Select a medication above to begin.
Trulicity
dulaglutide
Black Box Warnings .
Thyroid C-cell Tumor Risk
contraindicated in patients with medullary thyroid carcinoma (MTC) history or family history, or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2); dose-related and duration-dependent incr. in thyroid C-cell tumor incidence observed in rodents, but human relevance unknown; uncertain value of routine serum calcitonin or thyroid ultrasound monitoring; advise patients of potential MTC risk and thyroid tumor symptoms (e.g., neck mass, dysphagia, dyspnea, persistent hoarseness)
Adult Dosing .
Dosage forms: INJ (pen): 0.75 mg per injection, 1.5 mg per injection, 3 mg per injection, 4.5 mg per injection
diabetes mellitus, type 2
- [0.75-4.5 mg SC qwk]
- Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk x4wk, then may incr. by 1.5 mg/wk no more frequently than q4wk; Max: 4.5 mg/wk; Info: give doses >72h apart
cardiovascular event risk reduction (DM type 2 patients with established cardiovascular disease or multiple cardiovascular risk factors)
- [0.75-4.5 mg SC qwk]
- Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk x4wk, then may incr. by 1.5 mg/wk no more frequently than q4wk if additional glycemic control needed; Max: 4.5 mg/wk; Info: give doses >72h apart
renal dosing
- [see below]
- renal impairment: no adjustment; Info: caution advised if ESRD
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (pen): 0.75 mg per injection, 1.5 mg per injection, 3 mg per injection, 4.5 mg per injection
diabetes mellitus, type 2
- [10 yo and older]
- Dose: 0.75-1.5 mg SC qwk; Start: 0.75 mg SC qwk x4wk, then may incr. to 1.5 mg SC qwk; Max: 1.5 mg/wk; Info: give doses >72h apart
renal dosing
- [see below]
- renal impairment: no adjustment; Info: caution advised if ESRD
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- medullary thyroid CA history
- medullary thyroid CA family history
- multiple endocrine neoplasia syndrome type 2
- diabetes mellitus, type 1
- caution: hypersensitivity to GLP-1 agonists
- caution: hepatic impairment
- caution: renal impairment
- caution: volume depletion
- caution: pancreatitis risk
- caution: pancreatitis history
- caution: GI disease, severe
- caution: gastroparesis, severe
- caution: diabetic retinopathy
- caution: surgery
Drug Interactions .
Overview
dulaglutide
GLP-1 agonist
- antidiabetic agent
- decreases gastrointestinal motility
- delays atrioventricular conduction
- caution advised with oral narrow therapeutic index drugs; dulaglutide delays gastric emptying, may reduce rate and extent of oral drug absorption
Contraindicated
- potassium chloride
- potassium citrate
Avoid/Use Alternative
- brigatinib
- clonidine
- crizotinib
- desogestrel (contraceptive)
- dienogest (contraceptive)
- drospirenone (contraceptive)
- dulaglutide
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethinyl estradiol (contraceptive)
- ethynodiol (contraceptive)
- etrasimod
- exenatide
- fingolimod
- landiolol
- levonorgestrel (contraceptive)
- levonorgestrel (post-coital contraceptive)
- liraglutide
- lixisenatide
- lofexidine
- norethindrone (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- ozanimod
- ponesimod
- semaglutide
- siponimod
- tirzepatide
- ulipristal (post-coital contraceptive)
Monitor/Modify Tx
- acebutolol
- adenosine
- alclometasone topical
- alectinib
- alfentanil
- alpelisib
- amcinonide topical
- amiodarone
- apraclonidine ophthalmic
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- arsenic trioxide
- articaine
- asenapine
- asparaginase
- atazanavir
- atenolol
- betamethasone
- betamethasone topical
- betaxolol
- betaxolol ophthalmic
- bisoprolol
- bortezomib
- brentuximab vedotin
- brexpiprazole
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposomal
- calaspargase
- capivasertib
- carbamazepine
- cariprazine
- carteolol ophthalmic
- carvedilol
- ceritinib
- chloroprocaine
- chlorothiazide
- chlorthalidone
- ciprofloxacin
- clobetasol topical
- clocortolone topical
- clozapine
- copanlisib
- corticotropin
- cortisone
- dabrafenib
- danazol
- darunavir
- decitabine
- deflazacort
- delafloxacin
- desonide topical
- desoximetasone topical
- dexamethasone
- dexmedetomidine
- dexmedetomidine injection
- diazoxide
- diflorasone topical
- digoxin
- diltiazem
- disopyramide
- donepezil
- dronedarone
- eliglustat
- enfortumab vedotin
- ensartinib
- ephedra
- epinephrine
- esmolol
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethinyl estradiol (hormone replacement)
- etonogestrel (contraceptive)
- etripamil nasal
- everolimus
- fentanyl
- flecainide
- fludrocortisone
- fluocinolone otic
- fluocinolone topical
- fluocinonide topical
- flurandrenolide topical
- fluticasone propionate topical
- fosamprenavir
- fosphenytoin
- furosemide
- gadobenate dimeglumine
- galantamine
- ginkgo
- glimepiride
- glipizide
- glyburide
- goserelin
- guanfacine
- halcinonide topical
- halobetasol topical
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- iloperidone
- inavolisib
- indapamide
- insulin
- isoniazid
- ivabradine
- labetalol
- lacosamide
- lamotrigine
- lanreotide
- leuprolide
- levobunolol ophthalmic
- levofloxacin
- levothyroxine
- lidocaine
- liothyronine
- lopinavir/ritonavir
- lorlatinib
- lumateperone
- lurasidone
- lutetium Lu 177 dotatate
- medroxyprogesterone (contraceptive)
- mefloquine
- megestrol
- mepivacaine
- methylprednisolone
- metolazone
- metoprolol
- midodrine
- milsaperidone
- mometasone topical
- moxifloxacin
- nadolol
- nateglinide
- nebivolol
- nelfinavir
- neostigmine
- niacin (vitamin B3)
- norelgestromin (contraceptive)
- norepinephrine
- octreotide
- ofloxacin
- olanzapine
- paliperidone
- paltusotine
- pasireotide
- pegaspargase
- peginterferon alfa 2a
- pentamidine
- phenylephrine
- phenytoin
- pindolol
- plozasiran
- praziquantel
- prednicarbate topical
- prednisolone
- prednisone
- procainamide
- propafenone
- propofol
- propranolol
- pseudoephedrine
- pyridostigmine
- quetiapine
- quinidine (antiarrhythmic)
- quinine
- regadenoson
- remifentanil
- remimazolam
- repaglinide
- risperidone
- ritonavir
- rivastigmine
- ropivacaine
- sacrosidase
- segesterone (contraceptive)
- sirolimus albumin-bound
- somapacitan
- somatrogon
- somatropin
- sotalol
- spironolactone
- succinylcholine
- sucralfate
- sufentanil
- sugammadex
- temsirolimus
- teprotumumab
- tesamorelin
- thalidomide
- thyroid
- ticagrelor
- timolol
- timolol ophthalmic
- tipranavir
- torsemide
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- vamorolone
- verapamil
- vorinostat
- warfarin
- ziprasidone
Caution Advised
- acetaminophen
- amoxicillin
- ampicillin
- azithromycin
- barium
- bedaquiline
- cefaclor
- cefadroxil
- cefdinir
- cefixime
- cefpodoxime
- cefprozil
- cefuroxime axetil
- cephalexin
- clarithromycin
- clindamycin
- cycloserine
- dapsone
- demeclocycline
- dicloxacillin
- doxazosin
- doxycycline
- erythromycin
- ethionamide
- fosfomycin oral
- gepotidacin
- lefamulin
- linezolid
- metoclopramide
- metronidazole
- mexiletine
- minocycline
- omadacycline
- penicillin V
- pivmecillinam
- potassium acid phosphate
- potassium gluconate
- potassium phosphate
- rifabutin
- rifampin
- rifapentine
- sarecycline
- secnidazole
- sulfadiazine
- sulfamethoxazole
- sulfasalazine
- sulopenem
- tedizolid
- tetracycline
- tinidazole
- trimethoprim
- zoliflodacin
Adverse Reactions .
Serious Reactions
- thyroid C-cell tumor (animal studies)
- medullary thyroid CA
- hypersensitivity reaction
- anaphylaxis
- angioedema
- acute kidney injury
- GI reaction, severe
- pancreatitis
- cholelithiasis
- cholecystitis
- ileus
- perioperative aspiration
Common Reactions
- nausea
- diarrhea
- vomiting
- abdominal pain
- appetite decr.
- dyspepsia
- fatigue
- tachycardia
- injection site reaction
- amylase incr.
- lipase incr.
- PR prolongation
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
Trulicity confused with: Tanzeum; Toujeo; Tradjenta; Tresiba
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; risk of teratogenicity and embyrotoxicity based on animal data at 13x and 14x MRHD and drug's mechanism of action
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for dulaglutide: proteolytic degradation; CYP450: unknown
Excretion: for dulaglutide: unknown; Half-life: 5 days
Subclass: Diabetes: GLP-1 Agonists ; GLP-1 Agonists, Cardiovascular
Mechanism of Action
for dulaglutide: activates glucagon-like-peptide-1 (GLP-1) receptor, increasing insulin secretion, decreasing glucagon secretion, and delaying gastric emptying (incretin mimetic)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Eli Lilly and Co.
DEA/FDA: Rx
Retail Price
Estimated prices only. For current pricing, visit GoodRx.
subcutaneous solution:
- 0.75 mg/0.5 mL (1 carton, 4 pens): $871.00
- 1.5 mg/0.5 mL (1 carton, 4 pens): $871.00
- 3 mg/0.5 mL (1 carton, 4 pens): $871.00
- 4.5 mg/0.5 mL (1 carton, 4 pens): $871.00
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.