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Accrufer
ferric maltol
Adult Dosing .
Dosage forms: CAP: 30 mg
iron deficiency
- [30 mg PO bid]
- Info: give 1h before or 2h after meals; do not open/crush/chew cap
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: CAP: 30 mg
iron deficiency
- [10 yo and older]
- Dose: 30 mg PO bid; Info: give 1h before or 2h after meals; do not open/crush/chew cap
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hemochromatosis
- iron overload syndrome
- blood transfusion, chronic
- inflammatory bowel disease, active
Drug Interactions .
Overview
ferric maltol
iron oral
- heavy metal
- iron oral
- polyvalent cation
- give oral drugs at least 4h before or after ferric maltol; iron may delay or decr. absorption of concomitant oral drugs
Avoid/Use Alternative
- acetohydroxamic acid
- ferric carboxymaltose
- ferric derisomaltose
- ferumoxytol
- iron dextran
- iron sucrose
- methyldopa
- sodium ferric gluconate complex
- trientine
Monitor/Modify Tx
- alendronate
- baloxavir marboxil
- bictegravir
- cabotegravir
- captopril
- carbidopa
- cefdinir
- chloroquine
- ciprofloxacin
- deferiprone
- delafloxacin
- demeclocycline
- dicyclomine
- diflunisal
- digoxin
- dolutegravir
- doxycycline
- eltrombopag
- elvitegravir
- entacapone
- ethambutol
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- fosamprenavir
- hyoscyamine
- ibandronate
- levodopa
- levofloxacin
- levothyroxine
- methscopolamine
- minocycline
- moxifloxacin
- mycophenolate mofetil
- mycophenolic acid
- naproxen
- ofloxacin
- omadacycline
- penicillamine
- phenytoin
- raltegravir
- rifampin
- risedronate
- sarecycline
- tetracycline
- thyroid
- tipranavir
- vadadustat
Caution Advised
- peppermint
- sodium polystyrene sulfonate
Adverse Reactions .
Serious Reactions
- iron overload
- inflammatory bowel disease exacerbation
Common Reactions
- flatulence
- diarrhea
- constipation
- fecal discoloration
- abdominal pain
Safety/Monitoring .
Monitoring Parameters
ferritin, transferrin saturation at baseline, then periodically
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on animal data with other PO iron and maltol compounds at 13x and 6x recommended human dose
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for iron: unknown; CYP450: unknown
Excretion: for iron: unknown; Half-life: unknown
Subclass: Iron Homeostasis ; Minerals
Mechanism of Action
for iron: provides an essential component in hemoglobin, myoglobin, and various enzymes
Formulary .
No Formulary Selected
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