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NovoLog
insulin aspart
Adult Dosing .
Dosage forms: INJ (PenFill U-100 cartridge): 100 units per mL; INJ (FlexPen U-100 pen, FlexPen ReliOn U-100 pen): 100 units per mL; INJ (U-100 vial, ReliOn U-100 vial): 100 units per mL
Special Note
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Start: 50-60% x (0.4-0.5 units/kg/day) SC in divided doses, may adjust dose by 1-4 units or 5-10% 1-2x/wk; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); give 5-10min before meals; use with intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immediately postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); dose adjustment may be needed during pregnancy and/or immediately postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immediately postpartum
diabetes mellitus, type 2
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Start: 4 units SC qd or 10% of basal insulin dose SC qd, may incr. dose by 1-2 units or 10-15% 2x/wk; Info: give 5-10min before meals; use with intermediate-acting or long-acting insulin; dose adjustment may be needed during pregnancy and/or immediately postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: dose adjustment may be needed during pregnancy and/or immediately postpartum; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [IV route]
- Dose: individualize dose via IV infusion; Info: refer to institutional protocol; dose adjustment may be needed during pregnancy and/or immediately postpartum
diabetic ketoacidosis, mild-moderate uncomplicated (off-label)
- [q1h dosing regimen]
- Dose: 0.1 units/kg/dose SC q1h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.05 units/kg/dose SC q1h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol
- [q2h dosing regimen]
- Dose: 0.2 units/kg/dose SC q2h; Start: 0.1 units/kg/dose SC x1; Info: when blood glucose <250 mg/dL, decr. dose to 0.1 units/kg/dose SC q2h and add dextrose 5-10%; maintain blood glucose at 150-200 mg/dL until DKA resolves; refer to institutional protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
- Dosage forms: INJ (PenFill U-100 cartridge): 100 units per mL; INJ (FlexPen U-100 pen, FlexPen ReliOn U-100 pen): 100 units per mL; INJ (U-100 vial, ReliOn U-100 vial): 100 units per mL
Special Note
- [additional info]
- Info: search Insulin Product Comparisons for comparison of onset, peak, duration, dosage form, and mixing compatibility
diabetes mellitus, type 1
- [intermittent SC injection, 2 yo and older]
- Dose: individualize dose SC bid-qid; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; give 5-10min before meals; use with intermediate-acting or long-acting insulin; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion, 2 yo and older]
- Dose: individualize dose via continuous SC infusion pump; Info: usual total daily insulin requirement 0.4-1 units/kg/day (basal + prandial); adolescents may require higher doses; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
diabetes mellitus, type 2
- [intermittent SC injection]
- Dose: individualize dose SC bid-qid; Info: give 5-10min before meals; use with intermediate-acting or long-acting insulin; onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
- [continuous SC infusion]
- Dose: individualize dose via continuous SC infusion pump; Info: onset <0.25h, peak 1-3h, duration 3-5h (rapid-acting insulin)
diabetic ketoacidosis, mild-moderate uncomplicated (off-label)
- [0.15 units/kg/dose SC q2h]
- Start: 1h after initial fluid tx; Info: add dextrose 5% when blood glucose 250-300 mg/dL or if blood glucose decr. at rate >90 mg/dL/h; may decr. dose to 0.1 units/kg/dose SC q2h if blood glucose continues to decr. by >90 mg/dL/h; maintain blood glucose at 200 mg/dL until DKA resolves; refer to institutional protocol
renal dosing
- [see below]
- renal impairment: consider decr. usual start dose
- HD: consider decr. usual start dose; no supplement after dialysis; PD: consider decr. usual start dose; no supplement
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypoglycemia
- caution: hypoglycemia unawareness
- caution: illness
- caution: stress
- caution: hypokalemia risk
- caution: renal impairment
- caution: hepatic impairment
- caution: visual impairment (pen form)
- caution: localized cutaneous amyloidosis
- caution: lipodystrophy
Drug Interactions .
Overview
insulin
insulin
- affects growth hormone diagnostic test results
- antidiabetic agent
- hypokalemia
zinc (inactive ingredient)
heavy metal
- heavy metal
Avoid/Use Alternative
Monitor/Modify Tx
Adverse Reactions .
Serious Reactions
- hypoglycemia
- hypokalemia
- hypersensitivity reaction
- anaphylaxis
Common Reactions
- hypoglycemia
- headache
- hyporeflexia
- onychomycosis
- sensory disturbance
- UTI
- nausea
- diarrhea
- chest pain
- pruritus
- rash
- abdominal pain
- URI
- weight gain
- edema, peripheral
- injection site reaction
- injection site lipodystrophy
- localized cutaneous amyloidosis
Safety/Monitoring .
Monitoring Parameters
Cr at baseline; K if hypokalemia risk
Look/Sound-Alike Drug Names
NovoLOG confused with: HumaLOG; HumuLIN R; Novolin N; Novolin R; NovoLOG Mix 70/30
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; drug of choice for diabetes use during pregnancy; dose adjustment may be needed during pregnancy and/or immediately postpartum; no known risk of fetal harm based on human data
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on drug properties; possible risk of delayed milk production based on conflicting human data
Pharmacology .
Metabolism: for insulin aspart: liver, kidney, fat; CYP450: none
Excretion: for insulin aspart: urine; Half-life: 81min; Info: onset, peak, duration vary among insulin products and routes; search Insulin Product Comparisons for more info
Subclass: Diabetes: Insulins
Mechanism of Action
for insulin aspart: stimulates peripheral glucose uptake, inhibits hepatic glucose production, inhibits lipolysis and proteolysis, regulating glucose metabolism (rapid-acting insulin)
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Novo Nordisk A/S
DEA/FDA: Rx
Retail Price
Estimated prices only. For current pricing, visit GoodRx.
injectable solution:
- 100 units/mL (5 cartridge, 3 mL): $558.00
injectable solution:
- 100 units/mL (5 flexpen, 3 mL): $580.00
injectable solution:
- 100 units/mL (1 vial, 10 mL): $305.00
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