Pneumovax 23

Overview

pneumococcal vaccine

vaccine

• non-live vaccine

Avoid/Use Alternative

• interferon gamma 1b
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

interferon gamma 1b

1 interaction

Avoid/Use Alternative

pneumococcal vaccine + interferon gamma 1b

avoid combo: combo may result in amplified immune response (immunomodulatory effects)

Monitor/Modify Tx

• abatacept
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

abatacept

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + abatacept

if possible, vaccinate at least 2wk before starting abatacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• abemaciclib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

abemaciclib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + abemaciclib

if possible, vaccinate at least 2wk before abemaciclib start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• abrocitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

abrocitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + abrocitinib

if possible, vaccinate at least 2wk before starting abrocitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• acalabrutinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

acalabrutinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + acalabrutinib

if possible, vaccinate at least 2wk before starting acalabrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• adalimumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

adalimumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + adalimumab

if possible, vaccinate at least 2wk before starting adalimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ado-trastuzumab emtansine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ado-trastuzumab emtansine

if possible, vaccinate at least 2wk before starting ado-trastuzumab emtansine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• afamitresgene autoleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

afamitresgene autoleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + afamitresgene autoleucel

if possible, vaccinate at least 2wk before starting afamitresgene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• aldesleukin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

aldesleukin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + aldesleukin

if possible, vaccinate at least 2wk before starting aldesleukin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• alemtuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

alemtuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + alemtuzumab

if possible, vaccinate at least 2wk before starting alemtuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• amivantamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

amivantamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + amivantamab

if possible, vaccinate at least 2wk before starting amivantamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anakinra
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

anakinra

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + anakinra

if possible, vaccinate at least 2wk before starting anakinra tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anifrolumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

anifrolumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + anifrolumab

if possible, vaccinate at least 2wk before starting anifrolumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anti-thymocyte globulin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + anti-thymocyte globulin

if possible, vaccinate at least 2wk before starting anti-thymocyte globulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• asciminib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

asciminib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + asciminib

if possible, vaccinate at least 2wk before starting asciminib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• atezolizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

atezolizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + atezolizumab

if possible, vaccinate at least 2wk before starting atezolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• atidarsagene autotemcel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

atidarsagene autotemcel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + atidarsagene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• avelumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

avelumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + avelumab

if possible, vaccinate at least 2wk before starting avelumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• avutometinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

avutometinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + avutometinib

if possible, vaccinate at least 2wk before starting avutometinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• axicabtagene ciloleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

axicabtagene ciloleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + axicabtagene ciloleucel

if possible, vaccinate at least 2wk before starting axicabtagene ciloleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• azacitidine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

azacitidine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + azacitidine

if possible, vaccinate at least 2wk before starting azacitidine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• azathioprine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

azathioprine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + azathioprine

if possible, vaccinate at least 2wk before starting azathioprine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• baricitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

baricitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + baricitinib

if possible, vaccinate at least 2wk before starting baricitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• basiliximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

basiliximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + basiliximab

if possible, vaccinate at least 2wk before starting basiliximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belantamab mafodotin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

belantamab mafodotin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + belantamab mafodotin

if possible, vaccinate at least 2wk before starting belantamab mafodotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belatacept
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

belatacept

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + belatacept

if possible, vaccinate at least 2wk before starting belatacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belimumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

belimumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + belimumab

if possible, vaccinate at least 2wk before starting belimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belinostat
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

belinostat

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + belinostat

if possible, vaccinate at least 2wk before starting belinostat tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belzutifan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

belzutifan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + belzutifan

if possible, vaccinate at least 2wk before starting belzutifan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• bendamustine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

bendamustine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + bendamustine

if possible, vaccinate at least 2wk before starting bendamustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• betamethasone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

betamethasone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + betamethasone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• bimekizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

bimekizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + bimekizumab

if possible, vaccinate at least 2wk before starting bimekizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• blinatumomab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

blinatumomab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + blinatumomab

if possible, vaccinate at least 2wk before starting blinatumomab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• bortezomib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

bortezomib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + bortezomib

if possible, vaccinate at least 2wk before starting bortezomib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brentuximab vedotin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + brentuximab vedotin

if possible, vaccinate at least 2wk before starting brentuximab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brexucabtagene autoleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

brexucabtagene autoleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + brexucabtagene autoleucel

if possible, vaccinate at least 2wk before starting brexucabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brodalumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

brodalumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + brodalumab

if possible, vaccinate at least 2wk before starting brodalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• budesonide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

budesonide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + budesonide

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• budesonide rectal
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

budesonide rectal

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + budesonide rectal

consider vaccinating at least 2wk before budesonide rectal use; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• busulfan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

busulfan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + busulfan

if possible, vaccinate at least 2wk before busulfan start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cabazitaxel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cabazitaxel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cabazitaxel

if possible, vaccinate at least 2wk before starting cabazitaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• canakinumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

canakinumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + canakinumab

if possible, vaccinate at least 2wk before starting canakinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• capecitabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

capecitabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + capecitabine

if possible, vaccinate at least 2wk before starting capecitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• capmatinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

capmatinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + capmatinib

if possible, vaccinate at least 2wk before starting capmatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carboplatin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

carboplatin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + carboplatin

if possible, vaccinate at least 2wk before starting carboplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carfilzomib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

carfilzomib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + carfilzomib

if possible, vaccinate at least 2wk before starting carfilzomib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carmustine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

carmustine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + carmustine

if possible, vaccinate at least 2wk before starting carmustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cemiplimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cemiplimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cemiplimab

if possible, vaccinate at least 2wk before starting cemiplimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• certolizumab pegol
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

certolizumab pegol

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + certolizumab pegol

if possible, vaccinate at least 2wk before starting certolizumab pegol tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• chlorambucil
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

chlorambucil

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + chlorambucil

if possible, vaccinate at least 2wk before starting chlorambucil tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ciltacabtagene autoleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ciltacabtagene autoleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ciltacabtagene autoleucel

if possible, vaccinate at least 2wk before starting ciltacabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cisplatin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cisplatin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cisplatin

if possible, vaccinate at least 2wk before starting cisplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cladribine injection
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cladribine injection

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cladribine injection

if possible, vaccinate at least 2wk before starting cladribine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cladribine oral
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cladribine oral

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cladribine oral

if possible, vaccinate at least 2wk before starting cladribine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• clofarabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

clofarabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + clofarabine

if possible, vaccinate at least 2wk before starting clofarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• copanlisib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

copanlisib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + copanlisib

if possible, vaccinate at least 2wk before starting copanlisib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• corticotropin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

corticotropin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + corticotropin

if possible, vaccinate at least 2wk before starting corticotropin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cortisone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cortisone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• cosibelimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cosibelimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cosibelimab

if possible, vaccinate at least 2wk before starting cosibelimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cyclophosphamide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cyclophosphamide

if possible, vaccinate at least 2wk before starting cyclophosphamide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cyclosporine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cyclosporine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cyclosporine

if possible, vaccinate at least 2wk before starting cyclosporine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cytarabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

cytarabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + cytarabine

if possible, vaccinate at least 2wk before cytarabine start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dactinomycin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dactinomycin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dactinomycin

if possible, vaccinate at least 2wk before starting dactinomycin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• daratumumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

daratumumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + daratumumab

if possible, vaccinate at least 2wk before starting daratumumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dasatinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dasatinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dasatinib

if possible, vaccinate at least 2wk before starting dasatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• daunorubicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

daunorubicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + daunorubicin

if possible, vaccinate at least 2wk before daunorubicin start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• decitabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

decitabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + decitabine

if possible, vaccinate at least 2wk before starting decitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• defactinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

defactinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + defactinib

if possible, vaccinate at least 2wk before starting defactinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deflazacort
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

deflazacort

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + deflazacort

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• delgocitinib topical
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

delgocitinib topical

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + delgocitinib topical

if possible, vaccinate at least 2wk before starting delgocitinib topical tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deucravacitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

deucravacitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + deucravacitinib

if possible, vaccinate at least 2wk before starting deucravacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deuruxolitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + deuruxolitinib

if possible, vaccinate at least 2wk before starting deuruxolitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dexamethasone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dexamethasone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dexamethasone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• dimethyl fumarate
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dimethyl fumarate

if possible, vaccinate at least 2wk before starting dimethyl fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dinutuximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dinutuximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dinutuximab

if possible, vaccinate at least 2wk before starting dinutuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• diroximel fumarate
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + diroximel fumarate

if possible, vaccinate at least 2wk before starting diroximel fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• docetaxel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

docetaxel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + docetaxel

if possible, vaccinate at least 2wk before starting docetaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dordaviprone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dordaviprone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dordaviprone

if possible, vaccinate at least 2wk before starting dordaviprone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dostarlimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dostarlimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dostarlimab

if possible, vaccinate at least 2wk before starting dostarlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• doxorubicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

doxorubicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + doxorubicin

if possible, vaccinate at least 2wk before doxorubicin start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dupilumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

dupilumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + dupilumab

if possible, vaccinate at least 2wk before starting dupilumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• durvalumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

durvalumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + durvalumab

if possible, vaccinate at least 2wk before starting durvalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• duvelisib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

duvelisib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + duvelisib

if possible, vaccinate at least 2wk before duvelisib start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• efgartigimod alfa
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

efgartigimod alfa

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + efgartigimod alfa

if possible, vaccinate at least 2wk before starting efgartigimod alfa tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• elivaldogene autotemcel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

elivaldogene autotemcel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + elivaldogene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• elotuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

elotuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + elotuzumab

if possible, vaccinate at least 2wk before starting elotuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• elranatamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

elranatamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + elranatamab

if possible, vaccinate at least 2wk before starting elranatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• emapalumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

emapalumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + emapalumab

if possible, vaccinate at least 2wk before starting emapalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• epcoritamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

epcoritamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + epcoritamab

if possible, vaccinate at least 2wk before starting epcoritamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• epirubicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

epirubicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + epirubicin

if possible, vaccinate at least 2wk before starting epirubicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• erdafitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

erdafitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + erdafitinib

if possible, vaccinate at least 2wk before starting erdafitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• eribulin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

eribulin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + eribulin

if possible, vaccinate at least 2wk before starting eribulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etanercept
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

etanercept

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + etanercept

if possible, vaccinate at least 2wk before starting etanercept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etoposide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

etoposide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + etoposide

if possible, vaccinate at least 2wk before etoposide start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etrasimod
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

etrasimod

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + etrasimod

if possible, vaccinate at least 2wk before starting etrasimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etuvetidigene autotemcel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

etuvetidigene autotemcel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + etuvetidigene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• everolimus
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

everolimus

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + everolimus

if possible, vaccinate at least 2wk before starting everolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fam-trastuzumab deruxtecan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fam-trastuzumab deruxtecan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fam-trastuzumab deruxtecan

if possible, vaccinate at least 2wk before starting fam-trastuzumab deruxtecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fingolimod
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fingolimod

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fingolimod

if possible, vaccinate at least 2wk before starting fingolimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• floxuridine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

floxuridine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + floxuridine

if possible, vaccinate at least 2wk before starting floxuridine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fludarabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fludarabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fludarabine

if possible, vaccinate at least 2wk before starting fludarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fludrocortisone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fludrocortisone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fludrocortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• fluorouracil
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fluorouracil

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fluorouracil

if possible, vaccinate at least 2wk before fluorouracil start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fruquintinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

fruquintinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + fruquintinib

if possible, vaccinate at least 2wk before starting fruquintinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• futibatinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

futibatinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + futibatinib

if possible, vaccinate at least 2wk before starting futibatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• gemcitabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

gemcitabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + gemcitabine

if possible, vaccinate at least 2wk before starting gemcitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• gemtuzumab ozogamicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + gemtuzumab ozogamicin

if possible, vaccinate at least 2wk before starting gemtuzumab ozogamicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• glofitamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

glofitamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + glofitamab

if possible, vaccinate at least 2wk before starting glofitamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• golimumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

golimumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + golimumab

if possible, vaccinate at least 2wk before starting golimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• guselkumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

guselkumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + guselkumab

if possible, vaccinate at least 2wk before starting guselkumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• hydrocortisone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

hydrocortisone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + hydrocortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• hydroxyurea
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

hydroxyurea

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + hydroxyurea

if possible, vaccinate at least 2wk before starting hydroxyurea tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ibritumomab tiuxetan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ibritumomab tiuxetan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ibritumomab tiuxetan

if possible, vaccinate at least 2wk before starting ibritumomab tiuxetan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ibrutinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ibrutinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ibrutinib

if possible, vaccinate at least 2wk before starting ibrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• icotrokinra
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

icotrokinra

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + icotrokinra

if possible, vaccinate at least 2wk before icotrokinra start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idarubicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

idarubicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + idarubicin

if possible, vaccinate at least 2wk before starting idarubicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idecabtagene vicleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

idecabtagene vicleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + idecabtagene vicleucel

if possible, vaccinate at least 2wk before starting idecabtagene vicleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idelalisib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

idelalisib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + idelalisib

if possible, vaccinate at least 2wk before starting idelalisib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ifosfamide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ifosfamide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ifosfamide

if possible, vaccinate at least 2wk before starting ifosfamide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• imatinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

imatinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + imatinib

if possible, vaccinate at least 2wk before starting imatinib; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• inebilizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

inebilizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + inebilizumab

if possible, vaccinate at least 4wk before starting inebilizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• infliximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

infliximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + infliximab

if possible, vaccinate at least 2wk before starting infliximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• inotuzumab ozogamicin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + inotuzumab ozogamicin

if possible, vaccinate at least 2wk before starting inotuzumab ozogamicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ipilimumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ipilimumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ipilimumab

if possible, vaccinate at least 2wk before starting ipilimumab; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• irinotecan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

irinotecan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + irinotecan

if possible, vaccinate at least 2wk before starting irinotecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• isatuximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

isatuximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + isatuximab

if possible, vaccinate at least 2wk before starting isatuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ixabepilone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ixabepilone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ixabepilone

if possible, vaccinate at least 2wk before starting ixabepilone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ixekizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ixekizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ixekizumab

if possible, vaccinate at least 2wk before starting ixekizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lazertinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lazertinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lazertinib

if possible, vaccinate at least 2wk before starting lazertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lebrikizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lebrikizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lebrikizumab

if possible, vaccinate at least 2wk before starting lebrikizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• leflunomide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

leflunomide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + leflunomide

if possible, vaccinate at least 2wk before starting leflunomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lenalidomide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lenalidomide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lenalidomide

if possible, vaccinate at least 2wk before starting lenalidomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• linvoseltamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

linvoseltamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + linvoseltamab

if possible, vaccinate at least 2wk before starting linvoseltamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lisocabtagene maraleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lisocabtagene maraleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lisocabtagene maraleucel

if possible, vaccinate at least 2wk before starting lisocabtagene maraleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lomustine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lomustine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lomustine

if possible, vaccinate at least 2wk before starting lomustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• loncastuximab tesirine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

loncastuximab tesirine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + loncastuximab tesirine

if possible, vaccinate at least 2wk before starting loncastuximab tesirine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lurbinectedin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lurbinectedin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lurbinectedin

if possible, vaccinate at least 2wk before starting lurbinectedin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lymphocyte immune globulin, anti-thymocyte globulin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

lymphocyte immune globulin, anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + lymphocyte immune globulin, anti-thymocyte globulin

if possible, vaccinate at least 2wk before starting anti-thymocyte globulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• margetuximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

margetuximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + margetuximab

if possible, vaccinate at least 2wk before starting margetuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• marnetegragene autotemcel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

marnetegragene autotemcel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + marnetegragene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• melphalan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

melphalan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + melphalan

if possible, vaccinate at least 2wk before starting melphalan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• meningococcal vaccine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

meningococcal vaccine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + meningococcal vaccine

complete pneumococcal vaccine series >4wk before starting meningococcal vaccine series in asplenic pts: combo may decr. immunologic response to pneumococcal vaccine if administered <4wk apart (mechanism unknown)

• mercaptopurine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mercaptopurine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mercaptopurine

if possible, vaccinate at least 2wk before starting mercaptopurine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• methotrexate
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

methotrexate

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + methotrexate

if possible, vaccinate at least 2wk before starting methotrexate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• methylprednisolone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

methylprednisolone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + methylprednisolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• mirikizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mirikizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mirikizumab

if possible, vaccinate at least 2wk before starting mirikizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mitomycin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mitomycin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mitomycin

if possible, vaccinate at least 2wk before starting mitomycin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mitoxantrone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mitoxantrone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mitoxantrone

if possible, vaccinate at least 2wk before starting mitoxantrone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mogamulizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mogamulizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mogamulizumab

if possible, vaccinate at least 2wk before starting mogamulizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• momelotinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

momelotinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + momelotinib

if possible, vaccinate at least 2wk before starting momelotinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• monomethyl fumarate
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + monomethyl fumarate

if possible, vaccinate at least 2wk before starting monomethyl fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mosunetuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mosunetuzumab

if possible, vaccinate at least 2wk before starting mosunetuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mycophenolate mofetil
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mycophenolate mofetil

if possible, vaccinate at least 2wk before starting mycophenolate mofetil tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mycophenolic acid
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + mycophenolic acid

if possible, vaccinate at least 2wk before starting mycophenolic acid tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• natalizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

natalizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + natalizumab

if possible, vaccinate at least 2wk before starting natalizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nelarabine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

nelarabine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + nelarabine

if possible, vaccinate at least 2wk before starting nelarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nemolizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

nemolizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + nemolizumab

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nilotinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

nilotinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + nilotinib

if possible, vaccinate at least 2wk before starting nilotinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nipocalimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

nipocalimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + nipocalimab

if possible, vaccinate at least 2wk before starting nipocalimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nivolumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

nivolumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + nivolumab

if possible, vaccinate at least 2wk before starting nivolumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• obecabtagene autoleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

obecabtagene autoleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + obecabtagene autoleucel

if possible, vaccinate at least 2wk before starting obecabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• obinutuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

obinutuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + obinutuzumab

if possible, vaccinate at least 2wk before starting obinutuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ocrelizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ocrelizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ocrelizumab

if possible, vaccinate at least 2wk before starting ocrelizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ofatumumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ofatumumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ofatumumab

if possible, vaccinate at least 2wk before starting ofatumumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• olaparib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

olaparib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + olaparib

if possible, vaccinate at least 2wk before starting olaparib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• oxaliplatin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

oxaliplatin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + oxaliplatin

if possible, vaccinate at least 2wk before starting oxaliplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ozanimod
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ozanimod

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ozanimod

if possible, vaccinate at least 2wk before starting ozanimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• paclitaxel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

paclitaxel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + paclitaxel

if possible, vaccinate at least 2wk before starting paclitaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• palbociclib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

palbociclib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + palbociclib

if possible, vaccinate at least 2wk before starting palbociclib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• peginterferon alfa 2a
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

peginterferon alfa 2a

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + peginterferon alfa 2a

if possible, vaccinate at least 2wk before starting peginterferon alfa 2a tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pembrolizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pembrolizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pembrolizumab

if possible, vaccinate at least 2wk before starting pembrolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pemetrexed
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pemetrexed

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pemetrexed

if possible, vaccinate at least 2wk before starting pemetrexed; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• penpulimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

penpulimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + penpulimab

if possible, vaccinate at least 2wk before starting penpulimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pentostatin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pentostatin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pentostatin

if possible, vaccinate at least 2wk before starting pentostatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pertuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pertuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pertuzumab

if possible, vaccinate at least 2wk before starting pertuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pirtobrutinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pirtobrutinib

if possible, vaccinate at least 2wk before starting pirtobrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• polatuzumab vedotin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

polatuzumab vedotin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + polatuzumab vedotin

if possible, vaccinate at least 2wk before starting polatuzumab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pomalidomide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

pomalidomide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + pomalidomide

if possible, vaccinate at least 2wk before starting pomalidomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ponatinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ponatinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ponatinib

if possible, vaccinate at least 2wk before starting ponatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ponesimod
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ponesimod

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ponesimod

if possible, vaccinate at least 2wk before starting ponesimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• prednisolone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

prednisolone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + prednisolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• prednisone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

prednisone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + prednisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• procarbazine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

procarbazine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + procarbazine

if possible, vaccinate at least 2wk before starting procarbazine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• quizartinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

quizartinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + quizartinib

if possible, vaccinate at least 2wk before quizartinib start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• regorafenib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

regorafenib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + regorafenib

if possible, vaccinate at least 2wk before starting regorafenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• relacorilant
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

relacorilant

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + relacorilant

if possible, vaccinate at least 2wk before relacorilant start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• retifanlimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

retifanlimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + retifanlimab

if possible, vaccinate at least 2wk before starting retifanlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• revumenib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

revumenib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + revumenib

if possible, vaccinate at least 2wk before starting revumenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rilonacept
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

rilonacept

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + rilonacept

if possible, vaccinate at least 2wk before starting rilonacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rilzabrutinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

rilzabrutinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + rilzabrutinib

if possible, vaccinate at least 2wk before starting rilzabrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ripretinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ripretinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ripretinib

if possible, vaccinate at least 2wk before starting ripretinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• risankizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

risankizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + risankizumab

if possible, vaccinate at least 2wk before starting risankizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ritlecitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ritlecitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ritlecitinib

if possible, vaccinate at least 2wk before starting ritlecitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rituximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

rituximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + rituximab

vaccinate at least 4wk before starting rituximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• romidepsin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

romidepsin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + romidepsin

if possible, vaccinate at least 2wk before starting romidepsin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ropeginterferon alfa-2b
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ropeginterferon alfa-2b

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ropeginterferon alfa-2b

if possible, vaccinate at least 2wk before starting ropeginterferon alfa-2b tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rozanolixizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

rozanolixizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + rozanolixizumab

if possible, vaccinate at least 2wk before starting rozanolixizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rucaparib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

rucaparib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + rucaparib

if possible, vaccinate at least 2wk before starting rucaparib; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ruxolitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ruxolitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ruxolitinib

if possible, vaccinate at least 2wk before starting ruxolitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sarilumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sarilumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sarilumab

if possible, vaccinate at least 2wk before starting sarilumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• satralizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

satralizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + satralizumab

if possible, vaccinate at least 2wk before starting satralizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• secukinumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

secukinumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + secukinumab

if possible, vaccinate at least 2wk before starting secukinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• selinexor
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

selinexor

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + selinexor

if possible, vaccinate at least 2wk before starting selinexor tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• selumetinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

selumetinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + selumetinib

if possible, vaccinate at least 2wk before starting selumetinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sevabertinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sevabertinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sevabertinib

if possible, vaccinate at least 2wk before starting sevabertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sibeprenlimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sibeprenlimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sibeprenlimab

if possible, vaccinate at least 2wk before starting sibeprenlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• siltuximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

siltuximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + siltuximab

if possible, vaccinate at least 2wk before starting siltuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• siponimod
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

siponimod

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + siponimod

if possible, vaccinate at least 2wk before starting siponimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sirolimus

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sirolimus

if possible, vaccinate at least 2wk before starting sirolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus albumin-bound
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sirolimus albumin-bound

if possible, vaccinate at least 2wk before starting sirolimus albumin-bound tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus topical
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sirolimus topical

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sirolimus topical

if possible, vaccinate at least 2wk before starting sirolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sonrotoclax
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sonrotoclax

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sonrotoclax

if possible, vaccinate at least 2wk before sonrotoclax start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sorafenib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sorafenib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sorafenib

if possible, vaccinate at least 2wk before starting sorafenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• spesolimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

spesolimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + spesolimab

if possible, vaccinate at least 2wk before starting spesolimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sunitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sunitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sunitinib

if possible, vaccinate at least 2wk before starting sunitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sunvozertinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

sunvozertinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + sunvozertinib

if possible, vaccinate at least 2wk before starting sunvozertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tacrolimus
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tacrolimus

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tacrolimus

if possible, vaccinate at least 2wk before starting tacrolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tafasitamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tafasitamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tafasitamab

if possible, vaccinate at least 2wk before starting tafasitamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• taletrectinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

taletrectinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + taletrectinib

if possible, vaccinate at least 2wk before starting taletrectinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• talquetamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

talquetamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + talquetamab

if possible, vaccinate at least 2wk before starting talquetamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tarlatamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tarlatamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tarlatamab

if possible, vaccinate at least 2wk before starting tarlatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• teclistamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

teclistamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + teclistamab

if possible, vaccinate at least 2wk before starting teclistamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• telisotuzumab vedotin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

telisotuzumab vedotin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + telisotuzumab vedotin

if possible, vaccinate at least 2wk before starting telisotuzumab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• temozolomide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

temozolomide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + temozolomide

if possible, vaccinate at least 2wk before starting temozolomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• temsirolimus
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

temsirolimus

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + temsirolimus

if possible, vaccinate at least 2wk before temsirolimus start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• teplizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

teplizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + teplizumab

vaccinate at least 2wk before or 6wk after teplizumab tx; otherwise, consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• teriflunomide
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

teriflunomide

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + teriflunomide

if possible, vaccinate at least 2wk before starting teriflunomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• thioguanine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

thioguanine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + thioguanine

if possible, vaccinate at least 2wk before starting thioguanine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• thiotepa
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

thiotepa

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + thiotepa

if possible, vaccinate at least 2wk before starting thiotepa tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tildrakizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tildrakizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tildrakizumab

if possible, vaccinate at least 2wk before starting tildrakizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tisagenlecleucel
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tisagenlecleucel

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tisagenlecleucel

if possible, vaccinate at least 2wk before starting tisagenlecleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tislelizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tislelizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tislelizumab

if possible, vaccinate at least 2wk before starting tislelizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tocilizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tocilizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tocilizumab

if possible, vaccinate at least 2wk before starting tocilizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tofacitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tofacitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tofacitinib

if possible, vaccinate at least 2wk before starting tofacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• topotecan
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

topotecan

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + topotecan

if possible, vaccinate at least 2wk before starting topotecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• toripalimab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

toripalimab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + toripalimab

if possible, vaccinate at least 2wk before starting toripalimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• trabectedin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

trabectedin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + trabectedin

if possible, vaccinate at least 2wk before starting trabectedin; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tralokinumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tralokinumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tralokinumab

if possible, vaccinate at least 2wk before starting tralokinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• trastuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

trastuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + trastuzumab

if possible, vaccinate at least 2wk before starting trastuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tremelimumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

tremelimumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + tremelimumab

if possible, vaccinate at least 2wk before starting tremelimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• triamcinolone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

triamcinolone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + triamcinolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• ublituximab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ublituximab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ublituximab

if possible, vaccinate at least 2wk before starting ublituximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• upadacitinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

upadacitinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + upadacitinib

if possible, vaccinate at least 2wk before starting upadacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ustekinumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ustekinumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ustekinumab

if possible, vaccinate at least 2wk before starting ustekinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vamorolone
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vamorolone

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vamorolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• vandetanib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vandetanib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vandetanib

if possible, vaccinate at least 2wk before starting vandetanib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vedolizumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vedolizumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vedolizumab

if possible, vaccinate at least 2wk before starting vedolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• venetoclax
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

venetoclax

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + venetoclax

if possible, vaccinate at least 2wk before starting venetoclax tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vinblastine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vinblastine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vinblastine

if possible, vaccinate at least 2wk before starting vinblastine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vincristine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vincristine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vincristine

if possible, vaccinate at least 2wk before starting vincristine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vinorelbine
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

vinorelbine

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + vinorelbine

if possible, vaccinate at least 2wk before starting vinorelbine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• voclosporin
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

voclosporin

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + voclosporin

if possible, vaccinate at least 2wk before starting voclosporin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zanidatamab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

zanidatamab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + zanidatamab

if possible, vaccinate at least 2wk before starting zanidatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zanubrutinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

zanubrutinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + zanubrutinib

if possible, vaccinate at least 2wk before starting zanubrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zenocutuzumab
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

zenocutuzumab

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + zenocutuzumab

if possible, vaccinate at least 2wk before starting zenocutuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ziftomenib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

ziftomenib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + ziftomenib

if possible, vaccinate at least 2wk before starting ziftomenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zongertinib
Pneumovax 23 (pneumococcal 23-valent polysaccharide vaccine (PPSV23))

+

zongertinib

1 interaction

Monitor/Modify Tx

pneumococcal vaccine + zongertinib

if possible, vaccinate at least 2wk before starting zongertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)