Mucinex InstaSoothe Sore Throat + Cough Relief

Overview

dextromethorphan

antitussive; NMDA antagonist; sigma-1 agonist

1. CYP2D6 substrate
2. serotonergic effects

1. add MAO inhibitor to Interaction Check if recent (14 days) use

hexylresorcinol

1. None

Contraindicated

• isocarboxazid
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

isocarboxazid

1 interaction

Contraindicated

dextromethorphan + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

• phenelzine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

phenelzine

1 interaction

Contraindicated

dextromethorphan + phenelzine

contraindicated w/in 14 days of phenelzine or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects)

• procarbazine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

procarbazine

1 interaction

Contraindicated

dextromethorphan + procarbazine

contraindicated w/in 14 days of procarbazine or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, procarbazine inhibits monoamine oxidase)

• rasagiline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

rasagiline

1 interaction

Contraindicated

dextromethorphan + rasagiline

contraindicated w/in 14 days of rasagiline or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

• safinamide
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

safinamide

1 interaction

Contraindicated

dextromethorphan + safinamide

contraindicated w/in 14 days of safinamide or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

• selegiline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

selegiline

1 interaction

Contraindicated

dextromethorphan + selegiline

contraindicated w/in 14 days of selegiline or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

• selegiline transdermal
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

selegiline transdermal

1 interaction

Contraindicated

dextromethorphan + selegiline transdermal

contraindicated w/in 14 days of selegiline transdermal or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects)

• tranylcypromine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

tranylcypromine

1 interaction

Contraindicated

dextromethorphan + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or dextromethorphan use: combo may incr. risk of serotonin syndrome, psychosis (additive effects)

• yohimbe
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

yohimbe

1 interaction

Contraindicated

dextromethorphan + yohimbe

contraindicated w/in 14 days of yohimbe or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, yohimbe inhibits monoamine oxidase)

Avoid/Use Alternative

• alfentanil
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

alfentanil

1 interaction

Avoid/Use Alternative

dextromethorphan + alfentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amphetamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

amphetamine

1 interaction

Avoid/Use Alternative

dextromethorphan + amphetamine

consider alternative or decr. amphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• buprenorphine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

buprenorphine

1 interaction

Avoid/Use Alternative

dextromethorphan + buprenorphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• butorphanol
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

butorphanol

1 interaction

Avoid/Use Alternative

dextromethorphan + butorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• citalopram
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

citalopram

1 interaction

Avoid/Use Alternative

dextromethorphan + citalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• clomipramine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

clomipramine

1 interaction

Avoid/Use Alternative

dextromethorphan + clomipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

codeine

1 interaction

Avoid/Use Alternative

dextromethorphan + codeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• cyclobenzaprine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

dextromethorphan + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• desipramine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

desipramine

1 interaction

Avoid/Use Alternative

dextromethorphan + desipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• desvenlafaxine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

dextromethorphan + desvenlafaxine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

dextromethorphan + dextroamphetamine

consider alternative or decr. dextroamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

dextromethorphan + dextromethorphan

avoid combo: combo may incr. risk of serotonin syndrome (additive effects, duplicate tx)

• dihydrocodeine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

dextromethorphan + dihydrocodeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• duloxetine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

duloxetine

1 interaction

Avoid/Use Alternative

dextromethorphan + duloxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• escitalopram
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

escitalopram

1 interaction

Avoid/Use Alternative

dextromethorphan + escitalopram

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• fentanyl
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

fentanyl

1 interaction

Avoid/Use Alternative

dextromethorphan + fentanyl

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• fluoxetine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

fluoxetine

1 interaction

Avoid/Use Alternative

dextromethorphan + fluoxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day: combo may incr. dextromethorphan levels, risk of serotonin syndrome, other adverse effects (hepatic metab. inhibited; additive effects)

• fluvoxamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

dextromethorphan + fluvoxamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• gepirone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

gepirone

1 interaction

Avoid/Use Alternative

dextromethorphan + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• granisetron
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

granisetron

1 interaction

Avoid/Use Alternative

dextromethorphan + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

hydrocodone

1 interaction

Avoid/Use Alternative

dextromethorphan + hydrocodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydromorphone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

hydromorphone

1 interaction

Avoid/Use Alternative

dextromethorphan + hydromorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• isoniazid
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

isoniazid

1 interaction

Avoid/Use Alternative

dextromethorphan + isoniazid

use alternative or monitor serotonin syndrome sx w/in 14 days of isoniazid or dextromethorphan use: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• levomilnacipran
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

dextromethorphan + levomilnacipran

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• levorphanol
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

levorphanol

1 interaction

Avoid/Use Alternative

dextromethorphan + levorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• linezolid
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

linezolid

1 interaction

Avoid/Use Alternative

dextromethorphan + linezolid

use alternative or hold dextromethorphan if urgent use; monitor serotonin syndrome sx x2wk after dextromethorphan D/C or 24h after last linezolid dose: combo may incr. risk of serotonin syndrome (additive effects, linezolid reversibly inhibits monoamine oxidase)

• lisdexamfetamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

dextromethorphan + lisdexamfetamine

consider alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

lithium

1 interaction

Avoid/Use Alternative

dextromethorphan + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• meperidine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

meperidine

1 interaction

Avoid/Use Alternative

dextromethorphan + meperidine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metaxalone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

metaxalone

1 interaction

Avoid/Use Alternative

dextromethorphan + metaxalone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methadone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methadone

1 interaction

Avoid/Use Alternative

dextromethorphan + methadone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methamphetamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methamphetamine

1 interaction

Avoid/Use Alternative

dextromethorphan + methamphetamine

consider alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylene blue oral
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

dextromethorphan + methylene blue oral

use alternative or monitor serotonin syndrome sx w/in 14 days of methylene blue use, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• milnacipran
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

milnacipran

1 interaction

Avoid/Use Alternative

dextromethorphan + milnacipran

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• mirtazapine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

mirtazapine

1 interaction

Avoid/Use Alternative

dextromethorphan + mirtazapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• morphine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

morphine

1 interaction

Avoid/Use Alternative

dextromethorphan + morphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nalbuphine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

nalbuphine

1 interaction

Avoid/Use Alternative

dextromethorphan + nalbuphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nortriptyline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

nortriptyline

1 interaction

Avoid/Use Alternative

dextromethorphan + nortriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oliceridine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

oliceridine

1 interaction

Avoid/Use Alternative

dextromethorphan + oliceridine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ondansetron
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

ondansetron

1 interaction

Avoid/Use Alternative

dextromethorphan + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

opium

1 interaction

Avoid/Use Alternative

dextromethorphan + opium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oxycodone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

oxycodone

1 interaction

Avoid/Use Alternative

dextromethorphan + oxycodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oxymorphone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

oxymorphone

1 interaction

Avoid/Use Alternative

dextromethorphan + oxymorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• paroxetine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

paroxetine

1 interaction

Avoid/Use Alternative

dextromethorphan + paroxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day: combo may incr. dextromethorphan levels, risk of serotonin syndrome, other adverse effects (hepatic metab. inhibited; additive effects)

• pentazocine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

pentazocine

1 interaction

Avoid/Use Alternative

dextromethorphan + pentazocine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• remifentanil
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

remifentanil

1 interaction

Avoid/Use Alternative

dextromethorphan + remifentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sertraline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

sertraline

1 interaction

Avoid/Use Alternative

dextromethorphan + sertraline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sufentanil
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

sufentanil

1 interaction

Avoid/Use Alternative

dextromethorphan + sufentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• tapentadol
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

tapentadol

1 interaction

Avoid/Use Alternative

dextromethorphan + tapentadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• tramadol
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

tramadol

1 interaction

Avoid/Use Alternative

dextromethorphan + tramadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• trimipramine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

trimipramine

1 interaction

Avoid/Use Alternative

dextromethorphan + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• venlafaxine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

venlafaxine

1 interaction

Avoid/Use Alternative

dextromethorphan + venlafaxine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• vilazodone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

vilazodone

1 interaction

Avoid/Use Alternative

dextromethorphan + vilazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• vortioxetine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

vortioxetine

1 interaction

Avoid/Use Alternative

dextromethorphan + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ziprasidone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

ziprasidone

1 interaction

Avoid/Use Alternative

dextromethorphan + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

• 5-HTP
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

5-HTP

1 interaction

Monitor/Modify Tx

dextromethorphan + 5-HTP

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• almotriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

almotriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + almotriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amitriptyline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

amitriptyline

1 interaction

Monitor/Modify Tx

dextromethorphan + amitriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amoxapine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

amoxapine

1 interaction

Monitor/Modify Tx

dextromethorphan + amoxapine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• black cohosh
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

black cohosh

1 interaction

Monitor/Modify Tx

dextromethorphan + black cohosh

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• bromocriptine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

bromocriptine

1 interaction

Monitor/Modify Tx

dextromethorphan + bromocriptine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• buspirone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

buspirone

1 interaction

Monitor/Modify Tx

dextromethorphan + buspirone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• carbamazepine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

carbamazepine

1 interaction

Monitor/Modify Tx

dextromethorphan + carbamazepine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• cocaine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

cocaine

1 interaction

Monitor/Modify Tx

dextromethorphan + cocaine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dacomitinib
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dacomitinib

1 interaction

Monitor/Modify Tx

dextromethorphan + dacomitinib

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metab. inhibited)

• dexmethylphenidate
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

dextromethorphan + dexmethylphenidate

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dihydroergotamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

dihydroergotamine

1 interaction

Monitor/Modify Tx

dextromethorphan + dihydroergotamine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• doxepin
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

doxepin

1 interaction

Monitor/Modify Tx

dextromethorphan + doxepin

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• doxepin topical
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

doxepin topical

1 interaction

Monitor/Modify Tx

dextromethorphan + doxepin topical

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• eletriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

eletriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + eletriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ergotamine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

ergotamine

1 interaction

Monitor/Modify Tx

dextromethorphan + ergotamine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• fenfluramine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

fenfluramine

1 interaction

Monitor/Modify Tx

dextromethorphan + fenfluramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• frovatriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

frovatriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + frovatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• imipramine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

imipramine

1 interaction

Monitor/Modify Tx

dextromethorphan + imipramine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lasmiditan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

lasmiditan

1 interaction

Monitor/Modify Tx

dextromethorphan + lasmiditan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• mavorixafor
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

mavorixafor

1 interaction

Monitor/Modify Tx

dextromethorphan + mavorixafor

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metab. inhibited)

• methylene blue injection
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

dextromethorphan + methylene blue injection

hold dextromethorphan if emergency use; monitor serotonin syndrome sx up to 4h after last methylene blue dose; may resume dextromethorphan 72h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methylergonovine

1 interaction

Monitor/Modify Tx

dextromethorphan + methylergonovine

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

methylphenidate

1 interaction

Monitor/Modify Tx

dextromethorphan + methylphenidate

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

metoclopramide

1 interaction

Monitor/Modify Tx

dextromethorphan + metoclopramide

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• naratriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

naratriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + naratriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nefazodone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

nefazodone

1 interaction

Monitor/Modify Tx

dextromethorphan + nefazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• palonosetron
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

palonosetron

1 interaction

Monitor/Modify Tx

dextromethorphan + palonosetron

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• protriptyline
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

protriptyline

1 interaction

Monitor/Modify Tx

dextromethorphan + protriptyline

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• quinidine (antiarrhythmic)
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

dextromethorphan + quinidine (antiarrhythmic)

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metab. inhibited)

• rizatriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

rizatriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + rizatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• SAMe
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

SAMe

1 interaction

Monitor/Modify Tx

dextromethorphan + SAMe

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• St. John's wort
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

St. John's wort

1 interaction

Monitor/Modify Tx

dextromethorphan + St. John's wort

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sumatriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

sumatriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + sumatriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• terbinafine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

terbinafine

1 interaction

Monitor/Modify Tx

dextromethorphan + terbinafine

if MDD use, adjust max dextromethorphan/bupropion dose to 1 tab/day; otherwise, caution advised: combo may incr. dextromethorphan levels, risk of adverse effects (hepatic metab. inhibited)

• trazodone
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

trazodone

1 interaction

Monitor/Modify Tx

dextromethorphan + trazodone

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• zolmitriptan
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

dextromethorphan + zolmitriptan

monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Caution Advised

• memantine
Mucinex InstaSoothe Sore Throat + Cough Relief (hexylresorcinol/ dextromethorphan oropharyngeal)

+

memantine

1 interaction

Caution Advised

dextromethorphan + memantine

caution advised: combo may incr. adverse effects of both drugs (additive effects, duplicate tx)