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Ajovy (fremanezumab-vfrm)
fremanezumab
Adult Dosing .
Dosage forms: INJ (auto-injector): 225 mg; INJ (pre-filled syringe): 225 mg per 1.5 mL
Special Note
- [formulation clarification]
- Info: nonproprietary name = fremanezumab-vfrm
migraine prophylaxis
- [225 mg SC qmo]
- Alt: 675 mg SC q3mo
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
fremanezumab
CGRP antagonist
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- angioedema
Common Reactions
- injection site rxn
- hypersensitivity rxn
- rash
- pruritus
- urticaria
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 3x recommended human dose
Pregnancy Registry
enroll pts or encourage pts to enroll in Ajovy Pregnancy Registry at 1-833-927-2605 or www.tevamigrainepregnancyregistry.com
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: unknown; CYP450: none
Excretion: unknown; Half-life: 31 days
Subclass: CGRP Inhibitors ; Headache/Migraine
Mechanism of Action
blocks calcitonin gene-related peptide (CGRP) activity (monoclonal antibody)
Formulary .
No Formulary Selected
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