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Eucrisa
crisaborole topical
Adult Dosing .
Dosage forms: OINTMENT: 2%
atopic dermatitis, mild-moderate
- [apply bid]
- Info: consider applying qd after clinical effect achieved
Peds Dosing .
- Dosage forms: OINTMENT: 2%
atopic dermatitis, mild-moderate
- [3 mo and older]
- Dose: apply bid; Info: consider applying qd after clinical effect achieved
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- breast administration (breastfeeding patients)
Drug Interactions .
Overview
crisaborole topical
PDE4 inhibitor topical
- UGT1A9 inhibitor
Monitor/Modify Tx
- atorvastatin
- ganaxolone
- mycophenolate mofetil
- mycophenolic acid
- propofol
- talazoparib
Caution Advised
- artesunate
- entacapone
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
Common Reactions
- application site pain
- burning
- stinging
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available, though risk of fetal harm low based on limited systemic absorption; no known risk of fetal harm based on animal data at 2x and 3x MRHD, though risk of stillbirth, decr. fetal weight, and delayed ossification based on animal data at 13x MRHD
Lactation
Clinical Summary
avoid use on breast while breastfeeding, otherwise weigh risk/benefit on other areas; no human data available, though risk of infant harm low based on limited systemic absorption in breastfeeding patients; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for crisaborole: hydrolysis, oxidation; CYP450: unknown; Info: limited systemic absorption
Excretion: for crisaborole: urine; Half-life: unknown
Subclass: Atopic Dermatitis, Topical Nonsteroidal Agents ; Phosphodiesterase 4 (PDE4) Inhibitors, Dermatologic
Mechanism of Action
for crisaborole: exact mechanism of action unknown; inhibits phosphodiesterase type 4 (PDE4), leading to increased intracellular cAMP levels
Formulary .
No Formulary Selected
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