

+

odevixibat

1 interaction

Avoid/Use Alternative

codeine + odevixibat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• olanzapine
codeine/ guaifenesin (generic)

+

olanzapine

1 interaction

Avoid/Use Alternative

codeine + olanzapine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects (additive effects)

• oliceridine
codeine/ guaifenesin (generic)

+

oliceridine

1 interaction

Avoid/Use Alternative

codeine + oliceridine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• olutasidenib
codeine/ guaifenesin (generic)

+

olutasidenib

1 interaction

Avoid/Use Alternative

codeine + olutasidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• omaveloxolone
codeine/ guaifenesin (generic)

+

omaveloxolone

1 interaction

Avoid/Use Alternative

codeine + omaveloxolone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• ondansetron
codeine/ guaifenesin (generic)

+

ondansetron

1 interaction

Avoid/Use Alternative

codeine + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opicapone
codeine/ guaifenesin (generic)

+

opicapone

1 interaction

Avoid/Use Alternative

codeine + opicapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• opium
codeine/ guaifenesin (generic)

+

opium

1 interaction

Avoid/Use Alternative

codeine + opium

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome (additive effects)

• orphenadrine
codeine/ guaifenesin (generic)

+

orphenadrine

1 interaction

Avoid/Use Alternative

codeine + orphenadrine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• osilodrostat
codeine/ guaifenesin (generic)

+

osilodrostat

1 interaction

Avoid/Use Alternative

codeine + osilodrostat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• oxazepam
codeine/ guaifenesin (generic)

+

oxazepam

1 interaction

Avoid/Use Alternative

codeine + oxazepam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxcarbazepine
codeine/ guaifenesin (generic)

+

oxcarbazepine

1 interaction

Avoid/Use Alternative

codeine + oxcarbazepine

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• oxybate
codeine/ guaifenesin (generic)

+

oxybate

1 interaction

Avoid/Use Alternative

codeine + oxybate

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; consider holding oxybate, especially if peri- or post-operative opioid analgesia required: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxybutynin
codeine/ guaifenesin (generic)

+

oxybutynin

1 interaction

Avoid/Use Alternative

codeine + oxybutynin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs or consider oxybutynin transdermal patch, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxycodone
codeine/ guaifenesin (generic)

+

oxycodone

1 interaction

Avoid/Use Alternative

codeine + oxycodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• oxymorphone
codeine/ guaifenesin (generic)

+

oxymorphone

1 interaction

Avoid/Use Alternative

codeine + oxymorphone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• pacritinib
codeine/ guaifenesin (generic)

+

pacritinib

1 interaction

Avoid/Use Alternative

codeine + pacritinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• palbociclib
codeine/ guaifenesin (generic)

+

palbociclib

1 interaction

Avoid/Use Alternative

codeine + palbociclib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• paliperidone
codeine/ guaifenesin (generic)

+

paliperidone

1 interaction

Avoid/Use Alternative

codeine + paliperidone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• palonosetron
codeine/ guaifenesin (generic)

+

palonosetron

1 interaction

Avoid/Use Alternative

codeine + palonosetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• panobinostat
codeine/ guaifenesin (generic)

+

panobinostat

1 interaction

Avoid/Use Alternative

codeine + panobinostat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• paroxetine
codeine/ guaifenesin (generic)

+

paroxetine

1 interaction

Avoid/Use Alternative

codeine + paroxetine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• passion flower
codeine/ guaifenesin (generic)

+

passion flower

1 interaction

Avoid/Use Alternative

codeine + passion flower

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• pazopanib
codeine/ guaifenesin (generic)

+

pazopanib

1 interaction

Avoid/Use Alternative

codeine + pazopanib

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• pentazocine
codeine/ guaifenesin (generic)

+

pentazocine

1 interaction

Avoid/Use Alternative

codeine + pentazocine

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent pts; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• pentobarbital
codeine/ guaifenesin (generic)

+

pentobarbital

1 interaction

Avoid/Use Alternative

codeine + pentobarbital

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, BP; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• peppermint
codeine/ guaifenesin (generic)

+

peppermint

1 interaction

Avoid/Use Alternative

codeine + peppermint

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• perampanel
codeine/ guaifenesin (generic)

+

perampanel

1 interaction

Avoid/Use Alternative

codeine + perampanel

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy if on perampanel 12 mg/day; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• perphenazine
codeine/ guaifenesin (generic)

+

perphenazine

1 interaction

Avoid/Use Alternative

codeine + perphenazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pexidartinib
codeine/ guaifenesin (generic)

+

pexidartinib

1 interaction

Avoid/Use Alternative

codeine + pexidartinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• pheniramine
codeine/ guaifenesin (generic)

+

pheniramine

1 interaction

Avoid/Use Alternative

codeine + pheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• phenobarbital
codeine/ guaifenesin (generic)

+

phenobarbital

1 interaction

Avoid/Use Alternative

codeine + phenobarbital

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• phenytoin
codeine/ guaifenesin (generic)

+

phenytoin

1 interaction

Avoid/Use Alternative

codeine + phenytoin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• pibrentasvir
codeine/ guaifenesin (generic)

+

pibrentasvir

1 interaction

Avoid/Use Alternative

codeine + pibrentasvir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• pimozide
codeine/ guaifenesin (generic)

+

pimozide

1 interaction

Avoid/Use Alternative

codeine + pimozide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pioglitazone
codeine/ guaifenesin (generic)

+

pioglitazone

1 interaction

Avoid/Use Alternative

codeine + pioglitazone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• pirtobrutinib
codeine/ guaifenesin (generic)

+

pirtobrutinib

1 interaction

Avoid/Use Alternative

codeine + pirtobrutinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• posaconazole
codeine/ guaifenesin (generic)

+

posaconazole

1 interaction

Avoid/Use Alternative

codeine + posaconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• pramipexole
codeine/ guaifenesin (generic)

+

pramipexole

1 interaction

Avoid/Use Alternative

codeine + pramipexole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• pramlintide
codeine/ guaifenesin (generic)

+

pramlintide

1 interaction

Avoid/Use Alternative

codeine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• prasugrel
codeine/ guaifenesin (generic)

+

prasugrel

1 interaction

Avoid/Use Alternative

codeine + prasugrel

consider alternative parenteral antiplatelet agent for acute tx of ACS; otherwise, caution advised: combo may decr. prasugrel active metabolite levels, efficacy (absorption of prasugrel possibly affected by delayed gastric emptying)

• prednisone
codeine/ guaifenesin (generic)

+

prednisone

1 interaction

Avoid/Use Alternative

codeine + prednisone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• pregabalin
codeine/ guaifenesin (generic)

+

pregabalin

1 interaction

Avoid/Use Alternative

codeine + pregabalin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• primidone
codeine/ guaifenesin (generic)

+

primidone

1 interaction

Avoid/Use Alternative

codeine + primidone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• prochlorperazine
codeine/ guaifenesin (generic)

+

prochlorperazine

1 interaction

Avoid/Use Alternative

codeine + prochlorperazine

avoid combo if antitussive use; otherwise consider alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• promethazine
codeine/ guaifenesin (generic)

+

promethazine

1 interaction

Avoid/Use Alternative

codeine + promethazine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. codeine dose by at least 25-50%, consider decr. promethazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, seizures, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• propafenone
codeine/ guaifenesin (generic)

+

propafenone

1 interaction

Avoid/Use Alternative

codeine + propafenone

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine, additive effects)

• propofol
codeine/ guaifenesin (generic)

+

propofol

1 interaction

Avoid/Use Alternative

codeine + propofol

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• propranolol
codeine/ guaifenesin (generic)

+

propranolol

1 interaction

Avoid/Use Alternative

codeine + propranolol

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• protriptyline
codeine/ guaifenesin (generic)

+

protriptyline

1 interaction

Avoid/Use Alternative

codeine + protriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pyrilamine
codeine/ guaifenesin (generic)

+

pyrilamine

1 interaction

Avoid/Use Alternative

codeine + pyrilamine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• quazepam
codeine/ guaifenesin (generic)

+

quazepam

1 interaction

Avoid/Use Alternative

codeine + quazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• quercetin
codeine/ guaifenesin (generic)

+

quercetin

1 interaction

Avoid/Use Alternative

codeine + quercetin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• quetiapine
codeine/ guaifenesin (generic)

+

quetiapine

1 interaction

Avoid/Use Alternative

codeine + quetiapine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• quinidine (antiarrhythmic)
codeine/ guaifenesin (generic)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

codeine + quinidine (antiarrhythmic)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• quinidine (CYP2D6 inhibitor)
codeine/ guaifenesin (generic)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Avoid/Use Alternative

codeine + quinidine (CYP2D6 inhibitor)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ramelteon
codeine/ guaifenesin (generic)

+

ramelteon

1 interaction

Avoid/Use Alternative

codeine + ramelteon

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ranolazine
codeine/ guaifenesin (generic)

+

ranolazine

1 interaction

Avoid/Use Alternative

codeine + ranolazine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• remdesivir
codeine/ guaifenesin (generic)

+

remdesivir

1 interaction

Avoid/Use Alternative

codeine + remdesivir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• remifentanil
codeine/ guaifenesin (generic)

+

remifentanil

1 interaction

Avoid/Use Alternative

codeine + remifentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• remimazolam
codeine/ guaifenesin (generic)

+

remimazolam

1 interaction

Avoid/Use Alternative

codeine + remimazolam

avoid combo if antitussive use; otherwise use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of severe hypotension (incl. orthostasis, syncope), profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
codeine/ guaifenesin (generic)

+

repotrectinib

1 interaction

Avoid/Use Alternative

codeine + repotrectinib

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• resveratrol
codeine/ guaifenesin (generic)

+

resveratrol

1 interaction

Avoid/Use Alternative

codeine + resveratrol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• revefenacin inhaled
codeine/ guaifenesin (generic)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

codeine + revefenacin inhaled

consider alternative: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• ribociclib
codeine/ guaifenesin (generic)

+

ribociclib

1 interaction

Avoid/Use Alternative

codeine + ribociclib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• rifabutin
codeine/ guaifenesin (generic)

+

rifabutin

1 interaction

Avoid/Use Alternative

codeine + rifabutin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• rifampin
codeine/ guaifenesin (generic)

+

rifampin

1 interaction

Avoid/Use Alternative

codeine + rifampin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• rifapentine
codeine/ guaifenesin (generic)

+

rifapentine

1 interaction

Avoid/Use Alternative

codeine + rifapentine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• risperidone
codeine/ guaifenesin (generic)

+

risperidone

1 interaction

Avoid/Use Alternative

codeine + risperidone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ritlecitinib
codeine/ guaifenesin (generic)

+

ritlecitinib

1 interaction

Avoid/Use Alternative

codeine + ritlecitinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ritonavir
codeine/ guaifenesin (generic)

+

ritonavir

1 interaction

Avoid/Use Alternative

codeine + ritonavir

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• rizatriptan
codeine/ guaifenesin (generic)

+

rizatriptan

1 interaction

Avoid/Use Alternative

codeine + rizatriptan

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• rolapitant
codeine/ guaifenesin (generic)

+

rolapitant

1 interaction

Avoid/Use Alternative

codeine + rolapitant

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ropeginterferon alfa-2b
codeine/ guaifenesin (generic)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

codeine + ropeginterferon alfa-2b

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ropinirole
codeine/ guaifenesin (generic)

+

ropinirole

1 interaction

Avoid/Use Alternative

codeine + ropinirole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• rotigotine transdermal
codeine/ guaifenesin (generic)

+

rotigotine transdermal

1 interaction

Avoid/Use Alternative

codeine + rotigotine transdermal

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• rucaparib
codeine/ guaifenesin (generic)

+

rucaparib

1 interaction

Avoid/Use Alternative

codeine + rucaparib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• rufinamide
codeine/ guaifenesin (generic)

+

rufinamide

1 interaction

Avoid/Use Alternative

codeine + rufinamide

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• SAMe
codeine/ guaifenesin (generic)

+

SAMe

1 interaction

Avoid/Use Alternative

codeine + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sarilumab
codeine/ guaifenesin (generic)

+

sarilumab

1 interaction

Avoid/Use Alternative

codeine + sarilumab

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered; sarilumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes upon tx start and downregulation upon D/C)

• scopolamine
codeine/ guaifenesin (generic)

+

scopolamine

1 interaction

Avoid/Use Alternative

codeine + scopolamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• selinexor
codeine/ guaifenesin (generic)

+

selinexor

1 interaction

Avoid/Use Alternative

codeine + selinexor

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• selpercatinib
codeine/ guaifenesin (generic)

+

selpercatinib

1 interaction

Avoid/Use Alternative

codeine + selpercatinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• sertraline
codeine/ guaifenesin (generic)

+

sertraline

1 interaction

Avoid/Use Alternative

codeine + sertraline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• sevoflurane
codeine/ guaifenesin (generic)

+

sevoflurane

1 interaction

Avoid/Use Alternative

codeine + sevoflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• solifenacin
codeine/ guaifenesin (generic)

+

solifenacin

1 interaction

Avoid/Use Alternative

codeine + solifenacin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of severe constipation, paralytic ileus, urinary retention, profound CNS and resp. depression, psychomotor impairment (additive effects)

• somatropin
codeine/ guaifenesin (generic)

+

somatropin

1 interaction

Avoid/Use Alternative

codeine + somatropin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• sotorasib
codeine/ guaifenesin (generic)

+

sotorasib

1 interaction

Avoid/Use Alternative

codeine + sotorasib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• spironolactone
codeine/ guaifenesin (generic)

+

spironolactone

1 interaction

Avoid/Use Alternative

codeine + spironolactone

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. spironolactone efficacy (hepatic metab. possibly inhibited, may incr. production of active metabolite morphine; additive effects; antagonistic effects, opioids may induce antidiuretic hormone release)

• St. John's wort
codeine/ guaifenesin (generic)

+

St. John's wort

1 interaction

Avoid/Use Alternative

codeine + St. John's wort

use alternative or monitor withdrawal sx, serotonin syndrome sx, especially during initiation/titration: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• stiripentol
codeine/ guaifenesin (generic)

+

stiripentol

1 interaction

Avoid/Use Alternative

codeine + stiripentol

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy; may alter seizure control (hepatic metab. possibly altered, may incr. or decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• sufentanil
codeine/ guaifenesin (generic)

+

sufentanil

1 interaction

Avoid/Use Alternative

codeine + sufentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. sufentanil start dose, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• sumatriptan
codeine/ guaifenesin (generic)

+

sumatriptan

1 interaction

Avoid/Use Alternative

codeine + sumatriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• sunvozertinib
codeine/ guaifenesin (generic)

+

sunvozertinib

1 interaction

Avoid/Use Alternative

codeine + sunvozertinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• suvorexant
codeine/ guaifenesin (generic)

+

suvorexant

1 interaction

Avoid/Use Alternative

codeine + suvorexant

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• suzetrigine
codeine/ guaifenesin (generic)

+

suzetrigine

1 interaction

Avoid/Use Alternative

codeine + suzetrigine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tapentadol
codeine/ guaifenesin (generic)

+

tapentadol

1 interaction

Avoid/Use Alternative

codeine + tapentadol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• tasimelteon
codeine/ guaifenesin (generic)

+

tasimelteon

1 interaction

Avoid/Use Alternative

codeine + tasimelteon

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tazemetostat
codeine/ guaifenesin (generic)

+

tazemetostat

1 interaction

Avoid/Use Alternative

codeine + tazemetostat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tecovirimat
codeine/ guaifenesin (generic)

+

tecovirimat

1 interaction

Avoid/Use Alternative

codeine + tecovirimat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• telotristat ethyl
codeine/ guaifenesin (generic)

+

telotristat ethyl

1 interaction

Avoid/Use Alternative

codeine + telotristat ethyl

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• temazepam
codeine/ guaifenesin (generic)

+

temazepam

1 interaction

Avoid/Use Alternative

codeine + temazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• terbinafine
codeine/ guaifenesin (generic)

+

terbinafine

1 interaction

Avoid/Use Alternative

codeine + terbinafine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• tetrabenazine
codeine/ guaifenesin (generic)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

codeine + tetrabenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• thalidomide
codeine/ guaifenesin (generic)

+

thalidomide

1 interaction

Avoid/Use Alternative

codeine + thalidomide

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• thioridazine
codeine/ guaifenesin (generic)

+

thioridazine

1 interaction

Avoid/Use Alternative

codeine + thioridazine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• thiotepa
codeine/ guaifenesin (generic)

+

thiotepa

1 interaction

Avoid/Use Alternative

codeine + thiotepa

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• thiothixene
codeine/ guaifenesin (generic)

+

thiothixene

1 interaction

Avoid/Use Alternative

codeine + thiothixene

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• tiagabine
codeine/ guaifenesin (generic)

+

tiagabine

1 interaction

Avoid/Use Alternative

codeine + tiagabine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• ticagrelor
codeine/ guaifenesin (generic)

+

ticagrelor

1 interaction

Avoid/Use Alternative

codeine + ticagrelor

use alternative or monitor resp. rate, consider decr. codeine dose; consider alternative parenteral antiplatelet agent for acute tx of ACS: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. ticagrelor and active metabolite levels, efficacy (hepatic metab. inhibited, may incr. production of active metabolite morphine; absorption of ticagrelor possibly affected by delayed gastric emptying)

• tipranavir
codeine/ guaifenesin (generic)

+

tipranavir

1 interaction

Avoid/Use Alternative

codeine + tipranavir

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• tizanidine
codeine/ guaifenesin (generic)

+

tizanidine

1 interaction

Avoid/Use Alternative

codeine + tizanidine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tocilizumab
codeine/ guaifenesin (generic)

+

tocilizumab

1 interaction

Avoid/Use Alternative

codeine + tocilizumab

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered; tocilizumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes)

• tolcapone
codeine/ guaifenesin (generic)

+

tolcapone

1 interaction

Avoid/Use Alternative

codeine + tolcapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tolterodine
codeine/ guaifenesin (generic)

+

tolterodine

1 interaction

Avoid/Use Alternative

codeine + tolterodine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• tolvaptan
codeine/ guaifenesin (generic)

+

tolvaptan

1 interaction

Avoid/Use Alternative

codeine + tolvaptan

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• topiramate
codeine/ guaifenesin (generic)

+

topiramate

1 interaction

Avoid/Use Alternative

codeine + topiramate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo w/ topiramate doses >200 mg/day may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• tovorafenib
codeine/ guaifenesin (generic)

+

tovorafenib

1 interaction

Avoid/Use Alternative

codeine + tovorafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tramadol
codeine/ guaifenesin (generic)

+

tramadol

1 interaction

Avoid/Use Alternative

codeine + tramadol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• trazodone
codeine/ guaifenesin (generic)

+

trazodone

1 interaction

Avoid/Use Alternative

codeine + trazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome (additive effects)

• treosulfan
codeine/ guaifenesin (generic)

+

treosulfan

1 interaction

Avoid/Use Alternative

codeine + treosulfan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects (hepatic metab. possibly inhibited, may incr. production of active metabolite morphine; additive effects)

• triazolam
codeine/ guaifenesin (generic)

+

triazolam

1 interaction

Avoid/Use Alternative

codeine + triazolam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• trifluoperazine
codeine/ guaifenesin (generic)

+

trifluoperazine

1 interaction

Avoid/Use Alternative

codeine + trifluoperazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• trihexyphenidyl
codeine/ guaifenesin (generic)

+

trihexyphenidyl

1 interaction

Avoid/Use Alternative

codeine + trihexyphenidyl

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• trimethobenzamide
codeine/ guaifenesin (generic)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

codeine + trimethobenzamide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trimipramine
codeine/ guaifenesin (generic)

+

trimipramine

1 interaction

Avoid/Use Alternative

codeine + trimipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• triprolidine
codeine/ guaifenesin (generic)

+

triprolidine

1 interaction

Avoid/Use Alternative

codeine + triprolidine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• trofinetide
codeine/ guaifenesin (generic)

+

trofinetide

1 interaction

Avoid/Use Alternative

codeine + trofinetide

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• trospium
codeine/ guaifenesin (generic)

+

trospium

1 interaction

Avoid/Use Alternative

codeine + trospium

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• tucatinib
codeine/ guaifenesin (generic)

+

tucatinib

1 interaction

Avoid/Use Alternative

codeine + tucatinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• upadacitinib
codeine/ guaifenesin (generic)

+

upadacitinib

1 interaction

Avoid/Use Alternative

codeine + upadacitinib

use alternative or monitor resp. rate, withdrawal sx if taking upadacitinib dose 45 mg qd: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• vaborbactam
codeine/ guaifenesin (generic)

+

vaborbactam

1 interaction

Avoid/Use Alternative

codeine + vaborbactam

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• valbenazine
codeine/ guaifenesin (generic)

+

valbenazine

1 interaction

Avoid/Use Alternative

codeine + valbenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valerian
codeine/ guaifenesin (generic)

+

valerian

1 interaction

Avoid/Use Alternative

codeine + valerian

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valproic acid
codeine/ guaifenesin (generic)

+

valproic acid

1 interaction

Avoid/Use Alternative

codeine + valproic acid

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• vamorolone
codeine/ guaifenesin (generic)

+

vamorolone

1 interaction

Avoid/Use Alternative

codeine + vamorolone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• vemurafenib
codeine/ guaifenesin (generic)

+

vemurafenib

1 interaction

Avoid/Use Alternative

codeine + vemurafenib

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and decr. active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may decr. production of active metabolite morphine)

• venlafaxine
codeine/ guaifenesin (generic)

+

venlafaxine

1 interaction

Avoid/Use Alternative

codeine + venlafaxine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• verapamil
codeine/ guaifenesin (generic)

+

verapamil

1 interaction

Avoid/Use Alternative

codeine + verapamil

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• vigabatrin
codeine/ guaifenesin (generic)

+

vigabatrin

1 interaction

Avoid/Use Alternative

codeine + vigabatrin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• vilazodone
codeine/ guaifenesin (generic)

+

vilazodone

1 interaction

Avoid/Use Alternative

codeine + vilazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• viloxazine
codeine/ guaifenesin (generic)

+

viloxazine

1 interaction

Avoid/Use Alternative

codeine + viloxazine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• vinblastine
codeine/ guaifenesin (generic)

+

vinblastine

1 interaction

Avoid/Use Alternative

codeine + vinblastine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• vonoprazan
codeine/ guaifenesin (generic)

+

vonoprazan

1 interaction

Avoid/Use Alternative

codeine + vonoprazan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• vorasidenib
codeine/ guaifenesin (generic)

+

vorasidenib

1 interaction

Avoid/Use Alternative

codeine + vorasidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• voriconazole
codeine/ guaifenesin (generic)

+

voriconazole

1 interaction

Avoid/Use Alternative

codeine + voriconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• vortioxetine
codeine/ guaifenesin (generic)

+

vortioxetine

1 interaction

Avoid/Use Alternative

codeine + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• voxelotor
codeine/ guaifenesin (generic)

+

voxelotor

1 interaction

Avoid/Use Alternative

codeine + voxelotor

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• xanomeline
codeine/ guaifenesin (generic)

+

xanomeline

1 interaction

Avoid/Use Alternative

codeine + xanomeline

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. possibly inhibited, may incr. production of active metabolite morphine)

• zaleplon
codeine/ guaifenesin (generic)

+

zaleplon

1 interaction

Avoid/Use Alternative

codeine + zaleplon

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zanubrutinib
codeine/ guaifenesin (generic)

+

zanubrutinib

1 interaction

Avoid/Use Alternative

codeine + zanubrutinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• ziconotide
codeine/ guaifenesin (generic)

+

ziconotide

1 interaction

Avoid/Use Alternative

codeine + ziconotide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zileuton
codeine/ guaifenesin (generic)

+

zileuton

1 interaction

Avoid/Use Alternative

codeine + zileuton

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ziprasidone
codeine/ guaifenesin (generic)

+

ziprasidone

1 interaction

Avoid/Use Alternative

codeine + ziprasidone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• zolmitriptan
codeine/ guaifenesin (generic)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

codeine + zolmitriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• zolpidem
codeine/ guaifenesin (generic)

+

zolpidem

1 interaction

Avoid/Use Alternative

codeine + zolpidem

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zonisamide
codeine/ guaifenesin (generic)

+

zonisamide

1 interaction

Avoid/Use Alternative

codeine + zonisamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• zuranolone
codeine/ guaifenesin (generic)

+

zuranolone

1 interaction

Avoid/Use Alternative

codeine + zuranolone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• acebutolol
codeine/ guaifenesin (generic)

+

acebutolol

1 interaction

Monitor/Modify Tx

codeine + acebutolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• alfuzosin
codeine/ guaifenesin (generic)

+

alfuzosin

1 interaction

Monitor/Modify Tx

codeine + alfuzosin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• aliskiren
codeine/ guaifenesin (generic)

+

aliskiren

1 interaction

Monitor/Modify Tx

codeine + aliskiren

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• amifostine
codeine/ guaifenesin (generic)

+

amifostine

1 interaction

Monitor/Modify Tx

codeine + amifostine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• amiloride
codeine/ guaifenesin (generic)

+

amiloride

1 interaction

Monitor/Modify Tx

codeine + amiloride

monitor BP: combo may decr. amiloride efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• aprocitentan
codeine/ guaifenesin (generic)

+

aprocitentan

1 interaction

Monitor/Modify Tx

codeine + aprocitentan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• articaine
codeine/ guaifenesin (generic)

+

articaine

1 interaction

Monitor/Modify Tx

codeine + articaine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• atenolol
codeine/ guaifenesin (generic)

+

atenolol

1 interaction

Monitor/Modify Tx

codeine + atenolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• atracurium
codeine/ guaifenesin (generic)

+

atracurium

1 interaction

Monitor/Modify Tx

codeine + atracurium

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of resp. depression, potentiate, prolong neuromuscular blockade (additive effects)

• avanafil
codeine/ guaifenesin (generic)

+

avanafil

1 interaction

Monitor/Modify Tx

codeine + avanafil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• azilsartan medoxomil
codeine/ guaifenesin (generic)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

codeine + azilsartan medoxomil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• benazepril
codeine/ guaifenesin (generic)

+

benazepril

1 interaction

Monitor/Modify Tx

codeine + benazepril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• betaxolol
codeine/ guaifenesin (generic)

+

betaxolol

1 interaction

Monitor/Modify Tx

codeine + betaxolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• betaxolol ophthalmic
codeine/ guaifenesin (generic)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

codeine + betaxolol ophthalmic

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bethanechol
codeine/ guaifenesin (generic)

+

bethanechol

1 interaction

Monitor/Modify Tx

codeine + bethanechol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bexagliflozin
codeine/ guaifenesin (generic)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

codeine + bexagliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bisoprolol
codeine/ guaifenesin (generic)

+

bisoprolol

1 interaction

Monitor/Modify Tx

codeine + bisoprolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bortezomib
codeine/ guaifenesin (generic)

+

bortezomib

1 interaction

Monitor/Modify Tx

codeine + bortezomib

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bumetanide
codeine/ guaifenesin (generic)

+

bumetanide

1 interaction

Monitor/Modify Tx

codeine + bumetanide

monitor BP: combo may decr. bumetanide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• bupivacaine
codeine/ guaifenesin (generic)

+

bupivacaine

1 interaction

Monitor/Modify Tx

codeine + bupivacaine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• bupivacaine liposomal
codeine/ guaifenesin (generic)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

codeine + bupivacaine liposomal

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• cabergoline
codeine/ guaifenesin (generic)

+

cabergoline

1 interaction

Monitor/Modify Tx

codeine + cabergoline

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• canagliflozin
codeine/ guaifenesin (generic)

+

canagliflozin

1 interaction

Monitor/Modify Tx

codeine + canagliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• candesartan cilexetil
codeine/ guaifenesin (generic)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

codeine + candesartan cilexetil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• captopril
codeine/ guaifenesin (generic)

+

captopril

1 interaction

Monitor/Modify Tx

codeine + captopril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• carteolol ophthalmic
codeine/ guaifenesin (generic)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

codeine + carteolol ophthalmic

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• carvedilol
codeine/ guaifenesin (generic)

+

carvedilol

1 interaction

Monitor/Modify Tx

codeine + carvedilol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• chloroprocaine
codeine/ guaifenesin (generic)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

codeine + chloroprocaine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• chlorothiazide
codeine/ guaifenesin (generic)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

codeine + chlorothiazide

monitor BP: combo may decr. chlorothiazide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• chlorthalidone
codeine/ guaifenesin (generic)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

codeine + chlorthalidone

monitor BP: combo may decr. chlorthalidone efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects; antagonistic effects, opioids may induce antidiuretic hormone release)

• cisatracurium
codeine/ guaifenesin (generic)

+

cisatracurium

1 interaction

Monitor/Modify Tx

codeine + cisatracurium

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of resp. depression, potentiate, prolong neuromuscular blockade (additive effects)

• clevidipine
codeine/ guaifenesin (generic)

+

clevidipine

1 interaction

Monitor/Modify Tx

codeine + clevidipine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• clofarabine
codeine/ guaifenesin (generic)

+

clofarabine

1 interaction

Monitor/Modify Tx

codeine + clofarabine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• coenzyme Q-10
codeine/ guaifenesin (generic)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

codeine + coenzyme Q-10

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• dapagliflozin
codeine/ guaifenesin (generic)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

codeine + dapagliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• denileukin diftitox
codeine/ guaifenesin (generic)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

codeine + denileukin diftitox

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• desmopressin
codeine/ guaifenesin (generic)

+

desmopressin

1 interaction

Monitor/Modify Tx

codeine + desmopressin

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• dinutuximab
codeine/ guaifenesin (generic)

+

dinutuximab

1 interaction

Monitor/Modify Tx

codeine + dinutuximab

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• dipyridamole
codeine/ guaifenesin (generic)

+

dipyridamole

1 interaction

Monitor/Modify Tx

codeine + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• doxazosin
codeine/ guaifenesin (generic)

+

doxazosin

1 interaction

Monitor/Modify Tx

codeine + doxazosin

monitor BP, especially during doxazosin initiation/titration: combo may incr. doxazosin levels, risk of severe hypotension (incl. orthostasis, syncope), other adverse effects (additive effects)

• empagliflozin
codeine/ guaifenesin (generic)

+

empagliflozin

1 interaction

Monitor/Modify Tx

codeine + empagliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• enalapril
codeine/ guaifenesin (generic)

+

enalapril

1 interaction

Monitor/Modify Tx

codeine + enalapril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• enalaprilat
codeine/ guaifenesin (generic)

+

enalaprilat

1 interaction

Monitor/Modify Tx

codeine + enalaprilat

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• eplerenone
codeine/ guaifenesin (generic)

+

eplerenone

1 interaction

Monitor/Modify Tx

codeine + eplerenone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• epoprostenol
codeine/ guaifenesin (generic)

+

epoprostenol

1 interaction

Monitor/Modify Tx

codeine + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ertugliflozin
codeine/ guaifenesin (generic)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

codeine + ertugliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• esmolol
codeine/ guaifenesin (generic)

+

esmolol

1 interaction

Monitor/Modify Tx

codeine + esmolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ethacrynic acid
codeine/ guaifenesin (generic)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

codeine + ethacrynic acid

monitor BP: combo may decr. ethacrynic acid efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• fenoldopam
codeine/ guaifenesin (generic)

+

fenoldopam

1 interaction

Monitor/Modify Tx

codeine + fenoldopam

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ferumoxytol
codeine/ guaifenesin (generic)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

codeine + ferumoxytol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• flaxseed
codeine/ guaifenesin (generic)

+

flaxseed

1 interaction

Monitor/Modify Tx

codeine + flaxseed

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• fosinopril
codeine/ guaifenesin (generic)

+

fosinopril

1 interaction

Monitor/Modify Tx

codeine + fosinopril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• furosemide
codeine/ guaifenesin (generic)

+

furosemide

1 interaction

Monitor/Modify Tx

codeine + furosemide

monitor BP: combo may decr. furosemide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• gilteritinib
codeine/ guaifenesin (generic)

+

gilteritinib

1 interaction

Monitor/Modify Tx

codeine + gilteritinib

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• hydrochlorothiazide
codeine/ guaifenesin (generic)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

codeine + hydrochlorothiazide

monitor BP: combo may decr. hydrochlorothiazide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• iloprost
codeine/ guaifenesin (generic)

+

iloprost

1 interaction

Monitor/Modify Tx

codeine + iloprost

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• iloprost inhaled
codeine/ guaifenesin (generic)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

codeine + iloprost inhaled

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• indapamide
codeine/ guaifenesin (generic)

+

indapamide

1 interaction

Monitor/Modify Tx

codeine + indapamide

monitor BP: combo may decr. indapamide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• iopamidol
codeine/ guaifenesin (generic)

+

iopamidol

1 interaction

Monitor/Modify Tx

codeine + iopamidol

caution advised if intrathecal iopamidol use; consider holding codeine at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• irbesartan
codeine/ guaifenesin (generic)

+

irbesartan

1 interaction

Monitor/Modify Tx

codeine + irbesartan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• iron sucrose
codeine/ guaifenesin (generic)

+

iron sucrose

1 interaction

Monitor/Modify Tx

codeine + iron sucrose

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isosorbide dinitrate
codeine/ guaifenesin (generic)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

codeine + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isosorbide mononitrate
codeine/ guaifenesin (generic)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

codeine + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isradipine
codeine/ guaifenesin (generic)

+

isradipine

1 interaction

Monitor/Modify Tx

codeine + isradipine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• landiolol
codeine/ guaifenesin (generic)

+

landiolol

1 interaction

Monitor/Modify Tx

codeine + landiolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• levobunolol ophthalmic
codeine/ guaifenesin (generic)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

codeine + levobunolol ophthalmic

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• lidocaine
codeine/ guaifenesin (generic)

+

lidocaine

1 interaction

Monitor/Modify Tx

codeine + lidocaine

monitor BP, HR: combo may incr. risk of bradycardia, severe hypotension, incl. orthostasis, syncope (additive effects)

• lisinopril
codeine/ guaifenesin (generic)

+

lisinopril

1 interaction

Monitor/Modify Tx

codeine + lisinopril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• losartan
codeine/ guaifenesin (generic)

+

losartan

1 interaction

Monitor/Modify Tx

codeine + losartan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• lubiprostone
codeine/ guaifenesin (generic)

+

lubiprostone

1 interaction

Monitor/Modify Tx

codeine + lubiprostone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• magnesium sulfate
codeine/ guaifenesin (generic)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

codeine + magnesium sulfate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• mannitol
codeine/ guaifenesin (generic)

+

mannitol

1 interaction

Monitor/Modify Tx

codeine + mannitol

monitor BP, consider incr. mannitol dose: combo may decr. mannitol efficacy (antagonistic effects, opioids may induce antidiuretic hormone release)

• maraviroc
codeine/ guaifenesin (generic)

+

maraviroc

1 interaction

Monitor/Modify Tx

codeine + maraviroc

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• mepivacaine
codeine/ guaifenesin (generic)

+

mepivacaine

1 interaction

Monitor/Modify Tx

codeine + mepivacaine

monitor BP, HR: combo may incr. risk of bradycardia, severe hypotension, incl. orthostasis, syncope (additive effects)

• metolazone
codeine/ guaifenesin (generic)

+

metolazone

1 interaction

Monitor/Modify Tx

codeine + metolazone

monitor BP: combo may decr. metolazone efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• metoprolol
codeine/ guaifenesin (generic)

+

metoprolol

1 interaction

Monitor/Modify Tx

codeine + metoprolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• milrinone
codeine/ guaifenesin (generic)

+

milrinone

1 interaction

Monitor/Modify Tx

codeine + milrinone

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• minoxidil
codeine/ guaifenesin (generic)

+

minoxidil

1 interaction

Monitor/Modify Tx

codeine + minoxidil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• moexipril
codeine/ guaifenesin (generic)

+

moexipril

1 interaction

Monitor/Modify Tx

codeine + moexipril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nadolol
codeine/ guaifenesin (generic)

+

nadolol

1 interaction

Monitor/Modify Tx

codeine + nadolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nattokinase
codeine/ guaifenesin (generic)

+

nattokinase

1 interaction

Monitor/Modify Tx

codeine + nattokinase

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• naxitamab
codeine/ guaifenesin (generic)

+

naxitamab

1 interaction

Monitor/Modify Tx

codeine + naxitamab

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nebivolol
codeine/ guaifenesin (generic)

+

nebivolol

1 interaction

Monitor/Modify Tx

codeine + nebivolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• niacin (vitamin B3)
codeine/ guaifenesin (generic)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

codeine + niacin (vitamin B3)

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nifedipine
codeine/ guaifenesin (generic)

+

nifedipine

1 interaction

Monitor/Modify Tx

codeine + nifedipine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nimodipine
codeine/ guaifenesin (generic)

+

nimodipine

1 interaction

Monitor/Modify Tx

codeine + nimodipine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nisoldipine
codeine/ guaifenesin (generic)

+

nisoldipine

1 interaction

Monitor/Modify Tx

codeine + nisoldipine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nitric oxide
codeine/ guaifenesin (generic)

+

nitric oxide

1 interaction

Monitor/Modify Tx

codeine + nitric oxide

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nitrite
codeine/ guaifenesin (generic)

+

nitrite

1 interaction

Monitor/Modify Tx

codeine + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• nitroglycerin
codeine/ guaifenesin (generic)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

codeine + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nitroprusside
codeine/ guaifenesin (generic)

+

nitroprusside

1 interaction

Monitor/Modify Tx

codeine + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• olmesartan medoxomil
codeine/ guaifenesin (generic)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

codeine + olmesartan medoxomil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• palopegteriparatide
codeine/ guaifenesin (generic)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

codeine + palopegteriparatide

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• pamabrom
codeine/ guaifenesin (generic)

+

pamabrom

1 interaction

Monitor/Modify Tx

codeine + pamabrom

monitor BP, consider incr. pamabrom dose: combo may decr. pamabrom efficacy (antagonistic effects, opioids may induce antidiuretic hormone release)

• pegvisomant
codeine/ guaifenesin (generic)

+

pegvisomant

1 interaction

Monitor/Modify Tx

codeine + pegvisomant

monitor IGF-1 levels, consider incr. pegvisomant dose: combo may decr. response to pegvisomant (mechanism unknown)

• pentamidine
codeine/ guaifenesin (generic)

+

pentamidine

1 interaction

Monitor/Modify Tx

codeine + pentamidine

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• perindopril
codeine/ guaifenesin (generic)

+

perindopril

1 interaction

Monitor/Modify Tx

codeine + perindopril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• phenoxybenzamine
codeine/ guaifenesin (generic)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

codeine + phenoxybenzamine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• phentolamine
codeine/ guaifenesin (generic)

+

phentolamine

1 interaction

Monitor/Modify Tx

codeine + phentolamine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• pindolol
codeine/ guaifenesin (generic)

+

pindolol

1 interaction

Monitor/Modify Tx

codeine + pindolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• prazosin
codeine/ guaifenesin (generic)

+

prazosin

1 interaction

Monitor/Modify Tx

codeine + prazosin

monitor BP, especially during prazosin initiation/titration: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• quinapril
codeine/ guaifenesin (generic)

+

quinapril

1 interaction

Monitor/Modify Tx

codeine + quinapril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ramipril
codeine/ guaifenesin (generic)

+

ramipril

1 interaction

Monitor/Modify Tx

codeine + ramipril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• riociguat
codeine/ guaifenesin (generic)

+

riociguat

1 interaction

Monitor/Modify Tx

codeine + riociguat

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• rocuronium
codeine/ guaifenesin (generic)

+

rocuronium

1 interaction

Monitor/Modify Tx

codeine + rocuronium

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of resp. depression, potentiate, prolong neuromuscular blockade (additive effects)

• ropivacaine
codeine/ guaifenesin (generic)

+

ropivacaine

1 interaction

Monitor/Modify Tx

codeine + ropivacaine

monitor BP, HR: combo may incr. risk of severe hypotension (incl. orthostasis, syncope), bradycardia (additive effects)

• sacubitril
codeine/ guaifenesin (generic)

+

sacubitril

1 interaction

Monitor/Modify Tx

codeine + sacubitril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sildenafil
codeine/ guaifenesin (generic)

+

sildenafil

1 interaction

Monitor/Modify Tx

codeine + sildenafil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• silodosin
codeine/ guaifenesin (generic)

+

silodosin

1 interaction

Monitor/Modify Tx

codeine + silodosin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sodium ferric gluconate complex
codeine/ guaifenesin (generic)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

codeine + sodium ferric gluconate complex

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sotagliflozin
codeine/ guaifenesin (generic)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

codeine + sotagliflozin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sotalol
codeine/ guaifenesin (generic)

+

sotalol

1 interaction

Monitor/Modify Tx

codeine + sotalol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• sparsentan
codeine/ guaifenesin (generic)

+

sparsentan

1 interaction

Monitor/Modify Tx

codeine + sparsentan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• succinylcholine
codeine/ guaifenesin (generic)

+

succinylcholine

1 interaction

Monitor/Modify Tx

codeine + succinylcholine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of resp. depression, potentiate, prolong neuromuscular blockade (additive effects)

• tadalafil
codeine/ guaifenesin (generic)

+

tadalafil

1 interaction

Monitor/Modify Tx

codeine + tadalafil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• tagraxofusp
codeine/ guaifenesin (generic)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

codeine + tagraxofusp

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• tamsulosin
codeine/ guaifenesin (generic)

+

tamsulosin

1 interaction

Monitor/Modify Tx

codeine + tamsulosin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• taurine
codeine/ guaifenesin (generic)

+

taurine

1 interaction

Monitor/Modify Tx

codeine + taurine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• telmisartan
codeine/ guaifenesin (generic)

+

telmisartan

1 interaction

Monitor/Modify Tx

codeine + telmisartan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• terazosin
codeine/ guaifenesin (generic)

+

terazosin

1 interaction

Monitor/Modify Tx

codeine + terazosin

monitor BP, especially during terazosin initiation/titration: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• timolol
codeine/ guaifenesin (generic)

+

timolol

1 interaction

Monitor/Modify Tx

codeine + timolol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• timolol ophthalmic
codeine/ guaifenesin (generic)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

codeine + timolol ophthalmic

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• torsemide
codeine/ guaifenesin (generic)

+

torsemide

1 interaction

Monitor/Modify Tx

codeine + torsemide

monitor BP: combo may decr. torsemide efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• trandolapril
codeine/ guaifenesin (generic)

+

trandolapril

1 interaction

Monitor/Modify Tx

codeine + trandolapril

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• treprostinil
codeine/ guaifenesin (generic)

+

treprostinil

1 interaction

Monitor/Modify Tx

codeine + treprostinil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• triamterene
codeine/ guaifenesin (generic)

+

triamterene

1 interaction

Monitor/Modify Tx

codeine + triamterene

monitor BP: combo may decr. triamterene efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (antagonistic effects, opioids may induce antidiuretic hormone release; additive effects)

• valsartan
codeine/ guaifenesin (generic)

+

valsartan

1 interaction

Monitor/Modify Tx

codeine + valsartan

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• vardenafil
codeine/ guaifenesin (generic)

+

vardenafil

1 interaction

Monitor/Modify Tx

codeine + vardenafil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• vasopressin
codeine/ guaifenesin (generic)

+

vasopressin

1 interaction

Monitor/Modify Tx

codeine + vasopressin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• vecuronium
codeine/ guaifenesin (generic)

+

vecuronium

1 interaction

Monitor/Modify Tx

codeine + vecuronium

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of resp. depression, potentiate, prolong neuromuscular blockade (additive effects)

• vosoritide
codeine/ guaifenesin (generic)

+

vosoritide

1 interaction

Monitor/Modify Tx

codeine + vosoritide

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

Caution Advised

• acetazolamide
codeine/ guaifenesin (generic)

+

acetazolamide

1 interaction

Caution Advised

codeine + acetazolamide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, codeine may decr. seizure threshold)

• aclidinium inhaled
codeine/ guaifenesin (generic)

+

aclidinium inhaled

1 interaction

Caution Advised

codeine + aclidinium inhaled

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• alosetron
codeine/ guaifenesin (generic)

+

alosetron

1 interaction

Caution Advised

codeine + alosetron

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• atropine
codeine/ guaifenesin (generic)

+

atropine

1 interaction

Caution Advised

codeine + atropine

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• barium
codeine/ guaifenesin (generic)

+

barium

1 interaction

Caution Advised

codeine + barium

caution advised: combo may incr. risk of intestinal obstruction (additive effects)

• belladonna alkaloids
codeine/ guaifenesin (generic)

+

belladonna alkaloids

1 interaction

Caution Advised

codeine + belladonna alkaloids

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• benztropine
codeine/ guaifenesin (generic)

+

benztropine

1 interaction

Caution Advised

codeine + benztropine

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• botulinum toxin
codeine/ guaifenesin (generic)

+

botulinum toxin

1 interaction

Caution Advised

codeine + botulinum toxin

caution advised: combo may incr. risk of urinary retention (additive effects)

• busulfan
codeine/ guaifenesin (generic)

+

busulfan

1 interaction

Caution Advised

codeine + busulfan

caution advised: combo may incr. risk of seizures (additive effects)

• chlorambucil
codeine/ guaifenesin (generic)

+

chlorambucil

1 interaction

Caution Advised

codeine + chlorambucil

caution advised: combo may incr. risk of seizures (additive effects)

• cisapride
codeine/ guaifenesin (generic)

+

cisapride

1 interaction

Caution Advised

codeine + cisapride

caution advised: combo may decr. cisapride efficacy (antagonistic effects)

• clidinium
codeine/ guaifenesin (generic)

+

clidinium

1 interaction

Caution Advised

codeine + clidinium

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dicyclomine
codeine/ guaifenesin (generic)

+

dicyclomine

1 interaction

Caution Advised

codeine + dicyclomine

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• disopyramide
codeine/ guaifenesin (generic)

+

disopyramide

1 interaction

Caution Advised

codeine + disopyramide

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other adverse effects (additive effects)

• erenumab
codeine/ guaifenesin (generic)

+

erenumab

1 interaction

Caution Advised

codeine + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• flavoxate
codeine/ guaifenesin (generic)

+

flavoxate

1 interaction

Caution Advised

codeine + flavoxate

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• glycopyrrolate inhaled
codeine/ guaifenesin (generic)

+

glycopyrrolate inhaled

1 interaction

Caution Advised

codeine + glycopyrrolate inhaled

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• glycopyrronium topical
codeine/ guaifenesin (generic)

+

glycopyrronium topical

1 interaction

Caution Advised

codeine + glycopyrronium topical

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• homatropine
codeine/ guaifenesin (generic)

+

homatropine

1 interaction

Caution Advised

codeine + homatropine

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• ipratropium inhaled
codeine/ guaifenesin (generic)

+

ipratropium inhaled

1 interaction

Caution Advised

codeine + ipratropium inhaled

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• loperamide
codeine/ guaifenesin (generic)

+

loperamide

1 interaction

Caution Advised

codeine + loperamide

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• magnesium citrate
codeine/ guaifenesin (generic)

+

magnesium citrate

1 interaction

Caution Advised

codeine + magnesium citrate

caution advised, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• methscopolamine
codeine/ guaifenesin (generic)

+

methscopolamine

1 interaction

Caution Advised

codeine + methscopolamine

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• mexiletine
codeine/ guaifenesin (generic)

+

mexiletine

1 interaction

Caution Advised

codeine + mexiletine

caution advised: combo may decr. peak mexiletine levels, delay antiarrhythmic onset (absorption delayed)

• polyethylene glycol
codeine/ guaifenesin (generic)

+

polyethylene glycol

1 interaction

Caution Advised

codeine + polyethylene glycol

caution advised, especially if polyethylene glycol bowel prep use: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
codeine/ guaifenesin (generic)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

codeine + polyethylene glycol/ electrolytes

caution advised: combo may incr. risk of seizures (additive effects)

• potassium acid phosphate
codeine/ guaifenesin (generic)

+

potassium acid phosphate

1 interaction

Caution Advised

codeine + potassium acid phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium gluconate
codeine/ guaifenesin (generic)

+

potassium gluconate

1 interaction

Caution Advised

codeine + potassium gluconate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium phosphate
codeine/ guaifenesin (generic)

+

potassium phosphate

1 interaction

Caution Advised

codeine + potassium phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• pyridostigmine
codeine/ guaifenesin (generic)

+

pyridostigmine

1 interaction

Caution Advised

codeine + pyridostigmine

caution advised: combo may incr. risk of bradycardia, hypotension (additive effects)

• sodium picosulfate
codeine/ guaifenesin (generic)

+

sodium picosulfate

1 interaction

Caution Advised

codeine + sodium picosulfate

caution advised: combo may incr. risk of seizures (additive effects)

• sofpironium topical
codeine/ guaifenesin (generic)

+

sofpironium topical

1 interaction

Caution Advised

codeine + sofpironium topical

caution advised: combo may incr. risk of severe constipation, paralytic ileus, urinary retention (additive effects)

• sulfate bowel prep
codeine/ guaifenesin (generic)

+

sulfate bowel prep

1 interaction

Caution Advised

codeine + sulfate bowel prep

caution advised: combo may incr. risk of seizures (additive effects)

• tiotropium inhaled
codeine/ guaifenesin (generic)

+

tiotropium inhaled

1 interaction

Caution Advised

codeine + tiotropium inhaled

caution advised: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)