Bromfed DM

Overview

brompheniramine

antihistamine, 1st generation

• anticholinergic effects
• CNS depression
• decreases central histamine effects
• tachycardia

dextromethorphan

antitussive; NMDA antagonist; sigma-1 agonist

• CYP2D6 substrate
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

pseudoephedrine

alpha-1/beta-2 agonist

• hyperglycemic effects
• hypertensive effects
• tachycardia
• urine pH sensitive

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• dihydroergotamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dihydroergotamine

2 interactions

Contraindicated

pseudoephedrine + dihydroergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

Monitor/Modify Tx

dextromethorphan + dihydroergotamine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ergotamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ergotamine

2 interactions

Contraindicated

pseudoephedrine + ergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

Monitor/Modify Tx

dextromethorphan + ergotamine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• isocarboxazid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

isocarboxazid

3 interactions

Contraindicated

brompheniramine + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dextromethorphan + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

pseudoephedrine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• phenelzine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenelzine

3 interactions

Contraindicated

dextromethorphan + phenelzine

contraindicated w/in 14 days of phenelzine or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + phenelzine

contraindicated w/in 14 days of phenelzine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Avoid/Use Alternative

brompheniramine + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• potassium chloride
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium chloride

1 interaction

Contraindicated

brompheniramine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium citrate

2 interactions

Contraindicated

brompheniramine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

Caution Advised

pseudoephedrine + potassium citrate

caution advised w/ frequent or high-dose potassium citrate: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion decreased in alkaline urine)

• procarbazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

procarbazine

3 interactions

Contraindicated

dextromethorphan + procarbazine

contraindicated w/in 14 days of procarbazine or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, procarbazine inhibits monoamine oxidase)

Avoid/Use Alternative

pseudoephedrine + procarbazine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rasagiline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rasagiline

3 interactions

Contraindicated

dextromethorphan + rasagiline

contraindicated w/in 14 days of rasagiline or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

Avoid/Use Alternative

pseudoephedrine + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

safinamide

3 interactions

Contraindicated

dextromethorphan + safinamide

contraindicated w/in 14 days of safinamide or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

Avoid/Use Alternative

pseudoephedrine + safinamide

avoid combo w/in 14 days of safinamide use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

selegiline

3 interactions

Contraindicated

dextromethorphan + selegiline

contraindicated w/in 14 days of selegiline or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

Avoid/Use Alternative

pseudoephedrine + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline transdermal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

selegiline transdermal

3 interactions

Contraindicated

dextromethorphan + selegiline transdermal

contraindicated w/in 14 days of selegiline transdermal or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects)

Avoid/Use Alternative

pseudoephedrine + selegiline transdermal

avoid combo w/in 2wk of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tranylcypromine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tranylcypromine

3 interactions

Contraindicated

brompheniramine + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dextromethorphan + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

pseudoephedrine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• yohimbe
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

yohimbe

2 interactions

Contraindicated

dextromethorphan + yohimbe

contraindicated w/in 14 days of yohimbe or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, yohimbe inhibits monoamine oxidase)

Avoid/Use Alternative

pseudoephedrine + yohimbe

avoid combo w/in 14 days of yohimbe use: combo may incr. risk of HTN, tachycardia (additive effects)

Avoid/Use Alternative

• aclidinium inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aclidinium inhaled

1 interaction

Avoid/Use Alternative

brompheniramine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• albuterol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

albuterol

1 interaction

Avoid/Use Alternative

pseudoephedrine + albuterol

use alternative or monitor BP, HR w/ oral albuterol; risk may be lower w/ inhaled albuterol: combo may incr. risk of HTN, tachycardia (additive effects)

• alfentanil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

alfentanil

2 interactions

Avoid/Use Alternative

dextromethorphan + alfentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• amphetamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amphetamine

2 interactions

Avoid/Use Alternative

dextromethorphan + amphetamine

consider alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + amphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• buprenorphine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

buprenorphine

2 interactions

Avoid/Use Alternative

dextromethorphan + buprenorphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + buprenorphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• butalbital
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

butalbital

1 interaction

Avoid/Use Alternative

brompheniramine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• butorphanol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

butorphanol

2 interactions

Avoid/Use Alternative

dextromethorphan + butorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + butorphanol

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• chlorcyclizine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorcyclizine

1 interaction

Avoid/Use Alternative

brompheniramine + chlorcyclizine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

• citalopram
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

citalopram

2 interactions

Avoid/Use Alternative

dextromethorphan + citalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + citalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clomipramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clomipramine

3 interactions

Avoid/Use Alternative

dextromethorphan + clomipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + clomipramine

monitor BP: combo may incr. risk of HTN (additive effects)

• clonidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clonidine

2 interactions

Avoid/Use Alternative

brompheniramine + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

pseudoephedrine + clonidine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clozapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clozapine

1 interaction

Avoid/Use Alternative

brompheniramine + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (including life-threatening), other anticholinergic adverse effects (additive effects)

• cocaine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cocaine

2 interactions

Avoid/Use Alternative

pseudoephedrine + cocaine

use alternative or monitor BP, HR, ECG: combo may incr. risk of severe vasoconstriction, HTN, tachycardia, arrhythmias (additive effects)

Monitor/Modify Tx

dextromethorphan + cocaine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

codeine

2 interactions

Avoid/Use Alternative

brompheniramine + codeine

avoid combo if antitussive use; otherwise monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

dextromethorphan + codeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• cyclobenzaprine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cyclobenzaprine

2 interactions

Avoid/Use Alternative

dextromethorphan + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + cyclobenzaprine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• desipramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

desipramine

3 interactions

Avoid/Use Alternative

dextromethorphan + desipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + desipramine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• desvenlafaxine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

desvenlafaxine

3 interactions

Avoid/Use Alternative

dextromethorphan + desvenlafaxine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + desvenlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

brompheniramine + dexbrompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)

• dextroamphetamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dextroamphetamine

2 interactions

Avoid/Use Alternative

dextromethorphan + dextroamphetamine

consider alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + dextroamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• dextromethorphan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

dextromethorphan + dextromethorphan

avoid combo: combo may incr. risk of serotonin syndrome (additive effects, duplicate therapy)

• dihydrocodeine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dihydrocodeine

2 interactions

Avoid/Use Alternative

dextromethorphan + dihydrocodeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + dihydrocodeine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• doxylamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

doxylamine

1 interaction

Avoid/Use Alternative

brompheniramine + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dronabinol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dronabinol

2 interactions

Avoid/Use Alternative

brompheniramine + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

Monitor/Modify Tx

pseudoephedrine + dronabinol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• duloxetine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

duloxetine

2 interactions

Avoid/Use Alternative

dextromethorphan + duloxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + duloxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eluxadoline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eluxadoline

1 interaction

Avoid/Use Alternative

brompheniramine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ephedra
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ephedra

1 interaction

Avoid/Use Alternative

pseudoephedrine + ephedra

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects, ephedra may contain pseudoephedrine)

• epinephrine inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

pseudoephedrine + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• escitalopram
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

escitalopram

2 interactions

Avoid/Use Alternative

dextromethorphan + escitalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + escitalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethanol (alcoholic beverage)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethanol (alcoholic beverage)

2 interactions

Avoid/Use Alternative

brompheniramine + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

pseudoephedrine + ethanol (alcoholic beverage)

monitor BP: combo may incr. risk of HTN (chronic alcohol use) (additive effects)

• ethanol injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethanol injection

1 interaction

Avoid/Use Alternative

brompheniramine + ethanol injection

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fentanyl
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fentanyl

2 interactions

Avoid/Use Alternative

dextromethorphan + fentanyl

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + fentanyl

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• fluoxetine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fluoxetine

2 interactions

Avoid/Use Alternative

dextromethorphan + fluoxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day: combo may incr. dextromethorphan levels, risk of serotonin syndrome, other adverse effects (hepatic metabolism inhibited; additive effects)

Caution Advised

brompheniramine + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluvoxamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fluvoxamine

2 interactions

Avoid/Use Alternative

dextromethorphan + fluvoxamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + fluvoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• furosemide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

furosemide

1 interaction

Avoid/Use Alternative

pseudoephedrine + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• gepirone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

gepirone

1 interaction

Avoid/Use Alternative

dextromethorphan + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• glucagon
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glucagon

1 interaction

Avoid/Use Alternative

brompheniramine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrronium topical
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glycopyrronium topical

1 interaction

Avoid/Use Alternative

brompheniramine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• granisetron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

granisetron

1 interaction

Avoid/Use Alternative

dextromethorphan + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• haloperidol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

haloperidol

1 interaction

Avoid/Use Alternative

brompheniramine + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hydrocodone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydrocodone

2 interactions

Avoid/Use Alternative

brompheniramine + hydrocodone

avoid combo if antitussive use; otherwise monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

dextromethorphan + hydrocodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydromorphone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydromorphone

2 interactions

Avoid/Use Alternative

dextromethorphan + hydromorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + hydromorphone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxyzine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

brompheniramine + hydroxyzine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

• isoniazid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

isoniazid

1 interaction

Avoid/Use Alternative

dextromethorphan + isoniazid

use alternative or monitor serotonin syndrome sx w/in 14 days of isoniazid or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• kava
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

kava

1 interaction

Avoid/Use Alternative

brompheniramine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

kratom

1 interaction

Avoid/Use Alternative

brompheniramine + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• landiolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

landiolol

1 interaction

Avoid/Use Alternative

pseudoephedrine + landiolol

use alternative or monitor HR, BP: combo may decr. landiolol efficacy (antagonistic effects)

• levomilnacipran
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levomilnacipran

3 interactions

Avoid/Use Alternative

dextromethorphan + levomilnacipran

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + levomilnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levorphanol

2 interactions

Avoid/Use Alternative

dextromethorphan + levorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + levorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• linezolid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

linezolid

2 interactions

Avoid/Use Alternative

dextromethorphan + linezolid

use alternative or hold dextromethorphan if urgent use; monitor serotonin syndrome sx x2wk after dextromethorphan D/C or 24h after last linezolid dose: combo may incr. risk of serotonin syndrome (additive effects, linezolid reversibly inhibits monoamine oxidase)

Monitor/Modify Tx

pseudoephedrine + linezolid

monitor BP: combo may incr. risk of HTN (additive effects)

• lisdexamfetamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lisdexamfetamine

2 interactions

Avoid/Use Alternative

dextromethorphan + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + lisdexamfetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• lithium
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lithium

1 interaction

Avoid/Use Alternative

dextromethorphan + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• meperidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

meperidine

2 interactions

Avoid/Use Alternative

dextromethorphan + meperidine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + meperidine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• metaxalone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metaxalone

2 interactions

Avoid/Use Alternative

brompheniramine + metaxalone

use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

dextromethorphan + metaxalone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methadone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methadone

2 interactions

Avoid/Use Alternative

dextromethorphan + methadone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + methadone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• methamphetamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methamphetamine

2 interactions

Avoid/Use Alternative

dextromethorphan + methamphetamine

consider alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + methamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• methylene blue oral
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

dextromethorphan + methylene blue oral

use alternative or monitor serotonin syndrome sx w/in 14 days of methylene blue use, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methylergonovine

2 interactions

Avoid/Use Alternative

pseudoephedrine + methylergonovine

consider alternative or monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

Monitor/Modify Tx

dextromethorphan + methylergonovine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metoclopramide

3 interactions

Avoid/Use Alternative

brompheniramine + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

Monitor/Modify Tx

dextromethorphan + metoclopramide

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + metoclopramide

monitor BP: combo may incr. risk of HTN (additive effects)

• midazolam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

midazolam

1 interaction

Avoid/Use Alternative

brompheniramine + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• midodrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

midodrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• milnacipran
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

milnacipran

3 interactions

Avoid/Use Alternative

dextromethorphan + milnacipran

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + milnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mirtazapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mirtazapine

2 interactions

Avoid/Use Alternative

dextromethorphan + mirtazapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• morphine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

morphine

2 interactions

Avoid/Use Alternative

dextromethorphan + morphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + morphine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• nalbuphine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nalbuphine

2 interactions

Avoid/Use Alternative

dextromethorphan + nalbuphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + nalbuphine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• nortriptyline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nortriptyline

3 interactions

Avoid/Use Alternative

dextromethorphan + nortriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + nortriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + nortriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• olanzapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

olanzapine

1 interaction

Avoid/Use Alternative

brompheniramine + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• oliceridine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oliceridine

2 interactions

Avoid/Use Alternative

dextromethorphan + oliceridine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + oliceridine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, other anticholinergic adverse effects (additive effects)

• ondansetron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ondansetron

1 interaction

Avoid/Use Alternative

dextromethorphan + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

opium

2 interactions

Avoid/Use Alternative

dextromethorphan + opium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + opium

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• oxybate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxybate

1 interaction

Avoid/Use Alternative

brompheniramine + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxycodone

2 interactions

Avoid/Use Alternative

dextromethorphan + oxycodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + oxycodone

monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. brompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• oxymorphone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxymorphone

2 interactions

Avoid/Use Alternative

dextromethorphan + oxymorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + oxymorphone

monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. brompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• ozanimod
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ozanimod

1 interaction

Avoid/Use Alternative

pseudoephedrine + ozanimod

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• paroxetine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

paroxetine

2 interactions

Avoid/Use Alternative

dextromethorphan + paroxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day: combo may incr. dextromethorphan levels, risk of serotonin syndrome, other adverse effects (hepatic metabolism inhibited; additive effects)

Caution Advised

brompheniramine + paroxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pentazocine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pentazocine

2 interactions

Avoid/Use Alternative

dextromethorphan + pentazocine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + pentazocine

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• phenylephrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenylephrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + phenylephrine

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)

• pitolisant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pitolisant

1 interaction

Avoid/Use Alternative

brompheniramine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• pramlintide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pramlintide

2 interactions

Avoid/Use Alternative

brompheniramine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

Monitor/Modify Tx

pseudoephedrine + pramlintide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• promethazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

promethazine

1 interaction

Avoid/Use Alternative

brompheniramine + promethazine

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pseudoephedrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pseudoephedrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + pseudoephedrine

avoid combo: combo may incr. risk of HTN, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)

• pyrilamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pyrilamine

1 interaction

Avoid/Use Alternative

brompheniramine + pyrilamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

• remifentanil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

remifentanil

2 interactions

Avoid/Use Alternative

dextromethorphan + remifentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + remifentanil

monitor respiratory rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• revefenacin inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

brompheniramine + revefenacin inhaled

avoid combo: combo may incr. anticholinergic adverse effects (additive effects)

• rivastigmine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rivastigmine

1 interaction

Avoid/Use Alternative

brompheniramine + rivastigmine

use alternative: combo may decrease efficacy of both drugs (antagonistic effects)

• ropeginterferon alfa-2b
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

brompheniramine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• scopolamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

scopolamine

1 interaction

Avoid/Use Alternative

brompheniramine + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• sertraline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sertraline

2 interactions

Avoid/Use Alternative

dextromethorphan + sertraline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + sertraline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sofpironium topical
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sofpironium topical

1 interaction

Avoid/Use Alternative

brompheniramine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• sufentanil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sufentanil

2 interactions

Avoid/Use Alternative

dextromethorphan + sufentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + sufentanil

monitor respiratory rate, decr. sufentanil start dose, consider decr. brompheniramine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• tapentadol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tapentadol

2 interactions

Avoid/Use Alternative

dextromethorphan + tapentadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• tedizolid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tedizolid

1 interaction

Avoid/Use Alternative

dextromethorphan + tedizolid

use alternative or monitor serotonin syndrome symptoms, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, tedizolid reversibly inhibits monoamine oxidase)

• thalidomide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

thalidomide

1 interaction

Avoid/Use Alternative

brompheniramine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tradipitant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tradipitant

1 interaction

Avoid/Use Alternative

brompheniramine + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tramadol

2 interactions

Avoid/Use Alternative

dextromethorphan + tramadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

brompheniramine + tramadol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• trimethobenzamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

brompheniramine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trimipramine

3 interactions

Avoid/Use Alternative

dextromethorphan + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + trimipramine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• venlafaxine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

venlafaxine

3 interactions

Avoid/Use Alternative

dextromethorphan + venlafaxine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

pseudoephedrine + venlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vilazodone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vilazodone

2 interactions

Avoid/Use Alternative

dextromethorphan + vilazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + vilazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vortioxetine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vortioxetine

1 interaction

Avoid/Use Alternative

dextromethorphan + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ziprasidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ziprasidone

2 interactions

Avoid/Use Alternative

dextromethorphan + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + ziprasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• zuranolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zuranolone

1 interaction

Avoid/Use Alternative

brompheniramine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

5-HTP

2 interactions

Monitor/Modify Tx

dextromethorphan + 5-HTP

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + 5-HTP

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• abiraterone acetate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

pseudoephedrine + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

• acarbose
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

acarbose

1 interaction

Monitor/Modify Tx

pseudoephedrine + acarbose

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• acebutolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

acebutolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + acebutolol

monitor BP: combo may decr. antihypertensive efficacy, exaggerate HTN response (antagonistic effects)

• albuterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + albuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• aldesleukin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aldesleukin

1 interaction

Monitor/Modify Tx

brompheniramine + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aliskiren
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aliskiren

1 interaction

Monitor/Modify Tx

pseudoephedrine + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• almotriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

almotriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + almotriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + almotriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alogliptin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

alogliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + alogliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• alprazolam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

alprazolam

1 interaction

Monitor/Modify Tx

brompheniramine + alprazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• aluminum hydroxide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aluminum hydroxide

1 interaction

Monitor/Modify Tx

pseudoephedrine + aluminum hydroxide

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• amiloride
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amiloride

1 interaction

Monitor/Modify Tx

pseudoephedrine + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amitriptyline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amitriptyline

3 interactions

Monitor/Modify Tx

dextromethorphan + amitriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + amitriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + amitriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• amlodipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amlodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amoxapine

3 interactions

Monitor/Modify Tx

dextromethorphan + amoxapine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + amoxapine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• angiotensin II
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

angiotensin II

1 interaction

Monitor/Modify Tx

pseudoephedrine + angiotensin II

monitor BP: combo may incr. risk of HTN (additive effects)

• aprocitentan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

pseudoephedrine + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + arformoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• armodafinil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

armodafinil

1 interaction

Monitor/Modify Tx

pseudoephedrine + armodafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• asciminib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

asciminib

1 interaction

Monitor/Modify Tx

pseudoephedrine + asciminib

monitor BP: combo may incr. risk of HTN (additive effects)

• atenolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

atenolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

atogepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• atomoxetine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

atomoxetine

1 interaction

Monitor/Modify Tx

pseudoephedrine + atomoxetine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• atropine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

atropine ophthalmic

2 interactions

Monitor/Modify Tx

pseudoephedrine + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• axitinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

axitinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + axitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• azilsartan medoxomil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

pseudoephedrine + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benazepril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

benazepril

1 interaction

Monitor/Modify Tx

pseudoephedrine + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

benzphetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + benzphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• betamethasone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

betamethasone

1 interaction

Monitor/Modify Tx

pseudoephedrine + betamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• betaxolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

betaxolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + bevacizumab

monitor BP: combo may incr. risk of HTN (additive effects)

• bexagliflozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + bexagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• bismuth subsalicylate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

pseudoephedrine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bisoprolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + bisoprolol

consider monitoring BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• black cohosh
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

black cohosh

1 interaction

Monitor/Modify Tx

dextromethorphan + black cohosh

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• brigatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brigatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• bromocriptine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bromocriptine

3 interactions

Monitor/Modify Tx

dextromethorphan + bromocriptine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + bromocriptine

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy; may incr. risk of HTN, tachycardia (antagonistic effects; mechanism unknown)

Caution Advised

brompheniramine + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• budesonide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

budesonide

1 interaction

Monitor/Modify Tx

pseudoephedrine + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

• bumetanide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bumetanide

1 interaction

Monitor/Modify Tx

pseudoephedrine + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bupropion
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bupropion

1 interaction

Monitor/Modify Tx

pseudoephedrine + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

• buspirone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

buspirone

2 interactions

Monitor/Modify Tx

dextromethorphan + buspirone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + buspirone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cabozantinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + cabozantinib

monitor BP: combo may incr. risk of HTN (additive effects)

• caffeine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

caffeine

1 interaction

Monitor/Modify Tx

pseudoephedrine + caffeine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

• caffeine citrate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

pseudoephedrine + caffeine citrate

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• calcium carbonate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

calcium carbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + calcium carbonate

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• canagliflozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

canagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + canagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• candesartan cilexetil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

pseudoephedrine + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cannabis
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cannabis

2 interactions

Monitor/Modify Tx

brompheniramine + cannabis

monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

pseudoephedrine + cannabis

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• captopril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

captopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carbamazepine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

carbamazepine

2 interactions

Monitor/Modify Tx

brompheniramine + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dextromethorphan + carbamazepine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• carfilzomib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

pseudoephedrine + carfilzomib

monitor BP: combo may incr. risk of HTN (additive effects)

• carvedilol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

carvedilol

1 interaction

Monitor/Modify Tx

pseudoephedrine + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• celecoxib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

celecoxib

1 interaction

Monitor/Modify Tx

pseudoephedrine + celecoxib

monitor BP: combo may incr. risk of HTN (additive effects)

• chlorothiazide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

pseudoephedrine + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpromazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

brompheniramine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorthalidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

pseudoephedrine + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clevidipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clevidipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clobazam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clobazam

1 interaction

Monitor/Modify Tx

brompheniramine + clobazam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clonazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clonazepam

1 interaction

Monitor/Modify Tx

brompheniramine + clonazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clorazepate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clorazepate

1 interaction

Monitor/Modify Tx

brompheniramine + clorazepate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• colesevelam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

colesevelam

1 interaction

Monitor/Modify Tx

pseudoephedrine + colesevelam

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• copanlisib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

copanlisib

1 interaction

Monitor/Modify Tx

pseudoephedrine + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects, copanlisib may cause infusion-related HTN)

• corticotropin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

corticotropin

1 interaction

Monitor/Modify Tx

pseudoephedrine + corticotropin

monitor BP: combo may incr. risk of HTN (additive effects)

• cortisone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + cortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• cyclosporine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

pseudoephedrine + cyclosporine

monitor BP: combo may incr. risk of HTN (additive effects)

• dacomitinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dacomitinib

1 interaction

Monitor/Modify Tx

dextromethorphan + dacomitinib

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metabolism inhibited)

• danazol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

danazol

1 interaction

Monitor/Modify Tx

pseudoephedrine + danazol

monitor BP: combo may incr. risk of HTN (additive effects)

• dapagliflozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + dapagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• darbepoetin alfa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

pseudoephedrine + darbepoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• daridorexant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

daridorexant

1 interaction

Monitor/Modify Tx

brompheniramine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deflazacort
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

deflazacort

1 interaction

Monitor/Modify Tx

pseudoephedrine + deflazacort

monitor BP: combo may incr. risk of HTN (additive effects)

• desflurane
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

desflurane

1 interaction

Monitor/Modify Tx

brompheniramine + desflurane

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• desmopressin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

desmopressin

1 interaction

Monitor/Modify Tx

pseudoephedrine + desmopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• dexamethasone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexamethasone

1 interaction

Monitor/Modify Tx

pseudoephedrine + dexamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• dexmedetomidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

brompheniramine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

brompheniramine + dexmedetomidine injection

monitor respiratory rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexmethylphenidate

2 interactions

Monitor/Modify Tx

dextromethorphan + dexmethylphenidate

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + dexmethylphenidate

monitor BP: combo may incr. risk of HTN (additive effects)

• diazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diazepam

1 interaction

Monitor/Modify Tx

brompheniramine + diazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dichlorphenamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dichlorphenamide

2 interactions

Monitor/Modify Tx

pseudoephedrine + dichlorphenamide

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

Caution Advised

brompheniramine + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diclofenac
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diclofenac

1 interaction

Monitor/Modify Tx

pseudoephedrine + diclofenac

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac topical
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

pseudoephedrine + diclofenac topical

monitor BP: combo may incr. risk of HTN (additive effects)

• diethylpropion
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diethylpropion

1 interaction

Monitor/Modify Tx

pseudoephedrine + diethylpropion

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• diflunisal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diflunisal

1 interaction

Monitor/Modify Tx

pseudoephedrine + diflunisal

monitor BP: combo may incr. risk of HTN (additive effects)

• diltiazem
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diltiazem

1 interaction

Monitor/Modify Tx

pseudoephedrine + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dobutamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dobutamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + dobutamine

monitor BP: combo may incr. risk of HTN (additive effects)

• dopamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dopamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + dopamine

monitor BP: combo may incr. risk of HTN (additive effects)

• doxapram
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

doxapram

1 interaction

Monitor/Modify Tx

pseudoephedrine + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

• doxazosin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

doxazosin

2 interactions

Monitor/Modify Tx

pseudoephedrine + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased, slower GI transit due to anticholinergic effects)

• doxepin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

doxepin

3 interactions

Monitor/Modify Tx

dextromethorphan + doxepin

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + doxepin

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• doxepin topical
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

doxepin topical

2 interactions

Monitor/Modify Tx

dextromethorphan + doxepin topical

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + doxepin topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• droperidol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

droperidol

1 interaction

Monitor/Modify Tx

brompheniramine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droxidopa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

droxidopa

1 interaction

Monitor/Modify Tx

pseudoephedrine + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

• dulaglutide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dulaglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + dulaglutide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• eletriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eletriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + eletriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + eletriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• empagliflozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

empagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + empagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• enalapril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

enalapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

pseudoephedrine + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ephedrine injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

pseudoephedrine + ephedrine injection

monitor BP, HR: combo may incr. risk of HTN, arrhythmias, tachycardia (additive effects)

• ephedrine oral
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

pseudoephedrine + ephedrine oral

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• epinephrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

epinephrine

2 interactions

Monitor/Modify Tx

brompheniramine + epinephrine

monitor HR, ECG: combo may incr. risk of tachycardia, cardiac arrhythmias (additive effects)

pseudoephedrine + epinephrine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• eplerenone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eplerenone

1 interaction

Monitor/Modify Tx

pseudoephedrine + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

pseudoephedrine + epoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• eptinezumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eptinezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erenumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

erenumab

2 interactions

Monitor/Modify Tx

pseudoephedrine + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ertugliflozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + ertugliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• esketamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

esketamine

2 interactions

Monitor/Modify Tx

brompheniramine + esketamine

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pseudoephedrine + esketamine

monitor BP: combo may incr. risk of HTN (additive effects)

• esmolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

esmolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estetrol (contraceptive)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (contraceptive)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• eszopiclone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eszopiclone

1 interaction

Monitor/Modify Tx

brompheniramine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

pseudoephedrine + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethinyl estradiol (contraceptive)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• etodolac
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

etodolac

1 interaction

Monitor/Modify Tx

pseudoephedrine + etodolac

monitor BP: combo may incr. risk of HTN (additive effects)

• etomidate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

etomidate

1 interaction

Monitor/Modify Tx

brompheniramine + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etrasimod
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

etrasimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• exenatide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

exenatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + exenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• felodipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

felodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenfluramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fenfluramine

3 interactions

Monitor/Modify Tx

dextromethorphan + fenfluramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + fenfluramine

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

brompheniramine + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenoldopam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

pseudoephedrine + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoprofen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + fenoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fingolimod
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fingolimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

• fludrocortisone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + fludrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• fluphenazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fluphenazine

1 interaction

Monitor/Modify Tx

brompheniramine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flurazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

flurazepam

1 interaction

Monitor/Modify Tx

brompheniramine + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• flurbiprofen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + flurbiprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• formoterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + formoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• fosinopril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fosinopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fostamatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• fremanezumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fremanezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• frovatriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

frovatriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + frovatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + frovatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fruquintinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + fruquintinib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• gabapentin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

gabapentin

1 interaction

Monitor/Modify Tx

brompheniramine + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

brompheniramine + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• galcanezumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

galcanezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• glimepiride
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glimepiride

1 interaction

Monitor/Modify Tx

pseudoephedrine + glimepiride

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glipizide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glipizide

1 interaction

Monitor/Modify Tx

pseudoephedrine + glipizide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glyburide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glyburide

1 interaction

Monitor/Modify Tx

pseudoephedrine + glyburide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glycopyrrolate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glycopyrrolate

2 interactions

Monitor/Modify Tx

brompheniramine + glycopyrrolate

monitor HR: combo may incr. risk of tachycardia, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + glycopyrrolate

monitor HR: combo may incr. risk of tachycardia (additive effects)

• guanfacine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

guanfacine

2 interactions

Monitor/Modify Tx

pseudoephedrine + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hoodia
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hoodia

1 interaction

Monitor/Modify Tx

pseudoephedrine + hoodia

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• hydralazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydralazine

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydrochlorothiazide

2 interactions

Monitor/Modify Tx

pseudoephedrine + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

• hydrocortisone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• hydroxocobalamin IV
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

• hyoscyamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

hyoscyamine

2 interactions

Monitor/Modify Tx

pseudoephedrine + hyoscyamine

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

brompheniramine + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ibrutinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ibrutinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ibuprofen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + ibuprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ifosfamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

brompheniramine + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• imipramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

imipramine

3 interactions

Monitor/Modify Tx

dextromethorphan + imipramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + imipramine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + imipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• indapamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

indapamide

1 interaction

Monitor/Modify Tx

pseudoephedrine + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• indomethacin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

indomethacin

1 interaction

Monitor/Modify Tx

pseudoephedrine + indomethacin

monitor BP: combo may incr. risk of HTN (additive effects)

• insulin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

insulin

1 interaction

Monitor/Modify Tx

pseudoephedrine + insulin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• irbesartan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

irbesartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isradipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

isradipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ketamine

2 interactions

Monitor/Modify Tx

brompheniramine + ketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

pseudoephedrine + ketamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other sympathomimetic adverse effects (additive effects)

• ketoprofen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + ketoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ketorolac
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ketorolac

1 interaction

Monitor/Modify Tx

pseudoephedrine + ketorolac

monitor BP: combo may incr. risk of HTN (additive effects)

• labetalol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

labetalol

1 interaction

Monitor/Modify Tx

pseudoephedrine + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lanreotide

1 interaction

Monitor/Modify Tx

pseudoephedrine + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

• leflunomide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

leflunomide

1 interaction

Monitor/Modify Tx

pseudoephedrine + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• lemborexant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lemborexant

1 interaction

Monitor/Modify Tx

brompheniramine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + lenvatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• levalbuterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + levalbuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• levothyroxine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levothyroxine

1 interaction

Monitor/Modify Tx

pseudoephedrine + levothyroxine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• licorice
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

licorice

1 interaction

Monitor/Modify Tx

pseudoephedrine + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

• lifileucel
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lifileucel

1 interaction

Monitor/Modify Tx

pseudoephedrine + lifileucel

monitor HR: combo may incr. risk of tachycardia (additive effects)

• linagliptin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

linagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + linagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• liothyronine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

liothyronine

1 interaction

Monitor/Modify Tx

pseudoephedrine + liothyronine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• liraglutide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

liraglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + liraglutide

monitor HR, glucose in type 2 diabetes mellitus pts: combo may incr. risk of tachycardia; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• lisinopril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lisinopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lixisenatide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lixisenatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + lixisenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lorazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lorazepam

1 interaction

Monitor/Modify Tx

brompheniramine + lorazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lorlatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + lorlatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• losartan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

losartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lumacaftor/ivacaftor
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

pseudoephedrine + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

• lumateperone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lumateperone

2 interactions

Monitor/Modify Tx

dextromethorphan + lumateperone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + lumateperone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• luspatercept
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

luspatercept

1 interaction

Monitor/Modify Tx

pseudoephedrine + luspatercept

monitor BP: combo may incr. risk of HTN (additive effects)

• magnesium carbonate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

magnesium carbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium carbonate

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• magnesium hydroxide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

magnesium hydroxide

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium hydroxide

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• magnesium salicylate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• mavorixafor
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mavorixafor

1 interaction

Monitor/Modify Tx

dextromethorphan + mavorixafor

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metabolism inhibited)

• meclofenamate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

pseudoephedrine + meclofenamate

monitor BP: combo may incr. risk of HTN (additive effects)

• mefenamic acid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

pseudoephedrine + mefenamic acid

monitor BP: combo may incr. risk of HTN (additive effects)

• meloxicam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

meloxicam

1 interaction

Monitor/Modify Tx

pseudoephedrine + meloxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• metformin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metformin

1 interaction

Monitor/Modify Tx

pseudoephedrine + metformin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• methoxy polyethylene glycol-epoetin beta
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

pseudoephedrine + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may incr. risk of HTN (additive effects)

• methyldopa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methyldopa

2 interactions

Monitor/Modify Tx

pseudoephedrine + methyldopa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

brompheniramine + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methylene blue injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

dextromethorphan + methylene blue injection

hold dextromethorphan if emergency use; monitor serotonin syndrome sx up to 4h after last methylene blue dose; may resume dextromethorphan 72h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylphenidate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methylphenidate

2 interactions

Monitor/Modify Tx

dextromethorphan + methylphenidate

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + methylphenidate

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

• methylprednisolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + methylprednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• methyltestosterone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

pseudoephedrine + methyltestosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• metolazone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metolazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metoprolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• miglitol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

miglitol

1 interaction

Monitor/Modify Tx

pseudoephedrine + miglitol

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• minoxidil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

minoxidil

1 interaction

Monitor/Modify Tx

pseudoephedrine + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mirabegron

2 interactions

Monitor/Modify Tx

pseudoephedrine + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• modafinil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

modafinil

1 interaction

Monitor/Modify Tx

pseudoephedrine + modafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• moexipril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

moexipril

1 interaction

Monitor/Modify Tx

pseudoephedrine + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nabumetone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nabumetone

1 interaction

Monitor/Modify Tx

pseudoephedrine + nabumetone

monitor BP: combo may incr. risk of HTN (additive effects)

• nadolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nadolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• naproxen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

naproxen

1 interaction

Monitor/Modify Tx

pseudoephedrine + naproxen

monitor BP: combo may incr. risk of HTN (additive effects)

• naratriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

naratriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + naratriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + naratriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nateglinide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nateglinide

1 interaction

Monitor/Modify Tx

pseudoephedrine + nateglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• naxitamab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

naxitamab

1 interaction

Monitor/Modify Tx

pseudoephedrine + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

• nebivolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nebivolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nefazodone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nefazodone

2 interactions

Monitor/Modify Tx

dextromethorphan + nefazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + nefazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelarabine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nelarabine

1 interaction

Monitor/Modify Tx

brompheniramine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nicardipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nicardipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nifedipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nifedipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nimodipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nimodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• niraparib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

niraparib

1 interaction

Monitor/Modify Tx

pseudoephedrine + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

• nisoldipine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norepinephrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

norepinephrine

1 interaction

Monitor/Modify Tx

pseudoephedrine + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

• obinutuzumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + obinutuzumab

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• olmesartan medoxomil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

pseudoephedrine + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• olodaterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + olodaterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• opicapone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

opicapone

1 interaction

Monitor/Modify Tx

brompheniramine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• orphenadrine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

orphenadrine

2 interactions

Monitor/Modify Tx

pseudoephedrine + orphenadrine

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

brompheniramine + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• osilodrostat
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

osilodrostat

1 interaction

Monitor/Modify Tx

pseudoephedrine + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

• oxaprozin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxaprozin

monitor BP: combo may incr. risk of HTN (additive effects)

• oxazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxazepam

1 interaction

Monitor/Modify Tx

brompheniramine + oxazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• oxybutynin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxybutynin

1 interaction

Monitor/Modify Tx

brompheniramine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxymetazoline nasal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• oxymetazoline ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxymetazoline ophthalmic

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxymetazoline ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• oxytocin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxytocin

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

• palonosetron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

palonosetron

1 interaction

Monitor/Modify Tx

dextromethorphan + palonosetron

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• pazopanib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pazopanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

• pentobarbital
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pentobarbital

1 interaction

Monitor/Modify Tx

brompheniramine + pentobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• perindopril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

perindopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• perphenazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

perphenazine

1 interaction

Monitor/Modify Tx

brompheniramine + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pexidartinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

• phendimetrazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phendimetrazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• phenobarbital
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenobarbital

1 interaction

Monitor/Modify Tx

brompheniramine + phenobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• phenoxybenzamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenoxybenzamine

monitor BP, HR: combo may incr. risk of hypotension, tachycardia (paradoxical effects, unopposed stimulation of beta receptors)

• phentermine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phentermine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phentermine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

• phentolamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phentolamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phentolamine

monitor BP, HR: combo may incr. risk of hypotension, tachycardia (paradoxical effects, unopposed stimulation of beta receptors)

• phenylephrine injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine nasal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine ophthalmic

monitor BP, HR; risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN, tachycardia (additive effects)

• phenylephrine rectal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• pindolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pindolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pioglitazone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pioglitazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + pioglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• piroxicam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

piroxicam

1 interaction

Monitor/Modify Tx

pseudoephedrine + piroxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• ponatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ponatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ponatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ponesimod
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ponesimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

• pralsetinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pralsetinib

monitor BP: combo may incr. risk of HTN (additive effects)

• prazosin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

prazosin

1 interaction

Monitor/Modify Tx

pseudoephedrine + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

prednisolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + prednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• prednisone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

prednisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + prednisone

monitor BP: combo may incr. risk of HTN (additive effects)

• pregabalin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pregabalin

1 interaction

Monitor/Modify Tx

brompheniramine + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

primidone

1 interaction

Monitor/Modify Tx

brompheniramine + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propofol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

propofol

1 interaction

Monitor/Modify Tx

brompheniramine + propofol

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propranolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

propranolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + propranolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• protriptyline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

protriptyline

3 interactions

Monitor/Modify Tx

dextromethorphan + protriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + protriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + protriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• quazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

quazepam

1 interaction

Monitor/Modify Tx

brompheniramine + quazepam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

quetiapine

2 interactions

Monitor/Modify Tx

pseudoephedrine + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• quinapril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

quinapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• quinidine (antiarrhythmic)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

quinidine (antiarrhythmic)

2 interactions

Monitor/Modify Tx

dextromethorphan + quinidine (antiarrhythmic)

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metabolism inhibited)

Caution Advised

brompheniramine + quinidine (antiarrhythmic)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ramipril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ramipril

1 interaction

Monitor/Modify Tx

pseudoephedrine + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + ramucirumab

monitor BP: combo may incr. risk of HTN (additive effects)

• regorafenib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

regorafenib

1 interaction

Monitor/Modify Tx

pseudoephedrine + regorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• remimazolam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

remimazolam

1 interaction

Monitor/Modify Tx

brompheniramine + remimazolam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repaglinide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

repaglinide

1 interaction

Monitor/Modify Tx

pseudoephedrine + repaglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rimegepant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rimegepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ripretinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ripretinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

• rizatriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rizatriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + rizatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + rizatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ropinirole

2 interactions

Monitor/Modify Tx

pseudoephedrine + ropinirole

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rosiglitazone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rosiglitazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + rosiglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rotigotine transdermal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rotigotine transdermal

2 interactions

Monitor/Modify Tx

pseudoephedrine + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• salmeterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + salmeterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• salsalate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

salsalate

1 interaction

Monitor/Modify Tx

pseudoephedrine + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• SAMe
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

SAMe

1 interaction

Monitor/Modify Tx

dextromethorphan + SAMe

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• saxagliptin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

saxagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + saxagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• selpercatinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + selpercatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• semaglutide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

semaglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sevoflurane
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sevoflurane

1 interaction

Monitor/Modify Tx

brompheniramine + sevoflurane

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• siponimod
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

siponimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

• sitagliptin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sitagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + sitagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sodium bicarbonate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sodium bicarbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + sodium bicarbonate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• sodium citrate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sodium citrate

1 interaction

Monitor/Modify Tx

pseudoephedrine + sodium citrate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• solriamfetol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

solriamfetol

1 interaction

Monitor/Modify Tx

pseudoephedrine + solriamfetol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• sorafenib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sorafenib

1 interaction

Monitor/Modify Tx

pseudoephedrine + sorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• spironolactone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

spironolactone

1 interaction

Monitor/Modify Tx

pseudoephedrine + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• St. John's wort
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

St. John's wort

1 interaction

Monitor/Modify Tx

dextromethorphan + St. John's wort

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sulindac
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sulindac

1 interaction

Monitor/Modify Tx

pseudoephedrine + sulindac

monitor BP: combo may incr. risk of HTN (additive effects)

• sumatriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sumatriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + sumatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + sumatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sunitinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

sunitinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + sunitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• suvorexant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

suvorexant

1 interaction

Monitor/Modify Tx

brompheniramine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

pseudoephedrine + tacrolimus

monitor BP: combo may incr. risk of HTN (additive effects)

• tagraxofusp
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

pseudoephedrine + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

• telmisartan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

telmisartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terazosin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

terazosin

1 interaction

Monitor/Modify Tx

pseudoephedrine + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbinafine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

terbinafine

1 interaction

Monitor/Modify Tx

dextromethorphan + terbinafine

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metabolism inhibited)

• terbutaline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

terbutaline

1 interaction

Monitor/Modify Tx

pseudoephedrine + terbutaline

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• teriflunomide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

teriflunomide

1 interaction

Monitor/Modify Tx

pseudoephedrine + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• testosterone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

testosterone

1 interaction

Monitor/Modify Tx

pseudoephedrine + testosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• thioridazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

thioridazine

1 interaction

Monitor/Modify Tx

brompheniramine + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thiothixene
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

thiothixene

1 interaction

Monitor/Modify Tx

brompheniramine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thyroid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

thyroid

1 interaction

Monitor/Modify Tx

pseudoephedrine + thyroid

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• timolol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

timolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tirzepatide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tirzepatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• tivozanib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tivozanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + tivozanib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• tolmetin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tolmetin

1 interaction

Monitor/Modify Tx

pseudoephedrine + tolmetin

monitor BP: combo may incr. risk of HTN (additive effects)

• topiramate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

topiramate

2 interactions

Monitor/Modify Tx

pseudoephedrine + topiramate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

Caution Advised

brompheniramine + topiramate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• torsemide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

torsemide

1 interaction

Monitor/Modify Tx

pseudoephedrine + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trametinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trametinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + trametinib

monitor BP: combo may incr. risk of HTN (additive effects)

• trandolapril
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trandolapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trazodone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trazodone

2 interactions

Monitor/Modify Tx

dextromethorphan + trazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

brompheniramine + trazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triamcinolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

triamcinolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + triamcinolone

monitor BP: combo may incr. risk of HTN (additive effects)

• triamterene
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

triamterene

1 interaction

Monitor/Modify Tx

pseudoephedrine + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

triazolam

1 interaction

Monitor/Modify Tx

brompheniramine + triazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trospium
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trospium

2 interactions

Monitor/Modify Tx

pseudoephedrine + trospium

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

brompheniramine + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ubrogepant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• vadadustat
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vadadustat

1 interaction

Monitor/Modify Tx

pseudoephedrine + vadadustat

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• valsartan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

valsartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vamorolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vamorolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + vamorolone

monitor BP: combo may incr. risk of HTN (additive effects)

• vandetanib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vandetanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + vandetanib

monitor BP: combo may incr. risk of HTN (additive effects)

• vasopressin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vasopressin

1 interaction

Monitor/Modify Tx

pseudoephedrine + vasopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• verapamil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

verapamil

1 interaction

Monitor/Modify Tx

pseudoephedrine + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + vilanterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• viloxazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

viloxazine

2 interactions

Monitor/Modify Tx

pseudoephedrine + viloxazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

brompheniramine + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• voclosporin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

voclosporin

1 interaction

Monitor/Modify Tx

pseudoephedrine + voclosporin

monitor BP: combo may incr. risk of HTN (additive effects)

• zaleplon
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zaleplon

1 interaction

Monitor/Modify Tx

brompheniramine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zavegepant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zavegepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ziconotide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ziconotide

1 interaction

Monitor/Modify Tx

brompheniramine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

pseudoephedrine + ziv-aflibercept

monitor BP: combo may incr. risk of HTN (additive effects)

• zolmitriptan
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zolmitriptan

3 interactions

Monitor/Modify Tx

dextromethorphan + zolmitriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

pseudoephedrine + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

brompheniramine + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zolpidem

1 interaction

Monitor/Modify Tx

brompheniramine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Caution Advised

• aceclidine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aceclidine ophthalmic

1 interaction

Caution Advised

brompheniramine + aceclidine ophthalmic

caution advised: combo may decr. aceclidine efficacy (antagonistic effects)

• acetazolamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

acetazolamide

1 interaction

Caution Advised

pseudoephedrine + acetazolamide

caution advised: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion may be decreased in alkaline urine)

• allopurinol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

allopurinol

1 interaction

Caution Advised

brompheniramine + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alosetron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

alosetron

1 interaction

Caution Advised

brompheniramine + alosetron

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• amantadine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

amantadine

1 interaction

Caution Advised

brompheniramine + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• apomorphine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

apomorphine

1 interaction

Caution Advised

brompheniramine + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

apraclonidine ophthalmic

1 interaction

Caution Advised

brompheniramine + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aripiprazole bimonthly injection

1 interaction

Caution Advised

brompheniramine + aripiprazole bimonthly injection

caution advised: combo may incr. risk of hyperthermia, CNS depression, psychomotor impairment (additive effects)

• aripiprazole lauroxil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aripiprazole lauroxil

1 interaction

Caution Advised

brompheniramine + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole monthly injection
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aripiprazole monthly injection

1 interaction

Caution Advised

brompheniramine + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole oral
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

aripiprazole oral

1 interaction

Caution Advised

brompheniramine + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ascorbic acid (vitamin C)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ascorbic acid (vitamin C)

1 interaction

Caution Advised

pseudoephedrine + ascorbic acid (vitamin C)

caution advised: combo may decr. pseudoephedrine levels, efficacy (renal excretion increased in acidic urine)

• asenapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

asenapine

1 interaction

Caution Advised

brompheniramine + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• atropine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

atropine

1 interaction

Caution Advised

brompheniramine + atropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• baclofen
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

baclofen

1 interaction

Caution Advised

brompheniramine + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

baclofen intrathecal

1 interaction

Caution Advised

brompheniramine + baclofen intrathecal

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• barium
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

barium

1 interaction

Caution Advised

brompheniramine + barium

caution advised: combo may incr. risk of intestinal obstruction (additive effects)

• belladonna alkaloids
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

belladonna alkaloids

1 interaction

Caution Advised

brompheniramine + belladonna alkaloids

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• benztropine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

benztropine

1 interaction

Caution Advised

brompheniramine + benztropine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• bethanechol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

bethanechol

1 interaction

Caution Advised

brompheniramine + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• botulinum toxin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

botulinum toxin

1 interaction

Caution Advised

brompheniramine + botulinum toxin

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• brexpiprazole
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brexpiprazole

1 interaction

Caution Advised

brompheniramine + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• brimonidine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brimonidine ophthalmic

1 interaction

Caution Advised

brompheniramine + brimonidine ophthalmic

caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine topical
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brimonidine topical

1 interaction

Caution Advised

brompheniramine + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brivaracetam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brivaracetam

1 interaction

Caution Advised

brompheniramine + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brompheniramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

brompheniramine

1 interaction

Caution Advised

brompheniramine + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

• cannabidiol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cannabidiol

1 interaction

Caution Advised

brompheniramine + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carbinoxamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

carbinoxamine

1 interaction

Caution Advised

brompheniramine + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cariprazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cariprazine

1 interaction

Caution Advised

brompheniramine + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• carisoprodol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

carisoprodol

1 interaction

Caution Advised

brompheniramine + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cenobamate

1 interaction

Caution Advised

brompheniramine + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cetirizine

1 interaction

Caution Advised

brompheniramine + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cevimeline
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cevimeline

1 interaction

Caution Advised

brompheniramine + cevimeline

caution advised: combo may decrease efficacy of both drugs (antagonistic effects)

• chamomile, German
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chamomile, German

1 interaction

Caution Advised

brompheniramine + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlophedianol

1 interaction

Caution Advised

brompheniramine + chlophedianol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlordiazepoxide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlordiazepoxide

1 interaction

Caution Advised

brompheniramine + chlordiazepoxide

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorpheniramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorpheniramine

1 interaction

Caution Advised

brompheniramine + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorzoxazone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

chlorzoxazone

1 interaction

Caution Advised

brompheniramine + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cisapride
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cisapride

1 interaction

Caution Advised

brompheniramine + cisapride

caution advised: combo may decr. cisapride efficacy (antagonistic effects)

• clemastine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clemastine

1 interaction

Caution Advised

brompheniramine + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clidinium
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

clidinium

1 interaction

Caution Advised

brompheniramine + clidinium

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• cyclopentolate ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cyclopentolate ophthalmic

1 interaction

Caution Advised

brompheniramine + cyclopentolate ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• cyproheptadine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

cyproheptadine

1 interaction

Caution Advised

brompheniramine + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dantrolene
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dantrolene

1 interaction

Caution Advised

brompheniramine + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

darifenacin

1 interaction

Caution Advised

brompheniramine + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• deutetrabenazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

deutetrabenazine

1 interaction

Caution Advised

brompheniramine + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dexchlorpheniramine

1 interaction

Caution Advised

brompheniramine + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dicyclomine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dicyclomine

1 interaction

Caution Advised

brompheniramine + dicyclomine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• difelikefalin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

difelikefalin

1 interaction

Caution Advised

brompheniramine + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

difenoxin

1 interaction

Caution Advised

brompheniramine + difenoxin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• digoxin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

digoxin

1 interaction

Caution Advised

pseudoephedrine + digoxin

caution advised: combo with decongestants may incr. risk of cardiac arrhythmias (additive effects)

• dimenhydrinate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

dimenhydrinate

1 interaction

Caution Advised

brompheniramine + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenhydramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diphenhydramine

1 interaction

Caution Advised

brompheniramine + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenoxylate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

diphenoxylate

1 interaction

Caution Advised

brompheniramine + diphenoxylate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• disopyramide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

disopyramide

1 interaction

Caution Advised

brompheniramine + disopyramide

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• domperidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

domperidone

1 interaction

Caution Advised

brompheniramine + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• donepezil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

donepezil

1 interaction

Caution Advised

brompheniramine + donepezil

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• efavirenz
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

efavirenz

1 interaction

Caution Advised

brompheniramine + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elinzanetant
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

elinzanetant

1 interaction

Caution Advised

brompheniramine + elinzanetant

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

entacapone

1 interaction

Caution Advised

brompheniramine + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

entrectinib

1 interaction

Caution Advised

brompheniramine + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• erythromycin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

erythromycin

1 interaction

Caution Advised

brompheniramine + erythromycin

caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)

• eslicarbazepine acetate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

eslicarbazepine acetate

1 interaction

Caution Advised

brompheniramine + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• estazolam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

estazolam

1 interaction

Caution Advised

brompheniramine + estazolam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethanol (in some formulations)

1 interaction

Caution Advised

brompheniramine + ethanol (in some formulations)

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethosuximide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ethosuximide

1 interaction

Caution Advised

brompheniramine + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• felbamate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

felbamate

1 interaction

Caution Advised

brompheniramine + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fesoterodine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fesoterodine

1 interaction

Caution Advised

brompheniramine + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flavoxate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

flavoxate

1 interaction

Caution Advised

brompheniramine + flavoxate

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• flibanserin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

flibanserin

1 interaction

Caution Advised

brompheniramine + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

foslevodopa

1 interaction

Caution Advised

brompheniramine + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fosphenytoin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

fosphenytoin

1 interaction

Caution Advised

brompheniramine + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• galantamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

galantamine

1 interaction

Caution Advised

brompheniramine + galantamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• ganaxolone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ganaxolone

1 interaction

Caution Advised

brompheniramine + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glofitamab

1 interaction

Caution Advised

brompheniramine + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

glycopyrrolate inhaled

1 interaction

Caution Advised

brompheniramine + glycopyrrolate inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• homatropine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

homatropine

1 interaction

Caution Advised

brompheniramine + homatropine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• iloperidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

iloperidone

1 interaction

Caution Advised

brompheniramine + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ipratropium inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ipratropium inhaled

1 interaction

Caution Advised

brompheniramine + ipratropium inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ipratropium nasal
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ipratropium nasal

1 interaction

Caution Advised

brompheniramine + ipratropium nasal

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• isoflurane
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

isoflurane

1 interaction

Caution Advised

brompheniramine + isoflurane

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• lacosamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lacosamide

1 interaction

Caution Advised

brompheniramine + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lamotrigine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lamotrigine

1 interaction

Caution Advised

brompheniramine + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levetiracetam

1 interaction

Caution Advised

brompheniramine + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levocetirizine

1 interaction

Caution Advised

brompheniramine + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

levodopa

1 interaction

Caution Advised

brompheniramine + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• linvoseltamab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

linvoseltamab

1 interaction

Caution Advised

brompheniramine + linvoseltamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lofexidine

1 interaction

Caution Advised

brompheniramine + lofexidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• loperamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

loperamide

1 interaction

Caution Advised

brompheniramine + loperamide

caution advised: combo may incr. risk of severe constipation/paralytic ileus (additive effects)

• loxapine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

loxapine

1 interaction

Caution Advised

brompheniramine + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• lurasidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

lurasidone

1 interaction

Caution Advised

brompheniramine + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• meclizine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

meclizine

1 interaction

Caution Advised

brompheniramine + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• melatonin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

melatonin

1 interaction

Caution Advised

brompheniramine + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• memantine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

memantine

1 interaction

Caution Advised

dextromethorphan + memantine

caution advised: combo may incr. adverse effects of both drugs (additive effects, duplicate therapy)

• meprobamate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

meprobamate

1 interaction

Caution Advised

brompheniramine + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methazolamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methazolamide

1 interaction

Caution Advised

pseudoephedrine + methazolamide

caution advised: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion decreased in alkaline urine)

• methocarbamol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methocarbamol

1 interaction

Caution Advised

brompheniramine + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methohexital

1 interaction

Caution Advised

brompheniramine + methohexital

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methscopolamine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methscopolamine

1 interaction

Caution Advised

brompheniramine + methscopolamine

caution advised: combo may incr. anticholinergic adverse effects (additive effects)

• methsuximide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

methsuximide

1 interaction

Caution Advised

brompheniramine + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrapone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metyrapone

1 interaction

Caution Advised

brompheniramine + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

metyrosine

1 interaction

Caution Advised

brompheniramine + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mexiletine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mexiletine

1 interaction

Caution Advised

brompheniramine + mexiletine

caution advised: combo may decr. peak mexiletine levels, delay antiarrhythmic onset (absorption delayed)

• milsaperidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

milsaperidone

1 interaction

Caution Advised

brompheniramine + milsaperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• mitotane
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mitotane

1 interaction

Caution Advised

brompheniramine + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

molindone

1 interaction

Caution Advised

brompheniramine + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• mosunetuzumab
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mosunetuzumab

1 interaction

Caution Advised

brompheniramine + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

mycophenolate mofetil

1 interaction

Caution Advised

brompheniramine + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naltrexone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

naltrexone

1 interaction

Caution Advised

brompheniramine + naltrexone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• neostigmine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

neostigmine

1 interaction

Caution Advised

brompheniramine + neostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• oxcarbazepine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

oxcarbazepine

1 interaction

Caution Advised

brompheniramine + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• paliperidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

paliperidone

1 interaction

Caution Advised

brompheniramine + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• passion flower
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

passion flower

1 interaction

Caution Advised

brompheniramine + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perampanel
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

perampanel

1 interaction

Caution Advised

brompheniramine + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pheniramine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pheniramine

1 interaction

Caution Advised

brompheniramine + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenytoin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

phenytoin

1 interaction

Caution Advised

brompheniramine + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pilocarpine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pilocarpine

1 interaction

Caution Advised

brompheniramine + pilocarpine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pilocarpine ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pilocarpine ophthalmic

1 interaction

Caution Advised

brompheniramine + pilocarpine ophthalmic

caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)

• pimozide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pimozide

1 interaction

Caution Advised

brompheniramine + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• potassium acid phosphate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium acid phosphate

2 interactions

Caution Advised

brompheniramine + potassium acid phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

pseudoephedrine + potassium acid phosphate

caution advised: combo may decr. pseudoephedrine efficacy (renal excretion increased in acidic urine)

• potassium bicarbonate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium bicarbonate

1 interaction

Caution Advised

pseudoephedrine + potassium bicarbonate

caution advised w/ frequent or high-dose urinary alkalinizers: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion decreased in alkaline urine)

• potassium gluconate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium gluconate

1 interaction

Caution Advised

brompheniramine + potassium gluconate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium phosphate
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

potassium phosphate

1 interaction

Caution Advised

brompheniramine + potassium phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• pramipexole
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pramipexole

1 interaction

Caution Advised

brompheniramine + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• prochlorperazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

prochlorperazine

1 interaction

Caution Advised

brompheniramine + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pyridostigmine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

pyridostigmine

1 interaction

Caution Advised

brompheniramine + pyridostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• quinidine (CYP2D6 inhibitor)
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Caution Advised

brompheniramine + quinidine (CYP2D6 inhibitor)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ramelteon
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

ramelteon

1 interaction

Caution Advised

brompheniramine + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• repotrectinib
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

repotrectinib

1 interaction

Caution Advised

brompheniramine + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

risperidone

1 interaction

Caution Advised

brompheniramine + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• rufinamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

rufinamide

1 interaction

Caution Advised

brompheniramine + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selinexor
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

selinexor

1 interaction

Caution Advised

brompheniramine + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• solifenacin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

solifenacin

1 interaction

Caution Advised

brompheniramine + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• stiripentol
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

stiripentol

1 interaction

Caution Advised

brompheniramine + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tasimelteon
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tasimelteon

1 interaction

Caution Advised

brompheniramine + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• temazepam
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

temazepam

1 interaction

Caution Advised

brompheniramine + temazepam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• tetrabenazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tetrabenazine

1 interaction

Caution Advised

brompheniramine + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiotepa
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

thiotepa

1 interaction

Caution Advised

brompheniramine + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiagabine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tiagabine

1 interaction

Caution Advised

brompheniramine + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tizanidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tizanidine

1 interaction

Caution Advised

brompheniramine + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tolcapone

1 interaction

Caution Advised

brompheniramine + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tolterodine

1 interaction

Caution Advised

brompheniramine + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trifluoperazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trifluoperazine

1 interaction

Caution Advised

brompheniramine + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trihexyphenidyl
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

trihexyphenidyl

1 interaction

Caution Advised

brompheniramine + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• triprolidine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

triprolidine

1 interaction

Caution Advised

brompheniramine + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tropicamide ophthalmic
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

tropicamide ophthalmic

1 interaction

Caution Advised

brompheniramine + tropicamide ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• umeclidinium inhaled
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

umeclidinium inhaled

1 interaction

Caution Advised

brompheniramine + umeclidinium inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• valbenazine
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

valbenazine

1 interaction

Caution Advised

brompheniramine + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

valerian

1 interaction

Caution Advised

brompheniramine + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

valproic acid

1 interaction

Caution Advised

brompheniramine + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vibegron
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vibegron

1 interaction

Caution Advised

brompheniramine + vibegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• vigabatrin
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

vigabatrin

1 interaction

Caution Advised

brompheniramine + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Bromfed DM (brompheniramine/ dextromethorphan/ pseudoephedrine)

+

zonisamide

2 interactions

Caution Advised

brompheniramine + zonisamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

pseudoephedrine + zonisamide

caution advised: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion decreased in alkaline urine)