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dapsone
generic
Adult Dosing .
Dosage forms: TAB: 25 mg, 100 mg
leprosy (Hansen dz), paucibacillary
- [100 mg PO qd x6mo]
- Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases
leprosy (Hansen dz), multibacillary
- [100 mg PO qd x12mo]
- Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases
dermatitis herpetiformis
- [50 mg PO qd]
PCP prophylaxis (off-label)
- [monotherapy]
- Dose: 100 mg/day PO divided qd-bid; Info: not 1st-line agent
- [combo tx w/ pyrimethamine, leucovorin]
- Dose: 50 mg PO qd; Alt: 200 mg PO qwk; Info: not 1st-line agent
PCP tx, mild-mod. (off-label)
- [100 mg PO qd x21 days]
- Info: not 1st-line agent; give w/ trimethoprim
toxoplasmosis prophylaxis, primary (off-label)
- [50 mg PO qd]
- Alt: 200 mg PO qwk; Info: not 1st-line agent; give w/ pyrimethamine, leucovorin
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: TAB: 25 mg, 100 mg
leprosy (Hansen dz), paucibacillary
- [<10 yo]
- Dose: 2 mg/kg/dose PO qd x6mo; Max: 50 mg/dose; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases
- [10-14 yo]
- Dose: 50 mg PO qd x6mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases
- [15 yo and older]
- Dose: 100 mg PO qd x6mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 6mo in non-resistant refractory cases
leprosy (Hansen dz), multibacillary
- [<10 yo]
- Dose: 2 mg/kg/dose PO qd x12mo; Max: 50 mg/dose; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases
- [10-14 yo]
- Dose: 50 mg PO qd x12mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases
- [15 yo and older]
- Dose: 100 mg PO qd x12mo; Info: part of multi-drug regimen; consider dapsone resistance if no response w/in 3-6mo; may continue tx beyond 12mo in non-resistant refractory cases
PCP prophylaxis (off-label)
- [1 mo and older]
- Dose: 2 mg/kg/dose PO qd; Alt: 4 mg/kg/dose PO qwk; Max: 100 mg/dose if qd, 200 mg/dose if qwk; Info: not 1st-line agent
toxoplasmosis prophylaxis, primary (off-label)
- [1 mo and older]
- Dose: 2 mg/kg/dose PO qd; Alt: 15 mg/m^2/dose PO qd; Max: 25 mg/day; Info: not 1st-line agent; give w/ pyrimethamine, leucovorin
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD: no adjustment, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: no adjustment; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to sulfonamides, severe
- avoid: sun exposure
- caution: hepatic impairment
- caution: cardiovascular fxn, impaired
- caution: methemoglobinemia
- caution: G6PD deficiency
Drug Interactions .
Overview
dapsone
antimicrobial
- CYP2C8 substrate
- CYP2C9 substrate
- CYP3A4 substrate
- affected by altered gastrointestinal motility
- alters GI flora
- impairs immunomodulatory bacterial infective agent
- methemoglobinemia
- myelosuppressive effects
- photosensitivity
Contraindicated
- lidocaine topical
- prilocaine topical
Avoid/Use Alternative
- aminolevulinic acid topical
- BCG live intravesical
- bremelanotide
- chloramphenicol
- cholera vaccine, live
- cladribine oral
- deferiprone
- fexinidazole
- ganciclovir
- methotrexate
- porfimer
- primaquine
- radium Ra 223 dichloride
- ropeginterferon alfa-2b
- tafenoquine
- typhoid vaccine, live
- valganciclovir
Monitor/Modify Tx
- abemaciclib
- acalabrutinib
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- albendazole
- aldesleukin
- alemtuzumab
- allopurinol
- anti-thymocyte globulin
- arsenic trioxide
- asciminib
- asenapine
- atidarsagene autotemcel
- auranofin
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- balsalazide
- baricitinib
- belantamab mafodotin
- belinostat
- bendamustine
- benznidazole
- betibeglogene autotemcel
- bevacizumab
- bexarotene
- blinatumomab
- bortezomib
- bosutinib
- brentuximab vedotin
- brexucabtagene autoleucel
- busulfan
- cabazitaxel
- capecitabine
- carboplatin
- carfilzomib
- carmustine
- chlorambucil
- cidofovir
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clofarabine
- clozapine
- colchicine
- copanlisib
- crizotinib
- cyclophosphamide
- cytarabine
- dacarbazine
- dactinomycin
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- deferasirox
- deuruxolitinib
- dexrazoxane
- dinutuximab
- docetaxel
- dostarlimab
- doxorubicin
- duvelisib
- eflornithine
- elivaldogene autotemcel
- elranatamab
- enfortumab vedotin
- entrectinib
- epcoritamab
- epirubicin
- eribulin
- etoposide
- everolimus
- exagamglogene autotemcel
- exenatide
- fam-trastuzumab deruxtecan
- fedratinib
- floxuridine
- flucytosine
- fludarabine
- fluorouracil
- fluphenazine
- flutamide
- foscarnet
- fostamatinib
- gemcitabine
- gemtuzumab ozogamicin
- givinostat
- glasdegib
- glofitamab
- hydroxychloroquine
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imetelstat
- inotuzumab ozogamicin
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- irinotecan
- isatuximab
- ivosidenib
- ixabepilone
- leflunomide
- lenalidomide
- lifileucel
- linezolid
- linvoseltamab
- lisocabtagene maraleucel
- lixisenatide
- lomustine
- lonafarnib
- loncastuximab tesirine
- lovotibeglogene autotemcel
- lumateperone
- lurbinectedin
- lutetium Lu 177 dotatate
- lutetium Lu 177 vipivotide tetraxetan
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- mesalamine
- mesalamine rectal
- midostaurin
- mitomycin
- mitotane
- mitoxantrone
- mogamulizumab
- momelotinib
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nelarabine
- nilotinib
- niraparib
- nitric oxide
- nitrite
- obecabtagene autoleucel
- obinutuzumab
- ofatumumab
- olaparib
- olsalazine
- oxaliplatin
- paclitaxel
- pacritinib
- palbociclib
- panobinostat
- peginterferon alfa 2a
- peginterferon beta 1a
- pemetrexed
- penicillamine
- pentamidine
- pentostatin
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- pralatrexate
- pramlintide
- procarbazine
- proguanil
- pyrimethamine
- quizartinib
- ribavirin
- ribociclib
- rifabutin
- rituximab
- romidepsin
- rucaparib
- ruxolitinib
- ruxolitinib topical
- sacituzumab govitecan
- sarilumab
- satralizumab
- selinexor
- sirolimus
- sirolimus albumin-bound
- stiripentol
- streptozocin
- succimer
- sulfasalazine
- tafasitamab
- tagraxofusp
- talazoparib
- talquetamab
- tarlatamab
- tazemetostat
- teclistamab
- temozolomide
- temsirolimus
- teplizumab
- teriflunomide
- thalidomide
- thioguanine
- thiotepa
- tisagenlecleucel
- tocilizumab
- tofacitinib
- topotecan
- trabectedin
- trastuzumab
- treosulfan
- trifluridine
- trimethoprim
- upadacitinib
- valproic acid
- vancomycin
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- warfarin
- zanubrutinib
- zidovudine
- ziv-aflibercept
Caution Advised
- acitretin
- apalutamide
- articaine
- benzocaine topical
- bosentan
- bupivacaine
- bupivacaine liposomal
- butalbital
- butamben
- carbamazepine
- cenobamate
- chloroprocaine
- dabrafenib
- dapsone topical
- dulaglutide
- efavirenz
- encorafenib
- enzalutamide
- etravirine
- fecal microbiota, live
- fosphenytoin
- isosorbide dinitrate
- isosorbide mononitrate
- lactulose
- lidocaine
- liraglutide
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- mepivacaine
- methoxsalen
- metoclopramide
- mitapivat
- modafinil
- nafcillin
- nitrofurantoin
- nitroglycerin
- nitroprusside
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- primidone
- probenecid
- procaine
- rasburicase
- repotrectinib
- resorcinol topical
- rifampin
- rifapentine
- ropivacaine
- sodium picosulfate
- sotorasib
- St. John's wort
- sulfadiazine
- sulfamethoxazole
- tetracaine
- tirzepatide
- verteporfin
Adverse Reactions .
Serious Reactions
- hemolytic anemia
- aplastic anemia
- agranulocytosis
- exfoliative dermatitis
- erythema multiforme
- toxic epidermal necrolysis
- photosensitivity
- methemoglobinemia
- acute tubular necrosis
- peripheral neuropathy
- hepatotoxicity
Common Reactions
- fever
- myalgia
- headache
- rigors
- fatigue
- malaise
- dizziness
- nausea
- arthralgia
- pancreatitis
- photosensitivity
- rash
- urticaria
- vomiting
- abdominal pain
- anorexia
- blurred vision
- tinnitus
- albuminuria
- LFTs elevated
Safety/Monitoring .
Monitoring Parameters
G6PD before tx start; CBC qwk x4, qmo x6, then q6mo thereafter; LFTs at baseline, then periodically
Look/Sound-Alike Drug Names
dapsone confused with: danazol
Pregnancy/Lactation .
Pregnancy
Clinical Summary
benefits outweigh risks during pregnancy; possible risk of teratogenicity and hemolytic anemia based on limited human data
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; possible risk of infant hemolytic anemia based on limited human data and drug's mechanism of action; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver extensively; CYP450: 2C9, 3A substrate; Info: toxic metabolite
Excretion: urine primarily (20% unchanged); Half-life: 28h
Subclass: Antiparasitics ; Folate Antagonists, Antimicrobial ; Leprosy (Hansen Disease) ; Pneumocystis Pneumonia (PCP)
Mechanism of Action
competes with para-aminobenzoic acid (PABA), inhibiting folic acid synthesis (sulfone)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: generic
DEA/FDA: Rx
Approximate Retail Price
from http://www.goodrx.com/dapsone
oral tablet:
- 25 mg (60 ea): $43.00
- 100 mg (30 ea): $30.00
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