Select a medication above to begin.
Actimmune
interferon gamma 1b
Adult Dosing .
Dosage forms: INJ: 100 mcg per 0.5 mL
Special Note
- [strength clarification]
- Info: doses expressed in mcg; 50 mcg = 1 million international units
severe infection reduction, chronic granulomatous disease-associated
- [50 mcg/m^2/dose SC 3x/wk]
- Max: 50 mcg/m^2/dose
malignant osteopetrosis, severe
- [50 mcg/m^2/dose SC 3x/wk]
- Max: 50 mcg/m^2/dose
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ: 100 mcg per 0.5 mL
Special Note
- [strength clarification]
- Info: doses expressed in mcg; 50 mcg = 1 million international units
severe infection reduction, chronic granulomatous disease-associated
- [BSA <0.5 m^2]
- Dose: 1.5 mcg/kg/dose SC 3x/wk; Max: 50 mcg/m^2/dose; Info: for patients 1 yo and older
- [BSA >0.5 m^2]
- Dose: 50 mcg/m^2/dose SC 3x/wk; Max: 50 mcg/m^2/dose; Info: for patients 1 yo and older
malignant osteopetrosis, severe
- [BSA <0.5 m^2]
- Dose: 1.5 mcg/kg/dose SC 3x/wk; Max: 50 mcg/m^2/dose; Info: for delaying disease progression in patients 1 mo and older
- [BSA >0.5 m^2]
- Dose: 50 mcg/m^2/dose SC 3x/wk; Max: 50 mcg/m^2/dose; Info: for delaying disease progression in patients 1 mo and older
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to E. coli protein
- caution: hypersensitivity to latex
- caution: cardiotoxic agent use, concurrent
- caution: neurotoxic agent use, concurrent
- caution: nephrotoxic agent use, concurrent
- caution: hepatotoxic agent use, concurrent
- caution: hepatic disease
- caution: myocardial ischemia
- caution: MI
- caution: CHF
- caution: arrhythmia
- caution: seizure disorder
- caution: CNS disorder
- caution: myelosuppression
Drug Interactions .
Overview
interferon gamma 1b
interferon
- cardiotoxic effects
- immunomodulatory effects
- myelosuppressive effects
- avoid combo with heterologous serum proteins or immunological preparations (e.g. E. coli-derived products); combo may result in amplified immune response
- caution advised with narrow therapeutic index drugs extensively metabolized in the liver; tx with interferon gamma 1b may decr. metabolic enzymes, resulting in altered levels of concomitant drugs
Avoid/Use Alternative
- adenovirus vaccine, live
- anthrax vaccine
- chikungunya vaccine
- chikungunya vaccine, live
- chloramphenicol
- cholera vaccine, live
- cladribine oral
- COVID-19 vaccine
- deferiprone
- dengue vaccine, live
- diphtheria/tetanus vaccine
- diphtheria/tetanus/pertussis vaccine
- ebola vaccine, live
- epirubicin
- fexinidazole
- ganciclovir
- Haemophilus b vaccine
- hepatitis A vaccine
- hepatitis B vaccine
- human papillomavirus vaccine
- idarubicin
- influenza H5N1 vaccine
- influenza nasal vaccine, live
- influenza vaccine
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- Japanese encephalitis vaccine
- measles/mumps/rubella vaccine, live
- meningococcal vaccine
- peginterferon alfa 2a
- peginterferon beta 1a
- penicillamine
- pneumococcal vaccine
- poliovirus vaccine
- primaquine
- rabies vaccine
- radium Ra 223 dichloride
- respiratory syncytial virus vaccine
- ropeginterferon alfa-2b
- rotavirus vaccine, live
- smallpox vaccine, live
- smallpox/mpox vaccine, live
- tick-borne encephalitis vaccine
- typhoid vaccine
- typhoid vaccine, live
- valganciclovir
- varicella vaccine, live
- yellow fever vaccine, live
- zoster vaccine, recombinant
Monitor/Modify Tx
- abemaciclib
- acalabrutinib
- adalimumab
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- aficamten
- albendazole
- aldesleukin
- alemtuzumab
- allopurinol
- alogliptin
- anagrelide
- anti-thymocyte globulin
- arsenic trioxide
- asciminib
- atidarsagene autotemcel
- auranofin
- avelumab
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- balsalazide
- baricitinib
- belantamab mafodotin
- belinostat
- bendamustine
- benznidazole
- betibeglogene autotemcel
- bevacizumab
- bexarotene
- bezlotoxumab
- binimetinib
- blinatumomab
- bortezomib
- bosutinib
- brentuximab vedotin
- brexucabtagene autoleucel
- busulfan
- cabazitaxel
- capecitabine
- carboplatin
- carfilzomib
- carmustine
- certolizumab pegol
- chlorambucil
- cidofovir
- cilostazol
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clofarabine
- clozapine
- cobimetinib
- colchicine
- copanlisib
- copper histidinate
- crizotinib
- cyclophosphamide
- cytarabine
- dabrafenib
- dacarbazine
- dactinomycin
- dapsone
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- deferasirox
- deuruxolitinib
- dexrazoxane
- dinutuximab
- docetaxel
- dostarlimab
- doxorubicin
- dronedarone
- duvelisib
- eflornithine
- elivaldogene autotemcel
- elranatamab
- encorafenib
- enfortumab vedotin
- entrectinib
- epcoritamab
- eribulin
- etanercept
- etoposide
- etuvetidigene autotemcel
- everolimus
- exagamglogene autotemcel
- fam-trastuzumab deruxtecan
- fedratinib
- floxuridine
- flucytosine
- fludarabine
- fluorouracil
- fluphenazine
- foscarnet
- fosfomycin injection
- fostamatinib
- gemcitabine
- gemtuzumab ozogamicin
- givinostat
- glasdegib
- glofitamab
- golimumab
- hydroxychloroquine
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- imetelstat
- infliximab
- inotuzumab ozogamicin
- irinotecan
- isatuximab
- itraconazole
- ivosidenib
- ixabepilone
- lapatinib
- leflunomide
- lenalidomide
- lenvatinib
- lifileucel
- linagliptin
- linezolid
- linvoseltamab
- lisocabtagene maraleucel
- lomustine
- lonafarnib
- loncastuximab tesirine
- lovotibeglogene autotemcel
- lurbinectedin
- lutetium Lu 177 dotatate
- lutetium Lu 177 vipivotide tetraxetan
- lymphocyte immune globulin, anti-thymocyte globulin
- margetuximab
- mavacamten
- melphalan
- mercaptopurine
- mesalamine
- mesalamine rectal
- methotrexate
- midostaurin
- mirdametinib
- mitomycin
- mitotane
- mitoxantrone
- mobocertinib
- mogamulizumab
- momelotinib
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nelarabine
- nilotinib
- niraparib
- obecabtagene autoleucel
- obinutuzumab
- ofatumumab
- olaparib
- olsalazine
- osimertinib
- oxaliplatin
- paclitaxel
- pacritinib
- palbociclib
- pazopanib
- pemetrexed
- pentamidine
- pentostatin
- pertuzumab
- pioglitazone
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- pralatrexate
- procarbazine
- proguanil
- propafenone
- pyrimethamine
- quizartinib
- ribavirin
- ribociclib
- rifabutin
- ripretinib
- rituximab
- romidepsin
- rosiglitazone
- rucaparib
- ruxolitinib
- ruxolitinib topical
- sacituzumab govitecan
- sarilumab
- satralizumab
- saxagliptin
- selinexor
- selumetinib
- sirolimus
- sirolimus albumin-bound
- sitagliptin
- sorafenib
- stiripentol
- streptozocin
- succimer
- sulfasalazine
- sunitinib
- tafasitamab
- tagraxofusp
- talazoparib
- talquetamab
- tarlatamab
- tazemetostat
- teclistamab
- temozolomide
- temsirolimus
- teplizumab
- teriflunomide
- thalidomide
- thioguanine
- thiotepa
- tisagenlecleucel
- tivozanib
- tocilizumab
- tofacitinib
- topotecan
- trabectedin
- trametinib
- trastuzumab
- treosulfan
- trifluridine
- trimethoprim
- upadacitinib
- valproic acid
- vancomycin
- vandetanib
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- zanidatamab
- zanubrutinib
- zenocutuzumab
- zidovudine
- ziv-aflibercept
- zongertinib
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- Stevens-Johnson syndrome
- neutropenia
- thrombocytopenia, severe
- febrile neutropenia
- leukopenia
- hepatotoxicity
- nephrotoxicity
- GI bleeding
- pancreatitis
- lupus-like syndrome
- seizures
- thromboembolism
- depression
- arrhythmia
- cardiac failure
- AV block
- MI
- infertility (animal studies)
Common Reactions
- fever
- headache
- rash
- rigors
- injection site inflammation
- fatigue
- diarrhea
- vomiting
- nausea
- myalgia
- arthralgia
- ALT or AST elevated
- altered mental status
- abnormal gait
Safety/Monitoring .
Monitoring Parameters
BUN/Cr, CBC with diff, chemistry profile, LFTs, urinalysis at baseline, then q3mo; LFTs qmo if <1 yo
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of teratogenicity, though possible risk of abortions based on animal data at 100x recommended human dose
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties and limited human data with other interferons; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for interferon gamma 1b: other; CYP450: unknown
Excretion: for interferon gamma 1b: other; Half-life: 5.9h
Subclass: Interferons ; Skeletal Dysplasias
Mechanism of Action
for interferon gamma 1b: exact mechanism of action unknown; binds to type 2 interferon receptors, enhancing macrophage oxidative metabolism and antibody dependent cellular cytotoxicity, activating natural killer cells
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.