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Yupelri
revefenacin inhaled
Adult Dosing .
Dosage forms: NEB: 175 mcg per 3 mL
COPD, maintenance tx
- [175 mcg NEB qd]
renal dosing
- [see below]
- renal impairment: no adjustment; Info: monitor for antimuscarinic side effects if CrCl <30
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- bronchospasm, acute
- hepatic impairment
- caution: CrCl <30
- caution: glaucoma, angle-closure
- caution: urinary retention
- caution: prostatic hypertrophy
- caution: bladder neck obstruction
Drug Interactions .
Overview
revefenacin inhaled
anticholinergic inhaled
- OATP1B1 substrate
- OATP1B3 substrate
- anticholinergic effects
- tachycardia
Avoid/Use Alternative
Monitor/Modify Tx
Caution Advised
Adverse Reactions .
Serious Reactions
- bronchospasm, paradoxical
- hypersensitivity reaction
- glaucoma, angle-closure
Common Reactions
- cough
- nasopharyngitis
- URI
- headache
- back pain
Safety/Monitoring .
Monitoring Parameters
antimuscarinic symptoms if CrCl <30
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of teratogenicity based on animal data at 209x MRHD
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on minimal drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for revefenacin: hydrolysis primarily; CYP450: unknown; Info: active metabolite
Excretion: for revefenacin: feces 54%, urine 27%; Half-life: (revefenacin) 22-70h, (active metabolite) 22-70h
Subclass: Muscarinic Antagonists, Inhaled Long-Acting (LAMAs)
Mechanism of Action
for revefenacin: antagonizes acetylcholine receptors, producing bronchodilation
Formulary .
No Formulary Selected
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