Contrave

Overview

bupropion

norepinephrine-dopamine reuptake inhibitor; aminoketone antidepressant

• CYP2B6 substrate
• CYP2D6 inhibitor, strong
• hypertensive effects
• lowers seizure threshold

• caution advised with concomitant drugs if smoking cessation use; dose adjustments may be necessary; smoking cessation may alter pharmacokinetics or pharmacodynamics of certain drugs
• add MAO inhibitor to Interaction Check if recent (14 days) use

naltrexone

opioid antagonist, central

• affected by altered gastrointestinal motility
• CNS depression
• central opioid antagonist

Contraindicated

• acetazolamide
Contrave (naltrexone/ bupropion hydrochloride)

+

acetazolamide

1 interaction

Contraindicated

bupropion + acetazolamide

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

• alfentanil
Contrave (naltrexone/ bupropion hydrochloride)

+

alfentanil

2 interactions

Contraindicated

naltrexone + alfentanil

contraindicated; D/C alfentanil at least 7-10 days before naltrexone start; monitor closely if emergency alfentanil use: combo may decr. alfentanil efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + alfentanil

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• brivaracetam
Contrave (naltrexone/ bupropion hydrochloride)

+

brivaracetam

2 interactions

Contraindicated

bupropion + brivaracetam

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• buprenorphine
Contrave (naltrexone/ bupropion hydrochloride)

+

buprenorphine

2 interactions

Contraindicated

naltrexone + buprenorphine

contraindicated; D/C buprenorphine at least 14 days before naltrexone start; monitor closely if emergency buprenorphine use: combo may decr. buprenorphine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + buprenorphine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• bupropion
Contrave (naltrexone/ bupropion hydrochloride)

+

bupropion

1 interaction

Contraindicated

bupropion + bupropion

contraindicated: combo may incr. risk of HTN, seizures, other adverse effects (additive effects, duplicate tx)

• butorphanol
Contrave (naltrexone/ bupropion hydrochloride)

+

butorphanol

2 interactions

Contraindicated

naltrexone + butorphanol

contraindicated; D/C butorphanol at least 7-10 days prior to naltrexone start; monitor closely if emergency butorphanol use: combo may decr. butorphanol efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + butorphanol

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cannabidiol
Contrave (naltrexone/ bupropion hydrochloride)

+

cannabidiol

2 interactions

Contraindicated

bupropion + cannabidiol

contraindicated: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carbamazepine
Contrave (naltrexone/ bupropion hydrochloride)

+

carbamazepine

2 interactions

Contraindicated

bupropion + carbamazepine

contraindicated if seizure disorder use; avoid combo if obesity tx; otherwise, consider alternative or bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Contrave (naltrexone/ bupropion hydrochloride)

+

cenobamate

2 interactions

Contraindicated

bupropion + cenobamate

contraindicated: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clobazam
Contrave (naltrexone/ bupropion hydrochloride)

+

clobazam

2 interactions

Contraindicated

bupropion + clobazam

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + clobazam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clonazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

clonazepam

2 interactions

Contraindicated

bupropion + clonazepam

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clorazepate
Contrave (naltrexone/ bupropion hydrochloride)

+

clorazepate

2 interactions

Contraindicated

bupropion + clorazepate

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• codeine
Contrave (naltrexone/ bupropion hydrochloride)

+

codeine

2 interactions

Contraindicated

naltrexone + codeine

contraindicated; D/C codeine at least 7-10 days before naltrexone start: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Avoid/Use Alternative

bupropion + codeine

use alternative or monitor resp. rate, withdrawal sx; consider lower bupropion doses: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metabolism inhibited, decr. conversion to morphine; additive effects)

• diazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

diazepam

2 interactions

Contraindicated

bupropion + diazepam

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + diazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dihydrocodeine
Contrave (naltrexone/ bupropion hydrochloride)

+

dihydrocodeine

2 interactions

Contraindicated

naltrexone + dihydrocodeine

contraindicated; D/C dihydrocodeine at least 7-10 days before naltrexone start: combo may decr. dihydrocodeine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Avoid/Use Alternative

bupropion + dihydrocodeine

use alternative or monitor resp. rate, withdrawal sx; consider lower bupropion doses: combo may incr. dihydrocodeine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects; may decr. active metabolite dihydromorphine levels, efficacy (hepatic metabolism inhibited, decr. conversion to dihydromorphine; additive effects)

• eliglustat
Contrave (naltrexone/ bupropion hydrochloride)

+

eliglustat

1 interaction

Contraindicated

bupropion + eliglustat

CYP2D6 EM: contraindicated if Child-Pugh Class A or if also combined w/ moderate to strong CYP3A4 inhibitor; otherwise, monitor ECG; decr. eliglustat dose to 84 mg qd; CYP2D6 IM: contraindicated if also combined w/ moderate to strong CYP3A4 inhibitor; otherwise, monitor ECG; decr. eliglustat dose to 84 mg qd; CYP2D6 PM: contraindicated if also combined w/ strong CYP3A4 inhibitor; avoid combo if also combined w/ weak to moderate CYP3A4 inhibitor; otherwise, monitor ECG: combo may incr. eliglustat levels, risk of PR or QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• eslicarbazepine acetate
Contrave (naltrexone/ bupropion hydrochloride)

+

eslicarbazepine acetate

2 interactions

Contraindicated

bupropion + eslicarbazepine acetate

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethosuximide
Contrave (naltrexone/ bupropion hydrochloride)

+

ethosuximide

2 interactions

Contraindicated

bupropion + ethosuximide

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• felbamate
Contrave (naltrexone/ bupropion hydrochloride)

+

felbamate

2 interactions

Contraindicated

bupropion + felbamate

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenfluramine
Contrave (naltrexone/ bupropion hydrochloride)

+

fenfluramine

2 interactions

Contraindicated

bupropion + fenfluramine

contraindicated: combo may alter seizure control; may incr. fenfluramine levels, risk of HTN (including hypertensive crisis), serotonin syndrome, other adverse effects (antagonistic effects, bupropion may decr. seizure threshold; hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fentanyl
Contrave (naltrexone/ bupropion hydrochloride)

+

fentanyl

2 interactions

Contraindicated

naltrexone + fentanyl

contraindicated; D/C fentanyl at least 7-10 days before naltrexone start; monitor closely if emergency fentanyl use: combo may decr. fentanyl efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + fentanyl

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• fosphenytoin
Contrave (naltrexone/ bupropion hydrochloride)

+

fosphenytoin

2 interactions

Contraindicated

bupropion + fosphenytoin

contraindicated: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• gabapentin
Contrave (naltrexone/ bupropion hydrochloride)

+

gabapentin

2 interactions

Contraindicated

bupropion + gabapentin

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ganaxolone
Contrave (naltrexone/ bupropion hydrochloride)

+

ganaxolone

2 interactions

Contraindicated

bupropion + ganaxolone

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hydrocodone
Contrave (naltrexone/ bupropion hydrochloride)

+

hydrocodone

2 interactions

Contraindicated

naltrexone + hydrocodone

contraindicated; D/C hydrocodone at least 7-10 days before naltrexone start: combo may decr. hydrocodone efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + hydrocodone

consider lower bupropion doses: combo may decr. hydrocodone analgesic efficacy; may incr. risk of seizures (hepatic metabolism inhibited, decr. conversion to active hydrocodone metabolite; additive effects)

• hydromorphone
Contrave (naltrexone/ bupropion hydrochloride)

+

hydromorphone

2 interactions

Contraindicated

naltrexone + hydromorphone

contraindicated; D/C hydromorphone at least 7-10 days before naltrexone start; monitor closely if emergency hydromorphone use: combo may decr. hydromorphone efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + hydromorphone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• isocarboxazid
Contrave (naltrexone/ bupropion hydrochloride)

+

isocarboxazid

2 interactions

Contraindicated

bupropion + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or bupropion use: combo may incr. risk of HTN (including hypertensive crisis), seizures (additive effects)

Avoid/Use Alternative

naltrexone + isocarboxazid

use alternative during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Contrave (naltrexone/ bupropion hydrochloride)

+

kratom

2 interactions

Contraindicated

naltrexone + kratom

contraindicated; D/C kratom at least 7-10 days before naltrexone start: combo may decr. kratom efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + kratom

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• lacosamide
Contrave (naltrexone/ bupropion hydrochloride)

+

lacosamide

2 interactions

Contraindicated

bupropion + lacosamide

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lamotrigine
Contrave (naltrexone/ bupropion hydrochloride)

+

lamotrigine

2 interactions

Contraindicated

bupropion + lamotrigine

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Contrave (naltrexone/ bupropion hydrochloride)

+

levetiracetam

2 interactions

Contraindicated

bupropion + levetiracetam

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
Contrave (naltrexone/ bupropion hydrochloride)

+

levorphanol

2 interactions

Contraindicated

naltrexone + levorphanol

contraindicated; D/C levorphanol at least 7-10 days before naltrexone start: combo may decr. levorphanol efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + levorphanol

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• linezolid
Contrave (naltrexone/ bupropion hydrochloride)

+

linezolid

1 interaction

Contraindicated

bupropion + linezolid

contraindicated; hold bupropion if urgent use; monitor BP, serotonin syndrome sx x2wk after bupropion D/C or 24h after last linezolid dose; may resume bupropion 24h after last linezolid dose: combo may incr. risk of HTN, seizures, serotonin syndrome (additive effects, linezolid reversibly inhibits monoamine oxidase)

• lorazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

lorazepam

2 interactions

Contraindicated

bupropion + lorazepam

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + lorazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meperidine
Contrave (naltrexone/ bupropion hydrochloride)

+

meperidine

2 interactions

Contraindicated

naltrexone + meperidine

contraindicated; D/C meperidine at least 7-10 days before naltrexone start; monitor closely if emergency meperidine use: combo may decr. meperidine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + meperidine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• methadone
Contrave (naltrexone/ bupropion hydrochloride)

+

methadone

2 interactions

Contraindicated

naltrexone + methadone

contraindicated; D/C methadone at least 14 days before naltrexone start: combo may decr. methadone efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Avoid/Use Alternative

bupropion + methadone

use alternative or monitor resp. rate, ECG; consider decr. dose of one or both drugs: combo may incr. methadone levels, risk of CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• methsuximide
Contrave (naltrexone/ bupropion hydrochloride)

+

methsuximide

2 interactions

Contraindicated

bupropion + methsuximide

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methylene blue injection
Contrave (naltrexone/ bupropion hydrochloride)

+

methylene blue injection

1 interaction

Contraindicated

bupropion + methylene blue injection

contraindicated; hold bupropion if emergency use; monitor serotonin syndrome sx, BP x2wk after bupropion D/C or 24h after last methylene blue dose; may resume bupropion 24h after last methylene blue dose: combo may incr. risk of HTN, serotonin syndrome (possible additive effects, methylene blue reversibly inhibits monoamine oxidase)

• midazolam
Contrave (naltrexone/ bupropion hydrochloride)

+

midazolam

2 interactions

Contraindicated

bupropion + midazolam

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Avoid/Use Alternative

naltrexone + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• morphine
Contrave (naltrexone/ bupropion hydrochloride)

+

morphine

2 interactions

Contraindicated

naltrexone + morphine

contraindicated; D/C morphine at least 7-10 days before naltrexone start; monitor closely if emergency morphine use: combo may decr. morphine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + morphine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• nalbuphine
Contrave (naltrexone/ bupropion hydrochloride)

+

nalbuphine

2 interactions

Contraindicated

naltrexone + nalbuphine

contraindicated; D/C nalbuphine at least 7-10 days prior to naltrexone start; monitor closely if emergency nalbuphine use: combo may decr. nalbuphine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + nalbuphine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• oliceridine
Contrave (naltrexone/ bupropion hydrochloride)

+

oliceridine

2 interactions

Contraindicated

naltrexone + oliceridine

contraindicated; D/C oliceridine at least 7-10 days before naltrexone start; monitor closely if emergency oliceridine use: combo may decr. oliceridine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Avoid/Use Alternative

bupropion + oliceridine

use alternative or monitor resp. rate, ECG; consider decr. oliceridine frequency, lower bupropion doses: combo may incr. oliceridine levels, risk of CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• opium
Contrave (naltrexone/ bupropion hydrochloride)

+

opium

1 interaction

Contraindicated

naltrexone + opium

contraindicated; D/C opium at least 7-10 days before naltrexone start: combo may decr. opium efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

• oxcarbazepine
Contrave (naltrexone/ bupropion hydrochloride)

+

oxcarbazepine

2 interactions

Contraindicated

bupropion + oxcarbazepine

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• oxycodone
Contrave (naltrexone/ bupropion hydrochloride)

+

oxycodone

2 interactions

Contraindicated

naltrexone + oxycodone

contraindicated; D/C oxycodone at least 7-10 days before naltrexone start: combo may decr. oxycodone efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + oxycodone

consider lower bupropion doses: combo may decr. active metabolite oxymorphone levels, efficacy; may incr. risk of seizures (hepatic metabolism inhibited, decr. conversion to oxymorphone; additive effects)

• oxymorphone
Contrave (naltrexone/ bupropion hydrochloride)

+

oxymorphone

2 interactions

Contraindicated

naltrexone + oxymorphone

contraindicated; D/C oxymorphone at least 7-10 days before naltrexone start; monitor closely if emergency oxymorphone use: combo may decr. oxymorphone efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + oxymorphone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• pentazocine
Contrave (naltrexone/ bupropion hydrochloride)

+

pentazocine

2 interactions

Contraindicated

naltrexone + pentazocine

contraindicated; D/C pentazocine at least 7-10 days prior to naltrexone start: combo may decr. pentazocine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + pentazocine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• perampanel
Contrave (naltrexone/ bupropion hydrochloride)

+

perampanel

2 interactions

Contraindicated

bupropion + perampanel

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenelzine
Contrave (naltrexone/ bupropion hydrochloride)

+

phenelzine

2 interactions

Contraindicated

bupropion + phenelzine

contraindicated w/in 14 days of phenelzine or bupropion use: combo may incr. risk of HTN (including hypertensive crisis), seizures (additive effects)

Avoid/Use Alternative

naltrexone + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenobarbital
Contrave (naltrexone/ bupropion hydrochloride)

+

phenobarbital

2 interactions

Contraindicated

bupropion + phenobarbital

contraindicated if seizure disorder use; otherwise, consider bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + phenobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• phenytoin
Contrave (naltrexone/ bupropion hydrochloride)

+

phenytoin

2 interactions

Contraindicated

bupropion + phenytoin

contraindicated: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pimozide
Contrave (naltrexone/ bupropion hydrochloride)

+

pimozide

2 interactions

Contraindicated

bupropion + pimozide

contraindicated: combo may incr. pimozide levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pregabalin
Contrave (naltrexone/ bupropion hydrochloride)

+

pregabalin

2 interactions

Contraindicated

bupropion + pregabalin

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• primidone
Contrave (naltrexone/ bupropion hydrochloride)

+

primidone

2 interactions

Contraindicated

bupropion + primidone

contraindicated if seizure disorder use; otherwise, consider bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, bupropion may decr. seizure threshold)

Monitor/Modify Tx

naltrexone + primidone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• remifentanil
Contrave (naltrexone/ bupropion hydrochloride)

+

remifentanil

2 interactions

Contraindicated

naltrexone + remifentanil

contraindicated; D/C remifentanil at least 7-10 days before naltrexone start; monitor closely if emergency remifentanil use: combo may decr. remifentanil efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + remifentanil

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• rufinamide
Contrave (naltrexone/ bupropion hydrochloride)

+

rufinamide

2 interactions

Contraindicated

bupropion + rufinamide

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline transdermal
Contrave (naltrexone/ bupropion hydrochloride)

+

selegiline transdermal

2 interactions

Contraindicated

bupropion + selegiline transdermal

contraindicated w/in 14 days of selegiline or bupropion use: combo may incr. risk of HTN (including hypertensive crisis), seizures (additive effects)

Caution Advised

naltrexone + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• stiripentol
Contrave (naltrexone/ bupropion hydrochloride)

+

stiripentol

2 interactions

Contraindicated

bupropion + stiripentol

contraindicated: combo may incr. or decr. bupropion levels, incr. risk of seizures, other adverse effects or decr. active metabolite levels, efficacy (hepatic metabolism possibly altered; antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sufentanil
Contrave (naltrexone/ bupropion hydrochloride)

+

sufentanil

2 interactions

Contraindicated

naltrexone + sufentanil

contraindicated; D/C sufentanil at least 7-10 days before naltrexone start; monitor closely if emergency sufentanil use: combo may decr. sufentanil efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + sufentanil

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• tapentadol
Contrave (naltrexone/ bupropion hydrochloride)

+

tapentadol

2 interactions

Contraindicated

naltrexone + tapentadol

contraindicated; discontinue tapentadol at least 7-10 days before naltrexone start: combo may decrease tapentadol efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Monitor/Modify Tx

bupropion + tapentadol

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• thioridazine
Contrave (naltrexone/ bupropion hydrochloride)

+

thioridazine

2 interactions

Contraindicated

bupropion + thioridazine

contraindicated: combo may incr. thioridazine levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects; may incr. risk of seizures (hepatic metabolism inhibited; additive effects)

Monitor/Modify Tx

naltrexone + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiagabine
Contrave (naltrexone/ bupropion hydrochloride)

+

tiagabine

2 interactions

Contraindicated

bupropion + tiagabine

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• topiramate
Contrave (naltrexone/ bupropion hydrochloride)

+

topiramate

2 interactions

Contraindicated

bupropion + topiramate

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + topiramate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Contrave (naltrexone/ bupropion hydrochloride)

+

tramadol

2 interactions

Contraindicated

naltrexone + tramadol

contraindicated; D/C tramadol at least 7-10 days before naltrexone start: combo may decr. tramadol efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

Avoid/Use Alternative

bupropion + tramadol

use alternative or monitor resp. rate, ECG, withdrawal sx; consider lower bupropion doses: combo may incr. tramadol levels, risk of CNS and resp. depression, psychomotor impairment, seizures, serotonin syndrome, QT prolongation, cardiac arrhythmias, other adverse effects; may decr. active metabolite levels, efficacy (hepatic metabolism inhibited, decr. conversion to active metabolite; additive effects)

• tranylcypromine
Contrave (naltrexone/ bupropion hydrochloride)

+

tranylcypromine

2 interactions

Contraindicated

bupropion + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or bupropion use: combo may incr. risk of HTN, seizures, serotonin syndrome (additive effects)

Avoid/Use Alternative

naltrexone + tranylcypromine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Contrave (naltrexone/ bupropion hydrochloride)

+

valproic acid

2 interactions

Contraindicated

bupropion + valproic acid

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vigabatrin
Contrave (naltrexone/ bupropion hydrochloride)

+

vigabatrin

2 interactions

Contraindicated

bupropion + vigabatrin

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Contrave (naltrexone/ bupropion hydrochloride)

+

zonisamide

2 interactions

Contraindicated

bupropion + zonisamide

contraindicated: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

Caution Advised

naltrexone + zonisamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Avoid/Use Alternative

• albuterol
Contrave (naltrexone/ bupropion hydrochloride)

+

albuterol

1 interaction

Avoid/Use Alternative

bupropion + albuterol

use alternative or monitor BP, HR w/ oral albuterol; risk may be lower w/ inhaled albuterol: combo may incr. risk of HTN (additive effects)

• aldesleukin
Contrave (naltrexone/ bupropion hydrochloride)

+

aldesleukin

2 interactions

Avoid/Use Alternative

bupropion + aldesleukin

avoid combo: combo may incr. risk of seizures (additive effects)

Monitor/Modify Tx

naltrexone + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• amifampridine
Contrave (naltrexone/ bupropion hydrochloride)

+

amifampridine

1 interaction

Avoid/Use Alternative

bupropion + amifampridine

consider alternative or consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• amphetamine
Contrave (naltrexone/ bupropion hydrochloride)

+

amphetamine

1 interaction

Avoid/Use Alternative

bupropion + amphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose, consider lower bupropion doses: combo may incr. amphetamine levels, risk of HTN, serotonin syndrome, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• aripiprazole bimonthly injection
Contrave (naltrexone/ bupropion hydrochloride)

+

aripiprazole bimonthly injection

2 interactions

Avoid/Use Alternative

bupropion + aripiprazole bimonthly injection

consider lower bupropion doses; for concurrent use >14 days, decr. aripiprazole dose to 720 mg q2mo; if also combined w/ strong CYP3A4 inhibitor, avoid combo: combo may incr. aripiprazole levels, risk of seizures, other adverse effects (hepatic metabolism inhibited; additive effects)

Caution Advised

naltrexone + aripiprazole bimonthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole lauroxil
Contrave (naltrexone/ bupropion hydrochloride)

+

aripiprazole lauroxil

2 interactions

Avoid/Use Alternative

bupropion + aripiprazole lauroxil

ARISTADA INITIO: avoid combo; ARISTADA: consider lower bupropion doses; if concurrent use >14 days, decr. aripiprazole lauroxil 1064 mg q2mo to 441 mg qmo, 882 mg q6wk to 441 mg qmo, 882 mg qmo to 662 mg qmo, 662 mg qmo to 441 mg qmo; if also combined w/ strong CYP3A4 inhibitor, avoid combo w/ 1064 mg, 882 mg, or 662 mg doses; no dose adjustment if on 441 mg dose or if CYP2D6 PM: combo may incr. aripiprazole levels, risk of seizures, other adverse effects (hepatic metabolism inhibited; additive effects)

Caution Advised

naltrexone + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole monthly injection
Contrave (naltrexone/ bupropion hydrochloride)

+

aripiprazole monthly injection

2 interactions

Avoid/Use Alternative

bupropion + aripiprazole monthly injection

1-DAY START REGIMEN: consider lower bupropion doses; for concurrent use >14 days, decr. IM aripiprazole 400 mg dose to 300 mg; if also combined w/ strong CYP3A4 inhibitor, avoid combo; 14-DAY START REGIMEN: consider lower bupropion doses; for concurrent use >14 days, decr. IM aripiprazole 400 mg dose to 300 mg or decr. 300 mg dose to 200 mg; if also combined w/ strong CYP3A4 inhibitor, decr. IM aripiprazole 400 mg dose to 200 mg and decr. 300 mg dose to 160 mg: combo may incr. aripiprazole levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• bremelanotide
Contrave (naltrexone/ bupropion hydrochloride)

+

bremelanotide

1 interaction

Avoid/Use Alternative

naltrexone + bremelanotide

avoid combo w/ oral naltrexone for alcohol or opioid addiction tx; naltrexone/bupropion for weight management use OK: combo may decr. naltrexone levels, efficacy (absorption delayed, decreased)

• butalbital
Contrave (naltrexone/ bupropion hydrochloride)

+

butalbital

2 interactions

Avoid/Use Alternative

naltrexone + butalbital

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

Caution Advised

bupropion + butalbital

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• clonidine
Contrave (naltrexone/ bupropion hydrochloride)

+

clonidine

2 interactions

Avoid/Use Alternative

naltrexone + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

bupropion + clonidine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dextroamphetamine
Contrave (naltrexone/ bupropion hydrochloride)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

bupropion + dextroamphetamine

consider alternative or monitor BP, serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose, consider lower bupropion doses: combo may incr. dextroamphetamine levels, risk of HTN, serotonin syndrome, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• doxorubicin
Contrave (naltrexone/ bupropion hydrochloride)

+

doxorubicin

1 interaction

Avoid/Use Alternative

bupropion + doxorubicin

avoid combo: combo may incr. doxorubicin levels, risk serious infection, myelosuppression, cardiotoxicity, other adverse effects (hepatic metabolism inhibited)

• doxylamine
Contrave (naltrexone/ bupropion hydrochloride)

+

doxylamine

1 interaction

Avoid/Use Alternative

naltrexone + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• efavirenz
Contrave (naltrexone/ bupropion hydrochloride)

+

efavirenz

2 interactions

Avoid/Use Alternative

bupropion + efavirenz

consider alternative or bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

Caution Advised

naltrexone + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• epinephrine inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

bupropion + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• ethanol
Contrave (naltrexone/ bupropion hydrochloride)

+

ethanol

2 interactions

Avoid/Use Alternative

bupropion + ethanol

avoid or minimize alcohol use: combo with oral ethanol may reduce alcohol tolerance; chronic oral ethanol may increase risk of HTN (mechanism unknown; additive effects)

naltrexone + ethanol

ORAL ETHANOL: avoid combo; IV ETHANOL: use alternative or monitor respiratory rate: combo with oral ethanol or IV ethanol may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• furosemide
Contrave (naltrexone/ bupropion hydrochloride)

+

furosemide

1 interaction

Avoid/Use Alternative

bupropion + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ginkgo
Contrave (naltrexone/ bupropion hydrochloride)

+

ginkgo

1 interaction

Avoid/Use Alternative

bupropion + ginkgo

avoid consumption of ginkgo seeds; otherwise, consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• haloperidol
Contrave (naltrexone/ bupropion hydrochloride)

+

haloperidol

2 interactions

Avoid/Use Alternative

naltrexone + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

bupropion + haloperidol

monitor ECG; consider decr. dose of one or both drugs: combo may incr. haloperidol levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• iohexol
Contrave (naltrexone/ bupropion hydrochloride)

+

iohexol

1 interaction

Avoid/Use Alternative

bupropion + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• kava
Contrave (naltrexone/ bupropion hydrochloride)

+

kava

1 interaction

Avoid/Use Alternative

naltrexone + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• landiolol
Contrave (naltrexone/ bupropion hydrochloride)

+

landiolol

1 interaction

Avoid/Use Alternative

bupropion + landiolol

use alternative or monitor HR, BP: combo may decr. landiolol efficacy (antagonistic effects)

• lisdexamfetamine
Contrave (naltrexone/ bupropion hydrochloride)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

bupropion + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose, consider lower bupropion doses; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. dextroamphetamine levels, risk of serotonin syndrome, seizures, HTN, other adverse effects (hepatic metabolism inhibited, additive effects)

• lixisenatide
Contrave (naltrexone/ bupropion hydrochloride)

+

lixisenatide

1 interaction

Avoid/Use Alternative

naltrexone + lixisenatide

avoid combo w/ oral naltrexone for alcohol or opioid addiction tx; naltrexone/bupropion for weight management use OK: combo may decr. naltrexone levels, efficacy (absorption delayed, decreased)

• lopinavir/ritonavir
Contrave (naltrexone/ bupropion hydrochloride)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

bupropion + lopinavir/ ritonavir

consider alternative or bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• lorlatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

lorlatinib

1 interaction

Avoid/Use Alternative

bupropion + lorlatinib

consider alternative or bupropion dose adjustment; monitor BP: combo may decr. bupropion and metabolite levels, efficacy; may incr. risk of seizures, HTN (hepatic metabolism induced; additive effects)

• metaxalone
Contrave (naltrexone/ bupropion hydrochloride)

+

metaxalone

1 interaction

Avoid/Use Alternative

naltrexone + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methamphetamine
Contrave (naltrexone/ bupropion hydrochloride)

+

methamphetamine

1 interaction

Avoid/Use Alternative

bupropion + methamphetamine

consider alternative or decr. methamphetamine start dose, consider lower bupropion doses; monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. methamphetamine levels, risk of serotonin syndrome, seizures, HTN, other adverse effects (hepatic metabolism inhibited, additive effects)

• methylnaltrexone
Contrave (naltrexone/ bupropion hydrochloride)

+

methylnaltrexone

1 interaction

Avoid/Use Alternative

naltrexone + methylnaltrexone

avoid combo: combo may incr. risk of GI or other adverse effects (additive effects, duplicate tx)

• metoclopramide
Contrave (naltrexone/ bupropion hydrochloride)

+

metoclopramide

2 interactions

Avoid/Use Alternative

bupropion + metoclopramide

NASAL METOCLOPRAMIDE: avoid combo; ALL OTHER FORMULATIONS: decr. metoclopramide dose 50%; consider lower bupropion doses; monitor BP: combo may incr. metoclopramide levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

naltrexone + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• midodrine
Contrave (naltrexone/ bupropion hydrochloride)

+

midodrine

1 interaction

Avoid/Use Alternative

bupropion + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• naldemedine
Contrave (naltrexone/ bupropion hydrochloride)

+

naldemedine

1 interaction

Avoid/Use Alternative

naltrexone + naldemedine

avoid combo: combo may incr. risk of GI or other adverse effects (additive effects, duplicate tx)

• naloxegol
Contrave (naltrexone/ bupropion hydrochloride)

+

naloxegol

1 interaction

Avoid/Use Alternative

naltrexone + naloxegol

avoid combo: combo may incr. risk of GI or other adverse effects (additive effects, duplicate tx)

• naltrexone
Contrave (naltrexone/ bupropion hydrochloride)

+

naltrexone

1 interaction

Avoid/Use Alternative

naltrexone + naltrexone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate tx)

• oxybate
Contrave (naltrexone/ bupropion hydrochloride)

+

oxybate

1 interaction

Avoid/Use Alternative

naltrexone + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• pirfenidone
Contrave (naltrexone/ bupropion hydrochloride)

+

pirfenidone

1 interaction

Avoid/Use Alternative

bupropion + pirfenidone

avoid combo if also combined w/ mod-strong CYP1A2 inhibitor; otherwise, caution advised: combo may incr. pirfenidone levels, risk of adverse effects (hepatic metabolism inhibited)

• procarbazine
Contrave (naltrexone/ bupropion hydrochloride)

+

procarbazine

2 interactions

Avoid/Use Alternative

bupropion + procarbazine

use alternative or monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• promethazine
Contrave (naltrexone/ bupropion hydrochloride)

+

promethazine

2 interactions

Avoid/Use Alternative

naltrexone + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

bupropion + promethazine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• propafenone
Contrave (naltrexone/ bupropion hydrochloride)

+

propafenone

1 interaction

Avoid/Use Alternative

bupropion + propafenone

if also combined w/ CYP3A4 inhibitor, avoid use; otherwise, monitor ECG, BP: combo may incr. propafenone levels, risk of QT prolongation, cardiac arrhythmias, hypotension, other adverse effects (hepatic metabolism inhibited)

• rifampin
Contrave (naltrexone/ bupropion hydrochloride)

+

rifampin

1 interaction

Avoid/Use Alternative

bupropion + rifampin

consider alternative or bupropion dose adjustment: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• ropeginterferon alfa-2b
Contrave (naltrexone/ bupropion hydrochloride)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

naltrexone + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• scopolamine
Contrave (naltrexone/ bupropion hydrochloride)

+

scopolamine

2 interactions

Avoid/Use Alternative

naltrexone + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

bupropion + scopolamine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• sofpironium topical
Contrave (naltrexone/ bupropion hydrochloride)

+

sofpironium topical

1 interaction

Avoid/Use Alternative

bupropion + sofpironium topical

avoid combo: combo may incr. sofpironium levels, risk of anticholinergic adverse effects (hepatic metabolism inhibited)

• tamsulosin
Contrave (naltrexone/ bupropion hydrochloride)

+

tamsulosin

1 interaction

Avoid/Use Alternative

bupropion + tamsulosin

avoid combo if also combined w/ strong CYP3A4 inhibitor; otherwise, monitor BP, especially w/ tamsulosin dose >0.4 mg: combo may incr. tamsulosin levels, risk of hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited)

• thalidomide
Contrave (naltrexone/ bupropion hydrochloride)

+

thalidomide

2 interactions

Avoid/Use Alternative

naltrexone + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

bupropion + thalidomide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• tradipitant
Contrave (naltrexone/ bupropion hydrochloride)

+

tradipitant

1 interaction

Avoid/Use Alternative

naltrexone + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimethobenzamide
Contrave (naltrexone/ bupropion hydrochloride)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

naltrexone + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zuranolone
Contrave (naltrexone/ bupropion hydrochloride)

+

zuranolone

1 interaction

Avoid/Use Alternative

naltrexone + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abiraterone acetate
Contrave (naltrexone/ bupropion hydrochloride)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

bupropion + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

• acebutolol
Contrave (naltrexone/ bupropion hydrochloride)

+

acebutolol

1 interaction

Monitor/Modify Tx

bupropion + acebutolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• acyclovir
Contrave (naltrexone/ bupropion hydrochloride)

+

acyclovir

1 interaction

Monitor/Modify Tx

bupropion + acyclovir

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• aficamten
Contrave (naltrexone/ bupropion hydrochloride)

+

aficamten

1 interaction

Monitor/Modify Tx

bupropion + aficamten

monitor cardiac fxn, incl. LVEF: combo may incr. aficamten levels, risk of cardiotoxicity, other adverse effects (hepatic metabolism inhibited)

• albuterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + albuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• aliskiren
Contrave (naltrexone/ bupropion hydrochloride)

+

aliskiren

1 interaction

Monitor/Modify Tx

bupropion + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• almotriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

almotriptan

2 interactions

Monitor/Modify Tx

bupropion + almotriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alprazolam
Contrave (naltrexone/ bupropion hydrochloride)

+

alprazolam

1 interaction

Monitor/Modify Tx

naltrexone + alprazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amiloride
Contrave (naltrexone/ bupropion hydrochloride)

+

amiloride

1 interaction

Monitor/Modify Tx

bupropion + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• aminophylline
Contrave (naltrexone/ bupropion hydrochloride)

+

aminophylline

1 interaction

Monitor/Modify Tx

bupropion + aminophylline

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• amitriptyline
Contrave (naltrexone/ bupropion hydrochloride)

+

amitriptyline

2 interactions

Monitor/Modify Tx

bupropion + amitriptyline

monitor amitriptyline levels, ECG, BP; consider lower bupropion doses: combo may incr. amitriptyline levels, risk of QT prolongation, cardiac arrhythmias, HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + amitriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• amlodipine
Contrave (naltrexone/ bupropion hydrochloride)

+

amlodipine

1 interaction

Monitor/Modify Tx

bupropion + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Contrave (naltrexone/ bupropion hydrochloride)

+

amoxapine

2 interactions

Monitor/Modify Tx

bupropion + amoxapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. amoxapine levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• amoxicillin
Contrave (naltrexone/ bupropion hydrochloride)

+

amoxicillin

1 interaction

Monitor/Modify Tx

bupropion + amoxicillin

consider lower bupropion doses, especially w/ high amoxicillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• ampicillin
Contrave (naltrexone/ bupropion hydrochloride)

+

ampicillin

1 interaction

Monitor/Modify Tx

bupropion + ampicillin

consider lower bupropion doses, especially w/ high ampicillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• angiotensin II
Contrave (naltrexone/ bupropion hydrochloride)

+

angiotensin II

1 interaction

Monitor/Modify Tx

bupropion + angiotensin II

monitor BP: combo may incr. risk of HTN (additive effects)

• apalutamide
Contrave (naltrexone/ bupropion hydrochloride)

+

apalutamide

1 interaction

Monitor/Modify Tx

bupropion + apalutamide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• aprocitentan
Contrave (naltrexone/ bupropion hydrochloride)

+

aprocitentan

1 interaction

Monitor/Modify Tx

bupropion + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + arformoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• aripiprazole oral
Contrave (naltrexone/ bupropion hydrochloride)

+

aripiprazole oral

2 interactions

Monitor/Modify Tx

bupropion + aripiprazole oral

consider lower bupropion doses; decr. PO aripiprazole dose 50%; if also combined w/ strong CYP3A4 inhibitor, decr. PO aripiprazole dose 75%; no dose adjustment if depression adjunct tx use: combo may incr. aripiprazole levels, risk of seizures, other adverse effects (hepatic metabolism inhibited; additive effects)

Caution Advised

naltrexone + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• armodafinil
Contrave (naltrexone/ bupropion hydrochloride)

+

armodafinil

1 interaction

Monitor/Modify Tx

bupropion + armodafinil

monitor BP: combo may incr. risk of HTN (additive effects)

• asciminib
Contrave (naltrexone/ bupropion hydrochloride)

+

asciminib

1 interaction

Monitor/Modify Tx

bupropion + asciminib

monitor BP: combo may incr. risk of HTN (additive effects)

• asenapine
Contrave (naltrexone/ bupropion hydrochloride)

+

asenapine

2 interactions

Monitor/Modify Tx

bupropion + asenapine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• atenolol
Contrave (naltrexone/ bupropion hydrochloride)

+

atenolol

1 interaction

Monitor/Modify Tx

bupropion + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Contrave (naltrexone/ bupropion hydrochloride)

+

atogepant

1 interaction

Monitor/Modify Tx

bupropion + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• atomoxetine
Contrave (naltrexone/ bupropion hydrochloride)

+

atomoxetine

1 interaction

Monitor/Modify Tx

bupropion + atomoxetine

monitor BP; maintain atomoxetine start dose x4wk, then incr. to target dose only if inadequate response and well-tolerated: combo may incr. atomoxetine levels, risk of HTN, other adverse effects (hepatic metabolism inhibited, additive effects)

• atropine ophthalmic
Contrave (naltrexone/ bupropion hydrochloride)

+

atropine ophthalmic

1 interaction

Monitor/Modify Tx

bupropion + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

• axicabtagene ciloleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

axicabtagene ciloleucel

1 interaction

Monitor/Modify Tx

bupropion + axicabtagene ciloleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• axitinib
Contrave (naltrexone/ bupropion hydrochloride)

+

axitinib

1 interaction

Monitor/Modify Tx

bupropion + axitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• azilsartan medoxomil
Contrave (naltrexone/ bupropion hydrochloride)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

bupropion + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• baclofen
Contrave (naltrexone/ bupropion hydrochloride)

+

baclofen

2 interactions

Monitor/Modify Tx

bupropion + baclofen

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• baclofen intrathecal
Contrave (naltrexone/ bupropion hydrochloride)

+

baclofen intrathecal

2 interactions

Monitor/Modify Tx

bupropion + baclofen intrathecal

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• benazepril
Contrave (naltrexone/ bupropion hydrochloride)

+

benazepril

1 interaction

Monitor/Modify Tx

bupropion + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Contrave (naltrexone/ bupropion hydrochloride)

+

benzphetamine

1 interaction

Monitor/Modify Tx

bupropion + benzphetamine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• betamethasone
Contrave (naltrexone/ bupropion hydrochloride)

+

betamethasone

1 interaction

Monitor/Modify Tx

bupropion + betamethasone

consider lower bupropion doses; monitor BP: combo may incr. risk of seizures, HTN (additive effects)

• betaxolol
Contrave (naltrexone/ bupropion hydrochloride)

+

betaxolol

1 interaction

Monitor/Modify Tx

bupropion + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Contrave (naltrexone/ bupropion hydrochloride)

+

bevacizumab

1 interaction

Monitor/Modify Tx

bupropion + bevacizumab

monitor BP: combo may incr. risk of HTN (additive effects)

• bismuth subsalicylate
Contrave (naltrexone/ bupropion hydrochloride)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

bupropion + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Contrave (naltrexone/ bupropion hydrochloride)

+

bisoprolol

1 interaction

Monitor/Modify Tx

bupropion + bisoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• brexpiprazole
Contrave (naltrexone/ bupropion hydrochloride)

+

brexpiprazole

2 interactions

Monitor/Modify Tx

bupropion + brexpiprazole

consider lower bupropion doses; decr. brexpiprazole dose 50%; if also combined w/ moderate or strong CYP3A4 inhibitor, decr. brexpiprazole dose 75%; no brexpiprazole adjustment if depression adjunct tx use: combo may incr. brexpiprazole levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brexucabtagene autoleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

brexucabtagene autoleucel

1 interaction

Monitor/Modify Tx

bupropion + brexucabtagene autoleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• brigatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

brigatinib

1 interaction

Monitor/Modify Tx

bupropion + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• budesonide
Contrave (naltrexone/ bupropion hydrochloride)

+

budesonide

1 interaction

Monitor/Modify Tx

bupropion + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

• bumetanide
Contrave (naltrexone/ bupropion hydrochloride)

+

bumetanide

1 interaction

Monitor/Modify Tx

bupropion + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• busulfan
Contrave (naltrexone/ bupropion hydrochloride)

+

busulfan

1 interaction

Monitor/Modify Tx

bupropion + busulfan

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cabozantinib
Contrave (naltrexone/ bupropion hydrochloride)

+

cabozantinib

1 interaction

Monitor/Modify Tx

bupropion + cabozantinib

monitor BP: combo may incr. risk of HTN (additive effects)

• caffeine
Contrave (naltrexone/ bupropion hydrochloride)

+

caffeine

1 interaction

Monitor/Modify Tx

bupropion + caffeine

monitor BP; avoid excessive caffeine intake: combo may incr. risk of HTN (additive effects)

• caffeine citrate
Contrave (naltrexone/ bupropion hydrochloride)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

bupropion + caffeine citrate

monitor BP: combo may incr. risk of HTN (additive effects)

• candesartan cilexetil
Contrave (naltrexone/ bupropion hydrochloride)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

bupropion + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cannabis
Contrave (naltrexone/ bupropion hydrochloride)

+

cannabis

2 interactions

Monitor/Modify Tx

bupropion + cannabis

monitor BP; consider lower bupropion doses, especially w/ high cannabis doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + cannabis

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• captopril
Contrave (naltrexone/ bupropion hydrochloride)

+

captopril

1 interaction

Monitor/Modify Tx

bupropion + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carfilzomib
Contrave (naltrexone/ bupropion hydrochloride)

+

carfilzomib

1 interaction

Monitor/Modify Tx

bupropion + carfilzomib

monitor BP: combo may incr. risk of HTN (additive effects)

• cariprazine
Contrave (naltrexone/ bupropion hydrochloride)

+

cariprazine

2 interactions

Monitor/Modify Tx

bupropion + cariprazine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carvedilol
Contrave (naltrexone/ bupropion hydrochloride)

+

carvedilol

1 interaction

Monitor/Modify Tx

bupropion + carvedilol

monitor BP, HR: combo may incr. carvedilol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

• cefazolin
Contrave (naltrexone/ bupropion hydrochloride)

+

cefazolin

1 interaction

Monitor/Modify Tx

bupropion + cefazolin

consider lower bupropion doses, especially w/ high cefazolin doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• cefepime
Contrave (naltrexone/ bupropion hydrochloride)

+

cefepime

1 interaction

Monitor/Modify Tx

bupropion + cefepime

consider lower bupropion doses, especially w/ high cefepime doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• cefiderocol
Contrave (naltrexone/ bupropion hydrochloride)

+

cefiderocol

1 interaction

Monitor/Modify Tx

bupropion + cefiderocol

consider lower bupropion doses, especially w/ high cefiderocol doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• ceftaroline
Contrave (naltrexone/ bupropion hydrochloride)

+

ceftaroline

1 interaction

Monitor/Modify Tx

bupropion + ceftaroline

consider lower bupropion doses, especially w/ high ceftaroline doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• ceftazidime
Contrave (naltrexone/ bupropion hydrochloride)

+

ceftazidime

1 interaction

Monitor/Modify Tx

bupropion + ceftazidime

consider lower bupropion doses, especially w/ high ceftazidime doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• ceftobiprole
Contrave (naltrexone/ bupropion hydrochloride)

+

ceftobiprole

1 interaction

Monitor/Modify Tx

bupropion + ceftobiprole

consider lower bupropion doses, especially w/ high ceftobiprole doses and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• celecoxib
Contrave (naltrexone/ bupropion hydrochloride)

+

celecoxib

1 interaction

Monitor/Modify Tx

bupropion + celecoxib

monitor BP: combo may incr. risk of HTN (additive effects)

• chlorambucil
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorambucil

1 interaction

Monitor/Modify Tx

bupropion + chlorambucil

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• chlordiazepoxide
Contrave (naltrexone/ bupropion hydrochloride)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

naltrexone + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chloroquine
Contrave (naltrexone/ bupropion hydrochloride)

+

chloroquine

1 interaction

Monitor/Modify Tx

bupropion + chloroquine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• chlorothiazide
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

bupropion + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpheniramine
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorpheniramine

2 interactions

Monitor/Modify Tx

bupropion + chlorpheniramine

consider decr. chlorpheniramine dose: combo may incr. chlorpheniramine levels, risk of adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorpromazine
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorpromazine

2 interactions

Monitor/Modify Tx

bupropion + chlorpromazine

monitor ECG; consider lower bupropion doses: combo may incr. chlorpromazine levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

naltrexone + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorthalidone
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

bupropion + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ciltacabtagene autoleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

ciltacabtagene autoleucel

1 interaction

Monitor/Modify Tx

bupropion + ciltacabtagene autoleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ciprofloxacin
Contrave (naltrexone/ bupropion hydrochloride)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

bupropion + ciprofloxacin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cisatracurium
Contrave (naltrexone/ bupropion hydrochloride)

+

cisatracurium

1 interaction

Monitor/Modify Tx

bupropion + cisatracurium

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• citalopram
Contrave (naltrexone/ bupropion hydrochloride)

+

citalopram

2 interactions

Monitor/Modify Tx

bupropion + citalopram

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + citalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clevidipine
Contrave (naltrexone/ bupropion hydrochloride)

+

clevidipine

1 interaction

Monitor/Modify Tx

bupropion + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clomipramine
Contrave (naltrexone/ bupropion hydrochloride)

+

clomipramine

2 interactions

Monitor/Modify Tx

bupropion + clomipramine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + clomipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clopidogrel
Contrave (naltrexone/ bupropion hydrochloride)

+

clopidogrel

1 interaction

Monitor/Modify Tx

bupropion + clopidogrel

consider bupropion dose adjustment based on clinical response; if incr. dose required of combo product, adjust max bupropion/naltrexone dose to 2 tabs/day: combo may incr. bupropion levels, risk of seizures, other adverse effects; may decr. bupropion active metabolite levels, efficacy (hepatic metabolism inhibited)

• clozapine
Contrave (naltrexone/ bupropion hydrochloride)

+

clozapine

2 interactions

Monitor/Modify Tx

bupropion + clozapine

monitor ECG, BP, HR; consider decr. dose of one or both drugs: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + clozapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cobicistat
Contrave (naltrexone/ bupropion hydrochloride)

+

cobicistat

1 interaction

Monitor/Modify Tx

bupropion + cobicistat

consider decr. bupropion dose when cobicistat is given as part of fixed-dose combo elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil: combo may incr. bupropion levels, risk of adverse effects (hepatic metabolism possibly inhibited)

• cocaine
Contrave (naltrexone/ bupropion hydrochloride)

+

cocaine

1 interaction

Monitor/Modify Tx

bupropion + cocaine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• copanlisib
Contrave (naltrexone/ bupropion hydrochloride)

+

copanlisib

1 interaction

Monitor/Modify Tx

bupropion + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects; copanlisib may cause infusion-related HTN)

• corticotropin
Contrave (naltrexone/ bupropion hydrochloride)

+

corticotropin

1 interaction

Monitor/Modify Tx

bupropion + corticotropin

monitor BP: combo may incr. risk of HTN (additive effects)

• cortisone
Contrave (naltrexone/ bupropion hydrochloride)

+

cortisone

1 interaction

Monitor/Modify Tx

bupropion + cortisone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• cyclobenzaprine
Contrave (naltrexone/ bupropion hydrochloride)

+

cyclobenzaprine

2 interactions

Monitor/Modify Tx

bupropion + cyclobenzaprine

monitor serotonin syndrome sx, especially during initiation/titration; consider lower bupropion doses: combo may incr. risk of seizures, serotonin syndrome (additive effects)

Caution Advised

naltrexone + cyclobenzaprine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cycloserine
Contrave (naltrexone/ bupropion hydrochloride)

+

cycloserine

1 interaction

Monitor/Modify Tx

bupropion + cycloserine

consider lower bupropion doses, especially w/ cycloserine daily doses >500 mg and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• cyclosporine
Contrave (naltrexone/ bupropion hydrochloride)

+

cyclosporine

1 interaction

Monitor/Modify Tx

bupropion + cyclosporine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• dalfampridine
Contrave (naltrexone/ bupropion hydrochloride)

+

dalfampridine

1 interaction

Monitor/Modify Tx

bupropion + dalfampridine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• danazol
Contrave (naltrexone/ bupropion hydrochloride)

+

danazol

1 interaction

Monitor/Modify Tx

bupropion + danazol

monitor BP: combo may incr. risk of HTN (additive effects)

• darbepoetin alfa
Contrave (naltrexone/ bupropion hydrochloride)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

bupropion + darbepoetin alfa

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• daridorexant
Contrave (naltrexone/ bupropion hydrochloride)

+

daridorexant

1 interaction

Monitor/Modify Tx

naltrexone + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darolutamide
Contrave (naltrexone/ bupropion hydrochloride)

+

darolutamide

1 interaction

Monitor/Modify Tx

bupropion + darolutamide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• deflazacort
Contrave (naltrexone/ bupropion hydrochloride)

+

deflazacort

1 interaction

Monitor/Modify Tx

bupropion + deflazacort

consider lower bupropion doses; monitor BP: combo may incr. risk of seizures, HTN (additive effects)

• delafloxacin
Contrave (naltrexone/ bupropion hydrochloride)

+

delafloxacin

1 interaction

Monitor/Modify Tx

bupropion + delafloxacin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• desflurane
Contrave (naltrexone/ bupropion hydrochloride)

+

desflurane

1 interaction

Monitor/Modify Tx

naltrexone + desflurane

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Contrave (naltrexone/ bupropion hydrochloride)

+

desipramine

2 interactions

Monitor/Modify Tx

bupropion + desipramine

monitor BP, ECG; consider monitoring desipramine levels; consider lower bupropion doses: combo may incr. desipramine levels, risk of QT prolongation, cardiac arrhythmias, HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + desipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• desmopressin
Contrave (naltrexone/ bupropion hydrochloride)

+

desmopressin

1 interaction

Monitor/Modify Tx

bupropion + desmopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• desvenlafaxine
Contrave (naltrexone/ bupropion hydrochloride)

+

desvenlafaxine

2 interactions

Monitor/Modify Tx

bupropion + desvenlafaxine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deutetrabenazine
Contrave (naltrexone/ bupropion hydrochloride)

+

deutetrabenazine

2 interactions

Monitor/Modify Tx

bupropion + deutetrabenazine

monitor ECG; adjust max deutetrabenazine dose to 36 mg/day: combo may incr. deutetrabenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexamethasone
Contrave (naltrexone/ bupropion hydrochloride)

+

dexamethasone

1 interaction

Monitor/Modify Tx

bupropion + dexamethasone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• dexmedetomidine
Contrave (naltrexone/ bupropion hydrochloride)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

naltrexone + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Contrave (naltrexone/ bupropion hydrochloride)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

naltrexone + dexmedetomidine injection

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Contrave (naltrexone/ bupropion hydrochloride)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

bupropion + dexmethylphenidate

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• diclofenac
Contrave (naltrexone/ bupropion hydrochloride)

+

diclofenac

1 interaction

Monitor/Modify Tx

bupropion + diclofenac

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac topical
Contrave (naltrexone/ bupropion hydrochloride)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

bupropion + diclofenac topical

monitor BP: combo may incr. risk of HTN (additive effects)

• dicloxacillin
Contrave (naltrexone/ bupropion hydrochloride)

+

dicloxacillin

1 interaction

Monitor/Modify Tx

bupropion + dicloxacillin

consider lower bupropion doses, especially w/ high dicloxacillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• diethylpropion
Contrave (naltrexone/ bupropion hydrochloride)

+

diethylpropion

1 interaction

Monitor/Modify Tx

bupropion + diethylpropion

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• diflunisal
Contrave (naltrexone/ bupropion hydrochloride)

+

diflunisal

1 interaction

Monitor/Modify Tx

bupropion + diflunisal

monitor BP: combo may incr. risk of HTN (additive effects)

• digoxin
Contrave (naltrexone/ bupropion hydrochloride)

+

digoxin

1 interaction

Monitor/Modify Tx

bupropion + digoxin

monitor digoxin levels: combo may decr. digoxin levels, efficacy (mechanism unknown)

• dihydroergotamine
Contrave (naltrexone/ bupropion hydrochloride)

+

dihydroergotamine

1 interaction

Monitor/Modify Tx

bupropion + dihydroergotamine

monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (additive effects)

• diltiazem
Contrave (naltrexone/ bupropion hydrochloride)

+

diltiazem

1 interaction

Monitor/Modify Tx

bupropion + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dobutamine
Contrave (naltrexone/ bupropion hydrochloride)

+

dobutamine

1 interaction

Monitor/Modify Tx

bupropion + dobutamine

monitor BP: combo may incr. risk of HTN (additive effects)

• donepezil
Contrave (naltrexone/ bupropion hydrochloride)

+

donepezil

1 interaction

Monitor/Modify Tx

bupropion + donepezil

consider lower bupropion doses: combo may incr. donepezil levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• dopamine
Contrave (naltrexone/ bupropion hydrochloride)

+

dopamine

1 interaction

Monitor/Modify Tx

bupropion + dopamine

monitor BP: combo may incr. risk of HTN (additive effects)

• doxapram
Contrave (naltrexone/ bupropion hydrochloride)

+

doxapram

1 interaction

Monitor/Modify Tx

bupropion + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

• doxazosin
Contrave (naltrexone/ bupropion hydrochloride)

+

doxazosin

1 interaction

Monitor/Modify Tx

bupropion + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• doxepin
Contrave (naltrexone/ bupropion hydrochloride)

+

doxepin

2 interactions

Monitor/Modify Tx

bupropion + doxepin

monitor BP; consider lower bupropion doses: combo may incr. doxepin levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dronabinol
Contrave (naltrexone/ bupropion hydrochloride)

+

dronabinol

2 interactions

Monitor/Modify Tx

bupropion + dronabinol

consider lower bupropion doses; monitor BP, HR: combo may incr. risk of seizures, HTN, tachycardia (additive effects)

Caution Advised

naltrexone + dronabinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droperidol
Contrave (naltrexone/ bupropion hydrochloride)

+

droperidol

1 interaction

Monitor/Modify Tx

naltrexone + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droxidopa
Contrave (naltrexone/ bupropion hydrochloride)

+

droxidopa

1 interaction

Monitor/Modify Tx

bupropion + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

• duloxetine
Contrave (naltrexone/ bupropion hydrochloride)

+

duloxetine

2 interactions

Monitor/Modify Tx

bupropion + duloxetine

consider lower bupropion doses: combo may incr. duloxetine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + duloxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eletriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

eletriptan

2 interactions

Monitor/Modify Tx

bupropion + eletriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elinzanetant
Contrave (naltrexone/ bupropion hydrochloride)

+

elinzanetant

2 interactions

Monitor/Modify Tx

bupropion + elinzanetant

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + elinzanetant

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• elivaldogene autotemcel
Contrave (naltrexone/ bupropion hydrochloride)

+

elivaldogene autotemcel

1 interaction

Monitor/Modify Tx

bupropion + elivaldogene autotemcel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• enalapril
Contrave (naltrexone/ bupropion hydrochloride)

+

enalapril

1 interaction

Monitor/Modify Tx

bupropion + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Contrave (naltrexone/ bupropion hydrochloride)

+

enalaprilat

1 interaction

Monitor/Modify Tx

bupropion + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enzalutamide
Contrave (naltrexone/ bupropion hydrochloride)

+

enzalutamide

1 interaction

Monitor/Modify Tx

bupropion + enzalutamide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ephedra
Contrave (naltrexone/ bupropion hydrochloride)

+

ephedra

1 interaction

Monitor/Modify Tx

bupropion + ephedra

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• ephedrine injection
Contrave (naltrexone/ bupropion hydrochloride)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

bupropion + ephedrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

• ephedrine oral
Contrave (naltrexone/ bupropion hydrochloride)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

bupropion + ephedrine oral

monitor BP: combo may incr. risk of HTN (additive effects)

• epinephrine
Contrave (naltrexone/ bupropion hydrochloride)

+

epinephrine

1 interaction

Monitor/Modify Tx

bupropion + epinephrine

monitor BP: combo may incr. risk of HTN (additive effects)

• eplerenone
Contrave (naltrexone/ bupropion hydrochloride)

+

eplerenone

1 interaction

Monitor/Modify Tx

bupropion + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Contrave (naltrexone/ bupropion hydrochloride)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

bupropion + epoetin alfa

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• eptinezumab
Contrave (naltrexone/ bupropion hydrochloride)

+

eptinezumab

1 interaction

Monitor/Modify Tx

bupropion + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erenumab
Contrave (naltrexone/ bupropion hydrochloride)

+

erenumab

1 interaction

Monitor/Modify Tx

bupropion + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

• ergotamine
Contrave (naltrexone/ bupropion hydrochloride)

+

ergotamine

1 interaction

Monitor/Modify Tx

bupropion + ergotamine

monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (additive effects)

• ertapenem
Contrave (naltrexone/ bupropion hydrochloride)

+

ertapenem

1 interaction

Monitor/Modify Tx

bupropion + ertapenem

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• escitalopram
Contrave (naltrexone/ bupropion hydrochloride)

+

escitalopram

2 interactions

Monitor/Modify Tx

bupropion + escitalopram

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + escitalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• esketamine
Contrave (naltrexone/ bupropion hydrochloride)

+

esketamine

2 interactions

Monitor/Modify Tx

bupropion + esketamine

monitor BP: combo may incr. risk of HTN (additive effects)

naltrexone + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• esmolol
Contrave (naltrexone/ bupropion hydrochloride)

+

esmolol

1 interaction

Monitor/Modify Tx

bupropion + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estazolam
Contrave (naltrexone/ bupropion hydrochloride)

+

estazolam

1 interaction

Monitor/Modify Tx

naltrexone + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• estetrol (contraceptive)
Contrave (naltrexone/ bupropion hydrochloride)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

bupropion + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (contraceptive)
Contrave (naltrexone/ bupropion hydrochloride)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

bupropion + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• eszopiclone
Contrave (naltrexone/ bupropion hydrochloride)

+

eszopiclone

1 interaction

Monitor/Modify Tx

naltrexone + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Contrave (naltrexone/ bupropion hydrochloride)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

bupropion + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethanol (in some formulations)
Contrave (naltrexone/ bupropion hydrochloride)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

naltrexone + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
Contrave (naltrexone/ bupropion hydrochloride)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

bupropion + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• etodolac
Contrave (naltrexone/ bupropion hydrochloride)

+

etodolac

1 interaction

Monitor/Modify Tx

bupropion + etodolac

monitor BP: combo may incr. risk of HTN (additive effects)

• etomidate
Contrave (naltrexone/ bupropion hydrochloride)

+

etomidate

1 interaction

Monitor/Modify Tx

naltrexone + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etrasimod
Contrave (naltrexone/ bupropion hydrochloride)

+

etrasimod

1 interaction

Monitor/Modify Tx

bupropion + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• felodipine
Contrave (naltrexone/ bupropion hydrochloride)

+

felodipine

1 interaction

Monitor/Modify Tx

bupropion + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoldopam
Contrave (naltrexone/ bupropion hydrochloride)

+

fenoldopam

1 interaction

Monitor/Modify Tx

bupropion + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoprofen
Contrave (naltrexone/ bupropion hydrochloride)

+

fenoprofen

1 interaction

Monitor/Modify Tx

bupropion + fenoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fingolimod
Contrave (naltrexone/ bupropion hydrochloride)

+

fingolimod

1 interaction

Monitor/Modify Tx

bupropion + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

• flecainide
Contrave (naltrexone/ bupropion hydrochloride)

+

flecainide

1 interaction

Monitor/Modify Tx

bupropion + flecainide

monitor flecainide levels, ECG: combo may incr. flecainide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• fludrocortisone
Contrave (naltrexone/ bupropion hydrochloride)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

bupropion + fludrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• fluoxetine
Contrave (naltrexone/ bupropion hydrochloride)

+

fluoxetine

2 interactions

Monitor/Modify Tx

bupropion + fluoxetine

monitor ECG; consider decr. bupropion doses: combo may incr. fluoxetine levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluphenazine
Contrave (naltrexone/ bupropion hydrochloride)

+

fluphenazine

2 interactions

Monitor/Modify Tx

bupropion + fluphenazine

consider lower bupropion doses: combo may incr. fluphenazine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

naltrexone + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• flurazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

flurazepam

1 interaction

Monitor/Modify Tx

naltrexone + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• flurbiprofen
Contrave (naltrexone/ bupropion hydrochloride)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

bupropion + flurbiprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fluvoxamine
Contrave (naltrexone/ bupropion hydrochloride)

+

fluvoxamine

2 interactions

Monitor/Modify Tx

bupropion + fluvoxamine

consider lower bupropion doses: combo may incr. fluvoxamine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + fluvoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• formoterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + formoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• foscarnet
Contrave (naltrexone/ bupropion hydrochloride)

+

foscarnet

1 interaction

Monitor/Modify Tx

bupropion + foscarnet

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• fosinopril
Contrave (naltrexone/ bupropion hydrochloride)

+

fosinopril

1 interaction

Monitor/Modify Tx

bupropion + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

fostamatinib

1 interaction

Monitor/Modify Tx

bupropion + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• fremanezumab
Contrave (naltrexone/ bupropion hydrochloride)

+

fremanezumab

1 interaction

Monitor/Modify Tx

bupropion + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• frovatriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

frovatriptan

2 interactions

Monitor/Modify Tx

bupropion + frovatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fruquintinib
Contrave (naltrexone/ bupropion hydrochloride)

+

fruquintinib

1 interaction

Monitor/Modify Tx

bupropion + fruquintinib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• gabapentin enacarbil
Contrave (naltrexone/ bupropion hydrochloride)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

naltrexone + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• galantamine
Contrave (naltrexone/ bupropion hydrochloride)

+

galantamine

1 interaction

Monitor/Modify Tx

bupropion + galantamine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• galcanezumab
Contrave (naltrexone/ bupropion hydrochloride)

+

galcanezumab

1 interaction

Monitor/Modify Tx

bupropion + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• ganciclovir
Contrave (naltrexone/ bupropion hydrochloride)

+

ganciclovir

1 interaction

Monitor/Modify Tx

bupropion + ganciclovir

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• goserelin
Contrave (naltrexone/ bupropion hydrochloride)

+

goserelin

1 interaction

Monitor/Modify Tx

bupropion + goserelin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• guanfacine
Contrave (naltrexone/ bupropion hydrochloride)

+

guanfacine

2 interactions

Monitor/Modify Tx

bupropion + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

naltrexone + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• histrelin
Contrave (naltrexone/ bupropion hydrochloride)

+

histrelin

1 interaction

Monitor/Modify Tx

bupropion + histrelin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• hoodia
Contrave (naltrexone/ bupropion hydrochloride)

+

hoodia

1 interaction

Monitor/Modify Tx

bupropion + hoodia

monitor BP: combo may incr. risk of HTN (additive effects)

• hydralazine
Contrave (naltrexone/ bupropion hydrochloride)

+

hydralazine

1 interaction

Monitor/Modify Tx

bupropion + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Contrave (naltrexone/ bupropion hydrochloride)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

bupropion + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrocortisone
Contrave (naltrexone/ bupropion hydrochloride)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

bupropion + hydrocortisone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• hydroxocobalamin IV
Contrave (naltrexone/ bupropion hydrochloride)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

bupropion + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

• hydroxychloroquine
Contrave (naltrexone/ bupropion hydrochloride)

+

hydroxychloroquine

1 interaction

Monitor/Modify Tx

bupropion + hydroxychloroquine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• hydroxyzine
Contrave (naltrexone/ bupropion hydrochloride)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

naltrexone + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ibrutinib
Contrave (naltrexone/ bupropion hydrochloride)

+

ibrutinib

1 interaction

Monitor/Modify Tx

bupropion + ibrutinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ibuprofen
Contrave (naltrexone/ bupropion hydrochloride)

+

ibuprofen

1 interaction

Monitor/Modify Tx

bupropion + ibuprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• idecabtagene vicleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

idecabtagene vicleucel

1 interaction

Monitor/Modify Tx

bupropion + idecabtagene vicleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ifosfamide
Contrave (naltrexone/ bupropion hydrochloride)

+

ifosfamide

2 interactions

Monitor/Modify Tx

bupropion + ifosfamide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloperidone
Contrave (naltrexone/ bupropion hydrochloride)

+

iloperidone

2 interactions

Monitor/Modify Tx

bupropion + iloperidone

monitor ECG; decr. iloperidone dose 50%, consider lower bupropion doses: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• imipenem
Contrave (naltrexone/ bupropion hydrochloride)

+

imipenem

1 interaction

Monitor/Modify Tx

bupropion + imipenem

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• imipramine
Contrave (naltrexone/ bupropion hydrochloride)

+

imipramine

2 interactions

Monitor/Modify Tx

bupropion + imipramine

monitor imipramine levels, BP; consider decr. dose of one or both drugs: combo may incr. imipramine levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + imipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• indapamide
Contrave (naltrexone/ bupropion hydrochloride)

+

indapamide

1 interaction

Monitor/Modify Tx

bupropion + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• indomethacin
Contrave (naltrexone/ bupropion hydrochloride)

+

indomethacin

1 interaction

Monitor/Modify Tx

bupropion + indomethacin

monitor BP: combo may incr. risk of HTN (additive effects)

• interferon beta 1a
Contrave (naltrexone/ bupropion hydrochloride)

+

interferon beta 1a

1 interaction

Monitor/Modify Tx

bupropion + interferon beta 1a

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• interferon beta 1b
Contrave (naltrexone/ bupropion hydrochloride)

+

interferon beta 1b

1 interaction

Monitor/Modify Tx

bupropion + interferon beta 1b

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• iopamidol
Contrave (naltrexone/ bupropion hydrochloride)

+

iopamidol

1 interaction

Monitor/Modify Tx

bupropion + iopamidol

caution advised if intrathecal iopamidol use; consider holding bupropion at least 48h before and at least 24h after intrathecal iopamidol; consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• irbesartan
Contrave (naltrexone/ bupropion hydrochloride)

+

irbesartan

1 interaction

Monitor/Modify Tx

bupropion + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isoflurane
Contrave (naltrexone/ bupropion hydrochloride)

+

isoflurane

1 interaction

Monitor/Modify Tx

naltrexone + isoflurane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• isoniazid
Contrave (naltrexone/ bupropion hydrochloride)

+

isoniazid

1 interaction

Monitor/Modify Tx

bupropion + isoniazid

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• isradipine
Contrave (naltrexone/ bupropion hydrochloride)

+

isradipine

1 interaction

Monitor/Modify Tx

bupropion + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketamine
Contrave (naltrexone/ bupropion hydrochloride)

+

ketamine

2 interactions

Monitor/Modify Tx

bupropion + ketamine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, other sympathomimetic adverse effects, seizures (additive effects)

naltrexone + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (including life-threatening), psychomotor impairment (additive effects)

• ketoprofen
Contrave (naltrexone/ bupropion hydrochloride)

+

ketoprofen

1 interaction

Monitor/Modify Tx

bupropion + ketoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ketorolac
Contrave (naltrexone/ bupropion hydrochloride)

+

ketorolac

1 interaction

Monitor/Modify Tx

bupropion + ketorolac

monitor BP: combo may incr. risk of HTN (additive effects)

• labetalol
Contrave (naltrexone/ bupropion hydrochloride)

+

labetalol

1 interaction

Monitor/Modify Tx

bupropion + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Contrave (naltrexone/ bupropion hydrochloride)

+

lanreotide

1 interaction

Monitor/Modify Tx

bupropion + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

• leflunomide
Contrave (naltrexone/ bupropion hydrochloride)

+

leflunomide

1 interaction

Monitor/Modify Tx

bupropion + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• lemborexant
Contrave (naltrexone/ bupropion hydrochloride)

+

lemborexant

2 interactions

Monitor/Modify Tx

naltrexone + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Caution Advised

bupropion + lemborexant

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• lenvatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

lenvatinib

1 interaction

Monitor/Modify Tx

bupropion + lenvatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• leuprolide
Contrave (naltrexone/ bupropion hydrochloride)

+

leuprolide

1 interaction

Monitor/Modify Tx

bupropion + leuprolide

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• levalbuterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + levalbuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• levocarnitine
Contrave (naltrexone/ bupropion hydrochloride)

+

levocarnitine

1 interaction

Monitor/Modify Tx

bupropion + levocarnitine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• levofloxacin
Contrave (naltrexone/ bupropion hydrochloride)

+

levofloxacin

1 interaction

Monitor/Modify Tx

bupropion + levofloxacin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• levoketoconazole
Contrave (naltrexone/ bupropion hydrochloride)

+

levoketoconazole

1 interaction

Monitor/Modify Tx

bupropion + levoketoconazole

consider bupropion dose adjustment based on clinical response; if incr. dose required of combo product, adjust max bupropion/naltrexone dose to 2 tabs/day: combo may incr. bupropion levels, risk of seizures, other adverse effects; may decr. bupropion active metabolite levels, efficacy (hepatic metabolism possibly inhibited)

• levomilnacipran
Contrave (naltrexone/ bupropion hydrochloride)

+

levomilnacipran

2 interactions

Monitor/Modify Tx

bupropion + levomilnacipran

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levothyroxine
Contrave (naltrexone/ bupropion hydrochloride)

+

levothyroxine

1 interaction

Monitor/Modify Tx

bupropion + levothyroxine

monitor BP: combo may incr. risk of HTN (additive effects)

• licorice
Contrave (naltrexone/ bupropion hydrochloride)

+

licorice

1 interaction

Monitor/Modify Tx

bupropion + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

• lidocaine
Contrave (naltrexone/ bupropion hydrochloride)

+

lidocaine

1 interaction

Monitor/Modify Tx

bupropion + lidocaine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• lidocaine topical
Contrave (naltrexone/ bupropion hydrochloride)

+

lidocaine topical

1 interaction

Monitor/Modify Tx

bupropion + lidocaine topical

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• liothyronine
Contrave (naltrexone/ bupropion hydrochloride)

+

liothyronine

1 interaction

Monitor/Modify Tx

bupropion + liothyronine

monitor BP: combo may incr. risk of HTN (additive effects)

• lisinopril
Contrave (naltrexone/ bupropion hydrochloride)

+

lisinopril

1 interaction

Monitor/Modify Tx

bupropion + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lisocabtagene maraleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

lisocabtagene maraleucel

1 interaction

Monitor/Modify Tx

bupropion + lisocabtagene maraleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• lithium
Contrave (naltrexone/ bupropion hydrochloride)

+

lithium

1 interaction

Monitor/Modify Tx

bupropion + lithium

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• lofexidine
Contrave (naltrexone/ bupropion hydrochloride)

+

lofexidine

2 interactions

Monitor/Modify Tx

bupropion + lofexidine

monitor ECG, BP, HR: combo may incr. lofexidine levels, risk of bradycardia, QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + lofexidine

caution advised: combo may decr. oral naltrexone efficacy; may incr. risk of CNS depression, psychomotor impairment (mechanism unknown; additive effects)

• losartan
Contrave (naltrexone/ bupropion hydrochloride)

+

losartan

1 interaction

Monitor/Modify Tx

bupropion + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• loxapine
Contrave (naltrexone/ bupropion hydrochloride)

+

loxapine

2 interactions

Monitor/Modify Tx

bupropion + loxapine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lumacaftor/ivacaftor
Contrave (naltrexone/ bupropion hydrochloride)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

bupropion + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

• lumateperone
Contrave (naltrexone/ bupropion hydrochloride)

+

lumateperone

2 interactions

Monitor/Modify Tx

bupropion + lumateperone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + lumateperone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lurasidone
Contrave (naltrexone/ bupropion hydrochloride)

+

lurasidone

2 interactions

Monitor/Modify Tx

bupropion + lurasidone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• luspatercept
Contrave (naltrexone/ bupropion hydrochloride)

+

luspatercept

1 interaction

Monitor/Modify Tx

bupropion + luspatercept

monitor BP: combo may incr. risk of HTN (additive effects)

• magnesium citrate
Contrave (naltrexone/ bupropion hydrochloride)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

bupropion + magnesium citrate

consider lower bupropion doses, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• magnesium salicylate
Contrave (naltrexone/ bupropion hydrochloride)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

bupropion + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• meclofenamate
Contrave (naltrexone/ bupropion hydrochloride)

+

meclofenamate

1 interaction

Monitor/Modify Tx

bupropion + meclofenamate

monitor BP: combo may incr. risk of HTN (additive effects)

• mefenamic acid
Contrave (naltrexone/ bupropion hydrochloride)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

bupropion + mefenamic acid

monitor BP: combo may incr. risk of HTN (additive effects)

• mefloquine
Contrave (naltrexone/ bupropion hydrochloride)

+

mefloquine

1 interaction

Monitor/Modify Tx

bupropion + mefloquine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• melatonin
Contrave (naltrexone/ bupropion hydrochloride)

+

melatonin

2 interactions

Monitor/Modify Tx

bupropion + melatonin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meloxicam
Contrave (naltrexone/ bupropion hydrochloride)

+

meloxicam

1 interaction

Monitor/Modify Tx

bupropion + meloxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• meropenem
Contrave (naltrexone/ bupropion hydrochloride)

+

meropenem

1 interaction

Monitor/Modify Tx

bupropion + meropenem

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• methocarbamol
Contrave (naltrexone/ bupropion hydrochloride)

+

methocarbamol

2 interactions

Monitor/Modify Tx

bupropion + methocarbamol

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methohexital
Contrave (naltrexone/ bupropion hydrochloride)

+

methohexital

1 interaction

Monitor/Modify Tx

naltrexone + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methotrexate
Contrave (naltrexone/ bupropion hydrochloride)

+

methotrexate

1 interaction

Monitor/Modify Tx

bupropion + methotrexate

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• methoxy polyethylene glycol-epoetin beta
Contrave (naltrexone/ bupropion hydrochloride)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

bupropion + methoxy polyethylene glycol-epoetin beta

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• methyldopa
Contrave (naltrexone/ bupropion hydrochloride)

+

methyldopa

2 interactions

Monitor/Modify Tx

bupropion + methyldopa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

naltrexone + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methylene blue oral
Contrave (naltrexone/ bupropion hydrochloride)

+

methylene blue oral

1 interaction

Monitor/Modify Tx

bupropion + methylene blue oral

monitor BP, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of HTN, serotonin syndrome (possible additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Contrave (naltrexone/ bupropion hydrochloride)

+

methylergonovine

1 interaction

Monitor/Modify Tx

bupropion + methylergonovine

monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (additive effects)

• methylphenidate
Contrave (naltrexone/ bupropion hydrochloride)

+

methylphenidate

1 interaction

Monitor/Modify Tx

bupropion + methylphenidate

monitor BP: combo may incr. risk of HTN (additive effects)

• methylprednisolone
Contrave (naltrexone/ bupropion hydrochloride)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

bupropion + methylprednisolone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• methyltestosterone
Contrave (naltrexone/ bupropion hydrochloride)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

bupropion + methyltestosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• metolazone
Contrave (naltrexone/ bupropion hydrochloride)

+

metolazone

1 interaction

Monitor/Modify Tx

bupropion + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Contrave (naltrexone/ bupropion hydrochloride)

+

metoprolol

1 interaction

Monitor/Modify Tx

bupropion + metoprolol

monitor BP, HR; consider lower metoprolol dose: combo may incr. metoprolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

• metronidazole
Contrave (naltrexone/ bupropion hydrochloride)

+

metronidazole

1 interaction

Monitor/Modify Tx

bupropion + metronidazole

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• mexiletine
Contrave (naltrexone/ bupropion hydrochloride)

+

mexiletine

1 interaction

Monitor/Modify Tx

bupropion + mexiletine

titrate slowly; consider monitoring mexiletine levels; consider lower bupropion doses: combo may incr. mexiletine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• mifepristone
Contrave (naltrexone/ bupropion hydrochloride)

+

mifepristone

1 interaction

Monitor/Modify Tx

bupropion + mifepristone

consider bupropion dose adjustment based on clinical response; if incr. dose required of combo product, adjust max bupropion/naltrexone dose to 2 tabs/day: combo may incr. bupropion levels, risk of seizures, other adverse effects; may decr. bupropion active metabolite levels, efficacy (hepatic metabolism possibly inhibited)

• milnacipran
Contrave (naltrexone/ bupropion hydrochloride)

+

milnacipran

2 interactions

Monitor/Modify Tx

bupropion + milnacipran

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• milsaperidone
Contrave (naltrexone/ bupropion hydrochloride)

+

milsaperidone

2 interactions

Monitor/Modify Tx

bupropion + milsaperidone

monitor ECG; decr. milsaperidone maintenance dose 50%, consider lower bupropion doses: combo may incr. milsaperidone levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + milsaperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• minoxidil
Contrave (naltrexone/ bupropion hydrochloride)

+

minoxidil

1 interaction

Monitor/Modify Tx

bupropion + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Contrave (naltrexone/ bupropion hydrochloride)

+

mirabegron

1 interaction

Monitor/Modify Tx

bupropion + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

• mirtazapine
Contrave (naltrexone/ bupropion hydrochloride)

+

mirtazapine

2 interactions

Monitor/Modify Tx

bupropion + mirtazapine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• modafinil
Contrave (naltrexone/ bupropion hydrochloride)

+

modafinil

1 interaction

Monitor/Modify Tx

bupropion + modafinil

monitor BP: combo may incr. risk of HTN (additive effects)

• moexipril
Contrave (naltrexone/ bupropion hydrochloride)

+

moexipril

1 interaction

Monitor/Modify Tx

bupropion + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• molindone
Contrave (naltrexone/ bupropion hydrochloride)

+

molindone

2 interactions

Monitor/Modify Tx

bupropion + molindone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• moxifloxacin
Contrave (naltrexone/ bupropion hydrochloride)

+

moxifloxacin

1 interaction

Monitor/Modify Tx

bupropion + moxifloxacin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• nabumetone
Contrave (naltrexone/ bupropion hydrochloride)

+

nabumetone

1 interaction

Monitor/Modify Tx

bupropion + nabumetone

monitor BP: combo may incr. risk of HTN (additive effects)

• nadolol
Contrave (naltrexone/ bupropion hydrochloride)

+

nadolol

1 interaction

Monitor/Modify Tx

bupropion + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nafarelin nasal
Contrave (naltrexone/ bupropion hydrochloride)

+

nafarelin nasal

1 interaction

Monitor/Modify Tx

bupropion + nafarelin nasal

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• nafcillin
Contrave (naltrexone/ bupropion hydrochloride)

+

nafcillin

1 interaction

Monitor/Modify Tx

bupropion + nafcillin

consider lower bupropion doses, especially w/ high nafcillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• naproxen
Contrave (naltrexone/ bupropion hydrochloride)

+

naproxen

1 interaction

Monitor/Modify Tx

bupropion + naproxen

monitor BP: combo may incr. risk of HTN (additive effects)

• naratriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

naratriptan

2 interactions

Monitor/Modify Tx

bupropion + naratriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naxitamab
Contrave (naltrexone/ bupropion hydrochloride)

+

naxitamab

1 interaction

Monitor/Modify Tx

bupropion + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

• nebivolol
Contrave (naltrexone/ bupropion hydrochloride)

+

nebivolol

1 interaction

Monitor/Modify Tx

bupropion + nebivolol

monitor BP, HR: combo may incr. nebivolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

• nefazodone
Contrave (naltrexone/ bupropion hydrochloride)

+

nefazodone

2 interactions

Monitor/Modify Tx

bupropion + nefazodone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + nefazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelarabine
Contrave (naltrexone/ bupropion hydrochloride)

+

nelarabine

2 interactions

Monitor/Modify Tx

bupropion + nelarabine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nicardipine
Contrave (naltrexone/ bupropion hydrochloride)

+

nicardipine

1 interaction

Monitor/Modify Tx

bupropion + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nicotine
Contrave (naltrexone/ bupropion hydrochloride)

+

nicotine

1 interaction

Monitor/Modify Tx

bupropion + nicotine

monitor BP: combo may incr. risk of HTN (mechanism unknown, possible additive effects)

• nifedipine
Contrave (naltrexone/ bupropion hydrochloride)

+

nifedipine

1 interaction

Monitor/Modify Tx

bupropion + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nimodipine
Contrave (naltrexone/ bupropion hydrochloride)

+

nimodipine

1 interaction

Monitor/Modify Tx

bupropion + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• niraparib
Contrave (naltrexone/ bupropion hydrochloride)

+

niraparib

1 interaction

Monitor/Modify Tx

bupropion + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

• nisoldipine
Contrave (naltrexone/ bupropion hydrochloride)

+

nisoldipine

1 interaction

Monitor/Modify Tx

bupropion + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norepinephrine
Contrave (naltrexone/ bupropion hydrochloride)

+

norepinephrine

1 interaction

Monitor/Modify Tx

bupropion + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

• nortriptyline
Contrave (naltrexone/ bupropion hydrochloride)

+

nortriptyline

2 interactions

Monitor/Modify Tx

bupropion + nortriptyline

monitor nortriptyline levels, BP; consider lower bupropion doses: combo may incr. nortriptyline levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + nortriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• obecabtagene autoleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

obecabtagene autoleucel

1 interaction

Monitor/Modify Tx

bupropion + obecabtagene autoleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• obinutuzumab
Contrave (naltrexone/ bupropion hydrochloride)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

bupropion + obinutuzumab

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• ofloxacin
Contrave (naltrexone/ bupropion hydrochloride)

+

ofloxacin

1 interaction

Monitor/Modify Tx

bupropion + ofloxacin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• olanzapine
Contrave (naltrexone/ bupropion hydrochloride)

+

olanzapine

2 interactions

Monitor/Modify Tx

bupropion + olanzapine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + olanzapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis (additive effects)

• olmesartan medoxomil
Contrave (naltrexone/ bupropion hydrochloride)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

bupropion + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• olodaterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + olodaterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• opicapone
Contrave (naltrexone/ bupropion hydrochloride)

+

opicapone

1 interaction

Monitor/Modify Tx

naltrexone + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• osilodrostat
Contrave (naltrexone/ bupropion hydrochloride)

+

osilodrostat

1 interaction

Monitor/Modify Tx

bupropion + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

• oxacillin
Contrave (naltrexone/ bupropion hydrochloride)

+

oxacillin

1 interaction

Monitor/Modify Tx

bupropion + oxacillin

consider lower bupropion doses, especially w/ high oxacillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• oxaprozin
Contrave (naltrexone/ bupropion hydrochloride)

+

oxaprozin

1 interaction

Monitor/Modify Tx

bupropion + oxaprozin

monitor BP: combo may incr. risk of HTN (additive effects)

• oxazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

oxazepam

1 interaction

Monitor/Modify Tx

naltrexone + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxybutynin
Contrave (naltrexone/ bupropion hydrochloride)

+

oxybutynin

1 interaction

Monitor/Modify Tx

naltrexone + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxymetazoline nasal
Contrave (naltrexone/ bupropion hydrochloride)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

bupropion + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• oxytocin
Contrave (naltrexone/ bupropion hydrochloride)

+

oxytocin

1 interaction

Monitor/Modify Tx

bupropion + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

• ozanimod
Contrave (naltrexone/ bupropion hydrochloride)

+

ozanimod

1 interaction

Monitor/Modify Tx

bupropion + ozanimod

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• paliperidone
Contrave (naltrexone/ bupropion hydrochloride)

+

paliperidone

2 interactions

Monitor/Modify Tx

bupropion + paliperidone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• paroxetine
Contrave (naltrexone/ bupropion hydrochloride)

+

paroxetine

2 interactions

Monitor/Modify Tx

bupropion + paroxetine

consider lower bupropion doses: combo may incr. paroxetine levels, risk of adverse effects; may incr. risk of seizures (hepatic metabolism inhibited; additive effects)

Caution Advised

naltrexone + paroxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pazopanib
Contrave (naltrexone/ bupropion hydrochloride)

+

pazopanib

1 interaction

Monitor/Modify Tx

bupropion + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

• peginterferon beta 1a
Contrave (naltrexone/ bupropion hydrochloride)

+

peginterferon beta 1a

1 interaction

Monitor/Modify Tx

bupropion + peginterferon beta 1a

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• penicillin G
Contrave (naltrexone/ bupropion hydrochloride)

+

penicillin G

1 interaction

Monitor/Modify Tx

bupropion + penicillin G

consider lower bupropion doses, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• penicillin V
Contrave (naltrexone/ bupropion hydrochloride)

+

penicillin V

1 interaction

Monitor/Modify Tx

bupropion + penicillin V

consider lower bupropion doses, especially w/ high penicillin V doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• pentobarbital
Contrave (naltrexone/ bupropion hydrochloride)

+

pentobarbital

2 interactions

Monitor/Modify Tx

naltrexone + pentobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

Caution Advised

bupropion + pentobarbital

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• perindopril
Contrave (naltrexone/ bupropion hydrochloride)

+

perindopril

1 interaction

Monitor/Modify Tx

bupropion + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• perphenazine
Contrave (naltrexone/ bupropion hydrochloride)

+

perphenazine

2 interactions

Monitor/Modify Tx

bupropion + perphenazine

consider decr. dose of one or both drugs: combo may incr. perphenazine levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

naltrexone + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pexidartinib
Contrave (naltrexone/ bupropion hydrochloride)

+

pexidartinib

1 interaction

Monitor/Modify Tx

bupropion + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

• phendimetrazine
Contrave (naltrexone/ bupropion hydrochloride)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

bupropion + phendimetrazine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• phenoxybenzamine
Contrave (naltrexone/ bupropion hydrochloride)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

bupropion + phenoxybenzamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phentermine
Contrave (naltrexone/ bupropion hydrochloride)

+

phentermine

1 interaction

Monitor/Modify Tx

bupropion + phentermine

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• phentolamine
Contrave (naltrexone/ bupropion hydrochloride)

+

phentolamine

1 interaction

Monitor/Modify Tx

bupropion + phentolamine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• phenylephrine
Contrave (naltrexone/ bupropion hydrochloride)

+

phenylephrine

1 interaction

Monitor/Modify Tx

bupropion + phenylephrine

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine injection
Contrave (naltrexone/ bupropion hydrochloride)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

bupropion + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine nasal
Contrave (naltrexone/ bupropion hydrochloride)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

bupropion + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• phenylephrine ophthalmic
Contrave (naltrexone/ bupropion hydrochloride)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

bupropion + phenylephrine ophthalmic

monitor BP; HTN risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN (additive effects)

• phenylephrine rectal
Contrave (naltrexone/ bupropion hydrochloride)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

bupropion + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects)

• pindolol
Contrave (naltrexone/ bupropion hydrochloride)

+

pindolol

1 interaction

Monitor/Modify Tx

bupropion + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• piperacillin
Contrave (naltrexone/ bupropion hydrochloride)

+

piperacillin

1 interaction

Monitor/Modify Tx

bupropion + piperacillin

consider lower bupropion doses, especially w/ high piperacillin doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• piroxicam
Contrave (naltrexone/ bupropion hydrochloride)

+

piroxicam

1 interaction

Monitor/Modify Tx

bupropion + piroxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• pitolisant
Contrave (naltrexone/ bupropion hydrochloride)

+

pitolisant

1 interaction

Monitor/Modify Tx

bupropion + pitolisant

monitor ECG; if adding bupropion to stable pitolisant tx, decr. pitolisant dose by 50%; if adding pitolisant to existing bupropion tx in PEDS PTS <40kg: adjust pitolisant max dose to 8.9 mg qd; ADULTS and PEDS PTS 40kg or more: adjust pitolisant max dose to 17.8 mg qd: combo may incr. pitolisant levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• polyethylene glycol
Contrave (naltrexone/ bupropion hydrochloride)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

bupropion + polyethylene glycol

consider lower bupropion doses, especially if polyethylene glycol bowel prep use: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
Contrave (naltrexone/ bupropion hydrochloride)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

bupropion + polyethylene glycol/ electrolytes

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ponatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

ponatinib

1 interaction

Monitor/Modify Tx

bupropion + ponatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ponesimod
Contrave (naltrexone/ bupropion hydrochloride)

+

ponesimod

1 interaction

Monitor/Modify Tx

bupropion + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

• pralsetinib
Contrave (naltrexone/ bupropion hydrochloride)

+

pralsetinib

1 interaction

Monitor/Modify Tx

bupropion + pralsetinib

monitor BP: combo may incr. risk of HTN (additive effects)

• prazosin
Contrave (naltrexone/ bupropion hydrochloride)

+

prazosin

1 interaction

Monitor/Modify Tx

bupropion + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Contrave (naltrexone/ bupropion hydrochloride)

+

prednisolone

1 interaction

Monitor/Modify Tx

bupropion + prednisolone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• prednisone
Contrave (naltrexone/ bupropion hydrochloride)

+

prednisone

1 interaction

Monitor/Modify Tx

bupropion + prednisone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• procainamide
Contrave (naltrexone/ bupropion hydrochloride)

+

procainamide

1 interaction

Monitor/Modify Tx

bupropion + procainamide

monitor procainamide levels, ECG: combo may incr. procainamide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• prochlorperazine
Contrave (naltrexone/ bupropion hydrochloride)

+

prochlorperazine

2 interactions

Monitor/Modify Tx

bupropion + prochlorperazine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• propofol
Contrave (naltrexone/ bupropion hydrochloride)

+

propofol

2 interactions

Monitor/Modify Tx

bupropion + propofol

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• propranolol
Contrave (naltrexone/ bupropion hydrochloride)

+

propranolol

1 interaction

Monitor/Modify Tx

bupropion + propranolol

monitor BP, HR: combo may incr. propranolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

• protriptyline
Contrave (naltrexone/ bupropion hydrochloride)

+

protriptyline

2 interactions

Monitor/Modify Tx

bupropion + protriptyline

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + protriptyline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pseudoephedrine
Contrave (naltrexone/ bupropion hydrochloride)

+

pseudoephedrine

1 interaction

Monitor/Modify Tx

bupropion + pseudoephedrine

monitor BP: combo may incr. risk of HTN (additive effects)

• pyridostigmine
Contrave (naltrexone/ bupropion hydrochloride)

+

pyridostigmine

1 interaction

Monitor/Modify Tx

bupropion + pyridostigmine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• pyrimethamine
Contrave (naltrexone/ bupropion hydrochloride)

+

pyrimethamine

1 interaction

Monitor/Modify Tx

bupropion + pyrimethamine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• quazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

quazepam

1 interaction

Monitor/Modify Tx

naltrexone + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quetiapine
Contrave (naltrexone/ bupropion hydrochloride)

+

quetiapine

2 interactions

Monitor/Modify Tx

bupropion + quetiapine

consider lower bupropion doses; monitor BP, especially in pts <18 yo: combo may incr. risk of seizures, HTN (additive effects)

Caution Advised

naltrexone + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• quinapril
Contrave (naltrexone/ bupropion hydrochloride)

+

quinapril

1 interaction

Monitor/Modify Tx

bupropion + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• quinine
Contrave (naltrexone/ bupropion hydrochloride)

+

quinine

1 interaction

Monitor/Modify Tx

bupropion + quinine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ramipril
Contrave (naltrexone/ bupropion hydrochloride)

+

ramipril

1 interaction

Monitor/Modify Tx

bupropion + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Contrave (naltrexone/ bupropion hydrochloride)

+

ramucirumab

1 interaction

Monitor/Modify Tx

bupropion + ramucirumab

monitor BP: combo may incr. risk of HTN (additive effects)

• rasagiline
Contrave (naltrexone/ bupropion hydrochloride)

+

rasagiline

2 interactions

Monitor/Modify Tx

bupropion + rasagiline

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

naltrexone + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• regadenoson
Contrave (naltrexone/ bupropion hydrochloride)

+

regadenoson

1 interaction

Monitor/Modify Tx

bupropion + regadenoson

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• regorafenib
Contrave (naltrexone/ bupropion hydrochloride)

+

regorafenib

1 interaction

Monitor/Modify Tx

bupropion + regorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• remimazolam
Contrave (naltrexone/ bupropion hydrochloride)

+

remimazolam

1 interaction

Monitor/Modify Tx

naltrexone + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• rimegepant
Contrave (naltrexone/ bupropion hydrochloride)

+

rimegepant

1 interaction

Monitor/Modify Tx

bupropion + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ripretinib
Contrave (naltrexone/ bupropion hydrochloride)

+

ripretinib

1 interaction

Monitor/Modify Tx

bupropion + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

• risperidone
Contrave (naltrexone/ bupropion hydrochloride)

+

risperidone

2 interactions

Monitor/Modify Tx

bupropion + risperidone

consider lower bupropion doses; ORAL RISPERIDONE: adjust risperidone max dose to 8 mg/day; IM RISPERIDONE: consider decr. risperidone dose to 12.5 mg; SC RISPERIDONE: consider decr. to lowest risperidone dose prior to bupropion start: combo may incr. risperidone levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rivastigmine
Contrave (naltrexone/ bupropion hydrochloride)

+

rivastigmine

1 interaction

Monitor/Modify Tx

bupropion + rivastigmine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• rizatriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

rizatriptan

2 interactions

Monitor/Modify Tx

bupropion + rizatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Contrave (naltrexone/ bupropion hydrochloride)

+

ropinirole

2 interactions

Monitor/Modify Tx

bupropion + ropinirole

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Contrave (naltrexone/ bupropion hydrochloride)

+

rotigotine transdermal

2 interactions

Monitor/Modify Tx

bupropion + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

naltrexone + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Contrave (naltrexone/ bupropion hydrochloride)

+

safinamide

2 interactions

Monitor/Modify Tx

bupropion + safinamide

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• salmeterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + salmeterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• salsalate
Contrave (naltrexone/ bupropion hydrochloride)

+

salsalate

1 interaction

Monitor/Modify Tx

bupropion + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• selegiline
Contrave (naltrexone/ bupropion hydrochloride)

+

selegiline

2 interactions

Monitor/Modify Tx

bupropion + selegiline

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

naltrexone + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selpercatinib
Contrave (naltrexone/ bupropion hydrochloride)

+

selpercatinib

1 interaction

Monitor/Modify Tx

bupropion + selpercatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• sertraline
Contrave (naltrexone/ bupropion hydrochloride)

+

sertraline

2 interactions

Monitor/Modify Tx

bupropion + sertraline

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + sertraline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sevoflurane
Contrave (naltrexone/ bupropion hydrochloride)

+

sevoflurane

2 interactions

Monitor/Modify Tx

bupropion + sevoflurane

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + sevoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• siponimod
Contrave (naltrexone/ bupropion hydrochloride)

+

siponimod

1 interaction

Monitor/Modify Tx

bupropion + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

• sodium picosulfate
Contrave (naltrexone/ bupropion hydrochloride)

+

sodium picosulfate

1 interaction

Monitor/Modify Tx

bupropion + sodium picosulfate

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• solriamfetol
Contrave (naltrexone/ bupropion hydrochloride)

+

solriamfetol

1 interaction

Monitor/Modify Tx

bupropion + solriamfetol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• sorafenib
Contrave (naltrexone/ bupropion hydrochloride)

+

sorafenib

1 interaction

Monitor/Modify Tx

bupropion + sorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• spironolactone
Contrave (naltrexone/ bupropion hydrochloride)

+

spironolactone

1 interaction

Monitor/Modify Tx

bupropion + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sulfate bowel prep
Contrave (naltrexone/ bupropion hydrochloride)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

bupropion + sulfate bowel prep

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• sulindac
Contrave (naltrexone/ bupropion hydrochloride)

+

sulindac

1 interaction

Monitor/Modify Tx

bupropion + sulindac

monitor BP: combo may incr. risk of HTN (additive effects)

• sumatriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

sumatriptan

2 interactions

Monitor/Modify Tx

bupropion + sumatriptan

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

Caution Advised

naltrexone + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sunitinib
Contrave (naltrexone/ bupropion hydrochloride)

+

sunitinib

1 interaction

Monitor/Modify Tx

bupropion + sunitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• suvorexant
Contrave (naltrexone/ bupropion hydrochloride)

+

suvorexant

1 interaction

Monitor/Modify Tx

naltrexone + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Contrave (naltrexone/ bupropion hydrochloride)

+

tacrolimus

1 interaction

Monitor/Modify Tx

bupropion + tacrolimus

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• tagraxofusp
Contrave (naltrexone/ bupropion hydrochloride)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

bupropion + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

• teclistamab
Contrave (naltrexone/ bupropion hydrochloride)

+

teclistamab

1 interaction

Monitor/Modify Tx

bupropion + teclistamab

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• telmisartan
Contrave (naltrexone/ bupropion hydrochloride)

+

telmisartan

1 interaction

Monitor/Modify Tx

bupropion + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• temazepam
Contrave (naltrexone/ bupropion hydrochloride)

+

temazepam

1 interaction

Monitor/Modify Tx

naltrexone + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• terazosin
Contrave (naltrexone/ bupropion hydrochloride)

+

terazosin

1 interaction

Monitor/Modify Tx

bupropion + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbutaline
Contrave (naltrexone/ bupropion hydrochloride)

+

terbutaline

1 interaction

Monitor/Modify Tx

bupropion + terbutaline

monitor BP, HR; consider lower bupropion doses: combo may incr. risk of seizures, HTN, other cardiovascular adverse effects (additive effects)

• teriflunomide
Contrave (naltrexone/ bupropion hydrochloride)

+

teriflunomide

1 interaction

Monitor/Modify Tx

bupropion + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• testosterone
Contrave (naltrexone/ bupropion hydrochloride)

+

testosterone

1 interaction

Monitor/Modify Tx

bupropion + testosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• tetrabenazine
Contrave (naltrexone/ bupropion hydrochloride)

+

tetrabenazine

2 interactions

Monitor/Modify Tx

bupropion + tetrabenazine

decr. tetrabenazine dose, max 50 mg/day; monitor ECG: combo may incr. tetrabenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• theophylline
Contrave (naltrexone/ bupropion hydrochloride)

+

theophylline

1 interaction

Monitor/Modify Tx

bupropion + theophylline

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• thiotepa
Contrave (naltrexone/ bupropion hydrochloride)

+

thiotepa

2 interactions

Monitor/Modify Tx

bupropion + thiotepa

consider bupropion dose adjustment based on clinical response; if incr. dose required of combo product, adjust max bupropion/naltrexone dose to 2 tabs/day: combo may incr. bupropion levels, risk of seizures, other adverse effects; may decr. bupropion active metabolite levels, efficacy (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiothixene
Contrave (naltrexone/ bupropion hydrochloride)

+

thiothixene

2 interactions

Monitor/Modify Tx

bupropion + thiothixene

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

naltrexone + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thyroid
Contrave (naltrexone/ bupropion hydrochloride)

+

thyroid

1 interaction

Monitor/Modify Tx

bupropion + thyroid

monitor BP: combo may incr. risk of HTN (additive effects)

• timolol
Contrave (naltrexone/ bupropion hydrochloride)

+

timolol

1 interaction

Monitor/Modify Tx

bupropion + timolol

monitor BP, HR: combo may incr. timolol levels, risk of hypotension, bradycardia, AV block, other adverse effects; may decr. antihypertensive agent efficacy (hepatic metabolism inhibited; antagonistic effects)

• timolol ophthalmic
Contrave (naltrexone/ bupropion hydrochloride)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

bupropion + timolol ophthalmic

monitor BP, HR: combo may incr. timolol levels, risk of hypotension, bradycardia, other adverse effects (hepatic metabolism inhibited)

• tinidazole
Contrave (naltrexone/ bupropion hydrochloride)

+

tinidazole

1 interaction

Monitor/Modify Tx

bupropion + tinidazole

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• tisagenlecleucel
Contrave (naltrexone/ bupropion hydrochloride)

+

tisagenlecleucel

1 interaction

Monitor/Modify Tx

bupropion + tisagenlecleucel

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• tivozanib
Contrave (naltrexone/ bupropion hydrochloride)

+

tivozanib

1 interaction

Monitor/Modify Tx

bupropion + tivozanib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• tolmetin
Contrave (naltrexone/ bupropion hydrochloride)

+

tolmetin

1 interaction

Monitor/Modify Tx

bupropion + tolmetin

monitor BP: combo may incr. risk of HTN (additive effects)

• torsemide
Contrave (naltrexone/ bupropion hydrochloride)

+

torsemide

1 interaction

Monitor/Modify Tx

bupropion + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• trametinib
Contrave (naltrexone/ bupropion hydrochloride)

+

trametinib

1 interaction

Monitor/Modify Tx

bupropion + trametinib

monitor BP: combo may incr. risk of HTN (additive effects)

• trandolapril
Contrave (naltrexone/ bupropion hydrochloride)

+

trandolapril

1 interaction

Monitor/Modify Tx

bupropion + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tranexamic acid
Contrave (naltrexone/ bupropion hydrochloride)

+

tranexamic acid

1 interaction

Monitor/Modify Tx

bupropion + tranexamic acid

consider lower bupropion doses, especially w/ high-dose IV tranexamic acid: combo may incr. risk of seizures (additive effects)

• trazodone
Contrave (naltrexone/ bupropion hydrochloride)

+

trazodone

2 interactions

Monitor/Modify Tx

bupropion + trazodone

monitor ECG, BP: combo may incr. trazodone levels, risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + trazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• treosulfan
Contrave (naltrexone/ bupropion hydrochloride)

+

treosulfan

1 interaction

Monitor/Modify Tx

bupropion + treosulfan

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• triamcinolone
Contrave (naltrexone/ bupropion hydrochloride)

+

triamcinolone

1 interaction

Monitor/Modify Tx

bupropion + triamcinolone

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN, seizures (additive effects)

• triamterene
Contrave (naltrexone/ bupropion hydrochloride)

+

triamterene

1 interaction

Monitor/Modify Tx

bupropion + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Contrave (naltrexone/ bupropion hydrochloride)

+

triazolam

1 interaction

Monitor/Modify Tx

naltrexone + triazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trifluoperazine
Contrave (naltrexone/ bupropion hydrochloride)

+

trifluoperazine

2 interactions

Monitor/Modify Tx

bupropion + trifluoperazine

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Contrave (naltrexone/ bupropion hydrochloride)

+

trimipramine

2 interactions

Monitor/Modify Tx

bupropion + trimipramine

monitor BP; consider decr. dose of one or both drugs: combo may incr. trimipramine levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triptorelin
Contrave (naltrexone/ bupropion hydrochloride)

+

triptorelin

1 interaction

Monitor/Modify Tx

bupropion + triptorelin

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• ubrogepant
Contrave (naltrexone/ bupropion hydrochloride)

+

ubrogepant

1 interaction

Monitor/Modify Tx

bupropion + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• vadadustat
Contrave (naltrexone/ bupropion hydrochloride)

+

vadadustat

1 interaction

Monitor/Modify Tx

bupropion + vadadustat

monitor BP; consider lower bupropion doses: combo may incr. risk of HTN (including hypertensive crisis), seizures (additive effects)

• valacyclovir
Contrave (naltrexone/ bupropion hydrochloride)

+

valacyclovir

1 interaction

Monitor/Modify Tx

bupropion + valacyclovir

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• valbenazine
Contrave (naltrexone/ bupropion hydrochloride)

+

valbenazine

2 interactions

Monitor/Modify Tx

bupropion + valbenazine

monitor ECG; decr. valbenazine dose to 40 mg qd: combo may incr. valbenazine active metabolite levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

Caution Advised

naltrexone + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valganciclovir
Contrave (naltrexone/ bupropion hydrochloride)

+

valganciclovir

1 interaction

Monitor/Modify Tx

bupropion + valganciclovir

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• valsartan
Contrave (naltrexone/ bupropion hydrochloride)

+

valsartan

1 interaction

Monitor/Modify Tx

bupropion + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vamorolone
Contrave (naltrexone/ bupropion hydrochloride)

+

vamorolone

1 interaction

Monitor/Modify Tx

bupropion + vamorolone

monitor BP: combo may incr. risk of HTN (additive effects)

• vandetanib
Contrave (naltrexone/ bupropion hydrochloride)

+

vandetanib

1 interaction

Monitor/Modify Tx

bupropion + vandetanib

monitor BP: combo may incr. risk of HTN (additive effects)

• varenicline
Contrave (naltrexone/ bupropion hydrochloride)

+

varenicline

1 interaction

Monitor/Modify Tx

bupropion + varenicline

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• vasopressin
Contrave (naltrexone/ bupropion hydrochloride)

+

vasopressin

1 interaction

Monitor/Modify Tx

bupropion + vasopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• venlafaxine
Contrave (naltrexone/ bupropion hydrochloride)

+

venlafaxine

2 interactions

Monitor/Modify Tx

bupropion + venlafaxine

monitor BP; consider lower bupropion doses: combo may incr. venlafaxine levels, risk of HTN, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

Caution Advised

naltrexone + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• verapamil
Contrave (naltrexone/ bupropion hydrochloride)

+

verapamil

1 interaction

Monitor/Modify Tx

bupropion + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Contrave (naltrexone/ bupropion hydrochloride)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

bupropion + vilanterol inhaled

monitor BP, HR: combo may incr. risk of HTN, other cardiovascular adverse effects (additive effects)

• vilazodone
Contrave (naltrexone/ bupropion hydrochloride)

+

vilazodone

2 interactions

Monitor/Modify Tx

bupropion + vilazodone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + vilazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• viloxazine
Contrave (naltrexone/ bupropion hydrochloride)

+

viloxazine

2 interactions

Monitor/Modify Tx

bupropion + viloxazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

naltrexone + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• voclosporin
Contrave (naltrexone/ bupropion hydrochloride)

+

voclosporin

1 interaction

Monitor/Modify Tx

bupropion + voclosporin

monitor BP: combo may incr. risk of HTN (additive effects)

• voriconazole
Contrave (naltrexone/ bupropion hydrochloride)

+

voriconazole

1 interaction

Monitor/Modify Tx

bupropion + voriconazole

consider bupropion dose adjustment based on clinical response; if incr. dose required of combo product, adjust max bupropion/naltrexone dose to 2 tabs/day: combo may incr. bupropion levels, risk of seizures, other adverse effects; may decr. bupropion active metabolite levels, efficacy (hepatic metabolism inhibited)

• vortioxetine
Contrave (naltrexone/ bupropion hydrochloride)

+

vortioxetine

1 interaction

Monitor/Modify Tx

bupropion + vortioxetine

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metabolism inhibited, additive effects)

• warfarin
Contrave (naltrexone/ bupropion hydrochloride)

+

warfarin

1 interaction

Monitor/Modify Tx

bupropion + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (mechanism unknown)

• yohimbe
Contrave (naltrexone/ bupropion hydrochloride)

+

yohimbe

1 interaction

Monitor/Modify Tx

bupropion + yohimbe

monitor BP, HR: combo may incr. yohimbe levels, risk of HTN, tachycardia, other adverse effects (hepatic metabolism inhibited, additive effects)

• zaleplon
Contrave (naltrexone/ bupropion hydrochloride)

+

zaleplon

1 interaction

Monitor/Modify Tx

naltrexone + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zavegepant
Contrave (naltrexone/ bupropion hydrochloride)

+

zavegepant

1 interaction

Monitor/Modify Tx

bupropion + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ziconotide
Contrave (naltrexone/ bupropion hydrochloride)

+

ziconotide

1 interaction

Monitor/Modify Tx

naltrexone + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Contrave (naltrexone/ bupropion hydrochloride)

+

ziprasidone

2 interactions

Monitor/Modify Tx

bupropion + ziprasidone

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

Caution Advised

naltrexone + ziprasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Contrave (naltrexone/ bupropion hydrochloride)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

bupropion + ziv-aflibercept

monitor BP: combo may incr. risk of HTN (additive effects)

• zolmitriptan
Contrave (naltrexone/ bupropion hydrochloride)

+

zolmitriptan

2 interactions

Monitor/Modify Tx

bupropion + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

naltrexone + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Contrave (naltrexone/ bupropion hydrochloride)

+

zolpidem

1 interaction

Monitor/Modify Tx

naltrexone + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Caution Advised

• 5-HTP
Contrave (naltrexone/ bupropion hydrochloride)

+

5-HTP

1 interaction

Caution Advised

naltrexone + 5-HTP

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• allopurinol
Contrave (naltrexone/ bupropion hydrochloride)

+

allopurinol

1 interaction

Caution Advised

naltrexone + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• amantadine
Contrave (naltrexone/ bupropion hydrochloride)

+

amantadine

2 interactions

Caution Advised

bupropion + amantadine

caution advised: combo may incr. risk of CNS adverse effects (mechanism unknown)

naltrexone + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apomorphine
Contrave (naltrexone/ bupropion hydrochloride)

+

apomorphine

1 interaction

Caution Advised

naltrexone + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Contrave (naltrexone/ bupropion hydrochloride)

+

apraclonidine ophthalmic

1 interaction

Caution Advised

naltrexone + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine ophthalmic
Contrave (naltrexone/ bupropion hydrochloride)

+

brimonidine ophthalmic

1 interaction

Caution Advised

naltrexone + brimonidine ophthalmic

caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine topical
Contrave (naltrexone/ bupropion hydrochloride)

+

brimonidine topical

1 interaction

Caution Advised

naltrexone + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• bromocriptine
Contrave (naltrexone/ bupropion hydrochloride)

+

bromocriptine

1 interaction

Caution Advised

naltrexone + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brompheniramine
Contrave (naltrexone/ bupropion hydrochloride)

+

brompheniramine

1 interaction

Caution Advised

naltrexone + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• buspirone
Contrave (naltrexone/ bupropion hydrochloride)

+

buspirone

1 interaction

Caution Advised

naltrexone + buspirone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carbinoxamine
Contrave (naltrexone/ bupropion hydrochloride)

+

carbinoxamine

1 interaction

Caution Advised

naltrexone + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carisoprodol
Contrave (naltrexone/ bupropion hydrochloride)

+

carisoprodol

1 interaction

Caution Advised

naltrexone + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Contrave (naltrexone/ bupropion hydrochloride)

+

cetirizine

1 interaction

Caution Advised

naltrexone + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chamomile, German
Contrave (naltrexone/ bupropion hydrochloride)

+

chamomile, German

1 interaction

Caution Advised

naltrexone + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Contrave (naltrexone/ bupropion hydrochloride)

+

chlophedianol

1 interaction

Caution Advised

naltrexone + chlophedianol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorcyclizine
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorcyclizine

1 interaction

Caution Advised

naltrexone + chlorcyclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorzoxazone
Contrave (naltrexone/ bupropion hydrochloride)

+

chlorzoxazone

1 interaction

Caution Advised

naltrexone + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clemastine
Contrave (naltrexone/ bupropion hydrochloride)

+

clemastine

1 interaction

Caution Advised

naltrexone + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cyproheptadine
Contrave (naltrexone/ bupropion hydrochloride)

+

cyproheptadine

1 interaction

Caution Advised

naltrexone + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dantrolene
Contrave (naltrexone/ bupropion hydrochloride)

+

dantrolene

1 interaction

Caution Advised

naltrexone + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Contrave (naltrexone/ bupropion hydrochloride)

+

darifenacin

1 interaction

Caution Advised

naltrexone + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Contrave (naltrexone/ bupropion hydrochloride)

+

dexbrompheniramine

1 interaction

Caution Advised

naltrexone + dexbrompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Contrave (naltrexone/ bupropion hydrochloride)

+

dexchlorpheniramine

2 interactions

Caution Advised

bupropion + dexchlorpheniramine

caution advised: combo may incr. dexchlorpheniramine levels, risk of anticholinergic and other adverse effects (hepatic metabolism inhibited)

naltrexone + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dichlorphenamide
Contrave (naltrexone/ bupropion hydrochloride)

+

dichlorphenamide

1 interaction

Caution Advised

naltrexone + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difelikefalin
Contrave (naltrexone/ bupropion hydrochloride)

+

difelikefalin

1 interaction

Caution Advised

naltrexone + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Contrave (naltrexone/ bupropion hydrochloride)

+

difenoxin

1 interaction

Caution Advised

naltrexone + difenoxin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dimenhydrinate
Contrave (naltrexone/ bupropion hydrochloride)

+

dimenhydrinate

1 interaction

Caution Advised

naltrexone + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenhydramine
Contrave (naltrexone/ bupropion hydrochloride)

+

diphenhydramine

1 interaction

Caution Advised

naltrexone + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diphenoxylate
Contrave (naltrexone/ bupropion hydrochloride)

+

diphenoxylate

1 interaction

Caution Advised

naltrexone + diphenoxylate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• domperidone
Contrave (naltrexone/ bupropion hydrochloride)

+

domperidone

1 interaction

Caution Advised

naltrexone + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• doxepin topical
Contrave (naltrexone/ bupropion hydrochloride)

+

doxepin topical

2 interactions

Caution Advised

bupropion + doxepin topical

caution advised: combo may incr. doxepin levels, risk of adverse effects (hepatic metabolism inhibited)

naltrexone + doxepin topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Contrave (naltrexone/ bupropion hydrochloride)

+

entacapone

1 interaction

Caution Advised

naltrexone + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Contrave (naltrexone/ bupropion hydrochloride)

+

entrectinib

1 interaction

Caution Advised

naltrexone + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fesoterodine
Contrave (naltrexone/ bupropion hydrochloride)

+

fesoterodine

1 interaction

Caution Advised

naltrexone + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fexinidazole
Contrave (naltrexone/ bupropion hydrochloride)

+

fexinidazole

1 interaction

Caution Advised

bupropion + fexinidazole

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism possibly induced)

• flibanserin
Contrave (naltrexone/ bupropion hydrochloride)

+

flibanserin

1 interaction

Caution Advised

naltrexone + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Contrave (naltrexone/ bupropion hydrochloride)

+

foslevodopa

1 interaction

Caution Advised

naltrexone + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• gefitinib
Contrave (naltrexone/ bupropion hydrochloride)

+

gefitinib

1 interaction

Caution Advised

bupropion + gefitinib

caution advised: combo may incr. gefitinib levels, risk of adverse effects (hepatic metabolism inhibited)

• glofitamab
Contrave (naltrexone/ bupropion hydrochloride)

+

glofitamab

1 interaction

Caution Advised

naltrexone + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Contrave (naltrexone/ bupropion hydrochloride)

+

glycopyrrolate

1 interaction

Caution Advised

naltrexone + glycopyrrolate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hyoscyamine
Contrave (naltrexone/ bupropion hydrochloride)

+

hyoscyamine

1 interaction

Caution Advised

naltrexone + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• isavuconazonium
Contrave (naltrexone/ bupropion hydrochloride)

+

isavuconazonium

1 interaction

Caution Advised

bupropion + isavuconazonium

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• levocetirizine
Contrave (naltrexone/ bupropion hydrochloride)

+

levocetirizine

1 interaction

Caution Advised

naltrexone + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Contrave (naltrexone/ bupropion hydrochloride)

+

levodopa

2 interactions

Caution Advised

bupropion + levodopa

caution advised: combo may incr. risk of CNS adverse effects (mechanism unknown)

naltrexone + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• linvoseltamab
Contrave (naltrexone/ bupropion hydrochloride)

+

linvoseltamab

1 interaction

Caution Advised

naltrexone + linvoseltamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meclizine
Contrave (naltrexone/ bupropion hydrochloride)

+

meclizine

1 interaction

Caution Advised

naltrexone + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meprobamate
Contrave (naltrexone/ bupropion hydrochloride)

+

meprobamate

1 interaction

Caution Advised

naltrexone + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrapone
Contrave (naltrexone/ bupropion hydrochloride)

+

metyrapone

1 interaction

Caution Advised

naltrexone + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Contrave (naltrexone/ bupropion hydrochloride)

+

metyrosine

1 interaction

Caution Advised

naltrexone + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• midostaurin
Contrave (naltrexone/ bupropion hydrochloride)

+

midostaurin

1 interaction

Caution Advised

bupropion + midostaurin

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• mitapivat
Contrave (naltrexone/ bupropion hydrochloride)

+

mitapivat

1 interaction

Caution Advised

bupropion + mitapivat

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism possibly induced)

• mitotane
Contrave (naltrexone/ bupropion hydrochloride)

+

mitotane

1 interaction

Caution Advised

naltrexone + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mosunetuzumab
Contrave (naltrexone/ bupropion hydrochloride)

+

mosunetuzumab

1 interaction

Caution Advised

naltrexone + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Contrave (naltrexone/ bupropion hydrochloride)

+

mycophenolate mofetil

1 interaction

Caution Advised

naltrexone + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nevirapine
Contrave (naltrexone/ bupropion hydrochloride)

+

nevirapine

1 interaction

Caution Advised

bupropion + nevirapine

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• orphenadrine
Contrave (naltrexone/ bupropion hydrochloride)

+

orphenadrine

1 interaction

Caution Advised

naltrexone + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Contrave (naltrexone/ bupropion hydrochloride)

+

passion flower

1 interaction

Caution Advised

naltrexone + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pheniramine
Contrave (naltrexone/ bupropion hydrochloride)

+

pheniramine

1 interaction

Caution Advised

naltrexone + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pramipexole
Contrave (naltrexone/ bupropion hydrochloride)

+

pramipexole

1 interaction

Caution Advised

naltrexone + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pyrilamine
Contrave (naltrexone/ bupropion hydrochloride)

+

pyrilamine

1 interaction

Caution Advised

naltrexone + pyrilamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ramelteon
Contrave (naltrexone/ bupropion hydrochloride)

+

ramelteon

1 interaction

Caution Advised

naltrexone + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• repotrectinib
Contrave (naltrexone/ bupropion hydrochloride)

+

repotrectinib

1 interaction

Caution Advised

naltrexone + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ritonavir
Contrave (naltrexone/ bupropion hydrochloride)

+

ritonavir

1 interaction

Caution Advised

bupropion + ritonavir

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• selinexor
Contrave (naltrexone/ bupropion hydrochloride)

+

selinexor

1 interaction

Caution Advised

naltrexone + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• solifenacin
Contrave (naltrexone/ bupropion hydrochloride)

+

solifenacin

1 interaction

Caution Advised

naltrexone + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sparsentan
Contrave (naltrexone/ bupropion hydrochloride)

+

sparsentan

1 interaction

Caution Advised

bupropion + sparsentan

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism induced)

• tamoxifen
Contrave (naltrexone/ bupropion hydrochloride)

+

tamoxifen

1 interaction

Caution Advised

bupropion + tamoxifen

caution advised: combo may decr. active tamoxifen metabolite levels, efficacy (hepatic metabolism inhibited, decr. conversion to active metabolite)

• tasimelteon
Contrave (naltrexone/ bupropion hydrochloride)

+

tasimelteon

1 interaction

Caution Advised

naltrexone + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• telotristat ethyl
Contrave (naltrexone/ bupropion hydrochloride)

+

telotristat ethyl

1 interaction

Caution Advised

bupropion + telotristat ethyl

caution advised: combo may decr. bupropion and metabolite levels, efficacy (hepatic metabolism possibly induced)

• tizanidine
Contrave (naltrexone/ bupropion hydrochloride)

+

tizanidine

1 interaction

Caution Advised

naltrexone + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Contrave (naltrexone/ bupropion hydrochloride)

+

tolcapone

1 interaction

Caution Advised

naltrexone + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Contrave (naltrexone/ bupropion hydrochloride)

+

tolterodine

1 interaction

Caution Advised

naltrexone + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trihexyphenidyl
Contrave (naltrexone/ bupropion hydrochloride)

+

trihexyphenidyl

1 interaction

Caution Advised

naltrexone + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triprolidine
Contrave (naltrexone/ bupropion hydrochloride)

+

triprolidine

1 interaction

Caution Advised

naltrexone + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trospium
Contrave (naltrexone/ bupropion hydrochloride)

+

trospium

1 interaction

Caution Advised

naltrexone + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Contrave (naltrexone/ bupropion hydrochloride)

+

valerian

1 interaction

Caution Advised

naltrexone + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• xanomeline
Contrave (naltrexone/ bupropion hydrochloride)

+

xanomeline

1 interaction

Caution Advised

bupropion + xanomeline

caution advised: combo may incr. xanomeline levels, risk of adverse effects (hepatic metabolism possibly inhibited)