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Rezzayo
rezafungin
Adult Dosing .
Dosage forms: INJ
invasive candidiasis
- [400 mg IV x1, then 200 mg IV qwk]
- Max: 4 doses; Info: for patients with limited or no alternative tx options; may give infusion up to 3 days before or after scheduled dose, ensure at least 4 days between doses; restart dosing regimen if missed dose by 2wk or more
renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to echinocandins
- avoid: sun exposure
- avoid: artificial UV light exposure
- caution: hepatic disease
Drug Interactions .
Overview
rezafungin
echinocandin antifungal
- photosensitivity
Avoid/Use Alternative
- aminolevulinic acid topical
- porfimer
Caution Advised
- acitretin
- methoxsalen
- verteporfin
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
Common Reactions
- hypokalemia
- fever
- diarrhea
- anemia
- vomiting
- nausea
- hypomagnesemia
- abdominal pain
- constipation
- hypophosphatemia
- infusion reaction
- photosensitivity
- LFT incr.
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of embryo-fetal toxicity based on animal data at 5x recommended human doses
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for rezafungin: unknown; CYP450: none
Excretion: for rezafungin: feces 74.3% (primarily unchanged), urine 25.7%; Half-life: 152h
Subclass: Antifungals
Mechanism of Action
for rezafungin: inhibits synthesis of 1,3-beta-D-glucan, inhibiting fungal cell wall synthesis (echinocandin)
Formulary .
No Formulary Selected
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