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Journavx
suzetrigine
Adult Dosing .
Dosage forms: TAB: 50 mg
pain, moderate-severe acute
- [100 mg PO x1, then 50 mg PO q12h starting 12h later]
- Info: give 1st dose at least 1h before or 2h after food; do not cut/crush/chew tab; use shortest effective tx duration; see pkg insert for missed dose recommendations
renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class B: start 100 mg x1, then 50 mg q12h x3 doses, then after 12h start 50 mg q24h; Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hepatic impairment, Child-Pugh Class C
- caution: hepatic impairment, Child-Pugh Class B
- caution: patients of childbearing potential
Drug Interactions .
Overview
suzetrigine
sodium channel blocker
- CYP3A4 substrate
- CYP3A4 inducer, weak
Contraindicated
- adagrasib
- atazanavir
- ceritinib
- chloramphenicol
- clarithromycin
- cobicistat
- idelalisib
- itraconazole
- ketoconazole
- levoketoconazole
- lonafarnib
- lopinavir/ritonavir
- mifepristone
- nefazodone
- nelfinavir
- posaconazole
- ranolazine
- ribociclib
- ritonavir
- tipranavir
- tucatinib
- voriconazole
Avoid/Use Alternative
- apalutamide
- bosentan
- butalbital
- carbamazepine
- cenobamate
- codeine
- dabrafenib
- desogestrel (contraceptive)
- dienogest (contraceptive)
- dolutegravir
- drospirenone (contraceptive)
- efavirenz
- encorafenib
- enzalutamide
- estradiol (contraceptive)
- ethinyl estradiol (contraceptive)
- ethynodiol (contraceptive)
- etonogestrel (contraceptive)
- etravirine
- fentanyl
- fexinidazole
- fosamprenavir
- fosphenytoin
- grapefruit
- ivosidenib
- lorlatinib
- lumacaftor/ivacaftor
- lumateperone
- mavacamten
- medroxyprogesterone (contraceptive)
- meperidine
- mitapivat
- mitotane
- modafinil
- nafcillin
- norelgestromin (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- oliceridine
- oxycodone
- pacritinib
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- primidone
- repotrectinib
- rifabutin
- rifampin
- rifapentine
- segesterone (contraceptive)
- sotorasib
- St. John's wort
- tramadol
- ulipristal (post-coital contraceptive)
- zuranolone
Monitor/Modify Tx
- aficamten
- amlodipine
- aprepitant
- atogepant
- avacopan
- berotralstat
- buprenorphine
- ciprofloxacin
- clofazimine
- conivaptan
- crizotinib
- cyclophosphamide
- cyclosporine
- danazol
- darunavir
- diltiazem
- disopyramide
- dronedarone
- duvelisib
- erythromycin
- everolimus
- fedratinib
- fluconazole
- ifosfamide
- imatinib
- isavuconazonium
- isradipine
- lefamulin
- lenacapavir
- letermovir
- netupitant
- nicardipine
- nilotinib
- nimodipine
- nirogacestat
- nisoldipine
- quinidine (antiarrhythmic)
- rilzabrutinib
- sirolimus
- tacrolimus
- tiagabine
- ubrogepant
- verapamil
- warfarin
Caution Advised
- abemaciclib
- acalabrutinib
- alfentanil
- alprazolam
- amiodarone
- armodafinil
- artemether/lumefantrine
- atorvastatin
- avapritinib
- axitinib
- belzutifan
- bexarotene
- bictegravir
- bosutinib
- brigatinib
- budesonide
- buspirone
- cabozantinib
- capivasertib
- capmatinib
- clobazam
- cobimetinib
- danshen
- daridorexant
- darolutamide
- dasatinib
- defactinib
- deflazacort
- dexamethasone
- dicloxacillin
- doravirine
- dordaviprone
- drospirenone (hormone replacement)
- echinacea
- elacestrant
- elafibranor
- elagolix
- elbasvir
- elexacaftor/tezacaftor/ivacaftor
- eliglustat
- elvitegravir
- enasidenib
- entrectinib
- erdafitinib
- erlotinib
- eslicarbazepine acetate
- felbamate
- felodipine
- finerenone
- fosaprepitant
- fostamatinib
- fruquintinib
- garlic
- gepirone
- gilteritinib
- ginkgo
- ginseng, Asian
- glasdegib
- glecaprevir
- glycerol phenylbutyrate
- grazoprevir
- griseofulvin
- guanfacine
- haloperidol
- hydrocortisone
- ibrutinib
- irinotecan
- istradefylline
- ivacaftor
- lapatinib
- larotrectinib
- lazertinib
- leniolisib
- lurasidone
- macitentan
- maraviroc
- meropenem
- methadone
- midazolam
- midostaurin
- mobocertinib
- naldemedine
- naloxegol
- neratinib
- nevirapine
- nifedipine
- nirmatrelvir
- odevixibat
- olaparib
- olutasidenib
- omaveloxolone
- oxcarbazepine
- palbociclib
- pemigatinib
- perampanel
- pimavanserin
- pioglitazone
- pirtobrutinib
- ponatinib
- praziquantel
- prednisone
- pretomanid
- quetiapine
- quinine
- quizartinib
- rilpivirine
- ripretinib
- roflumilast
- rolapitant
- rufinamide
- samidorphan
- sarilumab
- sebetralstat
- selpercatinib
- selumetinib
- simvastatin
- sirolimus albumin-bound
- sonidegib
- stiripentol
- sunvozertinib
- tadalafil
- taletrectinib
- tamoxifen
- tasimelteon
- tazemetostat
- tecovirimat
- telotristat ethyl
- temsirolimus
- tezacaftor/ivacaftor
- ticagrelor
- tocilizumab
- tofacitinib
- tolvaptan
- topiramate
- toremifene
- tovorafenib
- vaborbactam
- vamorolone
- vanzacaftor/tezacaftor/deutivacaftor
- velpatasvir
- vemurafenib
- venetoclax
- vinblastine
- voclosporin
- vonoprazan
- vorasidenib
- voxilaprevir
- zanubrutinib
- ziftomenib
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- CPK incr.
- eGFR decr.
- pruritus
- muscle spasm
- rash
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of teratogenicity, though possible risk of embryo-fetal death based on animal data at >2.2x MRHD
Individuals of Reproductive Potential
in patients of childbearing potential using hormonal contraceptives without levonorgestrel or norethindrone, avoid pregnancy by using effective non-hormonal contraception or alternative hormonal contraceptive (e.g. combined oral contraceptive containing ethinyl estradiol with levonorgestrel or norethindrone, IUD) during tx and x28 days after D/C
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for suzetrigine: liver; CYP450: 3A substrate; Info: active metabolite
Excretion: for suzetrigine: feces 49.9% (9.1% unchanged), urine 44% (none unchanged); Half-life: 23.6h (parent drug), 33h (active metabolite)
Subclass: Analgesics, Peripherally-acting Nonopioids
Mechanism of Action
for suzetrigine: selectively inhibits NaV1.8 sodium channels in peripheral nociceptors, inhibiting pain signaling
Formulary .
No Formulary Selected
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