Lyrica

Overview

pregabalin

GABA analog

• affected by altered fat absorption
• angioedema
• antiepileptic agent
• CNS depression

Contraindicated

• amifampridine
Lyrica (pregabalin)

+

amifampridine

1 interaction

Contraindicated

pregabalin + amifampridine

contraindicated if seizure disorder use; otherwise, caution advised: combo may alter seizure control (antagonistic effects, amifampridine may decr. seizure threshold)

• bupropion
Lyrica (pregabalin)

+

bupropion

1 interaction

Contraindicated

pregabalin + bupropion

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

• dalfampridine
Lyrica (pregabalin)

+

dalfampridine

1 interaction

Contraindicated

pregabalin + dalfampridine

contraindicated if seizure disorder use; otherwise, caution advised: combo may alter seizure control (antagonistic effects, dalfampridine may decr. seizure threshold)

Avoid/Use Alternative

• buprenorphine
Lyrica (pregabalin)

+

buprenorphine

1 interaction

Avoid/Use Alternative

pregabalin + buprenorphine

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, buprenorphine may decr. seizure threshold)

• butalbital
Lyrica (pregabalin)

+

butalbital

1 interaction

Avoid/Use Alternative

pregabalin + butalbital

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• butorphanol
Lyrica (pregabalin)

+

butorphanol

1 interaction

Avoid/Use Alternative

pregabalin + butorphanol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, butorphanol may decr. seizure threshold)

• clonidine
Lyrica (pregabalin)

+

clonidine

1 interaction

Avoid/Use Alternative

pregabalin + clonidine

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• codeine
Lyrica (pregabalin)

+

codeine

1 interaction

Avoid/Use Alternative

pregabalin + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• diazepam
Lyrica (pregabalin)

+

diazepam

1 interaction

Avoid/Use Alternative

pregabalin + diazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dihydrocodeine
Lyrica (pregabalin)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

pregabalin + dihydrocodeine

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, dihydrocodeine may decr. seizure threshold)

• doxylamine
Lyrica (pregabalin)

+

doxylamine

1 interaction

Avoid/Use Alternative

pregabalin + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethanol
Lyrica (pregabalin)

+

ethanol

1 interaction

Avoid/Use Alternative

pregabalin + ethanol

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fentanyl
Lyrica (pregabalin)

+

fentanyl

1 interaction

Avoid/Use Alternative

pregabalin + fentanyl

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fentanyl may decr. seizure threshold)

• ginkgo
Lyrica (pregabalin)

+

ginkgo

1 interaction

Avoid/Use Alternative

pregabalin + ginkgo

if seizure disorder use, avoid consumption of ginkgo seeds; otherwise, caution advised: combo may alter seizure control (antagonistic effects, ginkgotoxin may decr. seizure threshold)

• hydrocodone
Lyrica (pregabalin)

+

hydrocodone

1 interaction

Avoid/Use Alternative

pregabalin + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, hydrocodone may decr. seizure threshold)

• hydromorphone
Lyrica (pregabalin)

+

hydromorphone

1 interaction

Avoid/Use Alternative

pregabalin + hydromorphone

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, hydromorphone may decr. seizure threshold)

• isocarboxazid
Lyrica (pregabalin)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

pregabalin + isocarboxazid

use alternative or monitor resp. rate during and x10 days after isocarboxazid use: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, isocarboxazid may decr. seizure threshold)

• kava
Lyrica (pregabalin)

+

kava

1 interaction

Avoid/Use Alternative

pregabalin + kava

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• kratom
Lyrica (pregabalin)

+

kratom

1 interaction

Avoid/Use Alternative

pregabalin + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, kratom may decr. seizure threshold)

• levorphanol
Lyrica (pregabalin)

+

levorphanol

1 interaction

Avoid/Use Alternative

pregabalin + levorphanol

use alternative or monitor resp. rate, decr. levorphanol start dose by at least 50%, consider decr. pregabalin dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, levorphanol may decr. seizure threshold)

• lindane topical
Lyrica (pregabalin)

+

lindane topical

1 interaction

Avoid/Use Alternative

pregabalin + lindane topical

use alternative if seizure disorder use; otherwise, caution advised: combo may alter seizure control (antagonistic effects, lindane may decr. seizure threshold)

• lorazepam
Lyrica (pregabalin)

+

lorazepam

1 interaction

Avoid/Use Alternative

pregabalin + lorazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meperidine
Lyrica (pregabalin)

+

meperidine

1 interaction

Avoid/Use Alternative

pregabalin + meperidine

use alternative or monitor resp. rate, decr. meperidine dose 25-50%, consider decr. pregabalin dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, meperidine may decr. seizure threshold)

• metaxalone
Lyrica (pregabalin)

+

metaxalone

1 interaction

Avoid/Use Alternative

pregabalin + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methadone
Lyrica (pregabalin)

+

methadone

1 interaction

Avoid/Use Alternative

pregabalin + methadone

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, methadone may decr. seizure threshold)

• metoclopramide
Lyrica (pregabalin)

+

metoclopramide

1 interaction

Avoid/Use Alternative

pregabalin + metoclopramide

use alternative or monitor resp. rate: combo may alter seizure control; may incr. risk of profound CNS and resp. depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• midazolam
Lyrica (pregabalin)

+

midazolam

1 interaction

Avoid/Use Alternative

pregabalin + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• morphine
Lyrica (pregabalin)

+

morphine

1 interaction

Avoid/Use Alternative

pregabalin + morphine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, morphine may decr. seizure threshold)

• nalbuphine
Lyrica (pregabalin)

+

nalbuphine

1 interaction

Avoid/Use Alternative

pregabalin + nalbuphine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nalbuphine may decr. seizure threshold)

• oliceridine
Lyrica (pregabalin)

+

oliceridine

1 interaction

Avoid/Use Alternative

pregabalin + oliceridine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension; may alter seizure control (additive effects; antagonistic effects, oliceridine may decr. seizure threshold)

• opium
Lyrica (pregabalin)

+

opium

1 interaction

Avoid/Use Alternative

pregabalin + opium

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, morphine in opium may decr. seizure threshold)

• oxybate
Lyrica (pregabalin)

+

oxybate

1 interaction

Avoid/Use Alternative

pregabalin + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Lyrica (pregabalin)

+

oxycodone

1 interaction

Avoid/Use Alternative

pregabalin + oxycodone

use alternative or monitor resp. rate; decr. oxycodone start dose by at least 50%, consider decr. pregabalin dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, oxycodone may decr. seizure threshold)

• oxymorphone
Lyrica (pregabalin)

+

oxymorphone

1 interaction

Avoid/Use Alternative

pregabalin + oxymorphone

use alternative or monitor resp. rate; decr. oxymorphone start dose by at least 50%, consider decr. pregabalin dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, oxymorphone may decr. seizure threshold)

• pentazocine
Lyrica (pregabalin)

+

pentazocine

1 interaction

Avoid/Use Alternative

pregabalin + pentazocine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, pentazocine may decr. seizure threshold)

• phenelzine
Lyrica (pregabalin)

+

phenelzine

1 interaction

Avoid/Use Alternative

pregabalin + phenelzine

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, phenelzine may decr. seizure threshold)

• promethazine
Lyrica (pregabalin)

+

promethazine

1 interaction

Avoid/Use Alternative

pregabalin + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, promethazine may decr. seizure threshold)

• ropeginterferon alfa-2b
Lyrica (pregabalin)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

pregabalin + ropeginterferon alfa-2b

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tapentadol
Lyrica (pregabalin)

+

tapentadol

1 interaction

Avoid/Use Alternative

pregabalin + tapentadol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, tapentadol may decr. seizure threshold)

• thalidomide
Lyrica (pregabalin)

+

thalidomide

1 interaction

Avoid/Use Alternative

pregabalin + thalidomide

use alternative or monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thalidomide may decr. seizure threshold)

• tramadol
Lyrica (pregabalin)

+

tramadol

1 interaction

Avoid/Use Alternative

pregabalin + tramadol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, tramadol may decr. seizure threshold)

• tranylcypromine
Lyrica (pregabalin)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

pregabalin + tranylcypromine

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, tranylcypromine may decr. seizure threshold)

• trimethobenzamide
Lyrica (pregabalin)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

pregabalin + trimethobenzamide

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zuranolone
Lyrica (pregabalin)

+

zuranolone

1 interaction

Avoid/Use Alternative

pregabalin + zuranolone

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Lyrica (pregabalin)

+

5-HTP

1 interaction

Monitor/Modify Tx

pregabalin + 5-HTP

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• aldesleukin
Lyrica (pregabalin)

+

aldesleukin

1 interaction

Monitor/Modify Tx

pregabalin + aldesleukin

monito resp. rate; withhold aldesleukin if mod-severe somnolence occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aldesleukin may decr. seizure threshold)

• alfentanil
Lyrica (pregabalin)

+

alfentanil

1 interaction

Monitor/Modify Tx

pregabalin + alfentanil

monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension; may alter seizure control (additive effects; antagonistic effects, alfentanil may decr. seizure threshold)

• allopurinol
Lyrica (pregabalin)

+

allopurinol

1 interaction

Monitor/Modify Tx

pregabalin + allopurinol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• almotriptan
Lyrica (pregabalin)

+

almotriptan

1 interaction

Monitor/Modify Tx

pregabalin + almotriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• alprazolam
Lyrica (pregabalin)

+

alprazolam

1 interaction

Monitor/Modify Tx

pregabalin + alprazolam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• amantadine
Lyrica (pregabalin)

+

amantadine

1 interaction

Monitor/Modify Tx

pregabalin + amantadine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• amitriptyline
Lyrica (pregabalin)

+

amitriptyline

1 interaction

Monitor/Modify Tx

pregabalin + amitriptyline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, amitriptyline may decr. seizure threshold)

• amoxapine
Lyrica (pregabalin)

+

amoxapine

1 interaction

Monitor/Modify Tx

pregabalin + amoxapine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, amoxapine may decr. seizure threshold)

• apomorphine
Lyrica (pregabalin)

+

apomorphine

1 interaction

Monitor/Modify Tx

pregabalin + apomorphine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Lyrica (pregabalin)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

pregabalin + apraclonidine ophthalmic

monitor resp. rate if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• aripiprazole lauroxil
Lyrica (pregabalin)

+

aripiprazole lauroxil

1 interaction

Monitor/Modify Tx

pregabalin + aripiprazole lauroxil

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• aripiprazole monthly injection
Lyrica (pregabalin)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

pregabalin + aripiprazole monthly injection

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• aripiprazole oral
Lyrica (pregabalin)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

pregabalin + aripiprazole oral

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• asenapine
Lyrica (pregabalin)

+

asenapine

1 interaction

Monitor/Modify Tx

pregabalin + asenapine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, asenapine may decr. seizure threshold)

• baclofen
Lyrica (pregabalin)

+

baclofen

1 interaction

Monitor/Modify Tx

pregabalin + baclofen

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, baclofen may decr. seizure threshold)

• baclofen intrathecal
Lyrica (pregabalin)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

pregabalin + baclofen intrathecal

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, baclofen may decr. seizure threshold)

• brexpiprazole
Lyrica (pregabalin)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

pregabalin + brexpiprazole

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, brexpiprazole may decr. seizure threshold)

• brimonidine topical
Lyrica (pregabalin)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

pregabalin + brimonidine topical

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• brivaracetam
Lyrica (pregabalin)

+

brivaracetam

1 interaction

Monitor/Modify Tx

pregabalin + brivaracetam

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• bromocriptine
Lyrica (pregabalin)

+

bromocriptine

1 interaction

Monitor/Modify Tx

pregabalin + bromocriptine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• brompheniramine
Lyrica (pregabalin)

+

brompheniramine

1 interaction

Monitor/Modify Tx

pregabalin + brompheniramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• buspirone
Lyrica (pregabalin)

+

buspirone

1 interaction

Monitor/Modify Tx

pregabalin + buspirone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• cannabidiol
Lyrica (pregabalin)

+

cannabidiol

1 interaction

Monitor/Modify Tx

pregabalin + cannabidiol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• cannabis
Lyrica (pregabalin)

+

cannabis

1 interaction

Monitor/Modify Tx

pregabalin + cannabis

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cannabis may decr. seizure threshold)

• carbamazepine
Lyrica (pregabalin)

+

carbamazepine

1 interaction

Monitor/Modify Tx

pregabalin + carbamazepine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• carbinoxamine
Lyrica (pregabalin)

+

carbinoxamine

1 interaction

Monitor/Modify Tx

pregabalin + carbinoxamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• cariprazine
Lyrica (pregabalin)

+

cariprazine

1 interaction

Monitor/Modify Tx

pregabalin + cariprazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cariprazine may decr. seizure threshold)

• carisoprodol
Lyrica (pregabalin)

+

carisoprodol

1 interaction

Monitor/Modify Tx

pregabalin + carisoprodol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• cenobamate
Lyrica (pregabalin)

+

cenobamate

1 interaction

Monitor/Modify Tx

pregabalin + cenobamate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• cetirizine
Lyrica (pregabalin)

+

cetirizine

1 interaction

Monitor/Modify Tx

pregabalin + cetirizine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chamomile, German
Lyrica (pregabalin)

+

chamomile, German

1 interaction

Monitor/Modify Tx

pregabalin + chamomile, German

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlophedianol
Lyrica (pregabalin)

+

chlophedianol

1 interaction

Monitor/Modify Tx

pregabalin + chlophedianol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlordiazepoxide
Lyrica (pregabalin)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

pregabalin + chlordiazepoxide

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlorpheniramine
Lyrica (pregabalin)

+

chlorpheniramine

1 interaction

Monitor/Modify Tx

pregabalin + chlorpheniramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlorpromazine
Lyrica (pregabalin)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

pregabalin + chlorpromazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, chlorpromazine may decr. seizure threshold)

• chlorzoxazone
Lyrica (pregabalin)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

pregabalin + chlorzoxazone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• citalopram
Lyrica (pregabalin)

+

citalopram

1 interaction

Monitor/Modify Tx

pregabalin + citalopram

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, citalopram may decr. seizure threshold)

• clemastine
Lyrica (pregabalin)

+

clemastine

1 interaction

Monitor/Modify Tx

pregabalin + clemastine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• clobazam
Lyrica (pregabalin)

+

clobazam

1 interaction

Monitor/Modify Tx

pregabalin + clobazam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• clomipramine
Lyrica (pregabalin)

+

clomipramine

1 interaction

Monitor/Modify Tx

pregabalin + clomipramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, clomipramine may decr. seizure threshold)

• clonazepam
Lyrica (pregabalin)

+

clonazepam

1 interaction

Monitor/Modify Tx

pregabalin + clonazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• clorazepate
Lyrica (pregabalin)

+

clorazepate

1 interaction

Monitor/Modify Tx

pregabalin + clorazepate

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• clozapine
Lyrica (pregabalin)

+

clozapine

1 interaction

Monitor/Modify Tx

pregabalin + clozapine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, clozapine may decr. seizure threshold)

• cyclobenzaprine
Lyrica (pregabalin)

+

cyclobenzaprine

1 interaction

Monitor/Modify Tx

pregabalin + cyclobenzaprine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cyclobenzaprine may decr. seizure threshold)

• cyproheptadine
Lyrica (pregabalin)

+

cyproheptadine

1 interaction

Monitor/Modify Tx

pregabalin + cyproheptadine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dantrolene
Lyrica (pregabalin)

+

dantrolene

1 interaction

Monitor/Modify Tx

pregabalin + dantrolene

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• daridorexant
Lyrica (pregabalin)

+

daridorexant

1 interaction

Monitor/Modify Tx

pregabalin + daridorexant

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• darifenacin
Lyrica (pregabalin)

+

darifenacin

1 interaction

Monitor/Modify Tx

pregabalin + darifenacin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• desflurane
Lyrica (pregabalin)

+

desflurane

1 interaction

Monitor/Modify Tx

pregabalin + desflurane

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Lyrica (pregabalin)

+

desipramine

1 interaction

Monitor/Modify Tx

pregabalin + desipramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desipramine may decr. seizure threshold)

• desvenlafaxine
Lyrica (pregabalin)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

pregabalin + desvenlafaxine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desvenlafaxine may decr. seizure threshold)

• deutetrabenazine
Lyrica (pregabalin)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

pregabalin + deutetrabenazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Lyrica (pregabalin)

+

dexbrompheniramine

1 interaction

Monitor/Modify Tx

pregabalin + dexbrompheniramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Lyrica (pregabalin)

+

dexchlorpheniramine

1 interaction

Monitor/Modify Tx

pregabalin + dexchlorpheniramine

monitor resp. rate: combo may incr. risk of profound CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine
Lyrica (pregabalin)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

pregabalin + dexmedetomidine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Lyrica (pregabalin)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

pregabalin + dexmedetomidine injection

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dichlorphenamide
Lyrica (pregabalin)

+

dichlorphenamide

1 interaction

Monitor/Modify Tx

pregabalin + dichlorphenamide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• difelikefalin
Lyrica (pregabalin)

+

difelikefalin

1 interaction

Monitor/Modify Tx

pregabalin + difelikefalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• difenoxin
Lyrica (pregabalin)

+

difenoxin

1 interaction

Monitor/Modify Tx

pregabalin + difenoxin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dimenhydrinate
Lyrica (pregabalin)

+

dimenhydrinate

1 interaction

Monitor/Modify Tx

pregabalin + dimenhydrinate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• diphenhydramine
Lyrica (pregabalin)

+

diphenhydramine

1 interaction

Monitor/Modify Tx

pregabalin + diphenhydramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• diphenoxylate
Lyrica (pregabalin)

+

diphenoxylate

1 interaction

Monitor/Modify Tx

pregabalin + diphenoxylate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• domperidone
Lyrica (pregabalin)

+

domperidone

1 interaction

Monitor/Modify Tx

pregabalin + domperidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• doxepin
Lyrica (pregabalin)

+

doxepin

1 interaction

Monitor/Modify Tx

pregabalin + doxepin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, doxepin may decr. seizure threshold)

• doxepin topical
Lyrica (pregabalin)

+

doxepin topical

1 interaction

Monitor/Modify Tx

pregabalin + doxepin topical

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dronabinol
Lyrica (pregabalin)

+

dronabinol

1 interaction

Monitor/Modify Tx

pregabalin + dronabinol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, dronabinol may decr. seizure threshold)

• droperidol
Lyrica (pregabalin)

+

droperidol

1 interaction

Monitor/Modify Tx

pregabalin + droperidol

monitor resp. rate, decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• duloxetine
Lyrica (pregabalin)

+

duloxetine

1 interaction

Monitor/Modify Tx

pregabalin + duloxetine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, duloxetine may decr. seizure threshold)

• efavirenz
Lyrica (pregabalin)

+

efavirenz

1 interaction

Monitor/Modify Tx

pregabalin + efavirenz

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eletriptan
Lyrica (pregabalin)

+

eletriptan

1 interaction

Monitor/Modify Tx

pregabalin + eletriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• entacapone
Lyrica (pregabalin)

+

entacapone

1 interaction

Monitor/Modify Tx

pregabalin + entacapone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• entrectinib
Lyrica (pregabalin)

+

entrectinib

1 interaction

Monitor/Modify Tx

pregabalin + entrectinib

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• escitalopram
Lyrica (pregabalin)

+

escitalopram

1 interaction

Monitor/Modify Tx

pregabalin + escitalopram

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• esketamine
Lyrica (pregabalin)

+

esketamine

1 interaction

Monitor/Modify Tx

pregabalin + esketamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Lyrica (pregabalin)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

pregabalin + eslicarbazepine acetate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• estazolam
Lyrica (pregabalin)

+

estazolam

1 interaction

Monitor/Modify Tx

pregabalin + estazolam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Lyrica (pregabalin)

+

eszopiclone

1 interaction

Monitor/Modify Tx

pregabalin + eszopiclone

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Lyrica (pregabalin)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

pregabalin + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethosuximide
Lyrica (pregabalin)

+

ethosuximide

1 interaction

Monitor/Modify Tx

pregabalin + ethosuximide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• etomidate
Lyrica (pregabalin)

+

etomidate

1 interaction

Monitor/Modify Tx

pregabalin + etomidate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• felbamate
Lyrica (pregabalin)

+

felbamate

1 interaction

Monitor/Modify Tx

pregabalin + felbamate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fenfluramine
Lyrica (pregabalin)

+

fenfluramine

1 interaction

Monitor/Modify Tx

pregabalin + fenfluramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fesoterodine
Lyrica (pregabalin)

+

fesoterodine

1 interaction

Monitor/Modify Tx

pregabalin + fesoterodine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• flibanserin
Lyrica (pregabalin)

+

flibanserin

1 interaction

Monitor/Modify Tx

pregabalin + flibanserin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fluoxetine
Lyrica (pregabalin)

+

fluoxetine

1 interaction

Monitor/Modify Tx

pregabalin + fluoxetine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)

• fluphenazine
Lyrica (pregabalin)

+

fluphenazine

1 interaction

Monitor/Modify Tx

pregabalin + fluphenazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• flurazepam
Lyrica (pregabalin)

+

flurazepam

1 interaction

Monitor/Modify Tx

pregabalin + flurazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fluvoxamine
Lyrica (pregabalin)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

pregabalin + fluvoxamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• foslevodopa
Lyrica (pregabalin)

+

foslevodopa

1 interaction

Monitor/Modify Tx

pregabalin + foslevodopa

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fosphenytoin
Lyrica (pregabalin)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

pregabalin + fosphenytoin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• frovatriptan
Lyrica (pregabalin)

+

frovatriptan

1 interaction

Monitor/Modify Tx

pregabalin + frovatriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin
Lyrica (pregabalin)

+

gabapentin

1 interaction

Monitor/Modify Tx

pregabalin + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Lyrica (pregabalin)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

pregabalin + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ganaxolone
Lyrica (pregabalin)

+

ganaxolone

1 interaction

Monitor/Modify Tx

pregabalin + ganaxolone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• glofitamab
Lyrica (pregabalin)

+

glofitamab

1 interaction

Monitor/Modify Tx

pregabalin + glofitamab

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• glycopyrrolate
Lyrica (pregabalin)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

pregabalin + glycopyrrolate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• guanfacine
Lyrica (pregabalin)

+

guanfacine

1 interaction

Monitor/Modify Tx

pregabalin + guanfacine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• haloperidol
Lyrica (pregabalin)

+

haloperidol

1 interaction

Monitor/Modify Tx

pregabalin + haloperidol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, haloperidol may decr. seizure threshold)

• hydroxyzine
Lyrica (pregabalin)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

pregabalin + hydroxyzine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• hyoscyamine
Lyrica (pregabalin)

+

hyoscyamine

1 interaction

Monitor/Modify Tx

pregabalin + hyoscyamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ifosfamide
Lyrica (pregabalin)

+

ifosfamide

1 interaction

Monitor/Modify Tx

pregabalin + ifosfamide

monitor resp. rate; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ifosfamide may decr. seizure threshold)

• iloperidone
Lyrica (pregabalin)

+

iloperidone

1 interaction

Monitor/Modify Tx

pregabalin + iloperidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• imipramine
Lyrica (pregabalin)

+

imipramine

1 interaction

Monitor/Modify Tx

pregabalin + imipramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, imipramine may decr. seizure threshold)

• isoflurane
Lyrica (pregabalin)

+

isoflurane

1 interaction

Monitor/Modify Tx

pregabalin + isoflurane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ketamine
Lyrica (pregabalin)

+

ketamine

1 interaction

Monitor/Modify Tx

pregabalin + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ketamine may decr. seizure threshold)

• lacosamide
Lyrica (pregabalin)

+

lacosamide

1 interaction

Monitor/Modify Tx

pregabalin + lacosamide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lamotrigine
Lyrica (pregabalin)

+

lamotrigine

1 interaction

Monitor/Modify Tx

pregabalin + lamotrigine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lasmiditan
Lyrica (pregabalin)

+

lasmiditan

1 interaction

Monitor/Modify Tx

pregabalin + lasmiditan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lemborexant
Lyrica (pregabalin)

+

lemborexant

1 interaction

Monitor/Modify Tx

pregabalin + lemborexant

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levetiracetam
Lyrica (pregabalin)

+

levetiracetam

1 interaction

Monitor/Modify Tx

pregabalin + levetiracetam

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levocetirizine
Lyrica (pregabalin)

+

levocetirizine

1 interaction

Monitor/Modify Tx

pregabalin + levocetirizine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levodopa
Lyrica (pregabalin)

+

levodopa

1 interaction

Monitor/Modify Tx

pregabalin + levodopa

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levomilnacipran
Lyrica (pregabalin)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

pregabalin + levomilnacipran

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, levomilnacipran may decr. seizure threshold)

• lofexidine
Lyrica (pregabalin)

+

lofexidine

1 interaction

Monitor/Modify Tx

pregabalin + lofexidine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• loxapine
Lyrica (pregabalin)

+

loxapine

1 interaction

Monitor/Modify Tx

pregabalin + loxapine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, loxapine may decr. seizure threshold)

• lumateperone
Lyrica (pregabalin)

+

lumateperone

1 interaction

Monitor/Modify Tx

pregabalin + lumateperone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, lumateperone may decr. seizure threshold)

• lurasidone
Lyrica (pregabalin)

+

lurasidone

1 interaction

Monitor/Modify Tx

pregabalin + lurasidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, lurasidone may decr. seizure threshold)

• meclizine
Lyrica (pregabalin)

+

meclizine

1 interaction

Monitor/Modify Tx

pregabalin + meclizine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• melatonin
Lyrica (pregabalin)

+

melatonin

1 interaction

Monitor/Modify Tx

pregabalin + melatonin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, melatonin may decr. seizure threshold)

• meprobamate
Lyrica (pregabalin)

+

meprobamate

1 interaction

Monitor/Modify Tx

pregabalin + meprobamate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methocarbamol
Lyrica (pregabalin)

+

methocarbamol

1 interaction

Monitor/Modify Tx

pregabalin + methocarbamol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, methocarbamol may decr. seizure threshold)

• methohexital
Lyrica (pregabalin)

+

methohexital

1 interaction

Monitor/Modify Tx

pregabalin + methohexital

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methsuximide
Lyrica (pregabalin)

+

methsuximide

1 interaction

Monitor/Modify Tx

pregabalin + methsuximide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methyldopa
Lyrica (pregabalin)

+

methyldopa

1 interaction

Monitor/Modify Tx

pregabalin + methyldopa

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• metyrapone
Lyrica (pregabalin)

+

metyrapone

1 interaction

Monitor/Modify Tx

pregabalin + metyrapone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• metyrosine
Lyrica (pregabalin)

+

metyrosine

1 interaction

Monitor/Modify Tx

pregabalin + metyrosine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• milnacipran
Lyrica (pregabalin)

+

milnacipran

1 interaction

Monitor/Modify Tx

pregabalin + milnacipran

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, milnacipran may decr. seizure threshold)

• mirtazapine
Lyrica (pregabalin)

+

mirtazapine

1 interaction

Monitor/Modify Tx

pregabalin + mirtazapine

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• mitotane
Lyrica (pregabalin)

+

mitotane

1 interaction

Monitor/Modify Tx

pregabalin + mitotane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• molindone
Lyrica (pregabalin)

+

molindone

1 interaction

Monitor/Modify Tx

pregabalin + molindone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, molindone may decr. seizure threshold)

• mosunetuzumab
Lyrica (pregabalin)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

pregabalin + mosunetuzumab

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Lyrica (pregabalin)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

pregabalin + mycophenolate mofetil

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• naltrexone
Lyrica (pregabalin)

+

naltrexone

1 interaction

Monitor/Modify Tx

pregabalin + naltrexone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• naratriptan
Lyrica (pregabalin)

+

naratriptan

1 interaction

Monitor/Modify Tx

pregabalin + naratriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• nefazodone
Lyrica (pregabalin)

+

nefazodone

1 interaction

Monitor/Modify Tx

pregabalin + nefazodone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nefazodone may decr. seizure threshold)

• nelarabine
Lyrica (pregabalin)

+

nelarabine

1 interaction

Monitor/Modify Tx

pregabalin + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs; otherwise, monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nelarabine may decr. seizure threshold)

• nortriptyline
Lyrica (pregabalin)

+

nortriptyline

1 interaction

Monitor/Modify Tx

pregabalin + nortriptyline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nortriptyline may decr. seizure threshold)

• olanzapine
Lyrica (pregabalin)

+

olanzapine

1 interaction

Monitor/Modify Tx

pregabalin + olanzapine

monitor BP, resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis; may alter seizure control (additive effects; antagonistic effects, olanzapine may decr. seizure threshold)

• opicapone
Lyrica (pregabalin)

+

opicapone

1 interaction

Monitor/Modify Tx

pregabalin + opicapone

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• orphenadrine
Lyrica (pregabalin)

+

orphenadrine

1 interaction

Monitor/Modify Tx

pregabalin + orphenadrine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxazepam
Lyrica (pregabalin)

+

oxazepam

1 interaction

Monitor/Modify Tx

pregabalin + oxazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxcarbazepine
Lyrica (pregabalin)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

pregabalin + oxcarbazepine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxybutynin
Lyrica (pregabalin)

+

oxybutynin

1 interaction

Monitor/Modify Tx

pregabalin + oxybutynin

monitor resp. rate, decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• paliperidone
Lyrica (pregabalin)

+

paliperidone

1 interaction

Monitor/Modify Tx

pregabalin + paliperidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• paroxetine
Lyrica (pregabalin)

+

paroxetine

1 interaction

Monitor/Modify Tx

pregabalin + paroxetine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, paroxetine may decr. seizure threshold)

• passion flower
Lyrica (pregabalin)

+

passion flower

1 interaction

Monitor/Modify Tx

pregabalin + passion flower

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• pentobarbital
Lyrica (pregabalin)

+

pentobarbital

1 interaction

Monitor/Modify Tx

pregabalin + pentobarbital

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• perampanel
Lyrica (pregabalin)

+

perampanel

1 interaction

Monitor/Modify Tx

pregabalin + perampanel

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• perphenazine
Lyrica (pregabalin)

+

perphenazine

1 interaction

Monitor/Modify Tx

pregabalin + perphenazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, perphenazine may decr. seizure threshold)

• pheniramine
Lyrica (pregabalin)

+

pheniramine

1 interaction

Monitor/Modify Tx

pregabalin + pheniramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• phenobarbital
Lyrica (pregabalin)

+

phenobarbital

1 interaction

Monitor/Modify Tx

pregabalin + phenobarbital

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• phenytoin
Lyrica (pregabalin)

+

phenytoin

1 interaction

Monitor/Modify Tx

pregabalin + phenytoin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• pimozide
Lyrica (pregabalin)

+

pimozide

1 interaction

Monitor/Modify Tx

pregabalin + pimozide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, pimozide may decr. seizure threshold)

• pramipexole
Lyrica (pregabalin)

+

pramipexole

1 interaction

Monitor/Modify Tx

pregabalin + pramipexole

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• primidone
Lyrica (pregabalin)

+

primidone

1 interaction

Monitor/Modify Tx

pregabalin + primidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• procarbazine
Lyrica (pregabalin)

+

procarbazine

1 interaction

Monitor/Modify Tx

pregabalin + procarbazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, procarbazine may decr. seizure threshold)

• prochlorperazine
Lyrica (pregabalin)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

pregabalin + prochlorperazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, prochlorperazine may decr. seizure threshold)

• propofol
Lyrica (pregabalin)

+

propofol

1 interaction

Monitor/Modify Tx

pregabalin + propofol

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, propofol may decr. seizure threshold)

• protriptyline
Lyrica (pregabalin)

+

protriptyline

1 interaction

Monitor/Modify Tx

pregabalin + protriptyline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, protriptyline may decr. seizure threshold)

• pyrilamine
Lyrica (pregabalin)

+

pyrilamine

1 interaction

Monitor/Modify Tx

pregabalin + pyrilamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• quazepam
Lyrica (pregabalin)

+

quazepam

1 interaction

Monitor/Modify Tx

pregabalin + quazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Lyrica (pregabalin)

+

quetiapine

1 interaction

Monitor/Modify Tx

pregabalin + quetiapine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, quetiapine may decr. seizure threshold)

• ramelteon
Lyrica (pregabalin)

+

ramelteon

1 interaction

Monitor/Modify Tx

pregabalin + ramelteon

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• rasagiline
Lyrica (pregabalin)

+

rasagiline

1 interaction

Monitor/Modify Tx

pregabalin + rasagiline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• remifentanil
Lyrica (pregabalin)

+

remifentanil

1 interaction

Monitor/Modify Tx

pregabalin + remifentanil

monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, remifentanil may decr. seizure threshold)

• remimazolam
Lyrica (pregabalin)

+

remimazolam

1 interaction

Monitor/Modify Tx

pregabalin + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
Lyrica (pregabalin)

+

repotrectinib

1 interaction

Monitor/Modify Tx

pregabalin + repotrectinib

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• risperidone
Lyrica (pregabalin)

+

risperidone

1 interaction

Monitor/Modify Tx

pregabalin + risperidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, risperidone may decr. seizure threshold)

• rizatriptan
Lyrica (pregabalin)

+

rizatriptan

1 interaction

Monitor/Modify Tx

pregabalin + rizatriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ropinirole
Lyrica (pregabalin)

+

ropinirole

1 interaction

Monitor/Modify Tx

pregabalin + ropinirole

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Lyrica (pregabalin)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

pregabalin + rotigotine transdermal

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• rufinamide
Lyrica (pregabalin)

+

rufinamide

1 interaction

Monitor/Modify Tx

pregabalin + rufinamide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• safinamide
Lyrica (pregabalin)

+

safinamide

1 interaction

Monitor/Modify Tx

pregabalin + safinamide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects)

• scopolamine
Lyrica (pregabalin)

+

scopolamine

1 interaction

Monitor/Modify Tx

pregabalin + scopolamine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, scopolamine may decr. seizure threshold)

• selegiline
Lyrica (pregabalin)

+

selegiline

1 interaction

Monitor/Modify Tx

pregabalin + selegiline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects)

• selegiline transdermal
Lyrica (pregabalin)

+

selegiline transdermal

1 interaction

Monitor/Modify Tx

pregabalin + selegiline transdermal

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, selegiline transdermal may decr. seizure threshold)

• selinexor
Lyrica (pregabalin)

+

selinexor

1 interaction

Monitor/Modify Tx

pregabalin + selinexor

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• sertraline
Lyrica (pregabalin)

+

sertraline

1 interaction

Monitor/Modify Tx

pregabalin + sertraline

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sertraline may decr. seizure threshold)

• sevoflurane
Lyrica (pregabalin)

+

sevoflurane

1 interaction

Monitor/Modify Tx

pregabalin + sevoflurane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sevoflurane may decr. seizure threshold)

• solifenacin
Lyrica (pregabalin)

+

solifenacin

1 interaction

Monitor/Modify Tx

pregabalin + solifenacin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• stiripentol
Lyrica (pregabalin)

+

stiripentol

1 interaction

Monitor/Modify Tx

pregabalin + stiripentol

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• sufentanil
Lyrica (pregabalin)

+

sufentanil

1 interaction

Monitor/Modify Tx

pregabalin + sufentanil

monitor resp. rate, decr. sufentanil start dose, consider decr. pregabalin dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sufentanil may decr. seizure threshold)

• sumatriptan
Lyrica (pregabalin)

+

sumatriptan

1 interaction

Monitor/Modify Tx

pregabalin + sumatriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sumatriptan may decr. seizure threshold)

• suvorexant
Lyrica (pregabalin)

+

suvorexant

1 interaction

Monitor/Modify Tx

pregabalin + suvorexant

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tasimelteon
Lyrica (pregabalin)

+

tasimelteon

1 interaction

Monitor/Modify Tx

pregabalin + tasimelteon

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• temazepam
Lyrica (pregabalin)

+

temazepam

1 interaction

Monitor/Modify Tx

pregabalin + temazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tetrabenazine
Lyrica (pregabalin)

+

tetrabenazine

1 interaction

Monitor/Modify Tx

pregabalin + tetrabenazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• thioridazine
Lyrica (pregabalin)

+

thioridazine

1 interaction

Monitor/Modify Tx

pregabalin + thioridazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thioridazine may decr. seizure threshold)

• thiotepa
Lyrica (pregabalin)

+

thiotepa

1 interaction

Monitor/Modify Tx

pregabalin + thiotepa

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thiotepa may decr. seizure threshold)

• thiothixene
Lyrica (pregabalin)

+

thiothixene

1 interaction

Monitor/Modify Tx

pregabalin + thiothixene

monitor resp. rate, consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thiothixene may decr. seizure threshold)

• tiagabine
Lyrica (pregabalin)

+

tiagabine

1 interaction

Monitor/Modify Tx

pregabalin + tiagabine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tizanidine
Lyrica (pregabalin)

+

tizanidine

1 interaction

Monitor/Modify Tx

pregabalin + tizanidine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tolcapone
Lyrica (pregabalin)

+

tolcapone

1 interaction

Monitor/Modify Tx

pregabalin + tolcapone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tolterodine
Lyrica (pregabalin)

+

tolterodine

1 interaction

Monitor/Modify Tx

pregabalin + tolterodine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• topiramate
Lyrica (pregabalin)

+

topiramate

1 interaction

Monitor/Modify Tx

pregabalin + topiramate

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trazodone
Lyrica (pregabalin)

+

trazodone

1 interaction

Monitor/Modify Tx

pregabalin + trazodone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• triazolam
Lyrica (pregabalin)

+

triazolam

1 interaction

Monitor/Modify Tx

pregabalin + triazolam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trifluoperazine
Lyrica (pregabalin)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

pregabalin + trifluoperazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, trifluoperazine may decr. seizure threshold)

• trihexyphenidyl
Lyrica (pregabalin)

+

trihexyphenidyl

1 interaction

Monitor/Modify Tx

pregabalin + trihexyphenidyl

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trimipramine
Lyrica (pregabalin)

+

trimipramine

1 interaction

Monitor/Modify Tx

pregabalin + trimipramine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, trimipramine may decr. seizure threshold)

• triprolidine
Lyrica (pregabalin)

+

triprolidine

1 interaction

Monitor/Modify Tx

pregabalin + triprolidine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trospium
Lyrica (pregabalin)

+

trospium

1 interaction

Monitor/Modify Tx

pregabalin + trospium

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valbenazine
Lyrica (pregabalin)

+

valbenazine

1 interaction

Monitor/Modify Tx

pregabalin + valbenazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valerian
Lyrica (pregabalin)

+

valerian

1 interaction

Monitor/Modify Tx

pregabalin + valerian

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valproic acid
Lyrica (pregabalin)

+

valproic acid

1 interaction

Monitor/Modify Tx

pregabalin + valproic acid

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• venlafaxine
Lyrica (pregabalin)

+

venlafaxine

1 interaction

Monitor/Modify Tx

pregabalin + venlafaxine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, venlafaxine may decr. seizure threshold)

• vigabatrin
Lyrica (pregabalin)

+

vigabatrin

1 interaction

Monitor/Modify Tx

pregabalin + vigabatrin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• vilazodone
Lyrica (pregabalin)

+

vilazodone

1 interaction

Monitor/Modify Tx

pregabalin + vilazodone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, vilazodone may decr. seizure threshold)

• viloxazine
Lyrica (pregabalin)

+

viloxazine

1 interaction

Monitor/Modify Tx

pregabalin + viloxazine

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zaleplon
Lyrica (pregabalin)

+

zaleplon

1 interaction

Monitor/Modify Tx

pregabalin + zaleplon

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ziconotide
Lyrica (pregabalin)

+

ziconotide

1 interaction

Monitor/Modify Tx

pregabalin + ziconotide

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ziprasidone
Lyrica (pregabalin)

+

ziprasidone

1 interaction

Monitor/Modify Tx

pregabalin + ziprasidone

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ziprasidone may decr. seizure threshold)

• zolmitriptan
Lyrica (pregabalin)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

pregabalin + zolmitriptan

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zolpidem
Lyrica (pregabalin)

+

zolpidem

1 interaction

Monitor/Modify Tx

pregabalin + zolpidem

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zonisamide
Lyrica (pregabalin)

+

zonisamide

1 interaction

Monitor/Modify Tx

pregabalin + zonisamide

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)