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Airsupra
albuterol/ budesonide inhaled
Adult Dosing .
Dosage forms: MDI: 90 mcg/80 mcg per actuation
asthma, prn tx
- [2 puffs inhaled prn]
- Max: 12 puffs/24h; Info: search 'asthma' for epocrates Asthma Long-Term Management NIH/NHLBI decision tools
renal dosing
- [see below]
- renal impairment: not defined; Info: caution advised if high-dose use
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: hypersensitivity to corticosteroids
- caution: MAO inhibitor use within 14 days
- caution: TCA use within 14 days
- caution: electrolyte abnormalities
- caution: long QT syndrome, congenital
- caution: QT prolongation
- caution: QT prolongation family history
- caution: torsades de pointes history
- caution: arrhythmia
- caution: bradycardia
- caution: MI, recent
- caution: CHF
- caution: cardiovascular disease
- caution: patients unusually responsive to sympathomimetic amines
- caution: hyperthyroidism
- caution: diabetes mellitus
- caution: ketoacidosis
- caution: seizure disorder
- caution: labor and delivery
- caution: renal impairment (high-dose use)
- caution: hepatic impairment
- caution: long-term systemic corticosteroid use, recent
- caution: immunosuppressed patients
- caution: infection, active
- caution: TB infection, active
- caution: TB infection, latent
- caution: measles exposure
- caution: varicella exposure
- caution: osteoporosis
- caution: osteoporosis risk
- caution: cataract
- caution: glaucoma
- caution: glaucoma risk
- caution: ocular HSV
Drug Interactions .
Overview
albuterol inhaled
beta-2 agonist
- hypertensive effects
- hypokalemia
- prolongs QT interval (conditional)
- tachycardia
budesonide inhaled
corticosteroid inhaled
- CYP3A4 substrate
- immunomodulatory effects
- interferes w/ ACTH analog test
Contraindicated
- desmopressin
- pimozide
- thioridazine
Avoid/Use Alternative
- acebutolol
- albuterol
- amitriptyline
- amoxapine
- arsenic trioxide
- atenolol
- bedaquiline
- betaxolol
- bisoprolol
- budesonide inhaled
- carvedilol
- cisapride
- cladribine oral
- clomipramine
- cobicistat
- cocaine
- crizotinib
- darunavir
- desipramine
- domperidone
- doxepin
- dronabinol
- dronedarone
- ephedra
- epinephrine inhaled
- esmolol
- fexinidazole
- fosfomycin injection
- furosemide
- hydroxychloroquine
- imipramine
- isocarboxazid
- labetalol
- landiolol
- lefamulin
- linezolid
- lonafarnib
- lopinavir/ritonavir
- metoprolol
- midodrine
- mobocertinib
- nadolol
- natalizumab
- nebivolol
- nortriptyline
- ozanimod
- phenelzine
- pimecrolimus topical
- pindolol
- procarbazine
- propranolol
- protriptyline
- quizartinib
- rasagiline
- ritonavir
- safinamide
- selegiline
- selegiline transdermal
- sotalol
- timolol
- toremifene
- tranylcypromine
- trimipramine
- vandetanib
- yohimbe
- ziprasidone
Monitor/Modify Tx
- abiraterone acetate
- acetazolamide
- adagrasib
- aliskiren
- almotriptan
- aloe
- amiloride
- aminophylline
- amiodarone
- amlodipine
- amphetamine
- amphotericin
- anagrelide
- angiotensin II
- apalutamide
- apomorphine
- aprocitentan
- arformoterol inhaled
- armodafinil
- artemether/lumefantrine
- asciminib
- asenapine
- asparaginase
- atogepant
- atomoxetine
- atropine
- atropine ophthalmic
- axitinib
- azilsartan medoxomil
- azithromycin
- benazepril
- benzphetamine
- benztropine
- betamethasone
- bevacizumab
- bismuth subsalicylate
- brigatinib
- budesonide
- bumetanide
- bupropion
- cabozantinib
- caffeine
- caffeine citrate
- candesartan cilexetil
- cannabis
- captopril
- carfilzomib
- celecoxib
- ceritinib
- cetuximab
- chloroquine
- chlorothiazide
- chlorthalidone
- cisplatin
- citalopram
- clarithromycin
- clevidipine
- clofazimine
- clonidine
- copanlisib
- corticotropin
- cortisone
- cosyntropin
- cyclosporine
- danazol
- darbepoetin alfa
- decitabine
- deflazacort
- degarelix
- desflurane
- desvenlafaxine
- dexamethasone
- dexmedetomidine
- dexmedetomidine injection
- dexmethylphenidate
- dextroamphetamine
- dichlorphenamide
- diclofenac
- diclofenac topical
- dicyclomine
- diethylpropion
- diflunisal
- digoxin
- dihydroergotamine
- diltiazem
- dinutuximab
- disopyramide
- dobutamine
- dofetilide
- donepezil
- dopamine
- dordaviprone
- doxapram
- doxazosin
- droperidol
- droxidopa
- eletriptan
- emapalumab
- enalapril
- enalaprilat
- encorafenib
- ephedrine injection
- ephedrine oral
- epinephrine
- epirubicin
- eplerenone
- epoetin alfa
- eptinezumab
- erenumab
- ergotamine
- eribulin
- erythromycin
- esketamine
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethacrynic acid
- ethanol (alcoholic beverage)
- ethinyl estradiol (contraceptive)
- etodolac
- etrasimod
- everolimus
- felodipine
- fenfluramine
- fenoldopam
- fenoprofen
- fingolimod
- flecainide
- fludrocortisone
- fluorouracil
- flurbiprofen
- formoterol inhaled
- foscarnet
- fosinopril
- fostamatinib
- fremanezumab
- frovatriptan
- fruquintinib
- galcanezumab
- gilteritinib
- glasdegib
- glycopyrrolate
- goserelin
- guanfacine
- haloperidol
- histrelin
- hoodia
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroxocobalamin IV
- hydroxyzine
- hyoscyamine
- ibrutinib
- ibuprofen
- ibutilide
- indapamide
- indomethacin
- inotuzumab ozogamicin
- insulin
- irbesartan
- isoflurane
- isoproterenol
- isradipine
- ivosidenib
- ketamine
- ketoprofen
- ketorolac
- lanreotide
- leflunomide
- lenalidomide
- lenvatinib
- leuprolide
- levalbuterol inhaled
- levofloxacin
- levoketoconazole
- levomilnacipran
- levothyroxine
- licorice
- lifileucel
- liothyronine
- liraglutide
- lisdexamfetamine
- lisinopril
- lofexidine
- lorlatinib
- losartan
- lumacaftor/ivacaftor
- luspatercept
- macimorelin
- magnesium citrate
- magnesium salicylate
- mannitol
- meclofenamate
- mefenamic acid
- meloxicam
- methacholine inhaled
- methadone
- methamphetamine
- methazolamide
- methoxy polyethylene glycol-epoetin beta
- methscopolamine
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- metolazone
- metyrapone
- mifepristone
- milnacipran
- minoxidil
- mirabegron
- mitomycin
- modafinil
- moexipril
- motixafortide
- moxifloxacin
- nabumetone
- naproxen
- naratriptan
- naxitamab
- necitumumab
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- niraparib
- nisoldipine
- norepinephrine
- obinutuzumab
- oliceridine
- olmesartan medoxomil
- olodaterol inhaled
- ondansetron
- orphenadrine
- osilodrostat
- osimertinib
- oxaprozin
- oxymetazoline nasal
- oxytocin
- pacritinib
- paliperidone
- palonosetron
- pamidronate
- panitumumab
- pasireotide
- pazopanib
- pentamidine
- perindopril
- pexidartinib
- phendimetrazine
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- piroxicam
- polyethylene glycol
- polyethylene glycol/electrolytes
- ponatinib
- ponesimod
- posaconazole
- pralsetinib
- prazosin
- prednisolone
- prednisone
- procainamide
- propafenone
- pseudoephedrine
- quetiapine
- quinapril
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- quinine
- ramipril
- ramucirumab
- regorafenib
- revumenib
- ribociclib
- rimegepant
- ripretinib
- rizatriptan
- romidepsin
- ropinirole
- rotigotine transdermal
- rucaparib
- sacituzumab govitecan
- salmeterol inhaled
- salsalate
- selinexor
- selpercatinib
- sevoflurane
- siponimod
- sirolimus albumin-bound
- sodium benzoate
- sodium phenylacetate
- sodium phenylbutyrate
- sodium polystyrene sulfonate
- sodium thiosulfate
- solriamfetol
- sorafenib
- spironolactone
- sulfate bowel prep
- sulindac
- sumatriptan
- sunitinib
- tacrolimus
- tafasitamab
- tagraxofusp
- taletrectinib
- telavancin
- telmisartan
- terazosin
- terbutaline
- teriflunomide
- testosterone
- tetrabenazine
- theophylline
- thyroid
- tivozanib
- tolmetin
- topiramate
- torsemide
- tramadol
- trametinib
- trandolapril
- triamcinolone
- triamterene
- triclabendazole
- trifluridine
- triptorelin
- trospium
- ubrogepant
- vadadustat
- valsartan
- vamorolone
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- vilanterol inhaled
- viloxazine
- voclosporin
- zavegepant
- ziftomenib
- ziv-aflibercept
- zolmitriptan
- zonisamide
Caution Advised
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- adalimumab
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- anakinra
- anifrolumab
- anti-thymocyte globulin
- atazanavir
- atidarsagene autotemcel
- avacopan
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- baricitinib
- basiliximab
- beclomethasone inhaled
- beclomethasone nasal
- belatacept
- belimumab
- belinostat
- bendamustine
- bimekizumab
- blinatumomab
- bortezomib
- brentuximab vedotin
- brexucabtagene autoleucel
- brodalumab
- budesonide nasal
- budesonide rectal
- busulfan
- cabazitaxel
- canakinumab
- carboplatin
- carmustine
- certolizumab pegol
- chlorambucil
- chloramphenicol
- ciltacabtagene autoleucel
- cladribine injection
- clobetasol ophthalmic
- clofarabine
- crovalimab
- cyclophosphamide
- cytarabine
- dactinomycin
- danicopan
- daratumumab
- daunorubicin
- delgocitinib topical
- deucravacitinib
- deuruxolitinib
- dexamethasone ophthalmic
- difluprednate ophthalmic
- dimethyl fumarate
- diroximel fumarate
- docetaxel
- doxorubicin
- dupilumab
- duvelisib
- eculizumab
- efgartigimod alfa
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- epcoritamab
- etanercept
- etoposide
- etuvetidigene autotemcel
- floxuridine
- fludarabine
- flunisolide nasal
- fluocinolone intravitreal
- fluorometholone ophthalmic
- fluticasone furoate
- fluticasone propionate
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone ophthalmic
- hydroxyurea
- ibritumomab tiuxetan
- icotrokinra
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- inebilizumab
- infliximab
- iptacopan
- irinotecan
- isatuximab
- itraconazole
- ixabepilone
- ixekizumab
- ketoconazole
- lebrikizumab
- linvoseltamab
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- loteprednol ophthalmic
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- methotrexate
- mirikizumab
- mitoxantrone
- mogamulizumab
- momelotinib
- mometasone implant
- mometasone inhaled
- mometasone nasal
- monomethyl fumarate
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- narsoplimab
- nefazodone
- nelarabine
- nelfinavir
- nipocalimab
- obecabtagene autoleucel
- ocrelizumab
- ofatumumab
- oxaliplatin
- paclitaxel
- pegcetacoplan
- pentostatin
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- pozelimab
- prednisolone ophthalmic
- ravulizumab
- rilonacept
- rilzabrutinib
- risankizumab
- ritlecitinib
- rituximab
- ropeginterferon alfa-2b
- rozanolixizumab
- ruxolitinib
- ruxolitinib topical
- sarilumab
- satralizumab
- secukinumab
- sibeprenlimab
- siltuximab
- sirolimus
- spesolimab
- sulfasalazine
- sutimlimab
- talquetamab
- tarlatamab
- teclistamab
- temozolomide
- temsirolimus
- teplizumab
- thioguanine
- thiotepa
- tildrakizumab
- tipranavir
- tisagenlecleucel
- tocilizumab
- tofacitinib
- topotecan
- trabectedin
- tralokinumab
- tucatinib
- ublituximab
- upadacitinib
- ustekinumab
- vedolizumab
- venetoclax
- vilobelimab
- vinblastine
- vincristine
- vinorelbine
- voriconazole
- zanubrutinib
- zilucoplan
Adverse Reactions .
Serious Reactions
- bronchospasm, paradoxical
- hypersensitivity reaction
- anaphylaxis
- angioedema
- HTN
- angina
- arrhythmia
- hypokalemia
- hyperglycemia
- metabolic acidosis
- eosinophilia
- Churg-Strauss syndrome
- adrenal suppression (long-term use)
- hypercorticism (long-term use)
- immunosuppression (long-term use)
- glaucoma (long-term use)
- cataracts (long-term use)
- osteoporosis (long-term use)
Common Reactions
- headache
- candidiasis, oral
Safety/Monitoring .
Monitoring Parameters
BMD at baseline if osteoporosis risk factors, then periodically; oral cavity exam periodically; consider ophthalmic exam if long-term use, change in vision, IOP/glaucoma/cataracts history
Pregnancy/Lactation .
Pregnancy
Clinical Summary
albuterol inhaled: may use during pregnancy; drug of choice for asthma use during pregnancy; weigh risk/benefit during labor and delivery; risk of fetal harm low based on human data; risk of interference with uterine contractility based on drug's mechanism of action
budesonide inhaled: may use during pregnancy; drug of choice for asthma use during pregnancy; risk of teratogenicity low based on human data
Pregnancy Registry
enroll patients or encourage patients to enroll in MotherToBaby Pregnancy Studies at 1-877-311-8972 or at www.mothertobaby.org/asthma/
Lactation
Clinical Summary
albuterol inhaled: may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal systemic absorption in breastfeeding patients
budesonide inhaled: may use while breastfeeding; no known risk of infant harm based on human data and minimal drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for albuterol: GI tract; CYP450: unknown; for budesonide: liver extensively; CYP450: 3A4 substrate
Excretion: for albuterol: urine 80-100%, feces <20%; Half-life: 7.1h; for budesonide: urine 60% (none unchanged), feces; Half-life: 4.1h
Subclass: Beta-2 Agonists, Inhaled Short-Acting (SABAs) ; Corticosteroids, Inhaled
Mechanism of Action
for albuterol: selectively stimulates beta-2 adrenergic receptors, relaxing airway smooth muscle; for budesonide: exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
Formulary .
No Formulary Selected
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