Ninjacof-D

Overview

chlophedianol

antitussive

1. anticholinergic effects
2. CNS depression
3. decreases central histamine effects
4. tachycardia

pseudoephedrine

alpha-1/beta-2 agonist

1. hyperglycemic effects
2. hypertensive effects
3. tachycardia
4. urine pH sensitive

1. add MAO inhibitor to Interaction Check if recent (14 days) use

pyrilamine

antihistamine, 1st generation

1. anticholinergic effects
2. CNS depression
3. decreases central histamine effects
4. tachycardia

Contraindicated

• dihydroergotamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dihydroergotamine

1 interaction

Contraindicated

pseudoephedrine + dihydroergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• ergotamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ergotamine

1 interaction

Contraindicated

pseudoephedrine + ergotamine

contraindicated: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• isocarboxazid
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

isocarboxazid

3 interactions

Contraindicated

chlophedianol + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pseudoephedrine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

pyrilamine + isocarboxazid

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• phenelzine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenelzine

3 interactions

Contraindicated

pseudoephedrine + phenelzine

contraindicated w/in 14 days of phenelzine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Avoid/Use Alternative

chlophedianol + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + phenelzine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• potassium chloride
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

potassium chloride

2 interactions

Contraindicated

chlophedianol + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

pyrilamine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

potassium citrate

3 interactions

Contraindicated

chlophedianol + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

pyrilamine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

Caution Advised

pseudoephedrine + potassium citrate

caution advised w/ frequent or high-dose potassium citrate: combo may incr. pseudoephedrine levels, risk of adverse effects (renal excretion decreased in alkaline urine)

• tranylcypromine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tranylcypromine

3 interactions

Contraindicated

chlophedianol + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pseudoephedrine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

pyrilamine + tranylcypromine

contraindicated: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

Avoid/Use Alternative

• aclidinium inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

aclidinium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + aclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• albuterol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

albuterol

1 interaction

Avoid/Use Alternative

pseudoephedrine + albuterol

use alternative or monitor BP, HR w/ oral albuterol; risk may be lower w/ inhaled albuterol: combo may incr. risk of HTN, tachycardia (additive effects)

• benztropine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

benztropine

2 interactions

Avoid/Use Alternative

chlophedianol + benztropine

consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

pyrilamine + benztropine

consider alternative: combo may incr. risk of life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• brompheniramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

brompheniramine

2 interactions

Avoid/Use Alternative

pyrilamine + brompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + brompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• butalbital
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

butalbital

2 interactions

Avoid/Use Alternative

chlophedianol + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• carbinoxamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

carbinoxamine

2 interactions

Avoid/Use Alternative

pyrilamine + carbinoxamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + carbinoxamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorcyclizine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlorcyclizine

2 interactions

Avoid/Use Alternative

pyrilamine + chlorcyclizine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + chlorcyclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorpheniramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlorpheniramine

2 interactions

Avoid/Use Alternative

pyrilamine + chlorpheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + chlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clemastine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clemastine

2 interactions

Avoid/Use Alternative

pyrilamine + clemastine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + clemastine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clonidine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clonidine

3 interactions

Avoid/Use Alternative

chlophedianol + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

pseudoephedrine + clonidine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clozapine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clozapine

2 interactions

Avoid/Use Alternative

chlophedianol + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, life-threatening anticholinergic adverse effects, including constipation, paralytic ileus (additive effects)

pyrilamine + clozapine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, severe constipation, paralytic ileus (including life-threatening), other anticholinergic adverse effects (additive effects)

• cocaine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cocaine

1 interaction

Avoid/Use Alternative

pseudoephedrine + cocaine

use alternative or monitor BP, HR, ECG: combo may incr. risk of severe vasoconstriction, HTN, tachycardia, arrhythmias (additive effects)

• codeine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

codeine

2 interactions

Avoid/Use Alternative

chlophedianol + codeine

avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + codeine

avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• cyproheptadine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cyproheptadine

2 interactions

Avoid/Use Alternative

pyrilamine + cyproheptadine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + cyproheptadine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexbrompheniramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexbrompheniramine

2 interactions

Avoid/Use Alternative

pyrilamine + dexbrompheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects; duplicate therapy)

Caution Advised

chlophedianol + dexbrompheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dexchlorpheniramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexchlorpheniramine

2 interactions

Avoid/Use Alternative

pyrilamine + dexchlorpheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + dexchlorpheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dimenhydrinate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dimenhydrinate

2 interactions

Avoid/Use Alternative

pyrilamine + dimenhydrinate

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + dimenhydrinate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• diphenhydramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diphenhydramine

2 interactions

Avoid/Use Alternative

pyrilamine + diphenhydramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + diphenhydramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• doxylamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

doxylamine

2 interactions

Avoid/Use Alternative

pyrilamine + doxylamine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + doxylamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• dronabinol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dronabinol

3 interactions

Avoid/Use Alternative

chlophedianol + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

pyrilamine + dronabinol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

Monitor/Modify Tx

pseudoephedrine + dronabinol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• eluxadoline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

eluxadoline

2 interactions

Avoid/Use Alternative

chlophedianol + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

pyrilamine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ephedra
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ephedra

1 interaction

Avoid/Use Alternative

pseudoephedrine + ephedra

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects, ephedra may contain pseudoephedrine)

• epinephrine inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

epinephrine inhaled

1 interaction

Avoid/Use Alternative

pseudoephedrine + epinephrine inhaled

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• ethanol (alcoholic beverage)
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ethanol (alcoholic beverage)

3 interactions

Avoid/Use Alternative

chlophedianol + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

pseudoephedrine + ethanol (alcoholic beverage)

monitor BP: combo may incr. risk of HTN (chronic alcohol use) (additive effects)

• ethanol injection
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ethanol injection

2 interactions

Avoid/Use Alternative

chlophedianol + ethanol injection

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + ethanol injection

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• furosemide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

furosemide

1 interaction

Avoid/Use Alternative

pseudoephedrine + furosemide

use alternative or monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• glucagon
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glucagon

2 interactions

Avoid/Use Alternative

chlophedianol + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

pyrilamine + glucagon

avoid combo if glucagon used as radiologic diagnostic aid: combo may incr. risk of severe constipation, paralytic ileus, other GI adverse effects (additive effects)

• glycopyrrolate inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glycopyrrolate inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + glycopyrrolate inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

Caution Advised

pyrilamine + glycopyrrolate inhaled

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• glycopyrronium topical
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glycopyrronium topical

2 interactions

Avoid/Use Alternative

chlophedianol + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + glycopyrronium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• haloperidol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

haloperidol

2 interactions

Avoid/Use Alternative

chlophedianol + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + haloperidol

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hydrocodone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydrocodone

2 interactions

Avoid/Use Alternative

chlophedianol + hydrocodone

avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + hydrocodone

avoid combo if antitussive use; otherwise, monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxyzine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydroxyzine

2 interactions

Avoid/Use Alternative

pyrilamine + hydroxyzine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic and other adverse effects (additive effects, duplicate therapy)

Monitor/Modify Tx

chlophedianol + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ipratropium inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ipratropium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + ipratropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + ipratropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• kava
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

kava

2 interactions

Avoid/Use Alternative

chlophedianol + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

kratom

2 interactions

Avoid/Use Alternative

chlophedianol + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• landiolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

landiolol

1 interaction

Avoid/Use Alternative

pseudoephedrine + landiolol

use alternative or monitor HR, BP: combo may decr. landiolol efficacy (antagonistic effects)

• meclizine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

meclizine

2 interactions

Avoid/Use Alternative

pyrilamine + meclizine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + meclizine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• metaxalone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

metaxalone

2 interactions

Avoid/Use Alternative

chlophedianol + metaxalone

use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + metaxalone

use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methylergonovine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methylergonovine

1 interaction

Avoid/Use Alternative

pseudoephedrine + methylergonovine

consider alternative or monitor BP: combo may incr. risk of severe HTN, vasospasm, ischemia (synergistic effects)

• metoclopramide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

metoclopramide

3 interactions

Avoid/Use Alternative

chlophedianol + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

pyrilamine + metoclopramide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

Monitor/Modify Tx

pseudoephedrine + metoclopramide

monitor BP: combo may incr. risk of HTN (additive effects)

• midazolam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

midazolam

2 interactions

Avoid/Use Alternative

chlophedianol + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• midodrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

midodrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + midodrine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

• olanzapine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

olanzapine

2 interactions

Avoid/Use Alternative

chlophedianol + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

pyrilamine + olanzapine

consider alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis), life-threatening anticholinergic adverse effects, including constipation, paralytic ileus, hyperthermia (additive effects)

• oxybate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxybate

2 interactions

Avoid/Use Alternative

chlophedianol + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

pyrilamine + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• ozanimod
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ozanimod

1 interaction

Avoid/Use Alternative

pseudoephedrine + ozanimod

avoid combo: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• pheniramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pheniramine

2 interactions

Avoid/Use Alternative

pyrilamine + pheniramine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + pheniramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• phenylephrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenylephrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + phenylephrine

avoid combo: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)

• pitolisant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pitolisant

2 interactions

Avoid/Use Alternative

chlophedianol + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

pyrilamine + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• pramlintide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pramlintide

3 interactions

Avoid/Use Alternative

chlophedianol + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

pyrilamine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

Monitor/Modify Tx

pseudoephedrine + pramlintide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• procarbazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

procarbazine

3 interactions

Avoid/Use Alternative

pseudoephedrine + procarbazine

use alternative or monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + procarbazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• promethazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

promethazine

2 interactions

Avoid/Use Alternative

chlophedianol + promethazine

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + promethazine

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pseudoephedrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pseudoephedrine

1 interaction

Avoid/Use Alternative

pseudoephedrine + pseudoephedrine

avoid combo: combo may incr. risk of HTN, other cardiovascular and CNS stimulatory effects (additive effects, duplicate therapy)

• rasagiline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rasagiline

3 interactions

Avoid/Use Alternative

pseudoephedrine + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

chlophedianol + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + rasagiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• revefenacin inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

revefenacin inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + revefenacin inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + revefenacin inhaled

avoid combo: combo may incr. anticholinergic adverse effects (additive effects)

• rivastigmine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rivastigmine

2 interactions

Avoid/Use Alternative

chlophedianol + rivastigmine

use alternative: combo may decr. efficacy of both drugs (antagonistic effects)

pyrilamine + rivastigmine

use alternative: combo may decr. efficacy of both drugs (antagonistic effects)

• ropeginterferon alfa-2b
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ropeginterferon alfa-2b

2 interactions

Avoid/Use Alternative

chlophedianol + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• safinamide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

safinamide

3 interactions

Avoid/Use Alternative

pseudoephedrine + safinamide

avoid combo w/in 14 days of safinamide use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

chlophedianol + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + safinamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• scopolamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

scopolamine

2 interactions

Avoid/Use Alternative

chlophedianol + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• selegiline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

selegiline

3 interactions

Avoid/Use Alternative

pseudoephedrine + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

chlophedianol + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + selegiline

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• selegiline transdermal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

selegiline transdermal

3 interactions

Avoid/Use Alternative

pseudoephedrine + selegiline transdermal

avoid combo w/in 2wk of selegiline use: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

chlophedianol + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + selegiline transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sofpironium topical
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sofpironium topical

2 interactions

Avoid/Use Alternative

chlophedianol + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + sofpironium topical

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• thalidomide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

thalidomide

2 interactions

Avoid/Use Alternative

chlophedianol + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tiotropium inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tiotropium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + tiotropium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + tiotropium inhaled

avoid combo: combo may incr. anticholinergic adverse effects (additive effects)

• tradipitant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tradipitant

2 interactions

Avoid/Use Alternative

chlophedianol + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimethobenzamide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

trimethobenzamide

2 interactions

Avoid/Use Alternative

chlophedianol + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• triprolidine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

triprolidine

2 interactions

Avoid/Use Alternative

pyrilamine + triprolidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects, duplicate therapy)

Caution Advised

chlophedianol + triprolidine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• umeclidinium inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

umeclidinium inhaled

2 interactions

Avoid/Use Alternative

chlophedianol + umeclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + umeclidinium inhaled

avoid combo: combo may incr. risk of anticholinergic adverse effects (additive effects)

• yohimbe
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

yohimbe

1 interaction

Avoid/Use Alternative

pseudoephedrine + yohimbe

avoid combo w/in 14 days of yohimbe use: combo may incr. risk of HTN, tachycardia (additive effects)

• zuranolone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

zuranolone

2 interactions

Avoid/Use Alternative

chlophedianol + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abiraterone acetate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

pseudoephedrine + abiraterone acetate

monitor BP: combo may incr. risk of HTN (additive effects)

• acarbose
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

acarbose

1 interaction

Monitor/Modify Tx

pseudoephedrine + acarbose

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• acebutolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

acebutolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + acebutolol

monitor BP: combo may decr. antihypertensive efficacy, exaggerate HTN response (antagonistic effects)

• albuterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + albuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• aldesleukin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

aldesleukin

2 interactions

Monitor/Modify Tx

chlophedianol + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + aldesleukin

withhold aldesleukin if mod-severe somnolence occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alfentanil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

alfentanil

2 interactions

Monitor/Modify Tx

chlophedianol + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• aliskiren
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

aliskiren

1 interaction

Monitor/Modify Tx

pseudoephedrine + aliskiren

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• almotriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

almotriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + almotriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + almotriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• alogliptin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

alogliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + alogliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• alprazolam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

alprazolam

2 interactions

Monitor/Modify Tx

chlophedianol + alprazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + alprazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• aluminum hydroxide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

aluminum hydroxide

1 interaction

Monitor/Modify Tx

pseudoephedrine + aluminum hydroxide

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• amiloride
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

amiloride

1 interaction

Monitor/Modify Tx

pseudoephedrine + amiloride

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amitriptyline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

amitriptyline

3 interactions

Monitor/Modify Tx

chlophedianol + amitriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

pseudoephedrine + amitriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + amitriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• amlodipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

amlodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + amlodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• amoxapine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

amoxapine

3 interactions

Monitor/Modify Tx

pseudoephedrine + amoxapine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + amoxapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• amphetamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

amphetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + amphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• angiotensin II
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

angiotensin II

1 interaction

Monitor/Modify Tx

pseudoephedrine + angiotensin II

monitor BP: combo may incr. risk of HTN (additive effects)

• aprocitentan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

aprocitentan

1 interaction

Monitor/Modify Tx

pseudoephedrine + aprocitentan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• arformoterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + arformoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• armodafinil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

armodafinil

1 interaction

Monitor/Modify Tx

pseudoephedrine + armodafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• asciminib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

asciminib

1 interaction

Monitor/Modify Tx

pseudoephedrine + asciminib

monitor BP: combo may incr. risk of HTN (additive effects)

• atenolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

atenolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + atenolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• atogepant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

atogepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + atogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• atomoxetine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

atomoxetine

1 interaction

Monitor/Modify Tx

pseudoephedrine + atomoxetine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• atropine ophthalmic
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

atropine ophthalmic

3 interactions

Monitor/Modify Tx

pseudoephedrine + atropine ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

pyrilamine + atropine ophthalmic

caution advised: combo may incr. risk of anticholinergic adverse effects (additive effects)

• axitinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

axitinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + axitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• azilsartan medoxomil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

pseudoephedrine + azilsartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• baclofen intrathecal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

baclofen intrathecal

2 interactions

Monitor/Modify Tx

chlophedianol + baclofen intrathecal

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + baclofen intrathecal

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• benazepril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

benazepril

1 interaction

Monitor/Modify Tx

pseudoephedrine + benazepril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• benzphetamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

benzphetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + benzphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• betamethasone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

betamethasone

1 interaction

Monitor/Modify Tx

pseudoephedrine + betamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• betaxolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

betaxolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + betaxolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• bevacizumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + bevacizumab

monitor BP: combo may incr. risk of HTN (additive effects)

• bexagliflozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + bexagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• bismuth subsalicylate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bismuth subsalicylate

1 interaction

Monitor/Modify Tx

pseudoephedrine + bismuth subsalicylate

monitor BP w/ high-dose bismuth subsalicylate: combo may incr. risk of HTN (additive effects)

• bisoprolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bisoprolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + bisoprolol

consider monitoring BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• brigatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

brigatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + brigatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• bromocriptine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bromocriptine

3 interactions

Monitor/Modify Tx

pseudoephedrine + bromocriptine

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy; may incr. risk of HTN, tachycardia (antagonistic effects; mechanism unknown)

Caution Advised

chlophedianol + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + bromocriptine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• budesonide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

budesonide

1 interaction

Monitor/Modify Tx

pseudoephedrine + budesonide

monitor BP: combo may incr. risk of HTN (additive effects)

• bumetanide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bumetanide

1 interaction

Monitor/Modify Tx

pseudoephedrine + bumetanide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• buprenorphine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

buprenorphine

2 interactions

Monitor/Modify Tx

chlophedianol + buprenorphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + buprenorphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• bupropion
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

bupropion

1 interaction

Monitor/Modify Tx

pseudoephedrine + bupropion

monitor BP: combo may incr. risk of HTN (additive effects)

• butorphanol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

butorphanol

2 interactions

Monitor/Modify Tx

chlophedianol + butorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + butorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• cabozantinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + cabozantinib

monitor BP: combo may incr. risk of HTN (additive effects)

• caffeine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

caffeine

1 interaction

Monitor/Modify Tx

pseudoephedrine + caffeine

monitor BP, HR; avoid excessive caffeine intake: combo may incr. risk of HTN, tachycardia (additive effects)

• caffeine citrate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

caffeine citrate

1 interaction

Monitor/Modify Tx

pseudoephedrine + caffeine citrate

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• calcium carbonate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

calcium carbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + calcium carbonate

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• canagliflozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

canagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + canagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• candesartan cilexetil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

pseudoephedrine + candesartan cilexetil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• cannabis
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cannabis

3 interactions

Monitor/Modify Tx

pseudoephedrine + cannabis

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

pyrilamine + cannabis

monitor HR: combo may incr. risk of CNS depression, psychomotor impairment, tachycardia (additive effects)

Caution Advised

chlophedianol + cannabis

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• captopril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

captopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + captopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• carbamazepine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

carbamazepine

2 interactions

Monitor/Modify Tx

chlophedianol + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + carbamazepine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• carfilzomib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

pseudoephedrine + carfilzomib

monitor BP: combo may incr. risk of HTN (additive effects)

• carvedilol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

carvedilol

1 interaction

Monitor/Modify Tx

pseudoephedrine + carvedilol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• celecoxib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

celecoxib

1 interaction

Monitor/Modify Tx

pseudoephedrine + celecoxib

monitor BP: combo may incr. risk of HTN (additive effects)

• chlordiazepoxide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlordiazepoxide

2 interactions

Monitor/Modify Tx

chlophedianol + chlordiazepoxide

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + chlordiazepoxide

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorothiazide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

pseudoephedrine + chlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• chlorpromazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlorpromazine

2 interactions

Monitor/Modify Tx

chlophedianol + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• chlorthalidone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

pseudoephedrine + chlorthalidone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clevidipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clevidipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + clevidipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• clobazam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clobazam

2 interactions

Monitor/Modify Tx

chlophedianol + clobazam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + clobazam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clomipramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clomipramine

3 interactions

Monitor/Modify Tx

chlophedianol + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + clomipramine

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + clomipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• clonazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clonazepam

2 interactions

Monitor/Modify Tx

chlophedianol + clonazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + clonazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• clorazepate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

clorazepate

2 interactions

Monitor/Modify Tx

chlophedianol + clorazepate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + clorazepate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• colesevelam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

colesevelam

1 interaction

Monitor/Modify Tx

pseudoephedrine + colesevelam

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• copanlisib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

copanlisib

1 interaction

Monitor/Modify Tx

pseudoephedrine + copanlisib

monitor BP: combo may incr. risk of HTN (additive effects, copanlisib may cause infusion-related HTN)

• corticotropin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

corticotropin

1 interaction

Monitor/Modify Tx

pseudoephedrine + corticotropin

monitor BP: combo may incr. risk of HTN (additive effects)

• cortisone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + cortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• cyclosporine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

cyclosporine

1 interaction

Monitor/Modify Tx

pseudoephedrine + cyclosporine

monitor BP: combo may incr. risk of HTN (additive effects)

• danazol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

danazol

1 interaction

Monitor/Modify Tx

pseudoephedrine + danazol

monitor BP: combo may incr. risk of HTN (additive effects)

• dapagliflozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + dapagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• darbepoetin alfa
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

darbepoetin alfa

1 interaction

Monitor/Modify Tx

pseudoephedrine + darbepoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• daridorexant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

daridorexant

2 interactions

Monitor/Modify Tx

chlophedianol + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• deflazacort
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

deflazacort

1 interaction

Monitor/Modify Tx

pseudoephedrine + deflazacort

monitor BP: combo may incr. risk of HTN (additive effects)

• desflurane
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

desflurane

2 interactions

Monitor/Modify Tx

chlophedianol + desflurane

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + desflurane

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• desipramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

desipramine

3 interactions

Monitor/Modify Tx

chlophedianol + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + desipramine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

pyrilamine + desipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• desmopressin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

desmopressin

1 interaction

Monitor/Modify Tx

pseudoephedrine + desmopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• desvenlafaxine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

desvenlafaxine

3 interactions

Monitor/Modify Tx

pseudoephedrine + desvenlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + desvenlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexamethasone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexamethasone

1 interaction

Monitor/Modify Tx

pseudoephedrine + dexamethasone

monitor BP: combo may incr. risk of HTN (additive effects)

• dexmedetomidine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexmedetomidine

2 interactions

Monitor/Modify Tx

chlophedianol + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + dexmedetomidine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexmedetomidine injection

2 interactions

Monitor/Modify Tx

chlophedianol + dexmedetomidine injection

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + dexmedetomidine injection

monitor respiratory rate, consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmethylphenidate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dexmethylphenidate

1 interaction

Monitor/Modify Tx

pseudoephedrine + dexmethylphenidate

monitor BP: combo may incr. risk of HTN (additive effects)

• dextroamphetamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dextroamphetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + dextroamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• diazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diazepam

2 interactions

Monitor/Modify Tx

chlophedianol + diazepam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + diazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dichlorphenamide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dichlorphenamide

3 interactions

Monitor/Modify Tx

pseudoephedrine + dichlorphenamide

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

Caution Advised

chlophedianol + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + dichlorphenamide

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• diclofenac
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diclofenac

1 interaction

Monitor/Modify Tx

pseudoephedrine + diclofenac

monitor BP: combo may incr. risk of HTN (additive effects)

• diclofenac topical
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

pseudoephedrine + diclofenac topical

monitor BP: combo may incr. risk of HTN (additive effects)

• diethylpropion
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diethylpropion

1 interaction

Monitor/Modify Tx

pseudoephedrine + diethylpropion

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• diflunisal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diflunisal

1 interaction

Monitor/Modify Tx

pseudoephedrine + diflunisal

monitor BP: combo may incr. risk of HTN (additive effects)

• dihydrocodeine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dihydrocodeine

2 interactions

Monitor/Modify Tx

chlophedianol + dihydrocodeine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + dihydrocodeine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• diltiazem
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

diltiazem

1 interaction

Monitor/Modify Tx

pseudoephedrine + diltiazem

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• dobutamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dobutamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + dobutamine

monitor BP: combo may incr. risk of HTN (additive effects)

• dopamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dopamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + dopamine

monitor BP: combo may incr. risk of HTN (additive effects)

• doxapram
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

doxapram

1 interaction

Monitor/Modify Tx

pseudoephedrine + doxapram

monitor BP: combo may incr. risk of HTN (additive effects)

• doxazosin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

doxazosin

3 interactions

Monitor/Modify Tx

pseudoephedrine + doxazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

chlophedianol + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)

pyrilamine + doxazosin

caution advised w/ doxazosin ER dosage form: combo may incr. doxazosin levels, risk of adverse effects (absorption increased)

• doxepin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

doxepin

3 interactions

Monitor/Modify Tx

pseudoephedrine + doxepin

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

pyrilamine + doxepin

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• droperidol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

droperidol

2 interactions

Monitor/Modify Tx

chlophedianol + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + droperidol

decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• droxidopa
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

droxidopa

1 interaction

Monitor/Modify Tx

pseudoephedrine + droxidopa

monitor BP: combo may incr. risk of supine HTN (additive effects)

• dulaglutide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

dulaglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + dulaglutide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• eletriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

eletriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + eletriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + eletriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• empagliflozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

empagliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + empagliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• enalapril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

enalapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + enalapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• enalaprilat
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

enalaprilat

1 interaction

Monitor/Modify Tx

pseudoephedrine + enalaprilat

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ephedrine injection
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ephedrine injection

1 interaction

Monitor/Modify Tx

pseudoephedrine + ephedrine injection

monitor BP, HR: combo may incr. risk of HTN, arrhythmias, tachycardia (additive effects)

• ephedrine oral
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ephedrine oral

1 interaction

Monitor/Modify Tx

pseudoephedrine + ephedrine oral

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• epinephrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

epinephrine

2 interactions

Monitor/Modify Tx

pseudoephedrine + epinephrine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

pyrilamine + epinephrine

monitor HR, ECG: combo may incr. risk of tachycardia, cardiac arrhythmias (additive effects)

• eplerenone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

eplerenone

1 interaction

Monitor/Modify Tx

pseudoephedrine + eplerenone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• epoetin alfa
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

epoetin alfa

1 interaction

Monitor/Modify Tx

pseudoephedrine + epoetin alfa

monitor BP: combo may incr. risk of HTN (additive effects)

• eptinezumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

eptinezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + eptinezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• erenumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

erenumab

3 interactions

Monitor/Modify Tx

pseudoephedrine + erenumab

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

pyrilamine + erenumab

caution advised: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• ertugliflozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + ertugliflozin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• esketamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

esketamine

3 interactions

Monitor/Modify Tx

chlophedianol + esketamine

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pseudoephedrine + esketamine

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + esketamine

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• esmolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

esmolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + esmolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• estazolam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

estazolam

2 interactions

Monitor/Modify Tx

chlophedianol + estazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + estazolam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• estetrol (contraceptive)
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

estetrol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + estetrol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• estradiol (contraceptive)
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• eszopiclone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

eszopiclone

2 interactions

Monitor/Modify Tx

chlophedianol + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

pseudoephedrine + ethacrynic acid

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ethanol (in some formulations)
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ethanol (in some formulations)

2 interactions

Monitor/Modify Tx

chlophedianol + ethanol (in some formulations)

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + ethanol (in some formulations)

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

pseudoephedrine + ethinyl estradiol (contraceptive)

monitor BP: combo may incr. risk of HTN (additive effects)

• etodolac
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

etodolac

1 interaction

Monitor/Modify Tx

pseudoephedrine + etodolac

monitor BP: combo may incr. risk of HTN (additive effects)

• etomidate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

etomidate

2 interactions

Monitor/Modify Tx

chlophedianol + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etrasimod
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

etrasimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + etrasimod

monitor BP: combo may incr. risk of HTN (additive effects)

• exenatide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

exenatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + exenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• felodipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

felodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + felodipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenfluramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fenfluramine

3 interactions

Monitor/Modify Tx

pseudoephedrine + fenfluramine

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

Caution Advised

chlophedianol + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + fenfluramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fenoldopam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fenoldopam

1 interaction

Monitor/Modify Tx

pseudoephedrine + fenoldopam

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fenoprofen
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + fenoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• fentanyl
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fentanyl

2 interactions

Monitor/Modify Tx

chlophedianol + fentanyl

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + fentanyl

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• fingolimod
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fingolimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + fingolimod

monitor BP: combo may incr. risk of HTN (additive effects)

• fludrocortisone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + fludrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• fluphenazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fluphenazine

2 interactions

Monitor/Modify Tx

chlophedianol + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• flurazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

flurazepam

2 interactions

Monitor/Modify Tx

chlophedianol + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + flurazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• flurbiprofen
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + flurbiprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• formoterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + formoterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• fosinopril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fosinopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + fosinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• fostamatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fostamatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + fostamatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• fremanezumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fremanezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + fremanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• frovatriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

frovatriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + frovatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + frovatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• fruquintinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + fruquintinib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• gabapentin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

gabapentin

2 interactions

Monitor/Modify Tx

chlophedianol + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

gabapentin enacarbil

2 interactions

Monitor/Modify Tx

chlophedianol + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• galcanezumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

galcanezumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + galcanezumab

monitor BP: combo may incr. risk of HTN (additive effects)

• glimepiride
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glimepiride

1 interaction

Monitor/Modify Tx

pseudoephedrine + glimepiride

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glipizide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glipizide

1 interaction

Monitor/Modify Tx

pseudoephedrine + glipizide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glyburide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glyburide

1 interaction

Monitor/Modify Tx

pseudoephedrine + glyburide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glycopyrrolate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

glycopyrrolate

3 interactions

Monitor/Modify Tx

pseudoephedrine + glycopyrrolate

monitor HR: combo may incr. risk of tachycardia (additive effects)

pyrilamine + glycopyrrolate

monitor HR: combo may incr. risk of tachycardia, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

Caution Advised

chlophedianol + glycopyrrolate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• guanfacine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

guanfacine

3 interactions

Monitor/Modify Tx

pseudoephedrine + guanfacine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

chlophedianol + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + guanfacine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• hoodia
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hoodia

1 interaction

Monitor/Modify Tx

pseudoephedrine + hoodia

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• hydralazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydralazine

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydralazine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• hydrochlorothiazide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydrochlorothiazide

3 interactions

Monitor/Modify Tx

pseudoephedrine + hydrochlorothiazide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

chlophedianol + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

pyrilamine + hydrochlorothiazide

caution advised: combo may incr. hydrochlorothiazide levels, risk of adverse effects (absorption increased)

• hydrocortisone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydrocortisone

monitor BP: combo may incr. risk of HTN (additive effects)

• hydromorphone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydromorphone

2 interactions

Monitor/Modify Tx

chlophedianol + hydromorphone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + hydromorphone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hydroxocobalamin IV
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hydroxocobalamin IV

1 interaction

Monitor/Modify Tx

pseudoephedrine + hydroxocobalamin IV

monitor BP: combo may incr. risk of HTN (additive effects)

• hyoscyamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

hyoscyamine

3 interactions

Monitor/Modify Tx

pseudoephedrine + hyoscyamine

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

chlophedianol + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + hyoscyamine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ibrutinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ibrutinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ibuprofen
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + ibuprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ifosfamide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ifosfamide

2 interactions

Monitor/Modify Tx

chlophedianol + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• imipramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

imipramine

3 interactions

Monitor/Modify Tx

chlophedianol + imipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + imipramine

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + imipramine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• indapamide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

indapamide

1 interaction

Monitor/Modify Tx

pseudoephedrine + indapamide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• indomethacin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

indomethacin

1 interaction

Monitor/Modify Tx

pseudoephedrine + indomethacin

monitor BP: combo may incr. risk of HTN (additive effects)

• insulin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

insulin

1 interaction

Monitor/Modify Tx

pseudoephedrine + insulin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• irbesartan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

irbesartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + irbesartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• isoflurane
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

isoflurane

2 interactions

Monitor/Modify Tx

chlophedianol + isoflurane

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + isoflurane

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• isradipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

isradipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + isradipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ketamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ketamine

3 interactions

Monitor/Modify Tx

chlophedianol + ketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

pseudoephedrine + ketamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other sympathomimetic adverse effects (additive effects)

pyrilamine + ketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

• ketoprofen
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

pseudoephedrine + ketoprofen

monitor BP: combo may incr. risk of HTN (additive effects)

• ketorolac
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ketorolac

1 interaction

Monitor/Modify Tx

pseudoephedrine + ketorolac

monitor BP: combo may incr. risk of HTN (additive effects)

• labetalol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

labetalol

1 interaction

Monitor/Modify Tx

pseudoephedrine + labetalol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lanreotide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lanreotide

1 interaction

Monitor/Modify Tx

pseudoephedrine + lanreotide

monitor BP: combo may incr. risk of HTN (additive effects)

• leflunomide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

leflunomide

1 interaction

Monitor/Modify Tx

pseudoephedrine + leflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• lemborexant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lemborexant

2 interactions

Monitor/Modify Tx

chlophedianol + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + lenvatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• levalbuterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + levalbuterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• levomilnacipran
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

levomilnacipran

3 interactions

Monitor/Modify Tx

pseudoephedrine + levomilnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

chlophedianol + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + levomilnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• levorphanol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

levorphanol

2 interactions

Monitor/Modify Tx

chlophedianol + levorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + levorphanol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• levothyroxine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

levothyroxine

1 interaction

Monitor/Modify Tx

pseudoephedrine + levothyroxine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• licorice
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

licorice

1 interaction

Monitor/Modify Tx

pseudoephedrine + licorice

monitor BP w/ large amounts of licorice: combo may incr. risk of HTN (additive effects)

• lifileucel
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lifileucel

1 interaction

Monitor/Modify Tx

pseudoephedrine + lifileucel

monitor HR: combo may incr. risk of tachycardia (additive effects)

• linagliptin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

linagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + linagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• linezolid
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

linezolid

1 interaction

Monitor/Modify Tx

pseudoephedrine + linezolid

monitor BP: combo may incr. risk of HTN (additive effects)

• liothyronine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

liothyronine

1 interaction

Monitor/Modify Tx

pseudoephedrine + liothyronine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• liraglutide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

liraglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + liraglutide

monitor HR, glucose in type 2 diabetes mellitus pts: combo may incr. risk of tachycardia; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• lisdexamfetamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lisdexamfetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + lisdexamfetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular and CNS stimulatory effects (additive effects)

• lisinopril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lisinopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + lisinopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lixisenatide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lixisenatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + lixisenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lorazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lorazepam

2 interactions

Monitor/Modify Tx

chlophedianol + lorazepam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + lorazepam

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lorlatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + lorlatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• losartan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

losartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + losartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• lumacaftor/ivacaftor
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

pseudoephedrine + lumacaftor/ ivacaftor

monitor BP: combo may incr. risk of HTN (additive effects)

• luspatercept
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

luspatercept

1 interaction

Monitor/Modify Tx

pseudoephedrine + luspatercept

monitor BP: combo may incr. risk of HTN (additive effects)

• magnesium carbonate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

magnesium carbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium carbonate

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• magnesium hydroxide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

magnesium hydroxide

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium hydroxide

monitor BP, HR: combo may increase pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• magnesium salicylate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

pseudoephedrine + magnesium salicylate

monitor BP w/ high-dose magnesium salicylate: combo may incr. risk of HTN (additive effects)

• meclofenamate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

pseudoephedrine + meclofenamate

monitor BP: combo may incr. risk of HTN (additive effects)

• mefenamic acid
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

pseudoephedrine + mefenamic acid

monitor BP: combo may incr. risk of HTN (additive effects)

• meloxicam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

meloxicam

1 interaction

Monitor/Modify Tx

pseudoephedrine + meloxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• meperidine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

meperidine

2 interactions

Monitor/Modify Tx

chlophedianol + meperidine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + meperidine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• metformin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

metformin

1 interaction

Monitor/Modify Tx

pseudoephedrine + metformin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• methadone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methadone

2 interactions

Monitor/Modify Tx

chlophedianol + methadone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + methadone

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• methamphetamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methamphetamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + methamphetamine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• methohexital
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methohexital

2 interactions

Monitor/Modify Tx

chlophedianol + methohexital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + methohexital

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methoxy polyethylene glycol-epoetin beta
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Monitor/Modify Tx

pseudoephedrine + methoxy polyethylene glycol-epoetin beta

monitor BP: combo may incr. risk of HTN (additive effects)

• methyldopa
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methyldopa

3 interactions

Monitor/Modify Tx

pseudoephedrine + methyldopa

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

Caution Advised

chlophedianol + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + methyldopa

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• methylphenidate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methylphenidate

1 interaction

Monitor/Modify Tx

pseudoephedrine + methylphenidate

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

• methylprednisolone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + methylprednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• methyltestosterone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

methyltestosterone

1 interaction

Monitor/Modify Tx

pseudoephedrine + methyltestosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• metolazone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

metolazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + metolazone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• metoprolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

metoprolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + metoprolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• miglitol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

miglitol

1 interaction

Monitor/Modify Tx

pseudoephedrine + miglitol

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• milnacipran
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

milnacipran

3 interactions

Monitor/Modify Tx

pseudoephedrine + milnacipran

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

chlophedianol + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + milnacipran

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• minoxidil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

minoxidil

1 interaction

Monitor/Modify Tx

pseudoephedrine + minoxidil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• mirabegron
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

mirabegron

3 interactions

Monitor/Modify Tx

pseudoephedrine + mirabegron

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

pyrilamine + mirabegron

caution advised: combo may incr. risk of urinary retention (additive effects)

• mirtazapine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

mirtazapine

2 interactions

Monitor/Modify Tx

chlophedianol + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• modafinil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

modafinil

1 interaction

Monitor/Modify Tx

pseudoephedrine + modafinil

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• moexipril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

moexipril

1 interaction

Monitor/Modify Tx

pseudoephedrine + moexipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• morphine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

morphine

2 interactions

Monitor/Modify Tx

chlophedianol + morphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + morphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• nabumetone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nabumetone

1 interaction

Monitor/Modify Tx

pseudoephedrine + nabumetone

monitor BP: combo may incr. risk of HTN (additive effects)

• nadolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nadolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + nadolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nalbuphine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nalbuphine

2 interactions

Monitor/Modify Tx

chlophedianol + nalbuphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + nalbuphine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• naproxen
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

naproxen

1 interaction

Monitor/Modify Tx

pseudoephedrine + naproxen

monitor BP: combo may incr. risk of HTN (additive effects)

• naratriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

naratriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + naratriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + naratriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nateglinide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nateglinide

1 interaction

Monitor/Modify Tx

pseudoephedrine + nateglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• naxitamab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

naxitamab

1 interaction

Monitor/Modify Tx

pseudoephedrine + naxitamab

monitor BP: combo may incr. risk of HTN (additive effects)

• nebivolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nebivolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + nebivolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nelarabine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nelarabine

2 interactions

Monitor/Modify Tx

chlophedianol + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nicardipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nicardipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nicardipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nicotine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nicotine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nicotine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• nifedipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nifedipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nifedipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• nimodipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nimodipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nimodipine

monitor BP: combo may decr. nimodipine efficacy (antagonistic effects)

• niraparib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

niraparib

1 interaction

Monitor/Modify Tx

pseudoephedrine + niraparib

monitor BP: combo may incr. risk of HTN (additive effects)

• nisoldipine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nisoldipine

1 interaction

Monitor/Modify Tx

pseudoephedrine + nisoldipine

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• norepinephrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

norepinephrine

1 interaction

Monitor/Modify Tx

pseudoephedrine + norepinephrine

monitor BP: combo may incr. risk of severe HTN (additive effects)

• nortriptyline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

nortriptyline

3 interactions

Monitor/Modify Tx

chlophedianol + nortriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pseudoephedrine + nortriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + nortriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• obinutuzumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + obinutuzumab

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• oliceridine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oliceridine

2 interactions

Monitor/Modify Tx

chlophedianol + oliceridine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + oliceridine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, severe constipation, paralytic ileus, urinary retention (additive effects)

• olmesartan medoxomil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

pseudoephedrine + olmesartan medoxomil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• olodaterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + olodaterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• opicapone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

opicapone

2 interactions

Monitor/Modify Tx

chlophedianol + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• opium
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

opium

2 interactions

Monitor/Modify Tx

chlophedianol + opium

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + opium

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• orphenadrine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

orphenadrine

3 interactions

Monitor/Modify Tx

pseudoephedrine + orphenadrine

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

chlophedianol + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + orphenadrine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• osilodrostat
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

osilodrostat

1 interaction

Monitor/Modify Tx

pseudoephedrine + osilodrostat

monitor BP: combo may incr. risk of HTN (additive effects)

• oxaprozin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxaprozin

monitor BP: combo may incr. risk of HTN (additive effects)

• oxazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxazepam

2 interactions

Monitor/Modify Tx

chlophedianol + oxazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + oxazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• oxybutynin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxybutynin

2 interactions

Monitor/Modify Tx

chlophedianol + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)

pyrilamine + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxycodone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxycodone

2 interactions

Monitor/Modify Tx

chlophedianol + oxycodone

monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + oxycodone

monitor respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. pyrilamine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• oxymetazoline nasal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxymetazoline nasal

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxymetazoline nasal

monitor BP: combo may incr. risk of HTN (additive effects)

• oxymetazoline ophthalmic
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxymetazoline ophthalmic

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxymetazoline ophthalmic

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• oxymorphone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxymorphone

2 interactions

Monitor/Modify Tx

chlophedianol + oxymorphone

monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. chlophedianol dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + oxymorphone

monitor respiratory rate; decr. oxymorphone start dose by at least 50%, consider decr. pyrilamine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• oxytocin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

oxytocin

1 interaction

Monitor/Modify Tx

pseudoephedrine + oxytocin

monitor BP: combo may incr. risk of HTN, including life-threatening (additive effects)

• pazopanib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pazopanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pazopanib

monitor BP: combo may incr. risk of HTN (additive effects)

• pentazocine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pentazocine

2 interactions

Monitor/Modify Tx

chlophedianol + pentazocine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + pentazocine

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pentobarbital
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pentobarbital

2 interactions

Monitor/Modify Tx

chlophedianol + pentobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + pentobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• perindopril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

perindopril

1 interaction

Monitor/Modify Tx

pseudoephedrine + perindopril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• perphenazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

perphenazine

2 interactions

Monitor/Modify Tx

chlophedianol + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• pexidartinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pexidartinib

monitor BP: combo may incr. risk of HTN (additive effects)

• phendimetrazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phendimetrazine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phendimetrazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• phenobarbital
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenobarbital

2 interactions

Monitor/Modify Tx

chlophedianol + phenobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + phenobarbital

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• phenoxybenzamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenoxybenzamine

monitor BP, HR: combo may incr. risk of hypotension, tachycardia (paradoxical effects, unopposed stimulation of beta receptors)

• phentermine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phentermine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phentermine

monitor BP, HR: combo may incr. risk of HTN, tachycardia, CNS stimulatory effects (additive effects)

• phentolamine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phentolamine

1 interaction

Monitor/Modify Tx

pseudoephedrine + phentolamine

monitor BP, HR: combo may incr. risk of hypotension, tachycardia (paradoxical effects, unopposed stimulation of beta receptors)

• phenylephrine injection
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine injection

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine nasal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenylephrine nasal

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine nasal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• phenylephrine ophthalmic
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenylephrine ophthalmic

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine ophthalmic

monitor BP, HR; risk may be lower w/ phenylephrine ophthalmic 2.5%: combo may incr. risk of HTN, tachycardia (additive effects)

• phenylephrine rectal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

phenylephrine rectal

1 interaction

Monitor/Modify Tx

pseudoephedrine + phenylephrine rectal

monitor BP: combo may incr. risk of HTN (additive effects, duplicate therapy)

• pindolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pindolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + pindolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• pioglitazone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pioglitazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + pioglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• piroxicam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

piroxicam

1 interaction

Monitor/Modify Tx

pseudoephedrine + piroxicam

monitor BP: combo may incr. risk of HTN (additive effects)

• ponatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ponatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ponatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• ponesimod
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ponesimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + ponesimod

monitor BP: combo may incr. risk of HTN (additive effects)

• pralsetinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + pralsetinib

monitor BP: combo may incr. risk of HTN (additive effects)

• prazosin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

prazosin

1 interaction

Monitor/Modify Tx

pseudoephedrine + prazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• prednisolone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

prednisolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + prednisolone

monitor BP: combo may incr. risk of HTN (additive effects)

• prednisone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

prednisone

1 interaction

Monitor/Modify Tx

pseudoephedrine + prednisone

monitor BP: combo may incr. risk of HTN (additive effects)

• pregabalin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

pregabalin

2 interactions

Monitor/Modify Tx

chlophedianol + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

primidone

2 interactions

Monitor/Modify Tx

chlophedianol + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propofol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

propofol

2 interactions

Monitor/Modify Tx

chlophedianol + propofol

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + propofol

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• propranolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

propranolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + propranolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• protriptyline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

protriptyline

3 interactions

Monitor/Modify Tx

chlophedianol + protriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

pseudoephedrine + protriptyline

monitor BP: combo may incr. risk of HTN (additive effects)

pyrilamine + protriptyline

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• quazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

quazepam

2 interactions

Monitor/Modify Tx

chlophedianol + quazepam

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + quazepam

consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

quetiapine

3 interactions

Monitor/Modify Tx

pseudoephedrine + quetiapine

monitor BP, especially in pts <18 yo: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

pyrilamine + quetiapine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, anticholinergic adverse effects (additive effects)

• quinapril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

quinapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + quinapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramipril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ramipril

1 interaction

Monitor/Modify Tx

pseudoephedrine + ramipril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• ramucirumab
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

pseudoephedrine + ramucirumab

monitor BP: combo may incr. risk of HTN (additive effects)

• regorafenib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

regorafenib

1 interaction

Monitor/Modify Tx

pseudoephedrine + regorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• remifentanil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

remifentanil

2 interactions

Monitor/Modify Tx

chlophedianol + remifentanil

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + remifentanil

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• remimazolam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

remimazolam

2 interactions

Monitor/Modify Tx

chlophedianol + remimazolam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + remimazolam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repaglinide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

repaglinide

1 interaction

Monitor/Modify Tx

pseudoephedrine + repaglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rimegepant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rimegepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + rimegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ripretinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ripretinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + ripretinib

monitor BP: combo may incr. risk of HTN (additive effects)

• rizatriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rizatriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + rizatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + rizatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ropinirole
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ropinirole

3 interactions

Monitor/Modify Tx

pseudoephedrine + ropinirole

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + ropinirole

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rosiglitazone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rosiglitazone

1 interaction

Monitor/Modify Tx

pseudoephedrine + rosiglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rotigotine transdermal
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

rotigotine transdermal

3 interactions

Monitor/Modify Tx

pseudoephedrine + rotigotine transdermal

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

chlophedianol + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + rotigotine transdermal

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• salmeterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + salmeterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• salsalate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

salsalate

1 interaction

Monitor/Modify Tx

pseudoephedrine + salsalate

monitor BP w/ high-dose salsalate: combo may incr. risk of HTN (additive effects)

• saxagliptin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

saxagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + saxagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• selpercatinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + selpercatinib

monitor BP: combo may incr. risk of HTN (additive effects)

• semaglutide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

semaglutide

1 interaction

Monitor/Modify Tx

pseudoephedrine + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sevoflurane
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sevoflurane

2 interactions

Monitor/Modify Tx

chlophedianol + sevoflurane

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + sevoflurane

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• siponimod
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

siponimod

1 interaction

Monitor/Modify Tx

pseudoephedrine + siponimod

monitor BP: combo may incr. risk of HTN (additive effects)

• sitagliptin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sitagliptin

1 interaction

Monitor/Modify Tx

pseudoephedrine + sitagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sodium bicarbonate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sodium bicarbonate

1 interaction

Monitor/Modify Tx

pseudoephedrine + sodium bicarbonate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• sodium citrate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sodium citrate

1 interaction

Monitor/Modify Tx

pseudoephedrine + sodium citrate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

• solriamfetol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

solriamfetol

1 interaction

Monitor/Modify Tx

pseudoephedrine + solriamfetol

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• sorafenib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sorafenib

1 interaction

Monitor/Modify Tx

pseudoephedrine + sorafenib

monitor BP: combo may incr. risk of HTN (additive effects)

• spironolactone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

spironolactone

1 interaction

Monitor/Modify Tx

pseudoephedrine + spironolactone

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• sufentanil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sufentanil

2 interactions

Monitor/Modify Tx

chlophedianol + sufentanil

monitor respiratory rate; decr. sufentanil start dose, consider decr. chlophedianol dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + sufentanil

monitor respiratory rate; decr. sufentanil start dose, consider decr. pyrilamine dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• sulindac
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sulindac

1 interaction

Monitor/Modify Tx

pseudoephedrine + sulindac

monitor BP: combo may incr. risk of HTN (additive effects)

• sumatriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sumatriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + sumatriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + sumatriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• sunitinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

sunitinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + sunitinib

monitor BP: combo may incr. risk of HTN (additive effects)

• suvorexant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

suvorexant

2 interactions

Monitor/Modify Tx

chlophedianol + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tacrolimus

1 interaction

Monitor/Modify Tx

pseudoephedrine + tacrolimus

monitor BP: combo may incr. risk of HTN (additive effects)

• tagraxofusp
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

pseudoephedrine + tagraxofusp

monitor BP: combo may incr. risk of HTN (additive effects)

• tapentadol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tapentadol

2 interactions

Monitor/Modify Tx

chlophedianol + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• telmisartan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

telmisartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + telmisartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• temazepam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

temazepam

2 interactions

Monitor/Modify Tx

chlophedianol + temazepam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

Caution Advised

pyrilamine + temazepam

caution advised: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• terazosin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

terazosin

1 interaction

Monitor/Modify Tx

pseudoephedrine + terazosin

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• terbutaline
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

terbutaline

1 interaction

Monitor/Modify Tx

pseudoephedrine + terbutaline

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• teriflunomide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

teriflunomide

1 interaction

Monitor/Modify Tx

pseudoephedrine + teriflunomide

monitor BP: combo may incr. risk of HTN (additive effects)

• testosterone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

testosterone

1 interaction

Monitor/Modify Tx

pseudoephedrine + testosterone

monitor BP: combo may incr. risk of HTN (additive effects)

• thioridazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

thioridazine

2 interactions

Monitor/Modify Tx

chlophedianol + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + thioridazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thiothixene
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

thiothixene

2 interactions

Monitor/Modify Tx

chlophedianol + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• thyroid
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

thyroid

1 interaction

Monitor/Modify Tx

pseudoephedrine + thyroid

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

• timolol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

timolol

1 interaction

Monitor/Modify Tx

pseudoephedrine + timolol

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tirzepatide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tirzepatide

1 interaction

Monitor/Modify Tx

pseudoephedrine + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• tivozanib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tivozanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + tivozanib

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• tolmetin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tolmetin

1 interaction

Monitor/Modify Tx

pseudoephedrine + tolmetin

monitor BP: combo may incr. risk of HTN (additive effects)

• topiramate
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

topiramate

3 interactions

Monitor/Modify Tx

pseudoephedrine + topiramate

monitor BP, HR: combo may incr. pseudoephedrine levels, risk of HTN, tachycardia, other adverse effects (renal excretion decreased at higher urine pH)

Caution Advised

chlophedianol + topiramate

caution advised, especially in Peds pts: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

pyrilamine + topiramate

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• torsemide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

torsemide

1 interaction

Monitor/Modify Tx

pseudoephedrine + torsemide

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• tramadol
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

tramadol

2 interactions

Monitor/Modify Tx

chlophedianol + tramadol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

pyrilamine + tramadol

monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• trametinib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

trametinib

1 interaction

Monitor/Modify Tx

pseudoephedrine + trametinib

monitor BP: combo may incr. risk of HTN (additive effects)

• trandolapril
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

trandolapril

1 interaction

Monitor/Modify Tx

pseudoephedrine + trandolapril

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triamcinolone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

triamcinolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + triamcinolone

monitor BP: combo may incr. risk of HTN (additive effects)

• triamterene
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

triamterene

1 interaction

Monitor/Modify Tx

pseudoephedrine + triamterene

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• triazolam
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

triazolam

2 interactions

Monitor/Modify Tx

chlophedianol + triazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

pyrilamine + triazolam

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• trimipramine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

trimipramine

3 interactions

Monitor/Modify Tx

pseudoephedrine + trimipramine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + trimipramine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• trospium
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

trospium

3 interactions

Monitor/Modify Tx

pseudoephedrine + trospium

monitor HR: combo may incr. risk of tachycardia (additive effects)

Caution Advised

chlophedianol + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

pyrilamine + trospium

caution advised: combo may incr. risk of CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects)

• ubrogepant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ubrogepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + ubrogepant

monitor BP: combo may incr. risk of HTN (additive effects)

• vadadustat
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

vadadustat

1 interaction

Monitor/Modify Tx

pseudoephedrine + vadadustat

monitor BP: combo may incr. risk of HTN, including hypertensive crisis (additive effects)

• valsartan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

valsartan

1 interaction

Monitor/Modify Tx

pseudoephedrine + valsartan

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vamorolone
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

vamorolone

1 interaction

Monitor/Modify Tx

pseudoephedrine + vamorolone

monitor BP: combo may incr. risk of HTN (additive effects)

• vandetanib
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

vandetanib

1 interaction

Monitor/Modify Tx

pseudoephedrine + vandetanib

monitor BP: combo may incr. risk of HTN (additive effects)

• vasopressin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

vasopressin

1 interaction

Monitor/Modify Tx

pseudoephedrine + vasopressin

monitor BP: combo may incr. risk of HTN (additive effects)

• venlafaxine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

venlafaxine

3 interactions

Monitor/Modify Tx

pseudoephedrine + venlafaxine

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + venlafaxine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• verapamil
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

verapamil

1 interaction

Monitor/Modify Tx

pseudoephedrine + verapamil

monitor BP: combo may decr. antihypertensive agent efficacy (antagonistic effects)

• vilanterol inhaled
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

pseudoephedrine + vilanterol inhaled

monitor BP, HR: combo may incr. risk of HTN, tachycardia, other cardiovascular adverse effects (additive effects)

• viloxazine
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

viloxazine

3 interactions

Monitor/Modify Tx

pseudoephedrine + viloxazine

monitor BP, HR: combo may incr. risk of HTN, tachycardia (additive effects)

Caution Advised

chlophedianol + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + viloxazine

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• voclosporin
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

voclosporin

1 interaction

Monitor/Modify Tx

pseudoephedrine + voclosporin

monitor BP: combo may incr. risk of HTN (additive effects)

• zaleplon
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

zaleplon

2 interactions

Monitor/Modify Tx

chlophedianol + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zavegepant
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

zavegepant

1 interaction

Monitor/Modify Tx

pseudoephedrine + zavegepant

monitor BP: combo may incr. risk of HTN (additive effects)

• ziconotide
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ziconotide

2 interactions

Monitor/Modify Tx

chlophedianol + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

pseudoephedrine + ziv-aflibercept

monitor BP: combo may incr. risk of HTN (additive effects)

• zolmitriptan
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

zolmitriptan

3 interactions

Monitor/Modify Tx

pseudoephedrine + zolmitriptan

monitor BP: combo may incr. risk of HTN (additive effects)

Caution Advised

chlophedianol + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + zolmitriptan

caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Ninjacof-D (pyrilamine/ chlophedianol/ pseudoephedrine)

+

zolpidem

2 interactions

Monitor/Modify Tx

chlophedianol + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

pyrilamine + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)