Chlo Hist

Overview

chlophedianol

antitussive

1. anticholinergic effects
2. CNS depression
3. decreases central histamine effects
4. tachycardia

dexbrompheniramine

antihistamine, 1st generation

1. anticholinergic effects
2. CNS depression
3. decreases central histamine effects
4. tachycardia

Contraindicated

• isocarboxazid
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

isocarboxazid

2 interactions

Contraindicated

chlophedianol + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• potassium chloride
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

potassium chloride

2 interactions

Contraindicated

chlophedianol + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

dexbrompheniramine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

potassium citrate

2 interactions

Contraindicated

chlophedianol + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

dexbrompheniramine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• tranylcypromine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tranylcypromine

2 interactions

Contraindicated

chlophedianol + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

Avoid/Use Alternative

• aclidinium inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aclidinium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• benztropine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

benztropine

2 interactions

Avoid/Use Alternative

chlophedianol + benztropine

consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus, hyperthermia (additive effects)

dexbrompheniramine + benztropine

consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus, hyperthermia (additive effects)

• brompheniramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

brompheniramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + brompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• butalbital
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

butalbital

2 interactions

Avoid/Use Alternative

chlophedianol + butalbital

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + butalbital

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• carbinoxamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

carbinoxamine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + carbinoxamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorpheniramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chlorpheniramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + chlorpheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clemastine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clemastine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + clemastine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clonidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clonidine

2 interactions

Avoid/Use Alternative

chlophedianol + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clozapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clozapine

2 interactions

Avoid/Use Alternative

chlophedianol + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus (additive effects)

dexbrompheniramine + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus (additive effects)

• codeine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

codeine

2 interactions

Avoid/Use Alternative

chlophedianol + codeine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + codeine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• cyproheptadine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cyproheptadine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + cyproheptadine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexbrompheniramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dexbrompheniramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + dexbrompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + dexbrompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexchlorpheniramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dexchlorpheniramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + dexchlorpheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dimenhydrinate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dimenhydrinate

2 interactions

Avoid/Use Alternative

dexbrompheniramine + dimenhydrinate

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenhydramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

diphenhydramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + diphenhydramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• doxylamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

doxylamine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + doxylamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + doxylamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dronabinol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dronabinol

2 interactions

Avoid/Use Alternative

chlophedianol + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

dexbrompheniramine + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

• eluxadoline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

eluxadoline

2 interactions

Avoid/Use Alternative

chlophedianol + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ethanol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ethanol

2 interactions

Avoid/Use Alternative

chlophedianol + ethanol

avoid combo: coingestion of oral alcohol w/ chlophedianol may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + ethanol

avoid combo: coingestion of oral alcohol w/ dexbrompheniramine may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• glucagon
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

glucagon

2 interactions

Avoid/Use Alternative

chlophedianol + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

dexbrompheniramine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrrolate inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

glycopyrrolate inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + glycopyrrolate inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + glycopyrrolate inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• glycopyrronium topical
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

glycopyrronium topical

2 interactions

Avoid/Use Alternative

chlophedianol + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• hydrocodone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

hydrocodone

2 interactions

Avoid/Use Alternative

chlophedianol + hydrocodone

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + hydrocodone

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxyzine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

hydroxyzine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + hydroxyzine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + hydroxyzine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ipratropium inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ipratropium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + ipratropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + ipratropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• kava
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

kava

2 interactions

Avoid/Use Alternative

chlophedianol + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

kratom

2 interactions

Avoid/Use Alternative

chlophedianol + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meclizine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

meclizine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + meclizine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• metaxalone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

metaxalone

2 interactions

Avoid/Use Alternative

chlophedianol + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• metoclopramide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

metoclopramide

2 interactions

Avoid/Use Alternative

chlophedianol + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

dexbrompheniramine + metoclopramide

use alternative: combo may decr. metoclopramide efficacy; may incr. risk of CNS depression, psychomotor impairment (antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying; additive effects)

• midazolam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

midazolam

2 interactions

Avoid/Use Alternative

chlophedianol + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• olanzapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

olanzapine

2 interactions

Avoid/Use Alternative

chlophedianol + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis), life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus, hyperthermia (additive effects)

dexbrompheniramine + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis), life-threatening anticholinergic adverse effects, incl. constipation, paralytic ileus, hyperthermia (additive effects)

• oxybate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxybate

2 interactions

Avoid/Use Alternative

chlophedianol + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

dexbrompheniramine + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• phenelzine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

phenelzine

2 interactions

Avoid/Use Alternative

chlophedianol + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pheniramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pheniramine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + pheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pitolisant
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pitolisant

2 interactions

Avoid/Use Alternative

chlophedianol + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

dexbrompheniramine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• pramlintide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pramlintide

2 interactions

Avoid/Use Alternative

chlophedianol + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• promethazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

promethazine

2 interactions

Avoid/Use Alternative

chlophedianol + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pyrilamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pyrilamine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + pyrilamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + pyrilamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• revefenacin inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

revefenacin inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + revefenacin inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + revefenacin inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• rivastigmine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

rivastigmine

2 interactions

Avoid/Use Alternative

chlophedianol + rivastigmine

use alternative: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + rivastigmine

use alternative: combo may decr. efficacy of both drugs (antagonistic effects)

• ropeginterferon alfa-2b
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ropeginterferon alfa-2b

2 interactions

Avoid/Use Alternative

chlophedianol + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sofpironium topical
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

sofpironium topical

2 interactions

Avoid/Use Alternative

chlophedianol + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• thalidomide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

thalidomide

2 interactions

Avoid/Use Alternative

chlophedianol + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiotropium inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tiotropium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + tiotropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + tiotropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• trimethobenzamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trimethobenzamide

2 interactions

Avoid/Use Alternative

chlophedianol + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triprolidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

triprolidine

2 interactions

Avoid/Use Alternative

dexbrompheniramine + triprolidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate tx)

Caution Advised

chlophedianol + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• umeclidinium inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

umeclidinium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + umeclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + umeclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• zuranolone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

zuranolone

2 interactions

Avoid/Use Alternative

chlophedianol + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• aldesleukin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aldesleukin

2 interactions

Monitor/Modify Tx

chlophedianol + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alfentanil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

alfentanil

2 interactions

Monitor/Modify Tx

chlophedianol + alfentanil

monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + alfentanil

monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• alprazolam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

alprazolam

2 interactions

Monitor/Modify Tx

chlophedianol + alprazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + alprazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amitriptyline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

amitriptyline

2 interactions

Monitor/Modify Tx

chlophedianol + amitriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

dexbrompheniramine + amitriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• baclofen intrathecal
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

baclofen intrathecal

2 interactions

Monitor/Modify Tx

chlophedianol + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• buprenorphine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

buprenorphine

2 interactions

Monitor/Modify Tx

chlophedianol + buprenorphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + buprenorphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• butorphanol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

butorphanol

2 interactions

Monitor/Modify Tx

chlophedianol + butorphanol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + butorphanol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• carbamazepine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

carbamazepine

2 interactions

Monitor/Modify Tx

chlophedianol + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlordiazepoxide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chlordiazepoxide

2 interactions

Monitor/Modify Tx

chlophedianol + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorpromazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chlorpromazine

2 interactions

Monitor/Modify Tx

chlophedianol + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clobazam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clobazam

2 interactions

Monitor/Modify Tx

chlophedianol + clobazam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + clobazam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clomipramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clomipramine

2 interactions

Monitor/Modify Tx

chlophedianol + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clonazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clonazepam

2 interactions

Monitor/Modify Tx

chlophedianol + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clorazepate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clorazepate

2 interactions

Monitor/Modify Tx

chlophedianol + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• daridorexant
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

daridorexant

2 interactions

Monitor/Modify Tx

chlophedianol + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• desflurane
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

desflurane

2 interactions

Monitor/Modify Tx

chlophedianol + desflurane

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + desflurane

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

desipramine

2 interactions

Monitor/Modify Tx

chlophedianol + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexmedetomidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dexmedetomidine

2 interactions

Monitor/Modify Tx

chlophedianol + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dexmedetomidine injection

2 interactions

Monitor/Modify Tx

chlophedianol + dexmedetomidine injection

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + dexmedetomidine injection

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• diazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

diazepam

2 interactions

Monitor/Modify Tx

chlophedianol + diazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + diazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dihydrocodeine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dihydrocodeine

2 interactions

Monitor/Modify Tx

chlophedianol + dihydrocodeine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + dihydrocodeine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• droperidol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

droperidol

2 interactions

Monitor/Modify Tx

chlophedianol + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• epinephrine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

epinephrine

1 interaction

Monitor/Modify Tx

dexbrompheniramine + epinephrine

monitor HR, ECG: combo may incr. risk of tachycardia, cardiac arrhythmias (additive effects)

• esketamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

esketamine

2 interactions

Monitor/Modify Tx

chlophedianol + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• estazolam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

estazolam

2 interactions

Monitor/Modify Tx

chlophedianol + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

eszopiclone

2 interactions

Monitor/Modify Tx

chlophedianol + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ethanol (in some formulations)

2 interactions

Monitor/Modify Tx

chlophedianol + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etomidate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

etomidate

2 interactions

Monitor/Modify Tx

chlophedianol + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fentanyl
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fentanyl

2 interactions

Monitor/Modify Tx

chlophedianol + fentanyl

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + fentanyl

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• fluphenazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fluphenazine

2 interactions

Monitor/Modify Tx

chlophedianol + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flurazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

flurazepam

2 interactions

Monitor/Modify Tx

chlophedianol + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

gabapentin

2 interactions

Monitor/Modify Tx

chlophedianol + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

gabapentin enacarbil

2 interactions

Monitor/Modify Tx

chlophedianol + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• hydromorphone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

hydromorphone

2 interactions

Monitor/Modify Tx

chlophedianol + hydromorphone

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + hydromorphone

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• ifosfamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ifosfamide

2 interactions

Monitor/Modify Tx

chlophedianol + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• imipramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

imipramine

2 interactions

Monitor/Modify Tx

chlophedianol + imipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + imipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• isoflurane
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

isoflurane

2 interactions

Monitor/Modify Tx

chlophedianol + isoflurane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + isoflurane

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ketamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ketamine

2 interactions

Monitor/Modify Tx

chlophedianol + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

dexbrompheniramine + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• lemborexant
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lemborexant

2 interactions

Monitor/Modify Tx

chlophedianol + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

levorphanol

2 interactions

Monitor/Modify Tx

chlophedianol + levorphanol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + levorphanol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• lorazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lorazepam

2 interactions

Monitor/Modify Tx

chlophedianol + lorazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + lorazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meperidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

meperidine

2 interactions

Monitor/Modify Tx

chlophedianol + meperidine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + meperidine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• methadone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methadone

2 interactions

Monitor/Modify Tx

chlophedianol + methadone

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + methadone

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• methohexital
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methohexital

2 interactions

Monitor/Modify Tx

chlophedianol + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mirtazapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mirtazapine

2 interactions

Monitor/Modify Tx

chlophedianol + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• morphine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

morphine

2 interactions

Monitor/Modify Tx

chlophedianol + morphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + morphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• nalbuphine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

nalbuphine

2 interactions

Monitor/Modify Tx

chlophedianol + nalbuphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + nalbuphine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• nelarabine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

nelarabine

2 interactions

Monitor/Modify Tx

chlophedianol + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nortriptyline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

nortriptyline

2 interactions

Monitor/Modify Tx

chlophedianol + nortriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + nortriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• oliceridine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oliceridine

2 interactions

Monitor/Modify Tx

chlophedianol + oliceridine

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + oliceridine

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• opicapone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

opicapone

2 interactions

Monitor/Modify Tx

chlophedianol + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• opium
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

opium

2 interactions

Monitor/Modify Tx

chlophedianol + opium

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + opium

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• oxazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxazepam

2 interactions

Monitor/Modify Tx

chlophedianol + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxybutynin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxybutynin

2 interactions

Monitor/Modify Tx

chlophedianol + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

dexbrompheniramine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxycodone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxycodone

2 interactions

Monitor/Modify Tx

chlophedianol + oxycodone

monitor resp. rate; decr. oxycodone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + oxycodone

monitor resp. rate; decr. oxycodone start dose by at least 50%, consider decr. dexbrompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• oxymorphone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxymorphone

2 interactions

Monitor/Modify Tx

chlophedianol + oxymorphone

monitor resp. rate; decr. oxymorphone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + oxymorphone

monitor resp. rate; decr. oxymorphone start dose by at least 50%, consider decr. dexbrompheniramine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pentazocine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pentazocine

2 interactions

Monitor/Modify Tx

chlophedianol + pentazocine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + pentazocine

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pentobarbital
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pentobarbital

2 interactions

Monitor/Modify Tx

chlophedianol + pentobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + pentobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• perphenazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

perphenazine

2 interactions

Monitor/Modify Tx

chlophedianol + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenobarbital
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

phenobarbital

2 interactions

Monitor/Modify Tx

chlophedianol + phenobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + phenobarbital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pregabalin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pregabalin

2 interactions

Monitor/Modify Tx

chlophedianol + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• primidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

primidone

2 interactions

Monitor/Modify Tx

chlophedianol + primidone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + primidone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• propofol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

propofol

2 interactions

Monitor/Modify Tx

chlophedianol + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• protriptyline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

protriptyline

2 interactions

Monitor/Modify Tx

chlophedianol + protriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

dexbrompheniramine + protriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• quazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

quazepam

2 interactions

Monitor/Modify Tx

chlophedianol + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• remifentanil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

remifentanil

2 interactions

Monitor/Modify Tx

chlophedianol + remifentanil

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + remifentanil

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• remimazolam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

remimazolam

2 interactions

Monitor/Modify Tx

chlophedianol + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• sevoflurane
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

sevoflurane

2 interactions

Monitor/Modify Tx

chlophedianol + sevoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + sevoflurane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• sufentanil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

sufentanil

2 interactions

Monitor/Modify Tx

chlophedianol + sufentanil

monitor resp. rate; decr. sufentanil start dose, consider decr. chlophedianol dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + sufentanil

monitor resp. rate; decr. sufentanil start dose, consider decr. dexbrompheniramine dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• suvorexant
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

suvorexant

2 interactions

Monitor/Modify Tx

chlophedianol + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tapentadol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tapentadol

2 interactions

Monitor/Modify Tx

chlophedianol + tapentadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + tapentadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• temazepam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

temazepam

2 interactions

Monitor/Modify Tx

chlophedianol + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• thioridazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

thioridazine

2 interactions

Monitor/Modify Tx

chlophedianol + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thiothixene
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

thiothixene

2 interactions

Monitor/Modify Tx

chlophedianol + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tramadol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tramadol

2 interactions

Monitor/Modify Tx

chlophedianol + tramadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

dexbrompheniramine + tramadol

monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• triazolam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

triazolam

2 interactions

Monitor/Modify Tx

chlophedianol + triazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

dexbrompheniramine + triazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• zaleplon
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

zaleplon

2 interactions

Monitor/Modify Tx

chlophedianol + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ziconotide

2 interactions

Monitor/Modify Tx

chlophedianol + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

zolpidem

2 interactions

Monitor/Modify Tx

chlophedianol + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Caution Advised

• 5-HTP
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

5-HTP

2 interactions

Caution Advised

chlophedianol + 5-HTP

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + 5-HTP

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• allopurinol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

allopurinol

2 interactions

Caution Advised

chlophedianol + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + allopurinol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• almotriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

almotriptan

2 interactions

Caution Advised

chlophedianol + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alosetron
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

alosetron

2 interactions

Caution Advised

chlophedianol + alosetron

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + alosetron

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• amantadine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

amantadine

2 interactions

Caution Advised

chlophedianol + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + amantadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• amoxapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

amoxapine

2 interactions

Caution Advised

chlophedianol + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• apomorphine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

apomorphine

2 interactions

Caution Advised

chlophedianol + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + apomorphine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

apraclonidine ophthalmic

2 interactions

Caution Advised

chlophedianol + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + apraclonidine ophthalmic

caution advised if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aripiprazole bimonthly injection

2 interactions

Caution Advised

chlophedianol + aripiprazole bimonthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + aripiprazole bimonthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole lauroxil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aripiprazole lauroxil

2 interactions

Caution Advised

chlophedianol + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + aripiprazole lauroxil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole monthly injection
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aripiprazole monthly injection

2 interactions

Caution Advised

chlophedianol + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + aripiprazole monthly injection

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• aripiprazole oral
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

aripiprazole oral

2 interactions

Caution Advised

chlophedianol + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + aripiprazole oral

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• asenapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

asenapine

2 interactions

Caution Advised

chlophedianol + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + asenapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• atropine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

atropine

2 interactions

Caution Advised

chlophedianol + atropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + atropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• atropine ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

atropine ophthalmic

2 interactions

Caution Advised

chlophedianol + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• baclofen
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

baclofen

2 interactions

Caution Advised

chlophedianol + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + baclofen

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• barium
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

barium

2 interactions

Caution Advised

chlophedianol + barium

caution advised: combo may incr. risk of intestinal obstruction (additive effects)

dexbrompheniramine + barium

caution advised: combo may incr. risk of intestinal obstruction (additive effects)

• belladonna alkaloids
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

belladonna alkaloids

2 interactions

Caution Advised

chlophedianol + belladonna alkaloids

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + belladonna alkaloids

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• bethanechol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

bethanechol

2 interactions

Caution Advised

chlophedianol + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + bethanechol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• botulinum toxin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

botulinum toxin

2 interactions

Caution Advised

chlophedianol + botulinum toxin

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + botulinum toxin

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• brexpiprazole
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

brexpiprazole

2 interactions

Caution Advised

chlophedianol + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + brexpiprazole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• brimonidine ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

brimonidine ophthalmic

2 interactions

Caution Advised

chlophedianol + brimonidine ophthalmic

caution advised if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + brimonidine ophthalmic

caution advised if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brimonidine topical
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

brimonidine topical

2 interactions

Caution Advised

chlophedianol + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + brimonidine topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• brivaracetam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

brivaracetam

2 interactions

Caution Advised

chlophedianol + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + brivaracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• bromocriptine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

bromocriptine

2 interactions

Caution Advised

chlophedianol + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• buspirone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

buspirone

2 interactions

Caution Advised

chlophedianol + buspirone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + buspirone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabidiol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cannabidiol

2 interactions

Caution Advised

chlophedianol + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + cannabidiol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cannabis
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cannabis

2 interactions

Caution Advised

chlophedianol + cannabis

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + cannabis

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cariprazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cariprazine

2 interactions

Caution Advised

chlophedianol + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + cariprazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• carisoprodol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

carisoprodol

2 interactions

Caution Advised

chlophedianol + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + carisoprodol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cenobamate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cenobamate

2 interactions

Caution Advised

chlophedianol + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + cenobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cetirizine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cetirizine

2 interactions

Caution Advised

chlophedianol + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + cetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects; duplicate tx)

• cevimeline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cevimeline

2 interactions

Caution Advised

chlophedianol + cevimeline

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + cevimeline

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• chamomile, German
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chamomile, German

2 interactions

Caution Advised

chlophedianol + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + chamomile, German

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlophedianol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chlophedianol

1 interaction

Caution Advised

dexbrompheniramine + chlophedianol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorzoxazone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

chlorzoxazone

2 interactions

Caution Advised

chlophedianol + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + chlorzoxazone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cisapride
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cisapride

2 interactions

Caution Advised

chlophedianol + cisapride

caution advised: combo may decr. cisapride efficacy (antagonistic effects)

dexbrompheniramine + cisapride

caution advised: combo may decr. cisapride efficacy (antagonistic effects)

• citalopram
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

citalopram

2 interactions

Caution Advised

chlophedianol + citalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + citalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• clidinium
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

clidinium

2 interactions

Caution Advised

chlophedianol + clidinium

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + clidinium

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• cyclobenzaprine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cyclobenzaprine

2 interactions

Caution Advised

chlophedianol + cyclobenzaprine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + cyclobenzaprine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• cyclopentolate ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

cyclopentolate ophthalmic

2 interactions

Caution Advised

chlophedianol + cyclopentolate ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + cyclopentolate ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• dantrolene
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dantrolene

2 interactions

Caution Advised

chlophedianol + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + dantrolene

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darifenacin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

darifenacin

2 interactions

Caution Advised

chlophedianol + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + darifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• desvenlafaxine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

desvenlafaxine

2 interactions

Caution Advised

chlophedianol + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deutetrabenazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

deutetrabenazine

2 interactions

Caution Advised

chlophedianol + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + deutetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dichlorphenamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dichlorphenamide

2 interactions

Caution Advised

chlophedianol + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dicyclomine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

dicyclomine

2 interactions

Caution Advised

chlophedianol + dicyclomine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + dicyclomine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• difelikefalin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

difelikefalin

2 interactions

Caution Advised

chlophedianol + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + difelikefalin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• difenoxin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

difenoxin

2 interactions

Caution Advised

chlophedianol + difenoxin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + difenoxin

caution advised: combo may incr. risk of severe constipation, paralytic ileus, CNS depression, psychomotor impairment (additive effects)

• diphenoxylate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

diphenoxylate

2 interactions

Caution Advised

chlophedianol + diphenoxylate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + diphenoxylate

caution advised: combo may incr. risk of severe constipation, paralytic ileus, CNS depression, psychomotor impairment (additive effects)

• disopyramide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

disopyramide

2 interactions

Caution Advised

chlophedianol + disopyramide

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + disopyramide

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• domperidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

domperidone

2 interactions

Caution Advised

chlophedianol + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

dexbrompheniramine + domperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• donepezil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

donepezil

2 interactions

Caution Advised

chlophedianol + donepezil

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + donepezil

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• doxazosin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

doxazosin

2 interactions

Caution Advised

chlophedianol + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)

dexbrompheniramine + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)

• doxepin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

doxepin

2 interactions

Caution Advised

chlophedianol + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

dexbrompheniramine + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• doxepin topical
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

doxepin topical

2 interactions

Caution Advised

chlophedianol + doxepin topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + doxepin topical

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• duloxetine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

duloxetine

2 interactions

Caution Advised

chlophedianol + duloxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + duloxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• efavirenz
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

efavirenz

2 interactions

Caution Advised

chlophedianol + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + efavirenz

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eletriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

eletriptan

2 interactions

Caution Advised

chlophedianol + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entacapone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

entacapone

2 interactions

Caution Advised

chlophedianol + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + entacapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• entrectinib
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

entrectinib

2 interactions

Caution Advised

chlophedianol + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + entrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• erenumab
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

erenumab

2 interactions

Caution Advised

chlophedianol + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• erythromycin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

erythromycin

2 interactions

Caution Advised

chlophedianol + erythromycin

caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)

dexbrompheniramine + erythromycin

caution advised: combo may decr. erythromycin efficacy when used for GI promotility (antagonistic effects)

• escitalopram
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

escitalopram

2 interactions

Caution Advised

chlophedianol + escitalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + escitalopram

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

eslicarbazepine acetate

2 interactions

Caution Advised

chlophedianol + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + eslicarbazepine acetate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethosuximide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ethosuximide

2 interactions

Caution Advised

chlophedianol + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ethosuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• felbamate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

felbamate

2 interactions

Caution Advised

chlophedianol + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + felbamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenfluramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fenfluramine

2 interactions

Caution Advised

chlophedianol + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fesoterodine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fesoterodine

2 interactions

Caution Advised

chlophedianol + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + fesoterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flavoxate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

flavoxate

2 interactions

Caution Advised

chlophedianol + flavoxate

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + flavoxate

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• flibanserin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

flibanserin

2 interactions

Caution Advised

chlophedianol + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + flibanserin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluoxetine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fluoxetine

2 interactions

Caution Advised

chlophedianol + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + fluoxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fluvoxamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fluvoxamine

2 interactions

Caution Advised

chlophedianol + fluvoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + fluvoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• foslevodopa
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

foslevodopa

2 interactions

Caution Advised

chlophedianol + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + foslevodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fosphenytoin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

fosphenytoin

2 interactions

Caution Advised

chlophedianol + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + fosphenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• frovatriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

frovatriptan

2 interactions

Caution Advised

chlophedianol + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• galantamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

galantamine

2 interactions

Caution Advised

chlophedianol + galantamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + galantamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• ganaxolone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ganaxolone

2 interactions

Caution Advised

chlophedianol + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ganaxolone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glofitamab
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

glofitamab

2 interactions

Caution Advised

chlophedianol + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + glofitamab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• glycopyrrolate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

glycopyrrolate

2 interactions

Caution Advised

chlophedianol + glycopyrrolate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + glycopyrrolate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• guanfacine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

guanfacine

2 interactions

Caution Advised

chlophedianol + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• haloperidol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

haloperidol

2 interactions

Caution Advised

chlophedianol + haloperidol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + haloperidol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• homatropine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

homatropine

2 interactions

Caution Advised

chlophedianol + homatropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + homatropine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• hydrochlorothiazide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

hydrochlorothiazide

2 interactions

Caution Advised

chlophedianol + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

dexbrompheniramine + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

• hyoscyamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

hyoscyamine

2 interactions

Caution Advised

chlophedianol + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• iloperidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

iloperidone

2 interactions

Caution Advised

chlophedianol + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + iloperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ipratropium nasal
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ipratropium nasal

2 interactions

Caution Advised

chlophedianol + ipratropium nasal

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + ipratropium nasal

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• lacosamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lacosamide

2 interactions

Caution Advised

chlophedianol + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + lacosamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lamotrigine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lamotrigine

2 interactions

Caution Advised

chlophedianol + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + lamotrigine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lasmiditan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lasmiditan

2 interactions

Caution Advised

chlophedianol + lasmiditan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + lasmiditan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levetiracetam
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

levetiracetam

2 interactions

Caution Advised

chlophedianol + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + levetiracetam

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levocetirizine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

levocetirizine

2 interactions

Caution Advised

chlophedianol + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + levocetirizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levodopa
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

levodopa

2 interactions

Caution Advised

chlophedianol + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + levodopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levomilnacipran
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

levomilnacipran

2 interactions

Caution Advised

chlophedianol + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lofexidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lofexidine

2 interactions

Caution Advised

chlophedianol + lofexidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + lofexidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• loperamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

loperamide

2 interactions

Caution Advised

chlophedianol + loperamide

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

dexbrompheniramine + loperamide

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• loxapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

loxapine

2 interactions

Caution Advised

chlophedianol + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + loxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• lumateperone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lumateperone

2 interactions

Caution Advised

chlophedianol + lumateperone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + lumateperone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• lurasidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

lurasidone

2 interactions

Caution Advised

chlophedianol + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + lurasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• melatonin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

melatonin

2 interactions

Caution Advised

chlophedianol + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + melatonin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• meprobamate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

meprobamate

2 interactions

Caution Advised

chlophedianol + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + meprobamate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methacholine inhaled
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methacholine inhaled

2 interactions

Caution Advised

chlophedianol + methacholine inhaled

caution advised: combo may interfere w/ test results (antagonistic effects)

dexbrompheniramine + methacholine inhaled

caution advised: combo may interfere w/ test results (antagonistic effects)

• methocarbamol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methocarbamol

2 interactions

Caution Advised

chlophedianol + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + methocarbamol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methscopolamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methscopolamine

2 interactions

Caution Advised

chlophedianol + methscopolamine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + methscopolamine

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• methsuximide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methsuximide

2 interactions

Caution Advised

chlophedianol + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + methsuximide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methyldopa
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

methyldopa

2 interactions

Caution Advised

chlophedianol + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrapone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

metyrapone

2 interactions

Caution Advised

chlophedianol + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + metyrapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• metyrosine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

metyrosine

2 interactions

Caution Advised

chlophedianol + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + metyrosine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mexiletine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mexiletine

2 interactions

Caution Advised

chlophedianol + mexiletine

caution advised: combo may delay antiarrhythmic onset, decr. peak mexiletine levels, efficacy (absorption delayed)

dexbrompheniramine + mexiletine

caution advised: combo may delay antiarrhythmic onset, decr. peak mexiletine levels, efficacy (absorption delayed)

• milnacipran
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

milnacipran

2 interactions

Caution Advised

chlophedianol + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mirabegron
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mirabegron

2 interactions

Caution Advised

chlophedianol + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

dexbrompheniramine + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• mitotane
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mitotane

2 interactions

Caution Advised

chlophedianol + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + mitotane

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• molindone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

molindone

2 interactions

Caution Advised

chlophedianol + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + molindone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• mosunetuzumab
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mosunetuzumab

2 interactions

Caution Advised

chlophedianol + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + mosunetuzumab

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

mycophenolate mofetil

2 interactions

Caution Advised

chlophedianol + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + mycophenolate mofetil

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naltrexone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

naltrexone

2 interactions

Caution Advised

chlophedianol + naltrexone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + naltrexone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• naratriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

naratriptan

2 interactions

Caution Advised

chlophedianol + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nefazodone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

nefazodone

2 interactions

Caution Advised

chlophedianol + nefazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + nefazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• neostigmine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

neostigmine

2 interactions

Caution Advised

chlophedianol + neostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + neostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• orphenadrine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

orphenadrine

2 interactions

Caution Advised

chlophedianol + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• oxcarbazepine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

oxcarbazepine

2 interactions

Caution Advised

chlophedianol + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + oxcarbazepine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• paliperidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

paliperidone

2 interactions

Caution Advised

chlophedianol + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + paliperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• paroxetine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

paroxetine

2 interactions

Caution Advised

chlophedianol + paroxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + paroxetine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• passion flower
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

passion flower

2 interactions

Caution Advised

chlophedianol + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + passion flower

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• perampanel
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

perampanel

2 interactions

Caution Advised

chlophedianol + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + perampanel

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• phenytoin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

phenytoin

2 interactions

Caution Advised

chlophedianol + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + phenytoin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• pilocarpine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pilocarpine

2 interactions

Caution Advised

chlophedianol + pilocarpine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + pilocarpine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pilocarpine ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pilocarpine ophthalmic

2 interactions

Caution Advised

chlophedianol + pilocarpine ophthalmic

caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)

dexbrompheniramine + pilocarpine ophthalmic

caution advised: combo may decr. pilocarpine efficacy (antagonistic effects)

• pimozide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pimozide

2 interactions

Caution Advised

chlophedianol + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + pimozide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• potassium acid phosphate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

potassium acid phosphate

2 interactions

Caution Advised

chlophedianol + potassium acid phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

dexbrompheniramine + potassium acid phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium gluconate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

potassium gluconate

2 interactions

Caution Advised

chlophedianol + potassium gluconate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

dexbrompheniramine + potassium gluconate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium phosphate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

potassium phosphate

2 interactions

Caution Advised

chlophedianol + potassium phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

dexbrompheniramine + potassium phosphate

caution advised w/ solid potassium formulations; liquid potassium formulations OK: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• pramipexole
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pramipexole

2 interactions

Caution Advised

chlophedianol + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + pramipexole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• procainamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

procainamide

2 interactions

Caution Advised

chlophedianol + procainamide

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + procainamide

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• procarbazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

procarbazine

2 interactions

Caution Advised

chlophedianol + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• prochlorperazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

prochlorperazine

2 interactions

Caution Advised

chlophedianol + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + prochlorperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pyridostigmine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

pyridostigmine

2 interactions

Caution Advised

chlophedianol + pyridostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

dexbrompheniramine + pyridostigmine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• quetiapine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

quetiapine

2 interactions

Caution Advised

chlophedianol + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

dexbrompheniramine + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• quinidine (antiarrhythmic)
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

quinidine (antiarrhythmic)

2 interactions

Caution Advised

chlophedianol + quinidine (antiarrhythmic)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + quinidine (antiarrhythmic)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• quinidine (CYP2D6 inhibitor)
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

quinidine (CYP2D6 inhibitor)

2 interactions

Caution Advised

chlophedianol + quinidine (CYP2D6 inhibitor)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + quinidine (CYP2D6 inhibitor)

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• ramelteon
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ramelteon

2 interactions

Caution Advised

chlophedianol + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ramelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rasagiline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

rasagiline

2 interactions

Caution Advised

chlophedianol + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• repotrectinib
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

repotrectinib

2 interactions

Caution Advised

chlophedianol + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + repotrectinib

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• risperidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

risperidone

2 interactions

Caution Advised

chlophedianol + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + risperidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• rizatriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

rizatriptan

2 interactions

Caution Advised

chlophedianol + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ropinirole

2 interactions

Caution Advised

chlophedianol + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

rotigotine transdermal

2 interactions

Caution Advised

chlophedianol + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rufinamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

rufinamide

2 interactions

Caution Advised

chlophedianol + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + rufinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

safinamide

2 interactions

Caution Advised

chlophedianol + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• scopolamine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

scopolamine

2 interactions

Caution Advised

chlophedianol + scopolamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + scopolamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• selegiline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

selegiline

2 interactions

Caution Advised

chlophedianol + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline transdermal
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

selegiline transdermal

2 interactions

Caution Advised

chlophedianol + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selinexor
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

selinexor

2 interactions

Caution Advised

chlophedianol + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + selinexor

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sertraline
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

sertraline

2 interactions

Caution Advised

chlophedianol + sertraline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + sertraline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• solifenacin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

solifenacin

2 interactions

Caution Advised

chlophedianol + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + solifenacin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• stiripentol
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

stiripentol

2 interactions

Caution Advised

chlophedianol + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + stiripentol

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sumatriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

sumatriptan

2 interactions

Caution Advised

chlophedianol + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tasimelteon
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tasimelteon

2 interactions

Caution Advised

chlophedianol + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + tasimelteon

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tetrabenazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tetrabenazine

2 interactions

Caution Advised

chlophedianol + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + tetrabenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• thiotepa
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

thiotepa

2 interactions

Caution Advised

chlophedianol + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + thiotepa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiagabine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tiagabine

2 interactions

Caution Advised

chlophedianol + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + tiagabine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tizanidine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tizanidine

2 interactions

Caution Advised

chlophedianol + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + tizanidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolcapone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tolcapone

2 interactions

Caution Advised

chlophedianol + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + tolcapone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tolterodine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tolterodine

2 interactions

Caution Advised

chlophedianol + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + tolterodine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• topiramate
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

topiramate

2 interactions

Caution Advised

chlophedianol + topiramate

caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + topiramate

caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• trazodone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trazodone

2 interactions

Caution Advised

chlophedianol + trazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + trazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trifluoperazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trifluoperazine

2 interactions

Caution Advised

chlophedianol + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + trifluoperazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trihexyphenidyl
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trihexyphenidyl

2 interactions

Caution Advised

chlophedianol + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

dexbrompheniramine + trihexyphenidyl

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• trimipramine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trimipramine

2 interactions

Caution Advised

chlophedianol + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• tropicamide ophthalmic
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

tropicamide ophthalmic

2 interactions

Caution Advised

chlophedianol + tropicamide ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

dexbrompheniramine + tropicamide ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• trospium
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

trospium

2 interactions

Caution Advised

chlophedianol + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

dexbrompheniramine + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• valbenazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

valbenazine

2 interactions

Caution Advised

chlophedianol + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + valbenazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valerian
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

valerian

2 interactions

Caution Advised

chlophedianol + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + valerian

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• valproic acid
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

valproic acid

2 interactions

Caution Advised

chlophedianol + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + valproic acid

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• venlafaxine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

venlafaxine

2 interactions

Caution Advised

chlophedianol + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vibegron
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

vibegron

2 interactions

Caution Advised

chlophedianol + vibegron

caution advised: combo may incr. risk of urinary retention (additive effects)

dexbrompheniramine + vibegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• vigabatrin
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

vigabatrin

2 interactions

Caution Advised

chlophedianol + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + vigabatrin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• vilazodone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

vilazodone

2 interactions

Caution Advised

chlophedianol + vilazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + vilazodone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• viloxazine
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

viloxazine

2 interactions

Caution Advised

chlophedianol + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziprasidone
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

ziprasidone

2 interactions

Caution Advised

chlophedianol + ziprasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + ziprasidone

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• zolmitriptan
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

zolmitriptan

2 interactions

Caution Advised

chlophedianol + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

dexbrompheniramine + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zonisamide
Chlo Hist (dexbrompheniramine/ chlophedianol)

+

zonisamide

2 interactions

Caution Advised

chlophedianol + zonisamide

caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

dexbrompheniramine + zonisamide

caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)