Select a medication above to begin.
Chlo Hist
dexbrompheniramine/ chlophedianol
Uses .
- [ chlophedianol ]
- antitussive for suppressing cough
- [ dexbrompheniramine ]
- antihistamine for relieving allergic rhinitis, sneezing, itchy/watery eyes, itchy nose/throat
Dosing .
6-11 yo
- [ oral solution ]
- Dose: 5 mL PO q6h prn; Max: 20 mL/24h
12 yo and older
- [ oral solution ]
- Dose: 10 mL PO q6h prn; Max: 40 mL/24h
renal considerations
- [ chlophedianol; dexbrompheniramine ]
- renal impairment: not defined
- HD/PD: not defined
hepatic considerations
- [ chlophedianol; dexbrompheniramine ]
- not defined
Formulations .
oral solution
- [active ingredients per 5 mL]
- chlophedianol 12.5 mg; dexbrompheniramine 1 mg
- [flavors/selected other ingredients]
- grape flavor contains sucralose, no alcohol, no dye, no phenylalanine, no saccharin, no sugar
Contraindications / Cautions .
- hypersensitivity to drug or ingredient ( chlophedianol; dexbrompheniramine )
- patients <2 yo ( dexbrompheniramine )
- caution: asthma ( dexbrompheniramine )
- caution: bladder neck obstruction ( dexbrompheniramine )
- caution: cardiovascular disease ( dexbrompheniramine )
- caution: COPD ( dexbrompheniramine )
- caution: elderly patients ( dexbrompheniramine )
- caution: environmental temperature, high ( dexbrompheniramine )
- caution: GI obstruction ( dexbrompheniramine )
- caution: glaucoma, angle-closure ( dexbrompheniramine )
- caution: HTN ( dexbrompheniramine )
- caution: hyperthyroidism ( dexbrompheniramine )
- caution: IOP incr. ( dexbrompheniramine )
- caution: lower respiratory tract symptoms ( dexbrompheniramine )
- caution: patients <6 yo ( chlophedianol; dexbrompheniramine )
- caution: prostatic hypertrophy ( dexbrompheniramine )
- caution: PUD ( dexbrompheniramine )
Drug Interactions .
Overview
chlophedianol
antitussive
- anticholinergic effects
- CNS depression
- decreases central histamine effects
- tachycardia
dexbrompheniramine
antihistamine, 1st generation
- anticholinergic effects
- CNS depression
- decreases central histamine effects
- tachycardia
Contraindicated
- isocarboxazid
- potassium chloride
- potassium citrate
- tranylcypromine
Contraindicated
chlophedianol + isocarboxazid
contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + isocarboxazid
contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Contraindicated
chlophedianol + potassium chloride
contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
dexbrompheniramine + potassium chloride
contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
Contraindicated
chlophedianol + potassium citrate
contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
dexbrompheniramine + potassium citrate
contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
Contraindicated
chlophedianol + tranylcypromine
contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + tranylcypromine
contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Avoid/Use Alternative
- aclidinium inhaled
- benztropine
- brompheniramine
- butalbital
- carbinoxamine
- chlorcyclizine
- chlorpheniramine
- clemastine
- clonidine
- clozapine
- codeine
- cyproheptadine
- dexbrompheniramine
- dexchlorpheniramine
- dimenhydrinate
- diphenhydramine
- doxylamine
- dronabinol
- eluxadoline
- ethanol (alcoholic beverage)
- ethanol injection
- glucagon
- glycopyrrolate inhaled
- glycopyrronium topical
- haloperidol
- hydrocodone
- hydroxyzine
- ipratropium inhaled
- kava
- kratom
- meclizine
- metaxalone
- metoclopramide
- midazolam
- olanzapine
- oxybate
- phenelzine
- pheniramine
- pitolisant
- pramlintide
- promethazine
- pyrilamine
- revefenacin inhaled
- rivastigmine
- ropeginterferon alfa-2b
- scopolamine
- sofpironium topical
- thalidomide
- tiotropium inhaled
- tradipitant
- trimethobenzamide
- triprolidine
- umeclidinium inhaled
- zuranolone
Avoid/Use Alternative
chlophedianol + aclidinium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + aclidinium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + benztropine
consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)
dexbrompheniramine + benztropine
consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)
Avoid/Use Alternative
dexbrompheniramine + brompheniramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + brompheniramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + butalbital
avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + butalbital
avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
dexbrompheniramine + carbinoxamine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + carbinoxamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + chlorcyclizine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)
Caution Advised
chlophedianol + chlorcyclizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + chlorpheniramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + chlorpheniramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + clemastine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + clemastine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + clonidine
if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + clonidine
if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + clozapine
use alternative: combo may incr. risk of CNS depression, psychomotor impairment, life-threatening anticholinergic adverse effects, including constipation, paralytic ileus (additive effects)
dexbrompheniramine + clozapine
use alternative: combo may incr. risk of CNS depression, psychomotor impairment, life-threatening anticholinergic adverse effects, including constipation, paralytic ileus (additive effects)
Avoid/Use Alternative
chlophedianol + codeine
avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + codeine
avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Avoid/Use Alternative
dexbrompheniramine + cyproheptadine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + cyproheptadine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + dexbrompheniramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + dexbrompheniramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + dexchlorpheniramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + dexchlorpheniramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + dimenhydrinate
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + dimenhydrinate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + diphenhydramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + diphenhydramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + doxylamine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + doxylamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + dronabinol
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)
dexbrompheniramine + dronabinol
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)
Avoid/Use Alternative
chlophedianol + eluxadoline
avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + eluxadoline
avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
Avoid/Use Alternative
chlophedianol + ethanol (alcoholic beverage)
avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + ethanol (alcoholic beverage)
avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + ethanol injection
use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + ethanol injection
use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + glucagon
avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)
dexbrompheniramine + glucagon
avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + glycopyrrolate inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + glycopyrrolate inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + glycopyrronium topical
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + glycopyrronium topical
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + haloperidol
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + haloperidol
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + hydrocodone
avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + hydrocodone
avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Avoid/Use Alternative
dexbrompheniramine + hydroxyzine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)
Monitor/Modify Tx
chlophedianol + hydroxyzine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + ipratropium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + ipratropium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + kava
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + kava
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + kratom
use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + kratom
use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
dexbrompheniramine + meclizine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + meclizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + metaxalone
use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + metaxalone
use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + metoclopramide
use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)
dexbrompheniramine + metoclopramide
use alternative: combo may decr. metoclopramide efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying; additive effects)
Avoid/Use Alternative
chlophedianol + midazolam
use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + midazolam
use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + olanzapine
consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)
dexbrompheniramine + olanzapine
consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)
Avoid/Use Alternative
chlophedianol + oxybate
use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)
dexbrompheniramine + oxybate
use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)
Avoid/Use Alternative
chlophedianol + phenelzine
use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + phenelzine
use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Avoid/Use Alternative
dexbrompheniramine + pheniramine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + pheniramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + pitolisant
avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)
dexbrompheniramine + pitolisant
avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)
Avoid/Use Alternative
chlophedianol + pramlintide
consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + pramlintide
consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
Avoid/Use Alternative
chlophedianol + promethazine
use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + promethazine
use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
dexbrompheniramine + pyrilamine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + pyrilamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + revefenacin inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + revefenacin inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + rivastigmine
use alternative: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + rivastigmine
use alternative: combo may decr. efficacy of both drugs (antagonistic effects)
Avoid/Use Alternative
chlophedianol + ropeginterferon alfa-2b
use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ropeginterferon alfa-2b
use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + scopolamine
use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + scopolamine
use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + sofpironium topical
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + sofpironium topical
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + thalidomide
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + thalidomide
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + tiotropium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + tiotropium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + tradipitant
use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tradipitant
use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
chlophedianol + trimethobenzamide
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + trimethobenzamide
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Avoid/Use Alternative
dexbrompheniramine + triprolidine
avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)
Caution Advised
chlophedianol + triprolidine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + umeclidinium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + umeclidinium inhaled
avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)
Avoid/Use Alternative
chlophedianol + zuranolone
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + zuranolone
use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
- aldesleukin
- alfentanil
- alprazolam
- amitriptyline
- baclofen intrathecal
- buprenorphine
- butorphanol
- carbamazepine
- chlordiazepoxide
- chlorpromazine
- clobazam
- clomipramine
- clonazepam
- clorazepate
- daridorexant
- desflurane
- desipramine
- dexmedetomidine
- dexmedetomidine injection
- diazepam
- dihydrocodeine
- droperidol
- epinephrine
- esketamine
- estazolam
- eszopiclone
- ethanol (in some formulations)
- etomidate
- fentanyl
- fluphenazine
- flurazepam
- gabapentin
- gabapentin enacarbil
- hydromorphone
- ifosfamide
- imipramine
- isoflurane
- ketamine
- lemborexant
- levorphanol
- lorazepam
- meperidine
- methadone
- methohexital
- mirtazapine
- morphine
- nalbuphine
- nelarabine
- nortriptyline
- oliceridine
- opicapone
- opium
- oxazepam
- oxybutynin
- oxycodone
- oxymorphone
- pentazocine
- pentobarbital
- perphenazine
- phenobarbital
- pregabalin
- primidone
- propofol
- protriptyline
- quazepam
- remifentanil
- remimazolam
- sevoflurane
- sufentanil
- suvorexant
- tapentadol
- temazepam
- thioridazine
- thiothixene
- tramadol
- triazolam
- zaleplon
- ziconotide
- zolpidem
Monitor/Modify Tx
chlophedianol + aldesleukin
withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + aldesleukin
withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + alfentanil
monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + alfentanil
monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + alprazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + alprazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + amitriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
dexbrompheniramine + amitriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + baclofen intrathecal
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + baclofen intrathecal
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + buprenorphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + buprenorphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + butorphanol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + butorphanol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + carbamazepine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + carbamazepine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + chlordiazepoxide
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + chlordiazepoxide
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + chlorpromazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + chlorpromazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + clobazam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + clobazam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + clomipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + clomipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + clonazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + clonazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + clorazepate
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + clorazepate
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + daridorexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + daridorexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + desflurane
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + desflurane
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + desipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + desipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + dexmedetomidine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + dexmedetomidine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + dexmedetomidine injection
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + dexmedetomidine injection
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + diazepam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + diazepam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + dihydrocodeine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + dihydrocodeine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + droperidol
decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + droperidol
decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
dexbrompheniramine + epinephrine
monitor HR, ECG: combo may incr. risk of tachycardia, cardiac arrhythmias (additive effects)
Monitor/Modify Tx
chlophedianol + esketamine
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + esketamine
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + estazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + estazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + eszopiclone
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + eszopiclone
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + ethanol (in some formulations)
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + ethanol (in some formulations)
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + etomidate
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + etomidate
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + fentanyl
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + fentanyl
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + fluphenazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + fluphenazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + flurazepam
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + flurazepam
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + gabapentin
monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + gabapentin
monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + gabapentin enacarbil
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + gabapentin enacarbil
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + hydromorphone
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + hydromorphone
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + ifosfamide
D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ifosfamide
D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + imipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + imipramine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + isoflurane
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + isoflurane
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + ketamine
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)
dexbrompheniramine + ketamine
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + lemborexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + lemborexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + levorphanol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + levorphanol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + lorazepam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + lorazepam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + meperidine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + meperidine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + methadone
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + methadone
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + methohexital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + methohexital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + mirtazapine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + mirtazapine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + morphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + morphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + nalbuphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + nalbuphine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + nelarabine
withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + nelarabine
withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + nortriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + nortriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + oliceridine
monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + oliceridine
monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + opicapone
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + opicapone
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + opium
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + opium
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + oxazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + oxazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + oxybutynin
decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)
dexbrompheniramine + oxybutynin
decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)
Monitor/Modify Tx
chlophedianol + oxycodone
monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + oxycodone
monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. dexbrompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + oxymorphone
monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + oxymorphone
monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. dexbrompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + pentazocine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + pentazocine
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + pentobarbital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + pentobarbital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + perphenazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + perphenazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + phenobarbital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + phenobarbital
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + pregabalin
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + pregabalin
monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + primidone
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + primidone
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + propofol
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + propofol
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + protriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
dexbrompheniramine + protriptyline
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + quazepam
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + quazepam
monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + remifentanil
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + remifentanil
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + remimazolam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + remimazolam
monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + sevoflurane
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + sevoflurane
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + sufentanil
monitor respiratory rate; decr. sufentanil start dose, consider decr. chlophedianol dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + sufentanil
monitor respiratory rate; decr. sufentanil start dose, consider decr. dexbrompheniramine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + suvorexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + suvorexant
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + tapentadol
monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + tapentadol
monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + temazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + temazepam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + thioridazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + thioridazine
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + thiothixene
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + thiothixene
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Monitor/Modify Tx
chlophedianol + tramadol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
dexbrompheniramine + tramadol
monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)
Monitor/Modify Tx
chlophedianol + triazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
dexbrompheniramine + triazolam
monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + zaleplon
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + zaleplon
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + ziconotide
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ziconotide
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Monitor/Modify Tx
chlophedianol + zolpidem
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + zolpidem
consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
- 5-HTP
- aceclidine ophthalmic
- allopurinol
- almotriptan
- alosetron
- amantadine
- amoxapine
- apomorphine
- apraclonidine ophthalmic
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- asenapine
- atropine
- atropine ophthalmic
- baclofen
- barium
- belladonna alkaloids
- bethanechol
- botulinum toxin
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- buspirone
- cannabidiol
- cannabis
- cariprazine
- carisoprodol
- cenobamate
- cetirizine
- cevimeline
- chamomile, German
- chlophedianol
- chlorzoxazone
- cisapride
- citalopram
- clidinium
- cyclobenzaprine
- cyclopentolate ophthalmic
- dantrolene
- darifenacin
- desvenlafaxine
- deutetrabenazine
- dichlorphenamide
- dicyclomine
- difelikefalin
- difenoxin
- diphenoxylate
- disopyramide
- domperidone
- donepezil
- doxazosin
- doxepin
- doxepin topical
- duloxetine
- efavirenz
- eletriptan
- elinzanetant
- entacapone
- entrectinib
- erenumab
- erythromycin
- escitalopram
- eslicarbazepine acetate
- ethosuximide
- felbamate
- fenfluramine
- fesoterodine
- flavoxate
- flibanserin
- fluoxetine
- fluvoxamine
- foslevodopa
- fosphenytoin
- frovatriptan
- galantamine
- ganaxolone
- glofitamab
- glycopyrrolate
- guanfacine
- homatropine
- hydrochlorothiazide
- hyoscyamine
- iloperidone
- ipratropium nasal
- lacosamide
- lamotrigine
- levetiracetam
- levocetirizine
- levodopa
- levomilnacipran
- linvoseltamab
- lofexidine
- loperamide
- loxapine
- lumateperone
- lurasidone
- melatonin
- meprobamate
- methacholine inhaled
- methocarbamol
- methscopolamine
- methsuximide
- methyldopa
- metyrapone
- metyrosine
- mexiletine
- milnacipran
- milsaperidone
- mirabegron
- mitotane
- molindone
- mosunetuzumab
- mycophenolate mofetil
- naltrexone
- naratriptan
- nefazodone
- neostigmine
- orphenadrine
- oxcarbazepine
- paliperidone
- paroxetine
- passion flower
- perampanel
- phenytoin
- pilocarpine
- pilocarpine ophthalmic
- pimozide
- potassium acid phosphate
- potassium gluconate
- potassium phosphate
- pramipexole
- procainamide
- procarbazine
- prochlorperazine
- pyridostigmine
- quetiapine
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- ramelteon
- rasagiline
- repotrectinib
- risperidone
- rizatriptan
- ropinirole
- rotigotine transdermal
- rufinamide
- safinamide
- selegiline
- selegiline transdermal
- selinexor
- sertraline
- solifenacin
- stiripentol
- sumatriptan
- tasimelteon
- tetrabenazine
- thiotepa
- tiagabine
- tizanidine
- tolcapone
- tolterodine
- topiramate
- trazodone
- trifluoperazine
- trihexyphenidyl
- trimipramine
- tropicamide ophthalmic
- trospium
- valbenazine
- valerian
- valproic acid
- venlafaxine
- vibegron
- vigabatrin
- vilazodone
- viloxazine
- ziprasidone
- zolmitriptan
- zonisamide
Caution Advised
chlophedianol + 5-HTP
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + 5-HTP
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + aceclidine ophthalmic
caution advised: combo may decr. aceclidine efficacy (antagonistic effects)
dexbrompheniramine + aceclidine ophthalmic
caution advised: combo may decr. aceclidine efficacy (antagonistic effects)
Caution Advised
chlophedianol + allopurinol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + allopurinol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + almotriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + almotriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + alosetron
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + alosetron
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
Caution Advised
chlophedianol + amantadine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + amantadine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + amoxapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + amoxapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + apomorphine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + apomorphine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + apraclonidine ophthalmic
caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + apraclonidine ophthalmic
caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + aripiprazole bimonthly injection
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + aripiprazole bimonthly injection
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + aripiprazole lauroxil
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + aripiprazole lauroxil
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + aripiprazole monthly injection
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + aripiprazole monthly injection
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + aripiprazole oral
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + aripiprazole oral
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + asenapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + asenapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + atropine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + atropine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + atropine ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + atropine ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + baclofen
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + baclofen
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + barium
caution advised: combo may incr. risk of intestinal obstruction (additive effects)
dexbrompheniramine + barium
caution advised: combo may incr. risk of intestinal obstruction (additive effects)
Caution Advised
chlophedianol + belladonna alkaloids
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + belladonna alkaloids
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + bethanechol
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + bethanechol
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + botulinum toxin
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + botulinum toxin
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + brexpiprazole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + brexpiprazole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + brimonidine ophthalmic
caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + brimonidine ophthalmic
caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + brimonidine topical
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + brimonidine topical
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + brivaracetam
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + brivaracetam
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + bromocriptine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + bromocriptine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + buspirone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + buspirone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cannabidiol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + cannabidiol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cannabis
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + cannabis
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cariprazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + cariprazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + carisoprodol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + carisoprodol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cenobamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + cenobamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cetirizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + cetirizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects; duplicate therapy)
Caution Advised
chlophedianol + cevimeline
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + cevimeline
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + chamomile, German
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + chamomile, German
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
dexbrompheniramine + chlophedianol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + chlorzoxazone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + chlorzoxazone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + cisapride
caution advised: combo may decr. cisapride efficacy (antagonistic effects)
dexbrompheniramine + cisapride
caution advised: combo may decr. cisapride efficacy (antagonistic effects)
Caution Advised
chlophedianol + citalopram
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + citalopram
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + clidinium
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + clidinium
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + cyclobenzaprine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + cyclobenzaprine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + cyclopentolate ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + cyclopentolate ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + dantrolene
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + dantrolene
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + darifenacin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + darifenacin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + desvenlafaxine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + desvenlafaxine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + deutetrabenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + deutetrabenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + dichlorphenamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + dichlorphenamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + dicyclomine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + dicyclomine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + difelikefalin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + difelikefalin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + difenoxin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + difenoxin
caution advised: combo may incr. risk of severe constipation, paralytic ileus, CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + diphenoxylate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + diphenoxylate
caution advised: combo may incr. risk of severe constipation, paralytic ileus, CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + disopyramide
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + disopyramide
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + domperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)
dexbrompheniramine + domperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)
Caution Advised
chlophedianol + donepezil
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + donepezil
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + doxazosin
caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)
dexbrompheniramine + doxazosin
caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)
Caution Advised
chlophedianol + doxepin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
dexbrompheniramine + doxepin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + doxepin topical
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + doxepin topical
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + duloxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + duloxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + efavirenz
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + efavirenz
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + eletriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + eletriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + elinzanetant
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + elinzanetant
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + entacapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + entacapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + entrectinib
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + entrectinib
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + erenumab
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + erenumab
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
Caution Advised
chlophedianol + erythromycin
caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)
dexbrompheniramine + erythromycin
caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)
Caution Advised
chlophedianol + escitalopram
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + escitalopram
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + eslicarbazepine acetate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + eslicarbazepine acetate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + ethosuximide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ethosuximide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + felbamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + felbamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + fenfluramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + fenfluramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + fesoterodine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + fesoterodine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + flavoxate
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + flavoxate
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + flibanserin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + flibanserin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + fluoxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + fluoxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + fluvoxamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + fluvoxamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + foslevodopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + foslevodopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + fosphenytoin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + fosphenytoin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + frovatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + frovatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + galantamine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + galantamine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + ganaxolone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ganaxolone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + glofitamab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + glofitamab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + glycopyrrolate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + glycopyrrolate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + guanfacine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + guanfacine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + homatropine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + homatropine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + hydrochlorothiazide
caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)
dexbrompheniramine + hydrochlorothiazide
caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)
Caution Advised
chlophedianol + hyoscyamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + hyoscyamine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + iloperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + iloperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + ipratropium nasal
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + ipratropium nasal
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + lacosamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + lacosamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + lamotrigine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + lamotrigine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + levetiracetam
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + levetiracetam
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + levocetirizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + levocetirizine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + levodopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + levodopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + levomilnacipran
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + levomilnacipran
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + linvoseltamab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + linvoseltamab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + lofexidine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + lofexidine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + loperamide
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
dexbrompheniramine + loperamide
caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)
Caution Advised
chlophedianol + loxapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + loxapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + lumateperone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + lumateperone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + lurasidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + lurasidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + melatonin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + melatonin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + meprobamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + meprobamate
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + methacholine inhaled
caution advised: combo may interfere with test results (antagonistic effects)
dexbrompheniramine + methacholine inhaled
caution advised: combo may interfere with test results (antagonistic effects)
Caution Advised
chlophedianol + methocarbamol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + methocarbamol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + methscopolamine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + methscopolamine
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + methsuximide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + methsuximide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + methyldopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + methyldopa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + metyrapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + metyrapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + metyrosine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + metyrosine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + mexiletine
caution advised: combo may delay antiarrhythmic onset, decr. peak mexiletine levels, efficacy (absorption delayed)
dexbrompheniramine + mexiletine
caution advised: combo may delay antiarrhythmic onset, decr. peak mexiletine levels, efficacy (absorption delayed)
Caution Advised
chlophedianol + milnacipran
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + milnacipran
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + milsaperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + milsaperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + mirabegron
caution advised: combo may incr. risk of urinary retention (additive effects)
dexbrompheniramine + mirabegron
caution advised: combo may incr. risk of urinary retention (additive effects)
Caution Advised
chlophedianol + mitotane
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + mitotane
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + molindone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + molindone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + mosunetuzumab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + mosunetuzumab
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + mycophenolate mofetil
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + mycophenolate mofetil
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + naltrexone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + naltrexone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + naratriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + naratriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + nefazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + nefazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + neostigmine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + neostigmine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + orphenadrine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + orphenadrine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + oxcarbazepine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + oxcarbazepine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + paliperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + paliperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + paroxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + paroxetine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + passion flower
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + passion flower
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + perampanel
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + perampanel
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + phenytoin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + phenytoin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + pilocarpine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + pilocarpine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + pilocarpine ophthalmic
caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)
dexbrompheniramine + pilocarpine ophthalmic
caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)
Caution Advised
chlophedianol + pimozide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + pimozide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + potassium acid phosphate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
dexbrompheniramine + potassium acid phosphate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
Caution Advised
chlophedianol + potassium gluconate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
dexbrompheniramine + potassium gluconate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
Caution Advised
chlophedianol + potassium phosphate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
dexbrompheniramine + potassium phosphate
caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)
Caution Advised
chlophedianol + pramipexole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + pramipexole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + procainamide
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + procainamide
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + procarbazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + procarbazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + prochlorperazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + prochlorperazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + pyridostigmine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
dexbrompheniramine + pyridostigmine
caution advised: combo may decr. efficacy of both drugs (antagonistic effects)
Caution Advised
chlophedianol + quetiapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
dexbrompheniramine + quetiapine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + quinidine (antiarrhythmic)
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + quinidine (antiarrhythmic)
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + quinidine (CYP2D6 inhibitor)
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + quinidine (CYP2D6 inhibitor)
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + ramelteon
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ramelteon
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + rasagiline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + rasagiline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + repotrectinib
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + repotrectinib
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + risperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + risperidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + rizatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + rizatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + ropinirole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + ropinirole
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + rotigotine transdermal
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + rotigotine transdermal
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + rufinamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + rufinamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + safinamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + safinamide
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + selegiline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + selegiline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + selegiline transdermal
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + selegiline transdermal
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + selinexor
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + selinexor
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + sertraline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + sertraline
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + solifenacin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + solifenacin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + stiripentol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + stiripentol
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + sumatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + sumatriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tasimelteon
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tasimelteon
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tetrabenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tetrabenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + thiotepa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + thiotepa
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tiagabine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tiagabine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tizanidine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tizanidine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tolcapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + tolcapone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + tolterodine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + tolterodine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + topiramate
caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + topiramate
caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + trazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + trazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + trifluoperazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + trifluoperazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + trihexyphenidyl
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
dexbrompheniramine + trihexyphenidyl
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + trimipramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + trimipramine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + tropicamide ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
dexbrompheniramine + tropicamide ophthalmic
caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + trospium
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
dexbrompheniramine + trospium
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)
Caution Advised
chlophedianol + valbenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + valbenazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + valerian
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + valerian
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + valproic acid
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + valproic acid
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + venlafaxine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + venlafaxine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + vibegron
caution advised: combo may incr. risk of urinary retention (additive effects)
dexbrompheniramine + vibegron
caution advised: combo may incr. risk of urinary retention (additive effects)
Caution Advised
chlophedianol + vigabatrin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + vigabatrin
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + vilazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + vilazodone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + viloxazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + viloxazine
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + ziprasidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + ziprasidone
caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Caution Advised
chlophedianol + zolmitriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
dexbrompheniramine + zolmitriptan
caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)
Caution Advised
chlophedianol + zonisamide
caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
dexbrompheniramine + zonisamide
caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)
Adverse Reactions .
Serious Reactions
- agranulocytosis ( dexbrompheniramine )
- anaphylactoid reaction ( dexbrompheniramine )
- anaphylaxis ( dexbrompheniramine )
- arrhythmia ( dexbrompheniramine )
- hallucinations ( chlophedianol )
- heat stroke ( dexbrompheniramine )
- hemolytic anemia ( dexbrompheniramine )
- hypersensitivity reaction ( chlophedianol )
- labyrinthitis, acute ( dexbrompheniramine )
- leukopenia ( dexbrompheniramine )
- pancytopenia ( dexbrompheniramine )
- seizures ( dexbrompheniramine )
- thrombocytopenia ( dexbrompheniramine )
- toxic psychosis ( dexbrompheniramine )
Common Reactions
- blurred vision ( dexbrompheniramine )
- CNS stimulation, paradoxical ( chlophedianol ; dexbrompheniramine )
- constipation ( dexbrompheniramine )
- diaphoresis ( dexbrompheniramine )
- diplopia ( dexbrompheniramine )
- dizziness ( chlophedianol ; dexbrompheniramine )
- drowsiness ( chlophedianol ; dexbrompheniramine )
- dry mouth ( chlophedianol )
- dry mucous membranes ( dexbrompheniramine )
- dysuria ( dexbrompheniramine )
- epigastric discomfort ( dexbrompheniramine )
- erectile dysfunction ( dexbrompheniramine )
- headache ( dexbrompheniramine )
- hypotension ( dexbrompheniramine )
- impaired coordination ( dexbrompheniramine )
- irritability ( chlophedianol )
- nausea ( chlophedianol )
- nightmares ( chlophedianol )
- palpitations ( dexbrompheniramine )
- photosensitivity ( dexbrompheniramine )
- tachycardia ( dexbrompheniramine )
- thickened bronchial secretions ( dexbrompheniramine )
- urinary retention ( dexbrompheniramine )
- urticaria ( chlophedianol )
- vertigo ( chlophedianol )
- visual disturbance ( chlophedianol )
- vomiting ( chlophedianol )