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Vevye
cyclosporine ophthalmic
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
cyclosporine ophthalmic
calcineurin inhibitor ophthalmic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- instillation site rxn
- visual acuity decr.
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on insignificant systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on insignificant maternal systemic absorption
Pharmacology .
Metabolism: liver extensively, GI tract, kidney; CYP450: 3A substrate; Info: minimal to no systemic absorption
Excretion: bile primarily, urine 6% (0.1% unchanged); Half-life: 5-27h
Subclass: Calcineurin Inhibitors, Ophthalmic ; Ocular Dryness/Irritation
Mechanism of Action
exact mechanism of action unknown; acts as a partial immunomodulator, resulting in tear production
Formulary .
No Formulary Selected
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