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Taltz
ixekizumab
Adult Dosing .
Dosage forms: INJ (auto-injector): 80 mg; INJ (pre-filled syringe): 20 mg per 0.25 mL, 40 mg per 0.5 mL, 80 mg per mL
psoriasis, moderate-severe plaque
- [80 mg SC q4wk]
- Start: 160 mg SC x1, then 80 mg SC q2wk x12wk
psoriatic arthritis
- [80 mg SC q4wk]
- Start: 160 mg SC x1
ankylosing spondylitis
- [80 mg SC q4wk]
- Start: 160 mg SC x1
axial spondyloarthritis, non-radiographic
- [80 mg SC q4wk]
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ (auto-injector): 80 mg; INJ (pre-filled syringe): 20 mg per 0.25 mL, 40 mg per 0.5 mL, 80 mg per mL
psoriasis, moderate-severe plaque
- [6 yo and older, <25 kg]
- Dose: 20 mg SC q4wk; Start: 40 mg SC x1
- [6 yo and older, 25-50 kg]
- Dose: 40 mg SC q4wk; Start: 80 mg SC x1
- [6 yo and older, >50 kg]
- Dose: 80 mg SC q4wk; Start: 160 mg SC x1
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- infection, serious
- TB infection, active
- caution: TB infection, latent
- caution: TB infection risk
- caution: infection risk
- caution: inflammatory bowel disease
Drug Interactions .
Overview
ixekizumab
IL-17 antagonist
- immunomodulatory effects
- caution advised w/ narrow therapeutic index drugs; chronic inflammatory conditions may alter metabolic enzyme formation; tx w/ immune modulators may reverse this effect, resulting in altered levels of concomitant drugs
Contraindicated
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- eczematous eruption, severe
- infection, serious
- opportunistic infection
- toxoplasmosis
- meningitis, cryptococcal
- tuberculosis
- inflammatory bowel disease
Common Reactions
- infection
- injection site reaction
- URI
- neutropenia
- thrombocytopenia
- nausea
- tinea infection
Safety/Monitoring .
Monitoring Parameters
TB test at baseline, then active TB signs/symptoms during and after tx D/C
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of teratogenicity based on animal data at up to 19x MRHD
Pregnancy Registry
encourage patients to enroll in Pregnancy Exposure Registry at 1-800-284-1695; additional info at www.pregnancyregistry.lilly.com
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for ixekizumab: unknown; CYP450: unknown
Excretion: for ixekizumab: unknown; Half-life: 13 days
Subclass: Interleukin-17 (IL-17) Antagonists ; Psoriasis, Systemic Agents ; Spondyloarthropathies
Mechanism of Action
for ixekizumab: binds to and inhibits interleukin-17A cytokine, reducing inflammation and altering immune response (monoclonal antibody)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Eli Lilly and Co.
DEA/FDA: Rx
Retail Price
Estimated prices only. For current pricing, visit GoodRx.
subcutaneous solution:
- 80 mg/mL (1 carton, 1 syringe): $5,644.00
subcutaneous solution:
- 80 mg/mL (1 carton, 3 autoinjectors): $23,124.00
subcutaneous solution:
- 80 mg/mL (1 carton, 1 autoinjector): $5,644.00
subcutaneous solution:
- 80 mg/mL (1 carton, 2 autoinjectors): $12,398.00
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