Heplisav-B

Overview

hepatitis B vaccine

vaccine

• non-live vaccine

Avoid/Use Alternative

• interferon gamma 1b
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

interferon gamma 1b

1 interaction

Avoid/Use Alternative

hepatitis B vaccine + interferon gamma 1b

avoid combo: combo may result in amplified immune response (immunomodulatory effects)

Monitor/Modify Tx

• abatacept
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

abatacept

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + abatacept

if possible, vaccinate at least 2wk before starting abatacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• abemaciclib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

abemaciclib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + abemaciclib

if possible, vaccinate at least 2wk before starting abemaciclib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• abrocitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

abrocitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + abrocitinib

if possible, vaccinate at least 2wk before starting abrocitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• acalabrutinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

acalabrutinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + acalabrutinib

if possible, vaccinate at least 2wk before starting acalabrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• adalimumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

adalimumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + adalimumab

if possible, vaccinate at least 2wk before starting adalimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ado-trastuzumab emtansine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ado-trastuzumab emtansine

if possible, vaccinate at least 2wk before starting ado-trastuzumab emtansine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• afamitresgene autoleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

afamitresgene autoleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + afamitresgene autoleucel

if possible, vaccinate at least 2wk before starting afamitresgene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• aldesleukin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

aldesleukin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + aldesleukin

if possible, vaccinate at least 2wk before starting aldesleukin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• alemtuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

alemtuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + alemtuzumab

if possible, vaccinate at least 2wk before starting alemtuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• amivantamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

amivantamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + amivantamab

if possible, vaccinate at least 2wk before starting amivantamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anakinra
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

anakinra

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + anakinra

if possible, vaccinate at least 2wk before starting anakinra tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anifrolumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

anifrolumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + anifrolumab

if possible, vaccinate at least 2wk before starting anifrolumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• anti-thymocyte globulin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + anti-thymocyte globulin

if possible, vaccinate at least 2wk before starting anti-thymocyte globulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• asciminib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

asciminib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + asciminib

if possible, vaccinate at least 2wk before starting asciminib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• atezolizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

atezolizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + atezolizumab

if possible, vaccinate at least 2wk before starting atezolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• atidarsagene autotemcel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

atidarsagene autotemcel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + atidarsagene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• avelumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

avelumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + avelumab

if possible, vaccinate at least 2wk before starting avelumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• avutometinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

avutometinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + avutometinib

if possible, vaccinate at least 2wk before starting avutometinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• axicabtagene ciloleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

axicabtagene ciloleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + axicabtagene ciloleucel

if possible, vaccinate at least 2wk before starting axicabtagene ciloleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• azacitidine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

azacitidine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + azacitidine

if possible, vaccinate at least 2wk before starting azacitidine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• azathioprine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

azathioprine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + azathioprine

if possible, vaccinate at least 2wk before starting azathioprine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• baricitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

baricitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + baricitinib

if possible, vaccinate at least 2wk before starting baricitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• basiliximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

basiliximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + basiliximab

if possible, vaccinate at least 2wk before starting basiliximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belantamab mafodotin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

belantamab mafodotin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + belantamab mafodotin

if possible, vaccinate at least 2wk before starting belantamab mafodotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belatacept
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

belatacept

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + belatacept

if possible, vaccinate at least 2wk before starting belatacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belimumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

belimumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + belimumab

if possible, vaccinate at least 2wk before starting belimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belinostat
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

belinostat

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + belinostat

if possible, vaccinate at least 2wk before starting belinostat tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• belzutifan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

belzutifan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + belzutifan

if possible, vaccinate at least 2wk before starting belzutifan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• bendamustine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

bendamustine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + bendamustine

if possible, vaccinate at least 2wk before starting bendamustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• betamethasone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

betamethasone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + betamethasone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• bimekizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

bimekizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + bimekizumab

if possible, vaccinate at least 2wk before starting bimekizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• blinatumomab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

blinatumomab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + blinatumomab

if possible, vaccinate at least 2wk before starting blinatumomab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• bortezomib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

bortezomib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + bortezomib

if possible, vaccinate at least 2wk before starting bortezomib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brentuximab vedotin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + brentuximab vedotin

if possible, vaccinate at least 2wk before starting brentuximab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brexucabtagene autoleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

brexucabtagene autoleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + brexucabtagene autoleucel

if possible, vaccinate at least 2wk before starting brexucabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• brodalumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

brodalumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + brodalumab

if possible, vaccinate at least 2wk before starting brodalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• budesonide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

budesonide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + budesonide

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• budesonide rectal
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

budesonide rectal

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + budesonide rectal

consider vaccinating at least 2wk before budesonide rectal use; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• busulfan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

busulfan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + busulfan

if possible, vaccinate at least 2wk before starting busulfan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cabazitaxel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cabazitaxel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cabazitaxel

if possible, vaccinate at least 2wk before starting cabazitaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• canakinumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

canakinumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + canakinumab

if possible, vaccinate at least 2wk before starting canakinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• capecitabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

capecitabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + capecitabine

if possible, vaccinate at least 2wk before starting capecitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• capmatinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

capmatinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + capmatinib

if possible, vaccinate at least 2wk before starting capmatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carboplatin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

carboplatin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + carboplatin

if possible, vaccinate at least 2wk before starting carboplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carfilzomib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

carfilzomib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + carfilzomib

if possible, vaccinate at least 2wk before starting carfilzomib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• carmustine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

carmustine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + carmustine

if possible, vaccinate at least 2wk before starting carmustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cemiplimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cemiplimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cemiplimab

if possible, vaccinate at least 2wk before starting cemiplimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• certolizumab pegol
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

certolizumab pegol

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + certolizumab pegol

if possible, vaccinate at least 2wk before starting certolizumab pegol tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• chlorambucil
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

chlorambucil

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + chlorambucil

if possible, vaccinate at least 2wk before starting chlorambucil tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ciltacabtagene autoleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ciltacabtagene autoleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ciltacabtagene autoleucel

if possible, vaccinate at least 2wk before starting ciltacabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cisplatin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cisplatin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cisplatin

if possible, vaccinate at least 2wk before starting cisplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cladribine injection
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cladribine injection

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cladribine injection

if possible, vaccinate at least 2wk before starting cladribine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cladribine oral
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cladribine oral

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cladribine oral

if possible, vaccinate at least 2wk before starting cladribine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• clofarabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

clofarabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + clofarabine

if possible, vaccinate at least 2wk before starting clofarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• copanlisib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

copanlisib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + copanlisib

if possible, vaccinate at least 2wk before starting copanlisib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• corticotropin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

corticotropin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + corticotropin

if possible, vaccinate at least 2wk before starting corticotropin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cortisone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cortisone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• cosibelimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cosibelimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cosibelimab

if possible, vaccinate at least 2wk before starting cosibelimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cyclophosphamide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cyclophosphamide

if possible, vaccinate at least 2wk before starting cyclophosphamide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cyclosporine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cyclosporine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cyclosporine

if possible, vaccinate at least 2wk before starting cyclosporine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• cytarabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

cytarabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + cytarabine

if possible, vaccinate at least 2wk before cytarabine start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dactinomycin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dactinomycin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dactinomycin

if possible, vaccinate at least 2wk before starting dactinomycin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• daratumumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

daratumumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + daratumumab

if possible, vaccinate at least 2wk before starting daratumumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dasatinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dasatinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dasatinib

if possible, vaccinate at least 2wk before starting dasatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• daunorubicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

daunorubicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + daunorubicin

if possible, vaccinate at least 2wk before daunorubicin start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• decitabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

decitabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + decitabine

if possible, vaccinate at least 2wk before starting decitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• defactinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

defactinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + defactinib

if possible, vaccinate at least 2wk before starting defactinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deflazacort
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

deflazacort

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + deflazacort

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• delgocitinib topical
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

delgocitinib topical

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + delgocitinib topical

if possible, vaccinate at least 2wk before starting delgocitinib topical tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deucravacitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

deucravacitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + deucravacitinib

if possible, vaccinate at least 2wk before starting deucravacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• deuruxolitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + deuruxolitinib

if possible, vaccinate at least 2wk before starting deuruxolitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dexamethasone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dexamethasone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dexamethasone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• dimethyl fumarate
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dimethyl fumarate

if possible, vaccinate at least 2wk before starting dimethyl fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dinutuximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dinutuximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dinutuximab

if possible, vaccinate at least 2wk before starting dinutuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• diroximel fumarate
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + diroximel fumarate

if possible, vaccinate at least 2wk before starting diroximel fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• docetaxel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

docetaxel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + docetaxel

if possible, vaccinate at least 2wk before starting docetaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dordaviprone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dordaviprone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dordaviprone

if possible, vaccinate at least 2wk before starting dordaviprone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dostarlimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dostarlimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dostarlimab

if possible, vaccinate at least 2wk before starting dostarlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• doxorubicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

doxorubicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + doxorubicin

if possible, vaccinate at least 2wk before starting doxorubicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• dupilumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

dupilumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + dupilumab

if possible, vaccinate at least 2wk before starting dupilumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• durvalumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

durvalumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + durvalumab

if possible, vaccinate at least 2wk before starting durvalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• duvelisib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

duvelisib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + duvelisib

if possible, vaccinate at least 2wk before starting duvelisib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• efgartigimod alfa
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

efgartigimod alfa

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + efgartigimod alfa

if possible, vaccinate at least 2wk before starting efgartigimod alfa tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• elivaldogene autotemcel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

elivaldogene autotemcel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + elivaldogene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• elotuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

elotuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + elotuzumab

if possible, vaccinate at least 2wk before starting elotuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• elranatamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

elranatamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + elranatamab

if possible, vaccinate at least 2wk before starting elranatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• emapalumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

emapalumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + emapalumab

if possible, vaccinate at least 2wk before starting emapalumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• epcoritamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

epcoritamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + epcoritamab

if possible, vaccinate at least 2wk before starting epcoritamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• epirubicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

epirubicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + epirubicin

if possible, vaccinate at least 2wk before starting epirubicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• erdafitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

erdafitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + erdafitinib

if possible, vaccinate at least 2wk before starting erdafitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• eribulin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

eribulin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + eribulin

if possible, vaccinate at least 2wk before starting eribulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etanercept
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

etanercept

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + etanercept

if possible, vaccinate at least 2wk before starting etanercept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etoposide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

etoposide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + etoposide

if possible, vaccinate at least 2wk before etoposide start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etrasimod
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

etrasimod

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + etrasimod

if possible, vaccinate at least 2wk before starting etrasimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• etuvetidigene autotemcel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

etuvetidigene autotemcel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + etuvetidigene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• everolimus
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

everolimus

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + everolimus

if possible, vaccinate at least 2wk before starting everolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fam-trastuzumab deruxtecan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fam-trastuzumab deruxtecan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fam-trastuzumab deruxtecan

if possible, vaccinate at least 2wk before starting fam-trastuzumab deruxtecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fingolimod
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fingolimod

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fingolimod

if possible, vaccinate at least 2wk before starting fingolimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• floxuridine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

floxuridine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + floxuridine

if possible, vaccinate at least 2wk before starting floxuridine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fludarabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fludarabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fludarabine

if possible, vaccinate at least 2wk before starting fludarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fludrocortisone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fludrocortisone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fludrocortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• fluorouracil
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fluorouracil

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fluorouracil

if possible, vaccinate at least 2wk before fluorouracil start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• fruquintinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

fruquintinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + fruquintinib

if possible, vaccinate at least 2wk before starting fruquintinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• futibatinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

futibatinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + futibatinib

if possible, vaccinate at least 2wk before starting futibatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• gemcitabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

gemcitabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + gemcitabine

if possible, vaccinate at least 2wk before starting gemcitabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• gemtuzumab ozogamicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + gemtuzumab ozogamicin

if possible, vaccinate at least 2wk before starting gemtuzumab ozogamicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• glofitamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

glofitamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + glofitamab

if possible, vaccinate at least 2wk before starting glofitamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• golimumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

golimumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + golimumab

if possible, vaccinate at least 2wk before starting golimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• guselkumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

guselkumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + guselkumab

if possible, vaccinate at least 2wk before starting guselkumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• hydrocortisone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

hydrocortisone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + hydrocortisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• hydroxyurea
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

hydroxyurea

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + hydroxyurea

if possible, vaccinate at least 2wk before starting hydroxyurea tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ibritumomab tiuxetan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ibritumomab tiuxetan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ibritumomab tiuxetan

if possible, vaccinate at least 2wk before starting ibritumomab tiuxetan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ibrutinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ibrutinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ibrutinib

if possible, vaccinate at least 2wk before starting ibrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• icotrokinra
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

icotrokinra

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + icotrokinra

if possible, vaccinate at least 2wk before icotrokinra start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idarubicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

idarubicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + idarubicin

if possible, vaccinate at least 2wk before starting idarubicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idecabtagene vicleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

idecabtagene vicleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + idecabtagene vicleucel

if possible, vaccinate at least 2wk before starting idecabtagene vicleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• idelalisib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

idelalisib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + idelalisib

if possible, vaccinate at least 2wk before starting idelalisib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ifosfamide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ifosfamide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ifosfamide

if possible, vaccinate at least 2wk before starting ifosfamide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• imatinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

imatinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + imatinib

if possible, vaccinate at least 2wk before starting imatinib; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• inebilizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

inebilizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + inebilizumab

if possible, vaccinate at least 4wk before starting inebilizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• infliximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

infliximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + infliximab

if possible, vaccinate at least 2wk before starting infliximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• inotuzumab ozogamicin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + inotuzumab ozogamicin

if possible, vaccinate at least 2wk before starting inotuzumab ozogamicin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ipilimumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ipilimumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ipilimumab

if possible, vaccinate at least 2wk before starting ipilimumab; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• irinotecan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

irinotecan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + irinotecan

if possible, vaccinate at least 2wk before starting irinotecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• isatuximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

isatuximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + isatuximab

if possible, vaccinate at least 2wk before starting isatuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ixabepilone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ixabepilone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ixabepilone

if possible, vaccinate at least 2wk before starting ixabepilone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ixekizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ixekizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ixekizumab

if possible, vaccinate at least 2wk before starting ixekizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lazertinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lazertinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lazertinib

if possible, vaccinate at least 2wk before starting lazertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lebrikizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lebrikizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lebrikizumab

if possible, vaccinate at least 2wk before starting lebrikizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• leflunomide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

leflunomide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + leflunomide

if possible, vaccinate at least 2wk before starting leflunomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lenalidomide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lenalidomide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lenalidomide

if possible, vaccinate at least 2wk before starting lenalidomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• linvoseltamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

linvoseltamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + linvoseltamab

if possible, vaccinate at least 2wk before starting linvoseltamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lisocabtagene maraleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lisocabtagene maraleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lisocabtagene maraleucel

if possible, vaccinate at least 2wk before starting lisocabtagene maraleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lomustine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lomustine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lomustine

if possible, vaccinate at least 2wk before starting lomustine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• loncastuximab tesirine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

loncastuximab tesirine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + loncastuximab tesirine

if possible, vaccinate at least 2wk before starting loncastuximab tesirine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lurbinectedin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lurbinectedin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lurbinectedin

if possible, vaccinate at least 2wk before starting lurbinectedin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• lymphocyte immune globulin, anti-thymocyte globulin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

lymphocyte immune globulin, anti-thymocyte globulin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + lymphocyte immune globulin, anti-thymocyte globulin

if possible, vaccinate at least 2wk before starting anti-thymocyte globulin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• margetuximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

margetuximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + margetuximab

if possible, vaccinate at least 2wk before starting margetuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• marnetegragene autotemcel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

marnetegragene autotemcel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + marnetegragene autotemcel

if possible, vaccinate at least 6wk before myeloablative conditioning or after hematologic recovery: combo may result in inadequate vaccine response (immunosuppressive effects)

• melphalan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

melphalan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + melphalan

if possible, vaccinate at least 2wk before starting melphalan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mercaptopurine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mercaptopurine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mercaptopurine

if possible, vaccinate at least 2wk before starting mercaptopurine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• methotrexate
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

methotrexate

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + methotrexate

if possible, vaccinate at least 2wk before starting methotrexate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• methylprednisolone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

methylprednisolone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + methylprednisolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• mirikizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mirikizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mirikizumab

if possible, vaccinate at least 2wk before starting mirikizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mitomycin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mitomycin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mitomycin

if possible, vaccinate at least 2wk before starting mitomycin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mitoxantrone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mitoxantrone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mitoxantrone

if possible, vaccinate at least 2wk before starting mitoxantrone tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mogamulizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mogamulizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mogamulizumab

if possible, vaccinate at least 2wk before starting mogamulizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• momelotinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

momelotinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + momelotinib

if possible, vaccinate at least 2wk before starting momelotinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• monomethyl fumarate
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + monomethyl fumarate

if possible, vaccinate at least 2wk before starting monomethyl fumarate tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mosunetuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mosunetuzumab

if possible, vaccinate at least 2wk before starting mosunetuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mycophenolate mofetil
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mycophenolate mofetil

if possible, vaccinate at least 2wk before starting mycophenolate mofetil tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• mycophenolic acid
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + mycophenolic acid

if possible, vaccinate at least 2wk before starting mycophenolic acid tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• natalizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

natalizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + natalizumab

if possible, vaccinate at least 2wk before starting natalizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nelarabine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

nelarabine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + nelarabine

if possible, vaccinate at least 2wk before starting nelarabine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nemolizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

nemolizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + nemolizumab

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nilotinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

nilotinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + nilotinib

if possible, vaccinate at least 2wk before starting nilotinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nipocalimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

nipocalimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + nipocalimab

if possible, vaccinate at least 2wk before starting nipocalimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• nivolumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

nivolumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + nivolumab

if possible, vaccinate at least 2wk before starting nivolumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• obecabtagene autoleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

obecabtagene autoleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + obecabtagene autoleucel

if possible, vaccinate at least 2wk before starting obecabtagene autoleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• obinutuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

obinutuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + obinutuzumab

if possible, vaccinate at least 2wk before starting obinutuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ocrelizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ocrelizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ocrelizumab

if possible, vaccinate at least 2wk before starting ocrelizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ofatumumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ofatumumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ofatumumab

if possible, vaccinate at least 2wk before starting ofatumumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• olaparib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

olaparib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + olaparib

if possible, vaccinate at least 2wk before starting olaparib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• oxaliplatin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

oxaliplatin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + oxaliplatin

if possible, vaccinate at least 2wk before starting oxaliplatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ozanimod
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ozanimod

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ozanimod

if possible, vaccinate at least 2wk before starting ozanimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• paclitaxel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

paclitaxel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + paclitaxel

if possible, vaccinate at least 2wk before starting paclitaxel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• palbociclib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

palbociclib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + palbociclib

if possible, vaccinate at least 2wk before starting palbociclib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• peginterferon alfa 2a
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

peginterferon alfa 2a

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + peginterferon alfa 2a

if possible, vaccinate at least 2wk before starting peginterferon alfa 2a tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pembrolizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pembrolizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pembrolizumab

if possible, vaccinate at least 2wk before starting pembrolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pemetrexed
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pemetrexed

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pemetrexed

if possible, vaccinate at least 2wk before starting pemetrexed; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• penpulimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

penpulimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + penpulimab

if possible, vaccinate at least 2wk before starting penpulimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pentostatin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pentostatin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pentostatin

if possible, vaccinate at least 2wk before starting pentostatin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pertuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pertuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pertuzumab

if possible, vaccinate at least 2wk before starting pertuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pirtobrutinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pirtobrutinib

if possible, vaccinate at least 2wk before starting pirtobrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• polatuzumab vedotin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

polatuzumab vedotin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + polatuzumab vedotin

if possible, vaccinate at least 2wk before starting polatuzumab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pomalidomide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

pomalidomide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + pomalidomide

if possible, vaccinate at least 2wk before starting pomalidomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ponatinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ponatinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ponatinib

if possible, vaccinate at least 2wk before starting ponatinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ponesimod
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ponesimod

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ponesimod

if possible, vaccinate at least 2wk before starting ponesimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• prednisolone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

prednisolone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + prednisolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• prednisone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

prednisone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + prednisone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• procarbazine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

procarbazine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + procarbazine

if possible, vaccinate at least 2wk before starting procarbazine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• regorafenib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

regorafenib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + regorafenib

if possible, vaccinate at least 2wk before starting regorafenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• relacorilant
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

relacorilant

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + relacorilant

if possible, vaccinate at least 2wk before relacorilant start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• retifanlimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

retifanlimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + retifanlimab

if possible, vaccinate at least 2wk before starting retifanlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• revumenib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

revumenib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + revumenib

if possible, vaccinate at least 2wk before starting revumenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rilonacept
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

rilonacept

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + rilonacept

if possible, vaccinate at least 2wk before starting rilonacept tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rilzabrutinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

rilzabrutinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + rilzabrutinib

if possible, vaccinate at least 2wk before starting rilzabrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ripretinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ripretinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ripretinib

if possible, vaccinate at least 2wk before starting ripretinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• risankizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

risankizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + risankizumab

if possible, vaccinate at least 2wk before starting risankizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ritlecitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ritlecitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ritlecitinib

if possible, vaccinate at least 2wk before starting ritlecitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rituximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

rituximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + rituximab

vaccinate at least 4wk before starting rituximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• romidepsin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

romidepsin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + romidepsin

if possible, vaccinate at least 2wk before starting romidepsin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ropeginterferon alfa-2b
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ropeginterferon alfa-2b

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ropeginterferon alfa-2b

if possible, vaccinate at least 2wk before starting ropeginterferon alfa-2b tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rozanolixizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

rozanolixizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + rozanolixizumab

if possible, vaccinate at least 2wk before starting rozanolixizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• rucaparib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

rucaparib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + rucaparib

if possible, vaccinate at least 2wk before starting rucaparib; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ruxolitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ruxolitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ruxolitinib

if possible, vaccinate at least 2wk before starting ruxolitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sarilumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sarilumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sarilumab

if possible, vaccinate at least 2wk before starting sarilumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• satralizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

satralizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + satralizumab

if possible, vaccinate at least 2wk before starting satralizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• secukinumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

secukinumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + secukinumab

if possible, vaccinate at least 2wk before starting secukinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• selinexor
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

selinexor

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + selinexor

if possible, vaccinate at least 2wk before starting selinexor tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• selumetinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

selumetinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + selumetinib

if possible, vaccinate at least 2wk before starting selumetinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sevabertinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sevabertinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sevabertinib

if possible, vaccinate at least 2wk before starting sevabertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sibeprenlimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sibeprenlimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sibeprenlimab

if possible, vaccinate at least 2wk before starting sibeprenlimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• siltuximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

siltuximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + siltuximab

if possible, vaccinate at least 2wk before starting siltuximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• siponimod
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

siponimod

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + siponimod

if possible, vaccinate at least 2wk before starting siponimod tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sirolimus

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sirolimus

if possible, vaccinate at least 2wk before starting sirolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus albumin-bound
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sirolimus albumin-bound

if possible, vaccinate at least 2wk before starting sirolimus albumin-bound tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sirolimus topical
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sirolimus topical

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sirolimus topical

if possible, vaccinate at least 2wk before starting sirolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sorafenib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sorafenib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sorafenib

if possible, vaccinate at least 2wk before starting sorafenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• spesolimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

spesolimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + spesolimab

if possible, vaccinate at least 2wk before starting spesolimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sunitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sunitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sunitinib

if possible, vaccinate at least 2wk before starting sunitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• sunvozertinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

sunvozertinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + sunvozertinib

if possible, vaccinate at least 2wk before starting sunvozertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tacrolimus
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tacrolimus

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tacrolimus

if possible, vaccinate at least 2wk before starting tacrolimus tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tafasitamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tafasitamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tafasitamab

if possible, vaccinate at least 2wk before starting tafasitamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• taletrectinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

taletrectinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + taletrectinib

if possible, vaccinate at least 2wk before starting taletrectinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• talquetamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

talquetamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + talquetamab

if possible, vaccinate at least 2wk before starting talquetamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tarlatamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tarlatamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tarlatamab

if possible, vaccinate at least 2wk before starting tarlatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• teclistamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

teclistamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + teclistamab

if possible, vaccinate at least 2wk before starting teclistamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• telisotuzumab vedotin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

telisotuzumab vedotin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + telisotuzumab vedotin

if possible, vaccinate at least 2wk before starting telisotuzumab vedotin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• temozolomide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

temozolomide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + temozolomide

if possible, vaccinate at least 2wk before starting temozolomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• temsirolimus
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

temsirolimus

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + temsirolimus

if possible, vaccinate at least 2wk before temsirolimus start; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• teplizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

teplizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + teplizumab

vaccinate at least 2wk before or 6wk after teplizumab tx; otherwise, consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• teriflunomide
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

teriflunomide

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + teriflunomide

if possible, vaccinate at least 2wk before starting teriflunomide tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• thioguanine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

thioguanine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + thioguanine

if possible, vaccinate at least 2wk before starting thioguanine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• thiotepa
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

thiotepa

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + thiotepa

if possible, vaccinate at least 2wk before starting thiotepa tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tildrakizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tildrakizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tildrakizumab

if possible, vaccinate at least 2wk before starting tildrakizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tisagenlecleucel
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tisagenlecleucel

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tisagenlecleucel

if possible, vaccinate at least 2wk before starting tisagenlecleucel tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tislelizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tislelizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tislelizumab

if possible, vaccinate at least 2wk before starting tislelizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tocilizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tocilizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tocilizumab

if possible, vaccinate at least 2wk before starting tocilizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tofacitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tofacitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tofacitinib

if possible, vaccinate at least 2wk before starting tofacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• topotecan
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

topotecan

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + topotecan

if possible, vaccinate at least 2wk before starting topotecan tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• toripalimab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

toripalimab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + toripalimab

if possible, vaccinate at least 2wk before starting toripalimab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• trabectedin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

trabectedin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + trabectedin

if possible, vaccinate at least 2wk before starting trabectedin; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tralokinumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tralokinumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tralokinumab

if possible, vaccinate at least 2wk before starting tralokinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• trastuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

trastuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + trastuzumab

if possible, vaccinate at least 2wk before starting trastuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• tremelimumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

tremelimumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + tremelimumab

if possible, vaccinate at least 2wk before starting tremelimumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• triamcinolone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

triamcinolone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + triamcinolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• ublituximab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ublituximab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ublituximab

if possible, vaccinate at least 2wk before starting ublituximab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• upadacitinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

upadacitinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + upadacitinib

if possible, vaccinate at least 2wk before starting upadacitinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ustekinumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ustekinumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ustekinumab

if possible, vaccinate at least 2wk before starting ustekinumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vamorolone
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vamorolone

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vamorolone

if possible, vaccinate at least 2wk before starting long-term (>2wk) high-dose systemic steroids; consider post-immunization titer check: combo may result in inadequate vaccine response (immunosuppressive effects)

• vandetanib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vandetanib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vandetanib

if possible, vaccinate at least 2wk before starting vandetanib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vedolizumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vedolizumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vedolizumab

if possible, vaccinate at least 2wk before starting vedolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• venetoclax
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

venetoclax

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + venetoclax

if possible, vaccinate at least 2wk before starting venetoclax tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vinblastine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vinblastine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vinblastine

if possible, vaccinate at least 2wk before starting vinblastine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vincristine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vincristine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vincristine

if possible, vaccinate at least 2wk before starting vincristine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• vinorelbine
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

vinorelbine

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + vinorelbine

if possible, vaccinate at least 2wk before starting vinorelbine tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• voclosporin
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

voclosporin

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + voclosporin

if possible, vaccinate at least 2wk before starting voclosporin tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zanidatamab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

zanidatamab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + zanidatamab

if possible, vaccinate at least 2wk before starting zanidatamab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zanubrutinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

zanubrutinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + zanubrutinib

if possible, vaccinate at least 2wk before starting zanubrutinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zenocutuzumab
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

zenocutuzumab

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + zenocutuzumab

if possible, vaccinate at least 2wk before starting zenocutuzumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ziftomenib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

ziftomenib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + ziftomenib

if possible, vaccinate at least 2wk before starting ziftomenib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• zongertinib
Heplisav-B (hepatitis B vaccine (recombinant), adjuvanted (HepB))

+

zongertinib

1 interaction

Monitor/Modify Tx

hepatitis B vaccine + zongertinib

if possible, vaccinate at least 2wk before starting zongertinib tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)