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Xdemvy
lotilaner ophthalmic
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
lotilaner ophthalmic
antiparasitic ophthalmic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- ocular burning
- ocular irritation
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on expected limited systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on limited maternal systemic absorption
Pharmacology .
Metabolism: unknown; CYP450: none; Info: minimal to no systemic absoprtion
Excretion: unknown; Half-life: 11 days
Subclass: Antiparasitics, Ophthalmic
Mechanism of Action
selectively inhibits gamma-aminobutyric acid-gated Cl channels in mites, causing paralytic action leading to death
Formulary .
No Formulary Selected
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