Bicillin L-A

Overview

penicillin G

penicillin

• OAT1 substrate
• OAT3 substrate
• alters GI flora
• antiplatelet effects
• bactericidal activity requires bacterial growth
• impairs immunomodulatory bacterial infective agent
• lowers seizure threshold

Avoid/Use Alternative

• aldesleukin
Bicillin L-A (penicillin G benzathine)

+

aldesleukin

1 interaction

Avoid/Use Alternative

penicillin G + aldesleukin

avoid combo: combo may incr. risk of seizures (additive effects)

• amifampridine
Bicillin L-A (penicillin G benzathine)

+

amifampridine

1 interaction

Avoid/Use Alternative

penicillin G + amifampridine

consider alternative, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• BCG live intravesical
Bicillin L-A (penicillin G benzathine)

+

BCG live intravesical

1 interaction

Avoid/Use Alternative

penicillin G + BCG live intravesical

avoid combo: combo may decr. BCG live intravesical efficacy (antibacterial effect may interfere with BCG activity)

• cholera vaccine, live
Bicillin L-A (penicillin G benzathine)

+

cholera vaccine, live

1 interaction

Avoid/Use Alternative

penicillin G + cholera vaccine, live

avoid vaccine until at least 14 days after penicillin G course complete: combo may result in inadequate vaccine response (antibiotic effect may inactivate vaccine)

• enoxaparin
Bicillin L-A (penicillin G benzathine)

+

enoxaparin

1 interaction

Avoid/Use Alternative

penicillin G + enoxaparin

use alternative or monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• fecal microbiota, live
Bicillin L-A (penicillin G benzathine)

+

fecal microbiota, live

1 interaction

Avoid/Use Alternative

penicillin G + fecal microbiota, live

ORAL MICROBIOTA: avoid combo; RECTAL MICROBIOTA: avoid combo up to 8wk after admin.: combo may decr. gut microbiota restoration (antibiotic effects)

• fondaparinux
Bicillin L-A (penicillin G benzathine)

+

fondaparinux

1 interaction

Avoid/Use Alternative

penicillin G + fondaparinux

use alternative or monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• iohexol
Bicillin L-A (penicillin G benzathine)

+

iohexol

1 interaction

Avoid/Use Alternative

penicillin G + iohexol

avoid combo if intrathecal iohexol use and high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• methotrexate
Bicillin L-A (penicillin G benzathine)

+

methotrexate

1 interaction

Avoid/Use Alternative

penicillin G + methotrexate

if oral methotrexate use, consider alternative or monitor CBC, renal fxn, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment; otherwise, monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening; combo with oral methotrexate may incr. methotrexate levels, risk of serious infection, myelosuppression, nephrotoxicity, other adverse effects; may decr. methotrexate active metabolite levels, efficacy (additive effects; decreased absorption; intestinal metabolism inhibited, decr. conversion to active metabolite)

• typhoid vaccine, live
Bicillin L-A (penicillin G benzathine)

+

typhoid vaccine, live

1 interaction

Avoid/Use Alternative

penicillin G + typhoid vaccine, live

avoid vaccine course during and w/in 72h of penicillin G use; if possible, delay penicillin G until at least 72h after last vaccine dose: combo may result in inadequate vaccine response (antibiotic effect may inactivate vaccine)

Monitor/Modify Tx

• abrocitinib
Bicillin L-A (penicillin G benzathine)

+

abrocitinib

1 interaction

Monitor/Modify Tx

penicillin G + abrocitinib

monitor platelets, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment during abrocitinib tx initiation or if abrocitinib 200 mg/day: combo may incr. risk of bleeding (additive effects)

• acalabrutinib
Bicillin L-A (penicillin G benzathine)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

penicillin G + acalabrutinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ado-trastuzumab emtansine
Bicillin L-A (penicillin G benzathine)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

penicillin G + ado-trastuzumab emtansine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• afatinib
Bicillin L-A (penicillin G benzathine)

+

afatinib

1 interaction

Monitor/Modify Tx

penicillin G + afatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• alpha-tocopherol (vitamin E)
Bicillin L-A (penicillin G benzathine)

+

alpha-tocopherol (vitamin E)

1 interaction

Monitor/Modify Tx

penicillin G + alpha-tocopherol (vitamin E)

monitor bleeding signs/symptoms, especially with alpha-tocopherol doses >800 units/day, large penicillin G doses, and/or concomitant renal impairment: combo may increase risk of bleeding (additive effects)

• alprostadil intracavernous
Bicillin L-A (penicillin G benzathine)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

penicillin G + alprostadil intracavernous

monitor injection site bleeding signs/symptoms: combo may increase risk of localized bleeding (additive effects)

• alprostadil intravenous
Bicillin L-A (penicillin G benzathine)

+

alprostadil intravenous

1 interaction

Monitor/Modify Tx

penicillin G + alprostadil intravenous

monitor bleeding signs/symptoms, especially with large penicillin G doses and/or concomitant renal impairment: combo may increase risk of bleeding (additive effects)

• alteplase
Bicillin L-A (penicillin G benzathine)

+

alteplase

1 interaction

Monitor/Modify Tx

penicillin G + alteplase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• anacaulase topical
Bicillin L-A (penicillin G benzathine)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

penicillin G + anacaulase topical

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• anagrelide
Bicillin L-A (penicillin G benzathine)

+

anagrelide

1 interaction

Monitor/Modify Tx

penicillin G + anagrelide

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• antithrombin
Bicillin L-A (penicillin G benzathine)

+

antithrombin

1 interaction

Monitor/Modify Tx

penicillin G + antithrombin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including severe (additive effects)

• apixaban
Bicillin L-A (penicillin G benzathine)

+

apixaban

1 interaction

Monitor/Modify Tx

penicillin G + apixaban

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• argatroban
Bicillin L-A (penicillin G benzathine)

+

argatroban

1 interaction

Monitor/Modify Tx

penicillin G + argatroban

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• asparaginase
Bicillin L-A (penicillin G benzathine)

+

asparaginase

1 interaction

Monitor/Modify Tx

penicillin G + asparaginase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• aspirin
Bicillin L-A (penicillin G benzathine)

+

aspirin

1 interaction

Monitor/Modify Tx

penicillin G + aspirin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• avapritinib
Bicillin L-A (penicillin G benzathine)

+

avapritinib

1 interaction

Monitor/Modify Tx

penicillin G + avapritinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• axitinib
Bicillin L-A (penicillin G benzathine)

+

axitinib

1 interaction

Monitor/Modify Tx

penicillin G + axitinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bevacizumab
Bicillin L-A (penicillin G benzathine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

penicillin G + bevacizumab

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• binimetinib
Bicillin L-A (penicillin G benzathine)

+

binimetinib

1 interaction

Monitor/Modify Tx

penicillin G + binimetinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bivalirudin
Bicillin L-A (penicillin G benzathine)

+

bivalirudin

1 interaction

Monitor/Modify Tx

penicillin G + bivalirudin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• brentuximab vedotin
Bicillin L-A (penicillin G benzathine)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

penicillin G + brentuximab vedotin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bromelain
Bicillin L-A (penicillin G benzathine)

+

bromelain

1 interaction

Monitor/Modify Tx

penicillin G + bromelain

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• bromfenac ophthalmic
Bicillin L-A (penicillin G benzathine)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

penicillin G + bromfenac ophthalmic

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of postop ocular bleeding (additive effects)

• bupropion
Bicillin L-A (penicillin G benzathine)

+

bupropion

1 interaction

Monitor/Modify Tx

penicillin G + bupropion

consider lower bupropion doses, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• cabazitaxel
Bicillin L-A (penicillin G benzathine)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

penicillin G + cabazitaxel

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• cabozantinib
Bicillin L-A (penicillin G benzathine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

penicillin G + cabozantinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• calaspargase
Bicillin L-A (penicillin G benzathine)

+

calaspargase

1 interaction

Monitor/Modify Tx

penicillin G + calaspargase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• cangrelor
Bicillin L-A (penicillin G benzathine)

+

cangrelor

1 interaction

Monitor/Modify Tx

penicillin G + cangrelor

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• caplacizumab
Bicillin L-A (penicillin G benzathine)

+

caplacizumab

1 interaction

Monitor/Modify Tx

penicillin G + caplacizumab

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• carfilzomib
Bicillin L-A (penicillin G benzathine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

penicillin G + carfilzomib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• celecoxib
Bicillin L-A (penicillin G benzathine)

+

celecoxib

1 interaction

Monitor/Modify Tx

penicillin G + celecoxib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• cilostazol
Bicillin L-A (penicillin G benzathine)

+

cilostazol

1 interaction

Monitor/Modify Tx

penicillin G + cilostazol

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• citalopram
Bicillin L-A (penicillin G benzathine)

+

citalopram

1 interaction

Monitor/Modify Tx

penicillin G + citalopram

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• clopidogrel
Bicillin L-A (penicillin G benzathine)

+

clopidogrel

1 interaction

Monitor/Modify Tx

penicillin G + clopidogrel

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• collagenase clostridium histolyticum
Bicillin L-A (penicillin G benzathine)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

penicillin G + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, including severe (additive effects)

• cysteamine
Bicillin L-A (penicillin G benzathine)

+

cysteamine

1 interaction

Monitor/Modify Tx

penicillin G + cysteamine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dabigatran
Bicillin L-A (penicillin G benzathine)

+

dabigatran

1 interaction

Monitor/Modify Tx

penicillin G + dabigatran

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• dalteparin
Bicillin L-A (penicillin G benzathine)

+

dalteparin

1 interaction

Monitor/Modify Tx

penicillin G + dalteparin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• danshen
Bicillin L-A (penicillin G benzathine)

+

danshen

1 interaction

Monitor/Modify Tx

penicillin G + danshen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• dasatinib
Bicillin L-A (penicillin G benzathine)

+

dasatinib

1 interaction

Monitor/Modify Tx

penicillin G + dasatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• deferasirox
Bicillin L-A (penicillin G benzathine)

+

deferasirox

1 interaction

Monitor/Modify Tx

penicillin G + deferasirox

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• defibrotide
Bicillin L-A (penicillin G benzathine)

+

defibrotide

1 interaction

Monitor/Modify Tx

penicillin G + defibrotide

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• desvenlafaxine
Bicillin L-A (penicillin G benzathine)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

penicillin G + desvenlafaxine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• deuruxolitinib
Bicillin L-A (penicillin G benzathine)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

penicillin G + deuruxolitinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diclofenac
Bicillin L-A (penicillin G benzathine)

+

diclofenac

1 interaction

Monitor/Modify Tx

penicillin G + diclofenac

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diclofenac ophthalmic
Bicillin L-A (penicillin G benzathine)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

penicillin G + diclofenac ophthalmic

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of postop ocular bleeding (additive effects)

• diclofenac topical
Bicillin L-A (penicillin G benzathine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

penicillin G + diclofenac topical

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diflunisal
Bicillin L-A (penicillin G benzathine)

+

diflunisal

1 interaction

Monitor/Modify Tx

penicillin G + diflunisal

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dimethyl fumarate
Bicillin L-A (penicillin G benzathine)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

penicillin G + dimethyl fumarate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diosmin
Bicillin L-A (penicillin G benzathine)

+

diosmin

1 interaction

Monitor/Modify Tx

penicillin G + diosmin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• dipyridamole
Bicillin L-A (penicillin G benzathine)

+

dipyridamole

1 interaction

Monitor/Modify Tx

penicillin G + dipyridamole

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• diroximel fumarate
Bicillin L-A (penicillin G benzathine)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

penicillin G + diroximel fumarate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• duloxetine
Bicillin L-A (penicillin G benzathine)

+

duloxetine

1 interaction

Monitor/Modify Tx

penicillin G + duloxetine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
Bicillin L-A (penicillin G benzathine)

+

edoxaban

1 interaction

Monitor/Modify Tx

penicillin G + edoxaban

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• encorafenib
Bicillin L-A (penicillin G benzathine)

+

encorafenib

1 interaction

Monitor/Modify Tx

penicillin G + encorafenib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• epoprostenol
Bicillin L-A (penicillin G benzathine)

+

epoprostenol

1 interaction

Monitor/Modify Tx

penicillin G + epoprostenol

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• eptifibatide
Bicillin L-A (penicillin G benzathine)

+

eptifibatide

1 interaction

Monitor/Modify Tx

penicillin G + eptifibatide

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• erlotinib
Bicillin L-A (penicillin G benzathine)

+

erlotinib

1 interaction

Monitor/Modify Tx

penicillin G + erlotinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• escitalopram
Bicillin L-A (penicillin G benzathine)

+

escitalopram

1 interaction

Monitor/Modify Tx

penicillin G + escitalopram

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ethanol (alcoholic beverage)
Bicillin L-A (penicillin G benzathine)

+

ethanol (alcoholic beverage)

1 interaction

Monitor/Modify Tx

penicillin G + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms, especially with large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• etodolac
Bicillin L-A (penicillin G benzathine)

+

etodolac

1 interaction

Monitor/Modify Tx

penicillin G + etodolac

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• evening primrose oil
Bicillin L-A (penicillin G benzathine)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

penicillin G + evening primrose oil

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• fenoprofen
Bicillin L-A (penicillin G benzathine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

penicillin G + fenoprofen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• fenugreek
Bicillin L-A (penicillin G benzathine)

+

fenugreek

1 interaction

Monitor/Modify Tx

penicillin G + fenugreek

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• fluoxetine
Bicillin L-A (penicillin G benzathine)

+

fluoxetine

1 interaction

Monitor/Modify Tx

penicillin G + fluoxetine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen
Bicillin L-A (penicillin G benzathine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

penicillin G + flurbiprofen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• flurbiprofen ophthalmic
Bicillin L-A (penicillin G benzathine)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

penicillin G + flurbiprofen ophthalmic

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of postop ocular bleeding (additive effects)

• fluvoxamine
Bicillin L-A (penicillin G benzathine)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

penicillin G + fluvoxamine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fruquintinib
Bicillin L-A (penicillin G benzathine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

penicillin G + fruquintinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• garlic
Bicillin L-A (penicillin G benzathine)

+

garlic

1 interaction

Monitor/Modify Tx

penicillin G + garlic

monitor bleeding s/sx, especially w/ supplemental garlic, large penicillin G doses and/or concomitant renal impairment; dietary intake OK: combo may incr. risk of GI or other bleeding (additive effects)

• gefitinib
Bicillin L-A (penicillin G benzathine)

+

gefitinib

1 interaction

Monitor/Modify Tx

penicillin G + gefitinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• gemtuzumab ozogamicin
Bicillin L-A (penicillin G benzathine)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

penicillin G + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ginkgo
Bicillin L-A (penicillin G benzathine)

+

ginkgo

1 interaction

Monitor/Modify Tx

penicillin G + ginkgo

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• heparin
Bicillin L-A (penicillin G benzathine)

+

heparin

1 interaction

Monitor/Modify Tx

penicillin G + heparin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• hydrocortisone
Bicillin L-A (penicillin G benzathine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

penicillin G + hydrocortisone

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ibrutinib
Bicillin L-A (penicillin G benzathine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

penicillin G + ibrutinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ibuprofen
Bicillin L-A (penicillin G benzathine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

penicillin G + ibuprofen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ibuprofen lysine
Bicillin L-A (penicillin G benzathine)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

penicillin G + ibuprofen lysine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• icosapent ethyl
Bicillin L-A (penicillin G benzathine)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

penicillin G + icosapent ethyl

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• imatinib
Bicillin L-A (penicillin G benzathine)

+

imatinib

1 interaction

Monitor/Modify Tx

penicillin G + imatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• indomethacin
Bicillin L-A (penicillin G benzathine)

+

indomethacin

1 interaction

Monitor/Modify Tx

penicillin G + indomethacin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• iopamidol
Bicillin L-A (penicillin G benzathine)

+

iopamidol

1 interaction

Monitor/Modify Tx

penicillin G + iopamidol

caution advised if intrathecal iopamidol use, especially w/ high penicillin G doses or concomitant renal impairment; consider holding penicillin G at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• ketoprofen
Bicillin L-A (penicillin G benzathine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

penicillin G + ketoprofen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ketorolac
Bicillin L-A (penicillin G benzathine)

+

ketorolac

1 interaction

Monitor/Modify Tx

penicillin G + ketorolac

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ketorolac ophthalmic
Bicillin L-A (penicillin G benzathine)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

penicillin G + ketorolac ophthalmic

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of postop ocular bleeding (additive effects)

• lenvatinib
Bicillin L-A (penicillin G benzathine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

penicillin G + lenvatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• levomilnacipran
Bicillin L-A (penicillin G benzathine)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

penicillin G + levomilnacipran

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lifileucel
Bicillin L-A (penicillin G benzathine)

+

lifileucel

1 interaction

Monitor/Modify Tx

penicillin G + lifileucel

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• magnesium salicylate
Bicillin L-A (penicillin G benzathine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

penicillin G + magnesium salicylate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• meclofenamate
Bicillin L-A (penicillin G benzathine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

penicillin G + meclofenamate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• mefenamic acid
Bicillin L-A (penicillin G benzathine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

penicillin G + mefenamic acid

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• meloxicam
Bicillin L-A (penicillin G benzathine)

+

meloxicam

1 interaction

Monitor/Modify Tx

penicillin G + meloxicam

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• methyl salicylate topical
Bicillin L-A (penicillin G benzathine)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

penicillin G + methyl salicylate topical

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, systemic salicylate absorption may occur from topical use)

• milnacipran
Bicillin L-A (penicillin G benzathine)

+

milnacipran

1 interaction

Monitor/Modify Tx

penicillin G + milnacipran

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mitotane
Bicillin L-A (penicillin G benzathine)

+

mitotane

1 interaction

Monitor/Modify Tx

penicillin G + mitotane

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• monomethyl fumarate
Bicillin L-A (penicillin G benzathine)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

penicillin G + monomethyl fumarate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• mycophenolate mofetil
Bicillin L-A (penicillin G benzathine)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

penicillin G + mycophenolate mofetil

monitor rejection s/sx, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may decr. mycophenolic acid levels, efficacy; may incr. risk of GI or other bleeding, including life-threatening (enterohepatic circulation altered; additive effects)

• mycophenolic acid
Bicillin L-A (penicillin G benzathine)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

penicillin G + mycophenolic acid

monitor rejection s/sx, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may decr. mycophenolic acid levels, efficacy; may incr. risk of GI or other bleeding, including life-threatening (enterohepatic circulation altered; additive effects)

• nabumetone
Bicillin L-A (penicillin G benzathine)

+

nabumetone

1 interaction

Monitor/Modify Tx

penicillin G + nabumetone

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• naproxen
Bicillin L-A (penicillin G benzathine)

+

naproxen

1 interaction

Monitor/Modify Tx

penicillin G + naproxen

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nattokinase
Bicillin L-A (penicillin G benzathine)

+

nattokinase

1 interaction

Monitor/Modify Tx

penicillin G + nattokinase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• nepafenac ophthalmic
Bicillin L-A (penicillin G benzathine)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

penicillin G + nepafenac ophthalmic

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of postop ocular bleeding (additive effects)

• niacin (vitamin B3)
Bicillin L-A (penicillin G benzathine)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

penicillin G + niacin (vitamin B3)

monitor platelets, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• nilotinib
Bicillin L-A (penicillin G benzathine)

+

nilotinib

1 interaction

Monitor/Modify Tx

penicillin G + nilotinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nintedanib
Bicillin L-A (penicillin G benzathine)

+

nintedanib

1 interaction

Monitor/Modify Tx

penicillin G + nintedanib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nusinersen
Bicillin L-A (penicillin G benzathine)

+

nusinersen

1 interaction

Monitor/Modify Tx

penicillin G + nusinersen

monitor platelets, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• obinutuzumab
Bicillin L-A (penicillin G benzathine)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

penicillin G + obinutuzumab

monitor platelets, bleeding s/sx; consider holding penicillin G, especially during first obinutuzumab cycle, large penicillin G doses, and/or concomitant renal impairment: combo may incr. risk of severe bleeding, including life-threatening (additive effects)

• omega-3-acid
Bicillin L-A (penicillin G benzathine)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

penicillin G + omega-3-acid

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• oxaliplatin
Bicillin L-A (penicillin G benzathine)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

penicillin G + oxaliplatin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding (additive effects)

• oxaprozin
Bicillin L-A (penicillin G benzathine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

penicillin G + oxaprozin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pacritinib
Bicillin L-A (penicillin G benzathine)

+

pacritinib

1 interaction

Monitor/Modify Tx

penicillin G + pacritinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• paroxetine
Bicillin L-A (penicillin G benzathine)

+

paroxetine

1 interaction

Monitor/Modify Tx

penicillin G + paroxetine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
Bicillin L-A (penicillin G benzathine)

+

pazopanib

1 interaction

Monitor/Modify Tx

penicillin G + pazopanib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pegaspargase
Bicillin L-A (penicillin G benzathine)

+

pegaspargase

1 interaction

Monitor/Modify Tx

penicillin G + pegaspargase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• pentosan polysulfate sodium
Bicillin L-A (penicillin G benzathine)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

penicillin G + pentosan polysulfate sodium

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• pentoxifylline
Bicillin L-A (penicillin G benzathine)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

penicillin G + pentoxifylline

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• piperacillin
Bicillin L-A (penicillin G benzathine)

+

piperacillin

1 interaction

Monitor/Modify Tx

penicillin G + piperacillin

monitor bleeding s/sx, especially w/ large penicillin G doses, prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• piroxicam
Bicillin L-A (penicillin G benzathine)

+

piroxicam

1 interaction

Monitor/Modify Tx

penicillin G + piroxicam

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pirtobrutinib
Bicillin L-A (penicillin G benzathine)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

penicillin G + pirtobrutinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• plasminogen, human
Bicillin L-A (penicillin G benzathine)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

penicillin G + plasminogen, human

monitor bleeding s/sx during and x4h after plasminogen infusion, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ponatinib
Bicillin L-A (penicillin G benzathine)

+

ponatinib

1 interaction

Monitor/Modify Tx

penicillin G + ponatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• porfimer
Bicillin L-A (penicillin G benzathine)

+

porfimer

1 interaction

Monitor/Modify Tx

penicillin G + porfimer

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pralsetinib
Bicillin L-A (penicillin G benzathine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

penicillin G + pralsetinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• prasugrel
Bicillin L-A (penicillin G benzathine)

+

prasugrel

1 interaction

Monitor/Modify Tx

penicillin G + prasugrel

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ramucirumab
Bicillin L-A (penicillin G benzathine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

penicillin G + ramucirumab

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ranibizumab
Bicillin L-A (penicillin G benzathine)

+

ranibizumab

1 interaction

Monitor/Modify Tx

penicillin G + ranibizumab

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of ocular hemorrhage (additive effects)

• regorafenib
Bicillin L-A (penicillin G benzathine)

+

regorafenib

1 interaction

Monitor/Modify Tx

penicillin G + regorafenib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• remibrutinib
Bicillin L-A (penicillin G benzathine)

+

remibrutinib

1 interaction

Monitor/Modify Tx

penicillin G + remibrutinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• resveratrol
Bicillin L-A (penicillin G benzathine)

+

resveratrol

1 interaction

Monitor/Modify Tx

penicillin G + resveratrol

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• reteplase
Bicillin L-A (penicillin G benzathine)

+

reteplase

1 interaction

Monitor/Modify Tx

penicillin G + reteplase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• revakinagene taroretcel
Bicillin L-A (penicillin G benzathine)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

penicillin G + revakinagene taroretcel

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of ocular hemorrhage (additive effects)

• rivaroxaban
Bicillin L-A (penicillin G benzathine)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

penicillin G + rivaroxaban

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• salsalate
Bicillin L-A (penicillin G benzathine)

+

salsalate

1 interaction

Monitor/Modify Tx

penicillin G + salsalate

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• saw palmetto
Bicillin L-A (penicillin G benzathine)

+

saw palmetto

1 interaction

Monitor/Modify Tx

penicillin G + saw palmetto

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• selpercatinib
Bicillin L-A (penicillin G benzathine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

penicillin G + selpercatinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• selumetinib
Bicillin L-A (penicillin G benzathine)

+

selumetinib

1 interaction

Monitor/Modify Tx

penicillin G + selumetinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules)

• sepiapterin
Bicillin L-A (penicillin G benzathine)

+

sepiapterin

1 interaction

Monitor/Modify Tx

penicillin G + sepiapterin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• sertraline
Bicillin L-A (penicillin G benzathine)

+

sertraline

1 interaction

Monitor/Modify Tx

penicillin G + sertraline

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sirolimus albumin-bound
Bicillin L-A (penicillin G benzathine)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

penicillin G + sirolimus albumin-bound

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• sorafenib
Bicillin L-A (penicillin G benzathine)

+

sorafenib

1 interaction

Monitor/Modify Tx

penicillin G + sorafenib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sotatercept
Bicillin L-A (penicillin G benzathine)

+

sotatercept

1 interaction

Monitor/Modify Tx

penicillin G + sotatercept

monitor platelets, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including severe (additive effects)

• sulindac
Bicillin L-A (penicillin G benzathine)

+

sulindac

1 interaction

Monitor/Modify Tx

penicillin G + sulindac

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sunitinib
Bicillin L-A (penicillin G benzathine)

+

sunitinib

1 interaction

Monitor/Modify Tx

penicillin G + sunitinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• temsirolimus
Bicillin L-A (penicillin G benzathine)

+

temsirolimus

1 interaction

Monitor/Modify Tx

penicillin G + temsirolimus

monitor bleeding signs/symptoms, especially with large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tenecteplase
Bicillin L-A (penicillin G benzathine)

+

tenecteplase

1 interaction

Monitor/Modify Tx

penicillin G + tenecteplase

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ticagrelor
Bicillin L-A (penicillin G benzathine)

+

ticagrelor

1 interaction

Monitor/Modify Tx

penicillin G + ticagrelor

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• tipranavir
Bicillin L-A (penicillin G benzathine)

+

tipranavir

1 interaction

Monitor/Modify Tx

penicillin G + tipranavir

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• tirofiban
Bicillin L-A (penicillin G benzathine)

+

tirofiban

1 interaction

Monitor/Modify Tx

penicillin G + tirofiban

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• tisotumab vedotin
Bicillin L-A (penicillin G benzathine)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

penicillin G + tisotumab vedotin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• tivozanib
Bicillin L-A (penicillin G benzathine)

+

tivozanib

1 interaction

Monitor/Modify Tx

penicillin G + tivozanib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tolmetin
Bicillin L-A (penicillin G benzathine)

+

tolmetin

1 interaction

Monitor/Modify Tx

penicillin G + tolmetin

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tovorafenib
Bicillin L-A (penicillin G benzathine)

+

tovorafenib

1 interaction

Monitor/Modify Tx

penicillin G + tovorafenib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• trametinib
Bicillin L-A (penicillin G benzathine)

+

trametinib

1 interaction

Monitor/Modify Tx

penicillin G + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use, large penicillin G doses, or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• trazodone
Bicillin L-A (penicillin G benzathine)

+

trazodone

1 interaction

Monitor/Modify Tx

penicillin G + trazodone

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• treosulfan
Bicillin L-A (penicillin G benzathine)

+

treosulfan

1 interaction

Monitor/Modify Tx

penicillin G + treosulfan

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• treprostinil
Bicillin L-A (penicillin G benzathine)

+

treprostinil

1 interaction

Monitor/Modify Tx

penicillin G + treprostinil

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• upadacitinib
Bicillin L-A (penicillin G benzathine)

+

upadacitinib

1 interaction

Monitor/Modify Tx

penicillin G + upadacitinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• vadadustat
Bicillin L-A (penicillin G benzathine)

+

vadadustat

1 interaction

Monitor/Modify Tx

penicillin G + vadadustat

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• valproic acid
Bicillin L-A (penicillin G benzathine)

+

valproic acid

1 interaction

Monitor/Modify Tx

penicillin G + valproic acid

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding; may alter seizure control (additive effects; antagonistic effects, penicillin G may decr. seizure threshold)

• vandetanib
Bicillin L-A (penicillin G benzathine)

+

vandetanib

1 interaction

Monitor/Modify Tx

penicillin G + vandetanib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• venlafaxine
Bicillin L-A (penicillin G benzathine)

+

venlafaxine

1 interaction

Monitor/Modify Tx

penicillin G + venlafaxine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Bicillin L-A (penicillin G benzathine)

+

vilazodone

1 interaction

Monitor/Modify Tx

penicillin G + vilazodone

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vinpocetine
Bicillin L-A (penicillin G benzathine)

+

vinpocetine

1 interaction

Monitor/Modify Tx

penicillin G + vinpocetine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding (additive effects)

• vorapaxar
Bicillin L-A (penicillin G benzathine)

+

vorapaxar

1 interaction

Monitor/Modify Tx

penicillin G + vorapaxar

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vortioxetine
Bicillin L-A (penicillin G benzathine)

+

vortioxetine

1 interaction

Monitor/Modify Tx

penicillin G + vortioxetine

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• warfarin
Bicillin L-A (penicillin G benzathine)

+

warfarin

1 interaction

Monitor/Modify Tx

penicillin G + warfarin

monitor INR, bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (synergistic effects, alteration of vitamin K producing gut flora)

• willow bark
Bicillin L-A (penicillin G benzathine)

+

willow bark

1 interaction

Monitor/Modify Tx

penicillin G + willow bark

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, willow bark may contain salicylates)

• zanubrutinib
Bicillin L-A (penicillin G benzathine)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

penicillin G + zanubrutinib

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ziv-aflibercept
Bicillin L-A (penicillin G benzathine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

penicillin G + ziv-aflibercept

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

Therapeutic Advantage

• amikacin
Bicillin L-A (penicillin G benzathine)

+

amikacin

1 interaction

Therapeutic Advantage

penicillin G + amikacin

use for therapeutic advantage: combo may enhance bactericidal efficacy (synergistic effects)

• gentamicin
Bicillin L-A (penicillin G benzathine)

+

gentamicin

1 interaction

Therapeutic Advantage

penicillin G + gentamicin

use for therapeutic advantage: combo may enhance bactericidal efficacy (synergistic effects)

• probenecid
Bicillin L-A (penicillin G benzathine)

+

probenecid

1 interaction

Therapeutic Advantage

penicillin G + probenecid

use for therapeutic advantage: combo may incr. penicillin G levels, prolong duration of action (renal transport inhibited)

• streptomycin
Bicillin L-A (penicillin G benzathine)

+

streptomycin

1 interaction

Therapeutic Advantage

penicillin G + streptomycin

use for therapeutic advantage: combo may enhance bactericidal efficacy (synergistic effects)

• tobramycin
Bicillin L-A (penicillin G benzathine)

+

tobramycin

1 interaction

Therapeutic Advantage

penicillin G + tobramycin

use for therapeutic advantage: combo may enhance bactericidal efficacy (synergistic effects)

Caution Advised

• acetazolamide
Bicillin L-A (penicillin G benzathine)

+

acetazolamide

1 interaction

Caution Advised

penicillin G + acetazolamide

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• brivaracetam
Bicillin L-A (penicillin G benzathine)

+

brivaracetam

1 interaction

Caution Advised

penicillin G + brivaracetam

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• busulfan
Bicillin L-A (penicillin G benzathine)

+

busulfan

1 interaction

Caution Advised

penicillin G + busulfan

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• cannabidiol
Bicillin L-A (penicillin G benzathine)

+

cannabidiol

1 interaction

Caution Advised

penicillin G + cannabidiol

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• carbamazepine
Bicillin L-A (penicillin G benzathine)

+

carbamazepine

1 interaction

Caution Advised

penicillin G + carbamazepine

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• cenobamate
Bicillin L-A (penicillin G benzathine)

+

cenobamate

1 interaction

Caution Advised

penicillin G + cenobamate

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• chlorambucil
Bicillin L-A (penicillin G benzathine)

+

chlorambucil

1 interaction

Caution Advised

penicillin G + chlorambucil

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• clobazam
Bicillin L-A (penicillin G benzathine)

+

clobazam

1 interaction

Caution Advised

penicillin G + clobazam

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• clomipramine
Bicillin L-A (penicillin G benzathine)

+

clomipramine

1 interaction

Caution Advised

penicillin G + clomipramine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• clonazepam
Bicillin L-A (penicillin G benzathine)

+

clonazepam

1 interaction

Caution Advised

penicillin G + clonazepam

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• clorazepate
Bicillin L-A (penicillin G benzathine)

+

clorazepate

1 interaction

Caution Advised

penicillin G + clorazepate

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• clozapine
Bicillin L-A (penicillin G benzathine)

+

clozapine

1 interaction

Caution Advised

penicillin G + clozapine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• demeclocycline
Bicillin L-A (penicillin G benzathine)

+

demeclocycline

1 interaction

Caution Advised

penicillin G + demeclocycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• diazepam
Bicillin L-A (penicillin G benzathine)

+

diazepam

1 interaction

Caution Advised

penicillin G + diazepam

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• doxycycline
Bicillin L-A (penicillin G benzathine)

+

doxycycline

1 interaction

Caution Advised

penicillin G + doxycycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• eravacycline
Bicillin L-A (penicillin G benzathine)

+

eravacycline

1 interaction

Caution Advised

penicillin G + eravacycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• eslicarbazepine acetate
Bicillin L-A (penicillin G benzathine)

+

eslicarbazepine acetate

1 interaction

Caution Advised

penicillin G + eslicarbazepine acetate

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• ethosuximide
Bicillin L-A (penicillin G benzathine)

+

ethosuximide

1 interaction

Caution Advised

penicillin G + ethosuximide

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• felbamate
Bicillin L-A (penicillin G benzathine)

+

felbamate

1 interaction

Caution Advised

penicillin G + felbamate

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• fenfluramine
Bicillin L-A (penicillin G benzathine)

+

fenfluramine

1 interaction

Caution Advised

penicillin G + fenfluramine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• fosphenytoin
Bicillin L-A (penicillin G benzathine)

+

fosphenytoin

1 interaction

Caution Advised

penicillin G + fosphenytoin

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• gabapentin
Bicillin L-A (penicillin G benzathine)

+

gabapentin

1 interaction

Caution Advised

penicillin G + gabapentin

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• ganaxolone
Bicillin L-A (penicillin G benzathine)

+

ganaxolone

1 interaction

Caution Advised

penicillin G + ganaxolone

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• hydroxychloroquine
Bicillin L-A (penicillin G benzathine)

+

hydroxychloroquine

1 interaction

Caution Advised

penicillin G + hydroxychloroquine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• lacosamide
Bicillin L-A (penicillin G benzathine)

+

lacosamide

1 interaction

Caution Advised

penicillin G + lacosamide

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• lactulose
Bicillin L-A (penicillin G benzathine)

+

lactulose

1 interaction

Caution Advised

penicillin G + lactulose

caution advised: combo may decr. lactulose efficacy (colonic metabolism inhibited)

• lamotrigine
Bicillin L-A (penicillin G benzathine)

+

lamotrigine

1 interaction

Caution Advised

penicillin G + lamotrigine

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• levetiracetam
Bicillin L-A (penicillin G benzathine)

+

levetiracetam

1 interaction

Caution Advised

penicillin G + levetiracetam

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• lorazepam
Bicillin L-A (penicillin G benzathine)

+

lorazepam

1 interaction

Caution Advised

penicillin G + lorazepam

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• magnesium citrate
Bicillin L-A (penicillin G benzathine)

+

magnesium citrate

1 interaction

Caution Advised

penicillin G + magnesium citrate

caution advised, especially if magnesium citrate bowel prep use, high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• methsuximide
Bicillin L-A (penicillin G benzathine)

+

methsuximide

1 interaction

Caution Advised

penicillin G + methsuximide

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• midazolam
Bicillin L-A (penicillin G benzathine)

+

midazolam

1 interaction

Caution Advised

penicillin G + midazolam

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• minocycline
Bicillin L-A (penicillin G benzathine)

+

minocycline

1 interaction

Caution Advised

penicillin G + minocycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• oxcarbazepine
Bicillin L-A (penicillin G benzathine)

+

oxcarbazepine

1 interaction

Caution Advised

penicillin G + oxcarbazepine

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• perampanel
Bicillin L-A (penicillin G benzathine)

+

perampanel

1 interaction

Caution Advised

penicillin G + perampanel

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• phenobarbital
Bicillin L-A (penicillin G benzathine)

+

phenobarbital

1 interaction

Caution Advised

penicillin G + phenobarbital

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• phenytoin
Bicillin L-A (penicillin G benzathine)

+

phenytoin

1 interaction

Caution Advised

penicillin G + phenytoin

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• polyethylene glycol
Bicillin L-A (penicillin G benzathine)

+

polyethylene glycol

1 interaction

Caution Advised

penicillin G + polyethylene glycol

caution advised, especially if polyethylene glycol bowel prep use, high penicillin G doses, and/or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
Bicillin L-A (penicillin G benzathine)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

penicillin G + polyethylene glycol/ electrolytes

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• pregabalin
Bicillin L-A (penicillin G benzathine)

+

pregabalin

1 interaction

Caution Advised

penicillin G + pregabalin

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• primidone
Bicillin L-A (penicillin G benzathine)

+

primidone

1 interaction

Caution Advised

penicillin G + primidone

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• promethazine
Bicillin L-A (penicillin G benzathine)

+

promethazine

1 interaction

Caution Advised

penicillin G + promethazine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• rufinamide
Bicillin L-A (penicillin G benzathine)

+

rufinamide

1 interaction

Caution Advised

penicillin G + rufinamide

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• sarecycline
Bicillin L-A (penicillin G benzathine)

+

sarecycline

1 interaction

Caution Advised

penicillin G + sarecycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• sodium benzoate
Bicillin L-A (penicillin G benzathine)

+

sodium benzoate

1 interaction

Caution Advised

penicillin G + sodium benzoate

caution advised: combo may incr. sodium benzoate levels, risk of adverse effects (renal transport possibly inhibited)

• sodium phenylacetate
Bicillin L-A (penicillin G benzathine)

+

sodium phenylacetate

1 interaction

Caution Advised

penicillin G + sodium phenylacetate

caution advised: combo may incr. levels of phenylacetate active metabolite, incr. risk of adverse effects (renal transport possibly inhibited)

• sodium picosulfate
Bicillin L-A (penicillin G benzathine)

+

sodium picosulfate

1 interaction

Caution Advised

penicillin G + sodium picosulfate

caution advised: combo may decr. sodium picosulfate efficacy; may incr. risk of seizures, especially with high penicillin G doses or concomitant renal impairment (colonic metabolism inhibited, decr. conversion to active metabolite; additive effects)

• stiripentol
Bicillin L-A (penicillin G benzathine)

+

stiripentol

1 interaction

Caution Advised

penicillin G + stiripentol

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• sulfate bowel prep
Bicillin L-A (penicillin G benzathine)

+

sulfate bowel prep

1 interaction

Caution Advised

penicillin G + sulfate bowel prep

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• tetracycline
Bicillin L-A (penicillin G benzathine)

+

tetracycline

1 interaction

Caution Advised

penicillin G + tetracycline

caution advised if bactericidal action necessary: combo with tetracyclines may decr. penicillin antibiotic efficacy (bacteriostatic effects may decr. bactericidal action)

• tiagabine
Bicillin L-A (penicillin G benzathine)

+

tiagabine

1 interaction

Caution Advised

penicillin G + tiagabine

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• topiramate
Bicillin L-A (penicillin G benzathine)

+

topiramate

1 interaction

Caution Advised

penicillin G + topiramate

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• tramadol
Bicillin L-A (penicillin G benzathine)

+

tramadol

1 interaction

Caution Advised

penicillin G + tramadol

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may incr. risk of seizures (additive effects)

• vigabatrin
Bicillin L-A (penicillin G benzathine)

+

vigabatrin

1 interaction

Caution Advised

penicillin G + vigabatrin

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• zonisamide
Bicillin L-A (penicillin G benzathine)

+

zonisamide

1 interaction

Caution Advised

penicillin G + zonisamide

caution advised, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)