Aricept

Overview

donepezil

cholinesterase inhibitor

• CYP2D6 substrate
• CYP3A4 substrate
• bradycardia
• cholinergic effects
• delays atrioventricular conduction
• GI mucosal injury/bleeding risk
• lowers seizure threshold
• prolongs QT interval (known)

Contraindicated

• cisapride
Aricept (donepezil)

+

cisapride

1 interaction

Contraindicated

donepezil + cisapride

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• domperidone
Aricept (donepezil)

+

domperidone

1 interaction

Contraindicated

donepezil + domperidone

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• dronedarone
Aricept (donepezil)

+

dronedarone

1 interaction

Contraindicated

donepezil + dronedarone

contraindicated: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• levoketoconazole
Aricept (donepezil)

+

levoketoconazole

1 interaction

Contraindicated

donepezil + levoketoconazole

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pimozide
Aricept (donepezil)

+

pimozide

1 interaction

Contraindicated

donepezil + pimozide

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• quinidine (CYP2D6 inhibitor)
Aricept (donepezil)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Contraindicated

donepezil + quinidine (CYP2D6 inhibitor)

contraindicated: combo may incr. donepezil levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects; may decr. donepezil efficacy (hepatic metabolism inhibited, additive effects; antagonistic effects)

• thioridazine
Aricept (donepezil)

+

thioridazine

1 interaction

Contraindicated

donepezil + thioridazine

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

Avoid/Use Alternative

• adagrasib
Aricept (donepezil)

+

adagrasib

1 interaction

Avoid/Use Alternative

donepezil + adagrasib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• aldesleukin
Aricept (donepezil)

+

aldesleukin

1 interaction

Avoid/Use Alternative

donepezil + aldesleukin

avoid combo: combo may incr. risk of seizures (additive effects)

• amifampridine
Aricept (donepezil)

+

amifampridine

1 interaction

Avoid/Use Alternative

donepezil + amifampridine

consider alternative: combo may incr. risk of seizures, cholinergic adverse effects (additive effects)

• amiodarone
Aricept (donepezil)

+

amiodarone

1 interaction

Avoid/Use Alternative

donepezil + amiodarone

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• anagrelide
Aricept (donepezil)

+

anagrelide

1 interaction

Avoid/Use Alternative

donepezil + anagrelide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• apomorphine
Aricept (donepezil)

+

apomorphine

1 interaction

Avoid/Use Alternative

donepezil + apomorphine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• arsenic trioxide
Aricept (donepezil)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

donepezil + arsenic trioxide

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• artemether/lumefantrine
Aricept (donepezil)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

donepezil + artemether/ lumefantrine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• asenapine
Aricept (donepezil)

+

asenapine

1 interaction

Avoid/Use Alternative

donepezil + asenapine

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• azithromycin
Aricept (donepezil)

+

azithromycin

1 interaction

Avoid/Use Alternative

donepezil + azithromycin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bedaquiline
Aricept (donepezil)

+

bedaquiline

1 interaction

Avoid/Use Alternative

donepezil + bedaquiline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• brigatinib
Aricept (donepezil)

+

brigatinib

1 interaction

Avoid/Use Alternative

donepezil + brigatinib

use alternative or monitor BP, HR: combo may incr. risk of bradycardia (additive effects)

• cabozantinib
Aricept (donepezil)

+

cabozantinib

1 interaction

Avoid/Use Alternative

donepezil + cabozantinib

use alternative or monitor ECG, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ceritinib
Aricept (donepezil)

+

ceritinib

1 interaction

Avoid/Use Alternative

donepezil + ceritinib

use alternative or monitor ECG, HR, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• citalopram
Aricept (donepezil)

+

citalopram

1 interaction

Avoid/Use Alternative

donepezil + citalopram

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clarithromycin
Aricept (donepezil)

+

clarithromycin

1 interaction

Avoid/Use Alternative

donepezil + clarithromycin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clonidine
Aricept (donepezil)

+

clonidine

1 interaction

Avoid/Use Alternative

donepezil + clonidine

if ADHD use, avoid combo; otherwise, monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• crizotinib
Aricept (donepezil)

+

crizotinib

1 interaction

Avoid/Use Alternative

donepezil + crizotinib

use alternative or monitor ECG, HR, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• degarelix
Aricept (donepezil)

+

degarelix

1 interaction

Avoid/Use Alternative

donepezil + degarelix

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• desipramine
Aricept (donepezil)

+

desipramine

1 interaction

Avoid/Use Alternative

donepezil + desipramine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• dexmedetomidine
Aricept (donepezil)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

donepezil + dexmedetomidine

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• dexmedetomidine injection
Aricept (donepezil)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

donepezil + dexmedetomidine injection

use alternative or monitor HR, ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• disopyramide
Aricept (donepezil)

+

disopyramide

1 interaction

Avoid/Use Alternative

donepezil + disopyramide

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• dofetilide
Aricept (donepezil)

+

dofetilide

1 interaction

Avoid/Use Alternative

donepezil + dofetilide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• donepezil
Aricept (donepezil)

+

donepezil

1 interaction

Avoid/Use Alternative

donepezil + donepezil

avoid combo: combo may incr. risk of GI ulceration, bleeding, QT and PR interval prolongation, AV block, bradycardia, cardiac arrhythmias, cholinergic and other adverse effects (additive effects, duplicate therapy)

• dordaviprone
Aricept (donepezil)

+

dordaviprone

1 interaction

Avoid/Use Alternative

donepezil + dordaviprone

use alternative or monitor ECG, electrolytes; separate admin.: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• droperidol
Aricept (donepezil)

+

droperidol

1 interaction

Avoid/Use Alternative

donepezil + droperidol

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• efavirenz
Aricept (donepezil)

+

efavirenz

1 interaction

Avoid/Use Alternative

donepezil + efavirenz

consider alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• encorafenib
Aricept (donepezil)

+

encorafenib

1 interaction

Avoid/Use Alternative

donepezil + encorafenib

use alternative or monitor ECG, electrolytes: combo may decr. donepezil levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metabolism induced; additive effects)

• entrectinib
Aricept (donepezil)

+

entrectinib

1 interaction

Avoid/Use Alternative

donepezil + entrectinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ephedra
Aricept (donepezil)

+

ephedra

1 interaction

Avoid/Use Alternative

donepezil + ephedra

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• eribulin
Aricept (donepezil)

+

eribulin

1 interaction

Avoid/Use Alternative

donepezil + eribulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• erythromycin
Aricept (donepezil)

+

erythromycin

1 interaction

Avoid/Use Alternative

donepezil + erythromycin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• etrasimod
Aricept (donepezil)

+

etrasimod

1 interaction

Avoid/Use Alternative

donepezil + etrasimod

consider alternative or monitor HR, ECG, especially when starting or restarting etrasimod tx: combo may incr. risk of bradycardia, AV block, QT and PR interval prolongation, cardiac arrhythmias (additive effects)

• fexinidazole
Aricept (donepezil)

+

fexinidazole

1 interaction

Avoid/Use Alternative

donepezil + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after donepezil D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, bradycardia may incr. risk of QT prolongation)

• fingolimod
Aricept (donepezil)

+

fingolimod

1 interaction

Avoid/Use Alternative

donepezil + fingolimod

use alternative or monitor HR, ECG overnight, esp. during fingolimod initiation/titration: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• flecainide
Aricept (donepezil)

+

flecainide

1 interaction

Avoid/Use Alternative

donepezil + flecainide

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• fluoxetine
Aricept (donepezil)

+

fluoxetine

1 interaction

Avoid/Use Alternative

donepezil + fluoxetine

use alternative or monitor ECG: combo may incr. donepezil levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• foscarnet
Aricept (donepezil)

+

foscarnet

1 interaction

Avoid/Use Alternative

donepezil + foscarnet

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fosfomycin injection
Aricept (donepezil)

+

fosfomycin injection

1 interaction

Avoid/Use Alternative

donepezil + fosfomycin injection

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• galantamine
Aricept (donepezil)

+

galantamine

1 interaction

Avoid/Use Alternative

donepezil + galantamine

avoid combo: combo may incr. risk of GI ulceration, bleeding, PR interval prolongation, AV block, bradycardia, cholinergic and other adverse effects (additive effects, duplicate therapy)

• gepotidacin
Aricept (donepezil)

+

gepotidacin

1 interaction

Avoid/Use Alternative

donepezil + gepotidacin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, cholinergic adverse effects (additive effects, gepotidacin reversibly inhibits acetylcholinesterase)

• givinostat
Aricept (donepezil)

+

givinostat

1 interaction

Avoid/Use Alternative

donepezil + givinostat

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• glasdegib
Aricept (donepezil)

+

glasdegib

1 interaction

Avoid/Use Alternative

donepezil + glasdegib

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• goserelin
Aricept (donepezil)

+

goserelin

1 interaction

Avoid/Use Alternative

donepezil + goserelin

PROSTATE CANCER: use alternative or monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• grapefruit
Aricept (donepezil)

+

grapefruit

1 interaction

Avoid/Use Alternative

donepezil + grapefruit

use alternative or monitor ECG w/ large amounts of grapefruit (>1L juice): combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• haloperidol
Aricept (donepezil)

+

haloperidol

1 interaction

Avoid/Use Alternative

donepezil + haloperidol

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• hydroxychloroquine
Aricept (donepezil)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

donepezil + hydroxychloroquine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• ibutilide
Aricept (donepezil)

+

ibutilide

1 interaction

Avoid/Use Alternative

donepezil + ibutilide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iloperidone
Aricept (donepezil)

+

iloperidone

1 interaction

Avoid/Use Alternative

donepezil + iloperidone

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• inotuzumab ozogamicin
Aricept (donepezil)

+

inotuzumab ozogamicin

1 interaction

Avoid/Use Alternative

donepezil + inotuzumab ozogamicin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iohexol
Aricept (donepezil)

+

iohexol

1 interaction

Avoid/Use Alternative

donepezil + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isoflurane
Aricept (donepezil)

+

isoflurane

1 interaction

Avoid/Use Alternative

donepezil + isoflurane

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. neuromuscular blocking effects of inhaled anesthetic, decr. efficacy of antimyasthenic agent (additive effects; mechanism unknown)

• ivabradine
Aricept (donepezil)

+

ivabradine

1 interaction

Avoid/Use Alternative

donepezil + ivabradine

consider alternative or monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia, QT prolongation, cardiac arrhythmias (additive effects)

• ivosidenib
Aricept (donepezil)

+

ivosidenib

1 interaction

Avoid/Use Alternative

donepezil + ivosidenib

use alternative or monitor ECG, electrolytes: combo may decr. donepezil levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metabolism induced; additive effects)

• landiolol
Aricept (donepezil)

+

landiolol

1 interaction

Avoid/Use Alternative

donepezil + landiolol

avoid combo: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• lefamulin
Aricept (donepezil)

+

lefamulin

1 interaction

Avoid/Use Alternative

donepezil + lefamulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• leuprolide
Aricept (donepezil)

+

leuprolide

1 interaction

Avoid/Use Alternative

donepezil + leuprolide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• levofloxacin
Aricept (donepezil)

+

levofloxacin

1 interaction

Avoid/Use Alternative

donepezil + levofloxacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lofexidine
Aricept (donepezil)

+

lofexidine

1 interaction

Avoid/Use Alternative

donepezil + lofexidine

use alternative or monitor ECG, HR: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• lonafarnib
Aricept (donepezil)

+

lonafarnib

1 interaction

Avoid/Use Alternative

donepezil + lonafarnib

use alternative or monitor HR, ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• loperamide
Aricept (donepezil)

+

loperamide

1 interaction

Avoid/Use Alternative

donepezil + loperamide

use alternative or monitor ECG, esp. if loperamide dose >16mg/day: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lopinavir/ritonavir
Aricept (donepezil)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

donepezil + lopinavir/ ritonavir

use alternative or monitor HR, ECG: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• macimorelin
Aricept (donepezil)

+

macimorelin

1 interaction

Avoid/Use Alternative

donepezil + macimorelin

avoid combo, allowing sufficient washout time before diagnostic test: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• methacholine inhaled
Aricept (donepezil)

+

methacholine inhaled

1 interaction

Avoid/Use Alternative

donepezil + methacholine inhaled

avoid combo: combo may incr. risk of cholinergic adverse effects (additive effects)

• mifepristone
Aricept (donepezil)

+

mifepristone

1 interaction

Avoid/Use Alternative

donepezil + mifepristone

use alternative or monitor ECG if daily mifepristone use: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• milsaperidone
Aricept (donepezil)

+

milsaperidone

1 interaction

Avoid/Use Alternative

donepezil + milsaperidone

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mobocertinib
Aricept (donepezil)

+

mobocertinib

1 interaction

Avoid/Use Alternative

donepezil + mobocertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• moxifloxacin
Aricept (donepezil)

+

moxifloxacin

1 interaction

Avoid/Use Alternative

donepezil + moxifloxacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• nilotinib
Aricept (donepezil)

+

nilotinib

1 interaction

Avoid/Use Alternative

donepezil + nilotinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• osimertinib
Aricept (donepezil)

+

osimertinib

1 interaction

Avoid/Use Alternative

donepezil + osimertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxaliplatin
Aricept (donepezil)

+

oxaliplatin

1 interaction

Avoid/Use Alternative

donepezil + oxaliplatin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ozanimod
Aricept (donepezil)

+

ozanimod

1 interaction

Avoid/Use Alternative

donepezil + ozanimod

use alternative or monitor HR, ECG, especially when starting or restarting ozanimod tx: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• pacritinib
Aricept (donepezil)

+

pacritinib

1 interaction

Avoid/Use Alternative

donepezil + pacritinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• paliperidone
Aricept (donepezil)

+

paliperidone

1 interaction

Avoid/Use Alternative

donepezil + paliperidone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pazopanib
Aricept (donepezil)

+

pazopanib

1 interaction

Avoid/Use Alternative

donepezil + pazopanib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• pentamidine
Aricept (donepezil)

+

pentamidine

1 interaction

Avoid/Use Alternative

donepezil + pentamidine

use alternative or monitor ECG; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• phenobarbital
Aricept (donepezil)

+

phenobarbital

1 interaction

Avoid/Use Alternative

donepezil + phenobarbital

avoid combo if neonatal seizure use; otherwise, consider monitoring ECG: combo may decr. donepezil levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• pimavanserin
Aricept (donepezil)

+

pimavanserin

1 interaction

Avoid/Use Alternative

donepezil + pimavanserin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pitolisant
Aricept (donepezil)

+

pitolisant

1 interaction

Avoid/Use Alternative

donepezil + pitolisant

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ponesimod
Aricept (donepezil)

+

ponesimod

1 interaction

Avoid/Use Alternative

donepezil + ponesimod

use alternative or monitor HR, ECG, especially when starting or restarting ponesimod tx: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• procainamide
Aricept (donepezil)

+

procainamide

1 interaction

Avoid/Use Alternative

donepezil + procainamide

avoid combo: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• propafenone
Aricept (donepezil)

+

propafenone

1 interaction

Avoid/Use Alternative

donepezil + propafenone

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• pyridostigmine
Aricept (donepezil)

+

pyridostigmine

1 interaction

Avoid/Use Alternative

donepezil + pyridostigmine

avoid combo: combo may incr. risk of GI ulceration, bleeding, bradycardia, cholinergic and other adverse effects (additive effects, duplicate therapy)

• quetiapine
Aricept (donepezil)

+

quetiapine

1 interaction

Avoid/Use Alternative

donepezil + quetiapine

use alternative or monitor ECG: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias (antagonistic effects; additive effects)

• quinidine (antiarrhythmic)
Aricept (donepezil)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

donepezil + quinidine (antiarrhythmic)

use alternative or monitor ECG, HR: combo may incr. donepezil levels, risk of QT prolongation, cardiac arrhythmias, bradycardia, other adverse effects; may decr. efficacy of both drugs (hepatic metabolism inhibited, additive effects; antagonistic effects)

• quinine
Aricept (donepezil)

+

quinine

1 interaction

Avoid/Use Alternative

donepezil + quinine

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• quizartinib
Aricept (donepezil)

+

quizartinib

1 interaction

Avoid/Use Alternative

donepezil + quizartinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• revumenib
Aricept (donepezil)

+

revumenib

1 interaction

Avoid/Use Alternative

donepezil + revumenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ribociclib
Aricept (donepezil)

+

ribociclib

1 interaction

Avoid/Use Alternative

donepezil + ribociclib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rilpivirine
Aricept (donepezil)

+

rilpivirine

1 interaction

Avoid/Use Alternative

donepezil + rilpivirine

consider alternative or monitor ECG; risk may be lower w/ IM rilpivirine: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rivastigmine
Aricept (donepezil)

+

rivastigmine

1 interaction

Avoid/Use Alternative

donepezil + rivastigmine

avoid combo: combo may incr. risk of GI ulceration, bleeding, bradycardia, cholinergic and other adverse effects (additive effects, duplicate therapy)

• rucaparib
Aricept (donepezil)

+

rucaparib

1 interaction

Avoid/Use Alternative

donepezil + rucaparib

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sertraline
Aricept (donepezil)

+

sertraline

1 interaction

Avoid/Use Alternative

donepezil + sertraline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sevoflurane
Aricept (donepezil)

+

sevoflurane

1 interaction

Avoid/Use Alternative

donepezil + sevoflurane

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. neuromuscular blocking effects of inhaled anesthetic, decr. efficacy of antimyasthenic agent (additive effects; mechanism unknown)

• siponimod
Aricept (donepezil)

+

siponimod

1 interaction

Avoid/Use Alternative

donepezil + siponimod

consider alternative or monitor HR, ECG, especially when starting or restarting siponimod tx: combo may incr. risk of PR interval prolongation, AV block, bradycardia, QT prolongation, cardiac arrhythmias (additive effects)

• solifenacin
Aricept (donepezil)

+

solifenacin

1 interaction

Avoid/Use Alternative

donepezil + solifenacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• sorafenib
Aricept (donepezil)

+

sorafenib

1 interaction

Avoid/Use Alternative

donepezil + sorafenib

use alternative or monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• sotalol
Aricept (donepezil)

+

sotalol

1 interaction

Avoid/Use Alternative

donepezil + sotalol

use alternative or monitor HR, ECG: combo may incr. risk of QT and PR interval prolongation, cardiac arrhythmias, AV block, bradycardia (additive effects)

• succinylcholine
Aricept (donepezil)

+

succinylcholine

1 interaction

Avoid/Use Alternative

donepezil + succinylcholine

use alternative: combo may incr. risk of bradycardia; may potentiate, prolong neuromuscular blockade (additive effects; succinylcholine metabolism decreased; plasma cholinesterase inhibited)

• taletrectinib
Aricept (donepezil)

+

taletrectinib

1 interaction

Avoid/Use Alternative

donepezil + taletrectinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tetrabenazine
Aricept (donepezil)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

donepezil + tetrabenazine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• toremifene
Aricept (donepezil)

+

toremifene

1 interaction

Avoid/Use Alternative

donepezil + toremifene

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tramadol
Aricept (donepezil)

+

tramadol

1 interaction

Avoid/Use Alternative

donepezil + tramadol

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• trazodone
Aricept (donepezil)

+

trazodone

1 interaction

Avoid/Use Alternative

donepezil + trazodone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• triptorelin
Aricept (donepezil)

+

triptorelin

1 interaction

Avoid/Use Alternative

donepezil + triptorelin

PROSTATE CANCER: use alternative or monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• vandetanib
Aricept (donepezil)

+

vandetanib

1 interaction

Avoid/Use Alternative

donepezil + vandetanib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vemurafenib
Aricept (donepezil)

+

vemurafenib

1 interaction

Avoid/Use Alternative

donepezil + vemurafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ziftomenib
Aricept (donepezil)

+

ziftomenib

1 interaction

Avoid/Use Alternative

donepezil + ziftomenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ziprasidone
Aricept (donepezil)

+

ziprasidone

1 interaction

Avoid/Use Alternative

donepezil + ziprasidone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

Monitor/Modify Tx

• acebutolol
Aricept (donepezil)

+

acebutolol

1 interaction

Monitor/Modify Tx

donepezil + acebutolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• adenosine
Aricept (donepezil)

+

adenosine

1 interaction

Monitor/Modify Tx

donepezil + adenosine

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• afatinib
Aricept (donepezil)

+

afatinib

1 interaction

Monitor/Modify Tx

donepezil + afatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• albuterol
Aricept (donepezil)

+

albuterol

1 interaction

Monitor/Modify Tx

donepezil + albuterol

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• albuterol inhaled
Aricept (donepezil)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + albuterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• alectinib
Aricept (donepezil)

+

alectinib

1 interaction

Monitor/Modify Tx

donepezil + alectinib

monitor HR: combo may incr. risk of bradycardia (additive effects)

• alendronate
Aricept (donepezil)

+

alendronate

1 interaction

Monitor/Modify Tx

donepezil + alendronate

monitor bleeding s/sx: combo may incr. risk of upper GI ulceration, perforation, bleeding (additive effects)

• alfentanil
Aricept (donepezil)

+

alfentanil

1 interaction

Monitor/Modify Tx

donepezil + alfentanil

monitor HR: combo may incr. risk of bradycardia (additive effects)

• alfuzosin
Aricept (donepezil)

+

alfuzosin

1 interaction

Monitor/Modify Tx

donepezil + alfuzosin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• amisulpride
Aricept (donepezil)

+

amisulpride

1 interaction

Monitor/Modify Tx

donepezil + amisulpride

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• amitriptyline
Aricept (donepezil)

+

amitriptyline

1 interaction

Monitor/Modify Tx

donepezil + amitriptyline

monitor ECG: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias (antagonistic effects; additive effects)

• apalutamide
Aricept (donepezil)

+

apalutamide

1 interaction

Monitor/Modify Tx

donepezil + apalutamide

monitor ECG: combo may decr. donepezil levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metabolism induced; additive effects)

• apraclonidine ophthalmic
Aricept (donepezil)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

donepezil + apraclonidine ophthalmic

monitor HR if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of bradycardia (additive effects)

• arformoterol inhaled
Aricept (donepezil)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + arformoterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• articaine
Aricept (donepezil)

+

articaine

1 interaction

Monitor/Modify Tx

donepezil + articaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• asciminib
Aricept (donepezil)

+

asciminib

1 interaction

Monitor/Modify Tx

donepezil + asciminib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• aspirin
Aricept (donepezil)

+

aspirin

1 interaction

Monitor/Modify Tx

donepezil + aspirin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• atazanavir
Aricept (donepezil)

+

atazanavir

1 interaction

Monitor/Modify Tx

donepezil + atazanavir

monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• atenolol
Aricept (donepezil)

+

atenolol

1 interaction

Monitor/Modify Tx

donepezil + atenolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• axitinib
Aricept (donepezil)

+

axitinib

1 interaction

Monitor/Modify Tx

donepezil + axitinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• berotralstat
Aricept (donepezil)

+

berotralstat

1 interaction

Monitor/Modify Tx

donepezil + berotralstat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• betamethasone
Aricept (donepezil)

+

betamethasone

1 interaction

Monitor/Modify Tx

donepezil + betamethasone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• betaxolol
Aricept (donepezil)

+

betaxolol

1 interaction

Monitor/Modify Tx

donepezil + betaxolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• betaxolol ophthalmic
Aricept (donepezil)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

donepezil + betaxolol ophthalmic

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• bevacizumab
Aricept (donepezil)

+

bevacizumab

1 interaction

Monitor/Modify Tx

donepezil + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• bisoprolol
Aricept (donepezil)

+

bisoprolol

1 interaction

Monitor/Modify Tx

donepezil + bisoprolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• brentuximab vedotin
Aricept (donepezil)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

donepezil + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• bupivacaine
Aricept (donepezil)

+

bupivacaine

1 interaction

Monitor/Modify Tx

donepezil + bupivacaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• bupivacaine liposomal
Aricept (donepezil)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

donepezil + bupivacaine liposomal

monitor HR: combo may incr. risk of bradycardia (additive effects)

• buprenorphine
Aricept (donepezil)

+

buprenorphine

1 interaction

Monitor/Modify Tx

donepezil + buprenorphine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bupropion
Aricept (donepezil)

+

bupropion

1 interaction

Monitor/Modify Tx

donepezil + bupropion

consider lower bupropion doses: combo may incr. donepezil levels, risk of seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• cabazitaxel
Aricept (donepezil)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

donepezil + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• carbamazepine
Aricept (donepezil)

+

carbamazepine

1 interaction

Monitor/Modify Tx

donepezil + carbamazepine

monitor HR: combo may decr. donepezil levels, efficacy; may incr. risk of PR interval prolongation, AV block, bradycardia; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• carteolol ophthalmic
Aricept (donepezil)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

donepezil + carteolol ophthalmic

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• carvedilol
Aricept (donepezil)

+

carvedilol

1 interaction

Monitor/Modify Tx

donepezil + carvedilol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• celecoxib
Aricept (donepezil)

+

celecoxib

1 interaction

Monitor/Modify Tx

donepezil + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• chloroprocaine
Aricept (donepezil)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

donepezil + chloroprocaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• chloroquine
Aricept (donepezil)

+

chloroquine

1 interaction

Monitor/Modify Tx

donepezil + chloroquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• chlorpromazine
Aricept (donepezil)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

donepezil + chlorpromazine

monitor ECG: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias (antagonistic effects; additive effects)

• cinacalcet
Aricept (donepezil)

+

cinacalcet

1 interaction

Monitor/Modify Tx

donepezil + cinacalcet

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• ciprofloxacin
Aricept (donepezil)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

donepezil + ciprofloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clofazimine
Aricept (donepezil)

+

clofazimine

1 interaction

Monitor/Modify Tx

donepezil + clofazimine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clomipramine
Aricept (donepezil)

+

clomipramine

1 interaction

Monitor/Modify Tx

donepezil + clomipramine

monitor ECG: combo may incr. risk of seizures, QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• clozapine
Aricept (donepezil)

+

clozapine

1 interaction

Monitor/Modify Tx

donepezil + clozapine

monitor HR, ECG, electrolytes: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias, severe bradycardia, seizures (antagonistic effects; additive effects)

• corticotropin
Aricept (donepezil)

+

corticotropin

1 interaction

Monitor/Modify Tx

donepezil + corticotropin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• cortisone
Aricept (donepezil)

+

cortisone

1 interaction

Monitor/Modify Tx

donepezil + cortisone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• cysteamine
Aricept (donepezil)

+

cysteamine

1 interaction

Monitor/Modify Tx

donepezil + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• dasatinib
Aricept (donepezil)

+

dasatinib

1 interaction

Monitor/Modify Tx

donepezil + dasatinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• deferasirox
Aricept (donepezil)

+

deferasirox

1 interaction

Monitor/Modify Tx

donepezil + deferasirox

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• deflazacort
Aricept (donepezil)

+

deflazacort

1 interaction

Monitor/Modify Tx

donepezil + deflazacort

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• desflurane
Aricept (donepezil)

+

desflurane

1 interaction

Monitor/Modify Tx

donepezil + desflurane

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. neuromuscular blocking effects of inhaled anesthetic, decr. efficacy of antimyasthenic agent (additive effects; mechanism unknown)

• deuruxolitinib
Aricept (donepezil)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

donepezil + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• deutetrabenazine
Aricept (donepezil)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

donepezil + deutetrabenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• dexamethasone
Aricept (donepezil)

+

dexamethasone

1 interaction

Monitor/Modify Tx

donepezil + dexamethasone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding; may decr. donepezil levels, efficacy (additive effects; hepatic metabolism induced)

• diclofenac
Aricept (donepezil)

+

diclofenac

1 interaction

Monitor/Modify Tx

donepezil + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• diclofenac topical
Aricept (donepezil)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

donepezil + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• diflunisal
Aricept (donepezil)

+

diflunisal

1 interaction

Monitor/Modify Tx

donepezil + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• digoxin
Aricept (donepezil)

+

digoxin

1 interaction

Monitor/Modify Tx

donepezil + digoxin

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• diltiazem
Aricept (donepezil)

+

diltiazem

1 interaction

Monitor/Modify Tx

donepezil + diltiazem

monitor HR, consider monitoring ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• dimethyl fumarate
Aricept (donepezil)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

donepezil + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• diroximel fumarate
Aricept (donepezil)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

donepezil + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• dulaglutide
Aricept (donepezil)

+

dulaglutide

1 interaction

Monitor/Modify Tx

donepezil + dulaglutide

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• eliglustat
Aricept (donepezil)

+

eliglustat

1 interaction

Monitor/Modify Tx

donepezil + eliglustat

monitor HR, ECG: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• ensartinib
Aricept (donepezil)

+

ensartinib

1 interaction

Monitor/Modify Tx

donepezil + ensartinib

monitor HR; consider decr. dose or hold one or both drugs: combo may incr. risk of bradycardia (additive effects)

• epirubicin
Aricept (donepezil)

+

epirubicin

1 interaction

Monitor/Modify Tx

donepezil + epirubicin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• erlotinib
Aricept (donepezil)

+

erlotinib

1 interaction

Monitor/Modify Tx

donepezil + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• escitalopram
Aricept (donepezil)

+

escitalopram

1 interaction

Monitor/Modify Tx

donepezil + escitalopram

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• esmolol
Aricept (donepezil)

+

esmolol

1 interaction

Monitor/Modify Tx

donepezil + esmolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• etelcalcetide
Aricept (donepezil)

+

etelcalcetide

1 interaction

Monitor/Modify Tx

donepezil + etelcalcetide

monitor bleeding s/sx: combo may incr. risk of GI ulceration, bleeding (additive effects)

• ethanol (alcoholic beverage)
Aricept (donepezil)

+

ethanol (alcoholic beverage)

1 interaction

Monitor/Modify Tx

donepezil + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• etodolac
Aricept (donepezil)

+

etodolac

1 interaction

Monitor/Modify Tx

donepezil + etodolac

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• etripamil nasal
Aricept (donepezil)

+

etripamil nasal

1 interaction

Monitor/Modify Tx

donepezil + etripamil nasal

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• fenoprofen
Aricept (donepezil)

+

fenoprofen

1 interaction

Monitor/Modify Tx

donepezil + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• fentanyl
Aricept (donepezil)

+

fentanyl

1 interaction

Monitor/Modify Tx

donepezil + fentanyl

monitor HR: combo may incr. risk of bradycardia (additive effects)

• fluconazole
Aricept (donepezil)

+

fluconazole

1 interaction

Monitor/Modify Tx

donepezil + fluconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fludrocortisone
Aricept (donepezil)

+

fludrocortisone

1 interaction

Monitor/Modify Tx

donepezil + fludrocortisone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• fluorouracil
Aricept (donepezil)

+

fluorouracil

1 interaction

Monitor/Modify Tx

donepezil + fluorouracil

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• flurbiprofen
Aricept (donepezil)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

donepezil + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• formoterol inhaled
Aricept (donepezil)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + formoterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fosphenytoin
Aricept (donepezil)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

donepezil + fosphenytoin

monitor HR: combo may decr. donepezil levels, efficacy; may incr. risk of PR interval prolongation, AV block, bradycardia; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• fostemsavir
Aricept (donepezil)

+

fostemsavir

1 interaction

Monitor/Modify Tx

donepezil + fostemsavir

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fruquintinib
Aricept (donepezil)

+

fruquintinib

1 interaction

Monitor/Modify Tx

donepezil + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• gadobenate dimeglumine
Aricept (donepezil)

+

gadobenate dimeglumine

1 interaction

Monitor/Modify Tx

donepezil + gadobenate dimeglumine

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• gefitinib
Aricept (donepezil)

+

gefitinib

1 interaction

Monitor/Modify Tx

donepezil + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• gemtuzumab ozogamicin
Aricept (donepezil)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

donepezil + gemtuzumab ozogamicin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• gepirone
Aricept (donepezil)

+

gepirone

1 interaction

Monitor/Modify Tx

donepezil + gepirone

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• gilteritinib
Aricept (donepezil)

+

gilteritinib

1 interaction

Monitor/Modify Tx

donepezil + gilteritinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• granisetron
Aricept (donepezil)

+

granisetron

1 interaction

Monitor/Modify Tx

donepezil + granisetron

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• guanfacine
Aricept (donepezil)

+

guanfacine

1 interaction

Monitor/Modify Tx

donepezil + guanfacine

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• histrelin
Aricept (donepezil)

+

histrelin

1 interaction

Monitor/Modify Tx

donepezil + histrelin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• hydrocodone
Aricept (donepezil)

+

hydrocodone

1 interaction

Monitor/Modify Tx

donepezil + hydrocodone

monitor ECG, electrolytes, especially if hydrocodone ER doses >160 mg/day: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• hydrocortisone
Aricept (donepezil)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

donepezil + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• hydroxyzine
Aricept (donepezil)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

donepezil + hydroxyzine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• ibandronate
Aricept (donepezil)

+

ibandronate

1 interaction

Monitor/Modify Tx

donepezil + ibandronate

monitor bleeding s/sx if oral ibandronate use: combo may incr. risk of upper GI ulceration, perforation, bleeding (additive effects)

• ibuprofen
Aricept (donepezil)

+

ibuprofen

1 interaction

Monitor/Modify Tx

donepezil + ibuprofen

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ibuprofen lysine
Aricept (donepezil)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

donepezil + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• imatinib
Aricept (donepezil)

+

imatinib

1 interaction

Monitor/Modify Tx

donepezil + imatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• indomethacin
Aricept (donepezil)

+

indomethacin

1 interaction

Monitor/Modify Tx

donepezil + indomethacin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• iopamidol
Aricept (donepezil)

+

iopamidol

1 interaction

Monitor/Modify Tx

donepezil + iopamidol

caution advised if intrathecal iopamidol use; consider holding donepezil at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• ketoprofen
Aricept (donepezil)

+

ketoprofen

1 interaction

Monitor/Modify Tx

donepezil + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ketorolac
Aricept (donepezil)

+

ketorolac

1 interaction

Monitor/Modify Tx

donepezil + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• labetalol
Aricept (donepezil)

+

labetalol

1 interaction

Monitor/Modify Tx

donepezil + labetalol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• lacosamide
Aricept (donepezil)

+

lacosamide

1 interaction

Monitor/Modify Tx

donepezil + lacosamide

monitor HR, ECG, especially during lacosamide initiation/titration: combo may incr. risk of PR interval prolongation, AV block, bradycardia; may alter seizure control (additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• lamotrigine
Aricept (donepezil)

+

lamotrigine

1 interaction

Monitor/Modify Tx

donepezil + lamotrigine

monitor HR: combo may incr. risk of bradycardia; may alter seizure control (additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• lanreotide
Aricept (donepezil)

+

lanreotide

1 interaction

Monitor/Modify Tx

donepezil + lanreotide

monitor HR: combo may incr. risk of bradycardia (additive effects)

• lanthanum
Aricept (donepezil)

+

lanthanum

1 interaction

Monitor/Modify Tx

donepezil + lanthanum

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• lapatinib
Aricept (donepezil)

+

lapatinib

1 interaction

Monitor/Modify Tx

donepezil + lapatinib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lenvatinib
Aricept (donepezil)

+

lenvatinib

1 interaction

Monitor/Modify Tx

donepezil + lenvatinib

monitor ECG, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• levalbuterol inhaled
Aricept (donepezil)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + levalbuterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levobunolol ophthalmic
Aricept (donepezil)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

donepezil + levobunolol ophthalmic

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• lidocaine
Aricept (donepezil)

+

lidocaine

1 interaction

Monitor/Modify Tx

donepezil + lidocaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• lorlatinib
Aricept (donepezil)

+

lorlatinib

1 interaction

Monitor/Modify Tx

donepezil + lorlatinib

monitor HR, ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• lumateperone
Aricept (donepezil)

+

lumateperone

1 interaction

Monitor/Modify Tx

donepezil + lumateperone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lurasidone
Aricept (donepezil)

+

lurasidone

1 interaction

Monitor/Modify Tx

donepezil + lurasidone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• magnesium salicylate
Aricept (donepezil)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

donepezil + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• mavorixafor
Aricept (donepezil)

+

mavorixafor

1 interaction

Monitor/Modify Tx

donepezil + mavorixafor

monitor ECG: combo may incr. donepezil levels, risk QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• meclofenamate
Aricept (donepezil)

+

meclofenamate

1 interaction

Monitor/Modify Tx

donepezil + meclofenamate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• mefenamic acid
Aricept (donepezil)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

donepezil + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• mefloquine
Aricept (donepezil)

+

mefloquine

1 interaction

Monitor/Modify Tx

donepezil + mefloquine

monitor HR, ECG: combo may incr. risk of QT prolongation, PR interval prolongation, AV block, bradycardia, other cardiac arrhythmias (additive effects)

• meloxicam
Aricept (donepezil)

+

meloxicam

1 interaction

Monitor/Modify Tx

donepezil + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• meperidine
Aricept (donepezil)

+

meperidine

1 interaction

Monitor/Modify Tx

donepezil + meperidine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mepivacaine
Aricept (donepezil)

+

mepivacaine

1 interaction

Monitor/Modify Tx

donepezil + mepivacaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• methadone
Aricept (donepezil)

+

methadone

1 interaction

Monitor/Modify Tx

donepezil + methadone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• methotrexate
Aricept (donepezil)

+

methotrexate

1 interaction

Monitor/Modify Tx

donepezil + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• methylprednisolone
Aricept (donepezil)

+

methylprednisolone

1 interaction

Monitor/Modify Tx

donepezil + methylprednisolone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• metoprolol
Aricept (donepezil)

+

metoprolol

1 interaction

Monitor/Modify Tx

donepezil + metoprolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• metronidazole
Aricept (donepezil)

+

metronidazole

1 interaction

Monitor/Modify Tx

donepezil + metronidazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• midodrine
Aricept (donepezil)

+

midodrine

1 interaction

Monitor/Modify Tx

donepezil + midodrine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• midostaurin
Aricept (donepezil)

+

midostaurin

1 interaction

Monitor/Modify Tx

donepezil + midostaurin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mirtazapine
Aricept (donepezil)

+

mirtazapine

1 interaction

Monitor/Modify Tx

donepezil + mirtazapine

monitor ECG: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias (antagonistic effects; additive effects)

• monomethyl fumarate
Aricept (donepezil)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

donepezil + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• mycophenolate mofetil
Aricept (donepezil)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

donepezil + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI ulceration, bleeding, perforation (additive effects)

• mycophenolic acid
Aricept (donepezil)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

donepezil + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI ulceration, bleeding, perforation (additive effects)

• nabumetone
Aricept (donepezil)

+

nabumetone

1 interaction

Monitor/Modify Tx

donepezil + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• nadolol
Aricept (donepezil)

+

nadolol

1 interaction

Monitor/Modify Tx

donepezil + nadolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• naproxen
Aricept (donepezil)

+

naproxen

1 interaction

Monitor/Modify Tx

donepezil + naproxen

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• nebivolol
Aricept (donepezil)

+

nebivolol

1 interaction

Monitor/Modify Tx

donepezil + nebivolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• neostigmine
Aricept (donepezil)

+

neostigmine

1 interaction

Monitor/Modify Tx

donepezil + neostigmine

monitor HR: combo may incr. risk of bradycardia, cholinergic adverse effects (additive effects)

• nintedanib
Aricept (donepezil)

+

nintedanib

1 interaction

Monitor/Modify Tx

donepezil + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• octreotide
Aricept (donepezil)

+

octreotide

1 interaction

Monitor/Modify Tx

donepezil + octreotide

monitor HR: combo may incr. risk of bradycardia (additive effects)

• ofloxacin
Aricept (donepezil)

+

ofloxacin

1 interaction

Monitor/Modify Tx

donepezil + ofloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oliceridine
Aricept (donepezil)

+

oliceridine

1 interaction

Monitor/Modify Tx

donepezil + oliceridine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• olodaterol inhaled
Aricept (donepezil)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + olodaterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ondansetron
Aricept (donepezil)

+

ondansetron

1 interaction

Monitor/Modify Tx

donepezil + ondansetron

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• osilodrostat
Aricept (donepezil)

+

osilodrostat

1 interaction

Monitor/Modify Tx

donepezil + osilodrostat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxaprozin
Aricept (donepezil)

+

oxaprozin

1 interaction

Monitor/Modify Tx

donepezil + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• palonosetron
Aricept (donepezil)

+

palonosetron

1 interaction

Monitor/Modify Tx

donepezil + palonosetron

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• paltusotine
Aricept (donepezil)

+

paltusotine

1 interaction

Monitor/Modify Tx

donepezil + paltusotine

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• pasireotide
Aricept (donepezil)

+

pasireotide

1 interaction

Monitor/Modify Tx

donepezil + pasireotide

monitor ECG, HR: combo may incr. risk of QT prolongation, cardiac arrhythmias, bradycardia (additive effects)

• phenytoin
Aricept (donepezil)

+

phenytoin

1 interaction

Monitor/Modify Tx

donepezil + phenytoin

monitor HR: combo may decr. donepezil levels, efficacy; may incr. risk of bradycardia; may alter seizure control (hepatic metabolism induced; additive effects; antagonistic effects, donepezil may decr. seizure threshold)

• pindolol
Aricept (donepezil)

+

pindolol

1 interaction

Monitor/Modify Tx

donepezil + pindolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• piroxicam
Aricept (donepezil)

+

piroxicam

1 interaction

Monitor/Modify Tx

donepezil + piroxicam

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ponatinib
Aricept (donepezil)

+

ponatinib

1 interaction

Monitor/Modify Tx

donepezil + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• porfimer
Aricept (donepezil)

+

porfimer

1 interaction

Monitor/Modify Tx

donepezil + porfimer

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• posaconazole
Aricept (donepezil)

+

posaconazole

1 interaction

Monitor/Modify Tx

donepezil + posaconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pralsetinib
Aricept (donepezil)

+

pralsetinib

1 interaction

Monitor/Modify Tx

donepezil + pralsetinib

monitor ECG; consider monitoring electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• praziquantel
Aricept (donepezil)

+

praziquantel

1 interaction

Monitor/Modify Tx

donepezil + praziquantel

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• prednisolone
Aricept (donepezil)

+

prednisolone

1 interaction

Monitor/Modify Tx

donepezil + prednisolone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• prednisone
Aricept (donepezil)

+

prednisone

1 interaction

Monitor/Modify Tx

donepezil + prednisone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding; may decr. cholinesterase inhibitor muscle-stimulating efficacy and cause extreme weakness in myasthenia gravis (additive effects)

• primaquine
Aricept (donepezil)

+

primaquine

1 interaction

Monitor/Modify Tx

donepezil + primaquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• promethazine
Aricept (donepezil)

+

promethazine

1 interaction

Monitor/Modify Tx

donepezil + promethazine

monitor ECG: combo may incr. risk of seizures, QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• propofol
Aricept (donepezil)

+

propofol

1 interaction

Monitor/Modify Tx

donepezil + propofol

monitor HR: combo may incr. risk of bradycardia (additive effects)

• propranolol
Aricept (donepezil)

+

propranolol

1 interaction

Monitor/Modify Tx

donepezil + propranolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• ramucirumab
Aricept (donepezil)

+

ramucirumab

1 interaction

Monitor/Modify Tx

donepezil + ramucirumab

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• ranolazine
Aricept (donepezil)

+

ranolazine

1 interaction

Monitor/Modify Tx

donepezil + ranolazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• regadenoson
Aricept (donepezil)

+

regadenoson

1 interaction

Monitor/Modify Tx

donepezil + regadenoson

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• regorafenib
Aricept (donepezil)

+

regorafenib

1 interaction

Monitor/Modify Tx

donepezil + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• relugolix
Aricept (donepezil)

+

relugolix

1 interaction

Monitor/Modify Tx

donepezil + relugolix

if prostate cancer use, monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• remifentanil
Aricept (donepezil)

+

remifentanil

1 interaction

Monitor/Modify Tx

donepezil + remifentanil

monitor HR: combo may incr. risk of bradycardia (additive effects)

• remimazolam
Aricept (donepezil)

+

remimazolam

1 interaction

Monitor/Modify Tx

donepezil + remimazolam

monitor HR: combo may incr. risk of bradycardia (additive effects)

• risedronate
Aricept (donepezil)

+

risedronate

1 interaction

Monitor/Modify Tx

donepezil + risedronate

monitor bleeding s/sx: combo may incr. risk of upper GI ulceration, perforation, bleeding (additive effects)

• ritonavir
Aricept (donepezil)

+

ritonavir

1 interaction

Monitor/Modify Tx

donepezil + ritonavir

monitor HR, consider monitoring ECG: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• romidepsin
Aricept (donepezil)

+

romidepsin

1 interaction

Monitor/Modify Tx

donepezil + romidepsin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ropivacaine
Aricept (donepezil)

+

ropivacaine

1 interaction

Monitor/Modify Tx

donepezil + ropivacaine

monitor HR: combo may incr. risk of bradycardia (additive effects)

• sacituzumab govitecan
Aricept (donepezil)

+

sacituzumab govitecan

1 interaction

Monitor/Modify Tx

donepezil + sacituzumab govitecan

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• salmeterol inhaled
Aricept (donepezil)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + salmeterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• salsalate
Aricept (donepezil)

+

salsalate

1 interaction

Monitor/Modify Tx

donepezil + salsalate

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• sebetralstat
Aricept (donepezil)

+

sebetralstat

1 interaction

Monitor/Modify Tx

donepezil + sebetralstat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• selpercatinib
Aricept (donepezil)

+

selpercatinib

1 interaction

Monitor/Modify Tx

donepezil + selpercatinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sufentanil
Aricept (donepezil)

+

sufentanil

1 interaction

Monitor/Modify Tx

donepezil + sufentanil

monitor HR: combo may incr. risk of bradycardia (additive effects)

• sugammadex
Aricept (donepezil)

+

sugammadex

1 interaction

Monitor/Modify Tx

donepezil + sugammadex

monitor HR: combo may incr. risk of bradycardia (additive effects)

• sulindac
Aricept (donepezil)

+

sulindac

1 interaction

Monitor/Modify Tx

donepezil + sulindac

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• sunitinib
Aricept (donepezil)

+

sunitinib

1 interaction

Monitor/Modify Tx

donepezil + sunitinib

monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• tacrolimus
Aricept (donepezil)

+

tacrolimus

1 interaction

Monitor/Modify Tx

donepezil + tacrolimus

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tazemetostat
Aricept (donepezil)

+

tazemetostat

1 interaction

Monitor/Modify Tx

donepezil + tazemetostat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• telavancin
Aricept (donepezil)

+

telavancin

1 interaction

Monitor/Modify Tx

donepezil + telavancin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• temsirolimus
Aricept (donepezil)

+

temsirolimus

1 interaction

Monitor/Modify Tx

donepezil + temsirolimus

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• terbutaline
Aricept (donepezil)

+

terbutaline

1 interaction

Monitor/Modify Tx

donepezil + terbutaline

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• thalidomide
Aricept (donepezil)

+

thalidomide

1 interaction

Monitor/Modify Tx

donepezil + thalidomide

monitor HR: combo may incr. risk of bradycardia (additive effects)

• ticagrelor
Aricept (donepezil)

+

ticagrelor

1 interaction

Monitor/Modify Tx

donepezil + ticagrelor

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• timolol
Aricept (donepezil)

+

timolol

1 interaction

Monitor/Modify Tx

donepezil + timolol

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia, bronchospasm (additive effects)

• timolol ophthalmic
Aricept (donepezil)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

donepezil + timolol ophthalmic

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• tivozanib
Aricept (donepezil)

+

tivozanib

1 interaction

Monitor/Modify Tx

donepezil + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• tocilizumab
Aricept (donepezil)

+

tocilizumab

1 interaction

Monitor/Modify Tx

donepezil + tocilizumab

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• tolmetin
Aricept (donepezil)

+

tolmetin

1 interaction

Monitor/Modify Tx

donepezil + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• tolterodine
Aricept (donepezil)

+

tolterodine

1 interaction

Monitor/Modify Tx

donepezil + tolterodine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• trametinib
Aricept (donepezil)

+

trametinib

1 interaction

Monitor/Modify Tx

donepezil + trametinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

• triamcinolone
Aricept (donepezil)

+

triamcinolone

1 interaction

Monitor/Modify Tx

donepezil + triamcinolone

monitor bleeding s/sx; D/C cholinesterase inhibitors >24h before starting corticosteroids: combo may incr. risk of GI ulceration, bleeding, perforation; may decr. cholinesterase inhibitor muscle-stimulating efficacy and cause extreme weakness in myasthenia gravis (additive effects; antagonistic effects, mechanism unknown)

• triclabendazole
Aricept (donepezil)

+

triclabendazole

1 interaction

Monitor/Modify Tx

donepezil + triclabendazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trifluridine
Aricept (donepezil)

+

trifluridine

1 interaction

Monitor/Modify Tx

donepezil + trifluridine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• upadacitinib
Aricept (donepezil)

+

upadacitinib

1 interaction

Monitor/Modify Tx

donepezil + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• vadadustat
Aricept (donepezil)

+

vadadustat

1 interaction

Monitor/Modify Tx

donepezil + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• valbenazine
Aricept (donepezil)

+

valbenazine

1 interaction

Monitor/Modify Tx

donepezil + valbenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vamorolone
Aricept (donepezil)

+

vamorolone

1 interaction

Monitor/Modify Tx

donepezil + vamorolone

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding (additive effects)

• vardenafil
Aricept (donepezil)

+

vardenafil

1 interaction

Monitor/Modify Tx

donepezil + vardenafil

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• venlafaxine
Aricept (donepezil)

+

venlafaxine

1 interaction

Monitor/Modify Tx

donepezil + venlafaxine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• verapamil
Aricept (donepezil)

+

verapamil

1 interaction

Monitor/Modify Tx

donepezil + verapamil

monitor HR: combo may incr. risk of PR interval prolongation, AV block, bradycardia (additive effects)

• vilanterol inhaled
Aricept (donepezil)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

donepezil + vilanterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• voclosporin
Aricept (donepezil)

+

voclosporin

1 interaction

Monitor/Modify Tx

donepezil + voclosporin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• voriconazole
Aricept (donepezil)

+

voriconazole

1 interaction

Monitor/Modify Tx

donepezil + voriconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• willow bark
Aricept (donepezil)

+

willow bark

1 interaction

Monitor/Modify Tx

donepezil + willow bark

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects, willow bark may contain salicylates)

• ziv-aflibercept
Aricept (donepezil)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

donepezil + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, including life-threatening (additive effects)

Caution Advised

• acetazolamide
Aricept (donepezil)

+

acetazolamide

1 interaction

Caution Advised

donepezil + acetazolamide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• aclidinium inhaled
Aricept (donepezil)

+

aclidinium inhaled

1 interaction

Caution Advised

donepezil + aclidinium inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• amantadine
Aricept (donepezil)

+

amantadine

1 interaction

Caution Advised

donepezil + amantadine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• amoxapine
Aricept (donepezil)

+

amoxapine

1 interaction

Caution Advised

donepezil + amoxapine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• atracurium
Aricept (donepezil)

+

atracurium

1 interaction

Caution Advised

donepezil + atracurium

caution advised: combo may decr. non-depolarizing neuromuscular blocker efficacy (antagonistic effects)

• atropine
Aricept (donepezil)

+

atropine

1 interaction

Caution Advised

donepezil + atropine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• belladonna alkaloids
Aricept (donepezil)

+

belladonna alkaloids

1 interaction

Caution Advised

donepezil + belladonna alkaloids

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• benztropine
Aricept (donepezil)

+

benztropine

1 interaction

Caution Advised

donepezil + benztropine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• bethanechol
Aricept (donepezil)

+

bethanechol

1 interaction

Caution Advised

donepezil + bethanechol

caution advised: combo may incr. risk of cholinergic adverse effects (additive effects)

• brivaracetam
Aricept (donepezil)

+

brivaracetam

1 interaction

Caution Advised

donepezil + brivaracetam

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• brompheniramine
Aricept (donepezil)

+

brompheniramine

1 interaction

Caution Advised

donepezil + brompheniramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• busulfan
Aricept (donepezil)

+

busulfan

1 interaction

Caution Advised

donepezil + busulfan

caution advised: combo may incr. risk of seizures (additive effects)

• butalbital
Aricept (donepezil)

+

butalbital

1 interaction

Caution Advised

donepezil + butalbital

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• cannabidiol
Aricept (donepezil)

+

cannabidiol

1 interaction

Caution Advised

donepezil + cannabidiol

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• carbinoxamine
Aricept (donepezil)

+

carbinoxamine

1 interaction

Caution Advised

donepezil + carbinoxamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• cenobamate
Aricept (donepezil)

+

cenobamate

1 interaction

Caution Advised

donepezil + cenobamate

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• cevimeline
Aricept (donepezil)

+

cevimeline

1 interaction

Caution Advised

donepezil + cevimeline

caution advised: combo may incr. risk of cholinergic adverse effects (additive effects)

• chlophedianol
Aricept (donepezil)

+

chlophedianol

1 interaction

Caution Advised

donepezil + chlophedianol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• chlorambucil
Aricept (donepezil)

+

chlorambucil

1 interaction

Caution Advised

donepezil + chlorambucil

caution advised: combo may incr. risk of seizures (additive effects)

• chlorcyclizine
Aricept (donepezil)

+

chlorcyclizine

1 interaction

Caution Advised

donepezil + chlorcyclizine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• chlorpheniramine
Aricept (donepezil)

+

chlorpheniramine

1 interaction

Caution Advised

donepezil + chlorpheniramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• cisatracurium
Aricept (donepezil)

+

cisatracurium

1 interaction

Caution Advised

donepezil + cisatracurium

caution advised: combo may decr. non-depolarizing neuromuscular blocker efficacy (antagonistic effects)

• clemastine
Aricept (donepezil)

+

clemastine

1 interaction

Caution Advised

donepezil + clemastine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• clidinium
Aricept (donepezil)

+

clidinium

1 interaction

Caution Advised

donepezil + clidinium

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• clobazam
Aricept (donepezil)

+

clobazam

1 interaction

Caution Advised

donepezil + clobazam

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• clonazepam
Aricept (donepezil)

+

clonazepam

1 interaction

Caution Advised

donepezil + clonazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• clorazepate
Aricept (donepezil)

+

clorazepate

1 interaction

Caution Advised

donepezil + clorazepate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• cyclobenzaprine
Aricept (donepezil)

+

cyclobenzaprine

1 interaction

Caution Advised

donepezil + cyclobenzaprine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• cyproheptadine
Aricept (donepezil)

+

cyproheptadine

1 interaction

Caution Advised

donepezil + cyproheptadine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• dacomitinib
Aricept (donepezil)

+

dacomitinib

1 interaction

Caution Advised

donepezil + dacomitinib

caution advised: combo may incr. donepezil levels, risk of adverse effects (hepatic metabolism inhibited)

• darifenacin
Aricept (donepezil)

+

darifenacin

1 interaction

Caution Advised

donepezil + darifenacin

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• dexbrompheniramine
Aricept (donepezil)

+

dexbrompheniramine

1 interaction

Caution Advised

donepezil + dexbrompheniramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• dexchlorpheniramine
Aricept (donepezil)

+

dexchlorpheniramine

1 interaction

Caution Advised

donepezil + dexchlorpheniramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• diazepam
Aricept (donepezil)

+

diazepam

1 interaction

Caution Advised

donepezil + diazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• dicyclomine
Aricept (donepezil)

+

dicyclomine

1 interaction

Caution Advised

donepezil + dicyclomine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• dimenhydrinate
Aricept (donepezil)

+

dimenhydrinate

1 interaction

Caution Advised

donepezil + dimenhydrinate

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• diphenhydramine
Aricept (donepezil)

+

diphenhydramine

1 interaction

Caution Advised

donepezil + diphenhydramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• dipyridamole
Aricept (donepezil)

+

dipyridamole

1 interaction

Caution Advised

donepezil + dipyridamole

caution advised: combo may decr. cholinesterase inhibitor efficacy (antagonistic effects)

• doxepin
Aricept (donepezil)

+

doxepin

1 interaction

Caution Advised

donepezil + doxepin

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• doxepin topical
Aricept (donepezil)

+

doxepin topical

1 interaction

Caution Advised

donepezil + doxepin topical

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• doxylamine
Aricept (donepezil)

+

doxylamine

1 interaction

Caution Advised

donepezil + doxylamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• enzalutamide
Aricept (donepezil)

+

enzalutamide

1 interaction

Caution Advised

donepezil + enzalutamide

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• eslicarbazepine acetate
Aricept (donepezil)

+

eslicarbazepine acetate

1 interaction

Caution Advised

donepezil + eslicarbazepine acetate

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• ethosuximide
Aricept (donepezil)

+

ethosuximide

1 interaction

Caution Advised

donepezil + ethosuximide

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• felbamate
Aricept (donepezil)

+

felbamate

1 interaction

Caution Advised

donepezil + felbamate

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• fenfluramine
Aricept (donepezil)

+

fenfluramine

1 interaction

Caution Advised

donepezil + fenfluramine

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• fesoterodine
Aricept (donepezil)

+

fesoterodine

1 interaction

Caution Advised

donepezil + fesoterodine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• flavoxate
Aricept (donepezil)

+

flavoxate

1 interaction

Caution Advised

donepezil + flavoxate

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• fluphenazine
Aricept (donepezil)

+

fluphenazine

1 interaction

Caution Advised

donepezil + fluphenazine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• gabapentin
Aricept (donepezil)

+

gabapentin

1 interaction

Caution Advised

donepezil + gabapentin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• ganaxolone
Aricept (donepezil)

+

ganaxolone

1 interaction

Caution Advised

donepezil + ganaxolone

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• glycopyrrolate
Aricept (donepezil)

+

glycopyrrolate

1 interaction

Caution Advised

donepezil + glycopyrrolate

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• glycopyrrolate inhaled
Aricept (donepezil)

+

glycopyrrolate inhaled

1 interaction

Caution Advised

donepezil + glycopyrrolate inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• glycopyrronium topical
Aricept (donepezil)

+

glycopyrronium topical

1 interaction

Caution Advised

donepezil + glycopyrronium topical

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• homatropine
Aricept (donepezil)

+

homatropine

1 interaction

Caution Advised

donepezil + homatropine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• hyoscyamine
Aricept (donepezil)

+

hyoscyamine

1 interaction

Caution Advised

donepezil + hyoscyamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• imipramine
Aricept (donepezil)

+

imipramine

1 interaction

Caution Advised

donepezil + imipramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• ipratropium inhaled
Aricept (donepezil)

+

ipratropium inhaled

1 interaction

Caution Advised

donepezil + ipratropium inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• levetiracetam
Aricept (donepezil)

+

levetiracetam

1 interaction

Caution Advised

donepezil + levetiracetam

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• lorazepam
Aricept (donepezil)

+

lorazepam

1 interaction

Caution Advised

donepezil + lorazepam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• loxapine
Aricept (donepezil)

+

loxapine

1 interaction

Caution Advised

donepezil + loxapine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• lumacaftor/ivacaftor
Aricept (donepezil)

+

lumacaftor/ ivacaftor

1 interaction

Caution Advised

donepezil + lumacaftor/ ivacaftor

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• magnesium citrate
Aricept (donepezil)

+

magnesium citrate

1 interaction

Caution Advised

donepezil + magnesium citrate

caution advised, especially if magnesium citrate bowel prep use: combo may incr. risk of seizures (additive effects)

• meclizine
Aricept (donepezil)

+

meclizine

1 interaction

Caution Advised

donepezil + meclizine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• methocarbamol
Aricept (donepezil)

+

methocarbamol

1 interaction

Caution Advised

donepezil + methocarbamol

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• methscopolamine
Aricept (donepezil)

+

methscopolamine

1 interaction

Caution Advised

donepezil + methscopolamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• methsuximide
Aricept (donepezil)

+

methsuximide

1 interaction

Caution Advised

donepezil + methsuximide

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• midazolam
Aricept (donepezil)

+

midazolam

1 interaction

Caution Advised

donepezil + midazolam

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• mitotane
Aricept (donepezil)

+

mitotane

1 interaction

Caution Advised

donepezil + mitotane

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• molindone
Aricept (donepezil)

+

molindone

1 interaction

Caution Advised

donepezil + molindone

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• nortriptyline
Aricept (donepezil)

+

nortriptyline

1 interaction

Caution Advised

donepezil + nortriptyline

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• olanzapine
Aricept (donepezil)

+

olanzapine

1 interaction

Caution Advised

donepezil + olanzapine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• orphenadrine
Aricept (donepezil)

+

orphenadrine

1 interaction

Caution Advised

donepezil + orphenadrine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• oxcarbazepine
Aricept (donepezil)

+

oxcarbazepine

1 interaction

Caution Advised

donepezil + oxcarbazepine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• oxybutynin
Aricept (donepezil)

+

oxybutynin

1 interaction

Caution Advised

donepezil + oxybutynin

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• paroxetine
Aricept (donepezil)

+

paroxetine

1 interaction

Caution Advised

donepezil + paroxetine

caution advised: combo may incr. donepezil levels, risk of adverse effects (hepatic metabolism inhibited)

• pentobarbital
Aricept (donepezil)

+

pentobarbital

1 interaction

Caution Advised

donepezil + pentobarbital

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• perampanel
Aricept (donepezil)

+

perampanel

1 interaction

Caution Advised

donepezil + perampanel

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• perphenazine
Aricept (donepezil)

+

perphenazine

1 interaction

Caution Advised

donepezil + perphenazine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pheniramine
Aricept (donepezil)

+

pheniramine

1 interaction

Caution Advised

donepezil + pheniramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pilocarpine
Aricept (donepezil)

+

pilocarpine

1 interaction

Caution Advised

donepezil + pilocarpine

caution advised: combo may incr. risk of cholinergic adverse effects (additive effects)

• polyethylene glycol
Aricept (donepezil)

+

polyethylene glycol

1 interaction

Caution Advised

donepezil + polyethylene glycol

caution advised, especially if polyethylene glycol bowel prep use: combo may incr. risk of seizures (additive effects)

• polyethylene glycol/electrolytes
Aricept (donepezil)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

donepezil + polyethylene glycol/ electrolytes

caution advised: combo may incr. risk of seizures (additive effects)

• pregabalin
Aricept (donepezil)

+

pregabalin

1 interaction

Caution Advised

donepezil + pregabalin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• primidone
Aricept (donepezil)

+

primidone

1 interaction

Caution Advised

donepezil + primidone

caution advised: combo may decr. donepezil levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, donepezil may decr. seizure threshold)

• prochlorperazine
Aricept (donepezil)

+

prochlorperazine

1 interaction

Caution Advised

donepezil + prochlorperazine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• protriptyline
Aricept (donepezil)

+

protriptyline

1 interaction

Caution Advised

donepezil + protriptyline

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• pyrilamine
Aricept (donepezil)

+

pyrilamine

1 interaction

Caution Advised

donepezil + pyrilamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• ramelteon
Aricept (donepezil)

+

ramelteon

1 interaction

Caution Advised

donepezil + ramelteon

caution advised: combo may incr. ramelteon levels, risk of adverse effects (mechanism unknown)

• revefenacin inhaled
Aricept (donepezil)

+

revefenacin inhaled

1 interaction

Caution Advised

donepezil + revefenacin inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• rifabutin
Aricept (donepezil)

+

rifabutin

1 interaction

Caution Advised

donepezil + rifabutin

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• rifampin
Aricept (donepezil)

+

rifampin

1 interaction

Caution Advised

donepezil + rifampin

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• rocuronium
Aricept (donepezil)

+

rocuronium

1 interaction

Caution Advised

donepezil + rocuronium

caution advised: combo may decr. non-depolarizing neuromuscular blocker efficacy (antagonistic effects)

• rufinamide
Aricept (donepezil)

+

rufinamide

1 interaction

Caution Advised

donepezil + rufinamide

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• scopolamine
Aricept (donepezil)

+

scopolamine

1 interaction

Caution Advised

donepezil + scopolamine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• sodium picosulfate
Aricept (donepezil)

+

sodium picosulfate

1 interaction

Caution Advised

donepezil + sodium picosulfate

caution advised: combo may incr. risk of seizures (additive effects)

• sofpironium topical
Aricept (donepezil)

+

sofpironium topical

1 interaction

Caution Advised

donepezil + sofpironium topical

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• St. John's wort
Aricept (donepezil)

+

St. John's wort

1 interaction

Caution Advised

donepezil + St. John's wort

caution advised: combo may decr. donepezil levels, efficacy (hepatic metabolism induced)

• stiripentol
Aricept (donepezil)

+

stiripentol

1 interaction

Caution Advised

donepezil + stiripentol

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• sulfate bowel prep
Aricept (donepezil)

+

sulfate bowel prep

1 interaction

Caution Advised

donepezil + sulfate bowel prep

caution advised: combo may incr. risk of seizures (additive effects)

• terbinafine
Aricept (donepezil)

+

terbinafine

1 interaction

Caution Advised

donepezil + terbinafine

caution advised: combo may incr. donepezil levels, risk of adverse effects (hepatic metabolism inhibited)

• thiothixene
Aricept (donepezil)

+

thiothixene

1 interaction

Caution Advised

donepezil + thiothixene

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• tiagabine
Aricept (donepezil)

+

tiagabine

1 interaction

Caution Advised

donepezil + tiagabine

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• tiotropium inhaled
Aricept (donepezil)

+

tiotropium inhaled

1 interaction

Caution Advised

donepezil + tiotropium inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• topiramate
Aricept (donepezil)

+

topiramate

1 interaction

Caution Advised

donepezil + topiramate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• treosulfan
Aricept (donepezil)

+

treosulfan

1 interaction

Caution Advised

donepezil + treosulfan

caution advised: combo may incr. risk of seizures (additive effects)

• trifluoperazine
Aricept (donepezil)

+

trifluoperazine

1 interaction

Caution Advised

donepezil + trifluoperazine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• trihexyphenidyl
Aricept (donepezil)

+

trihexyphenidyl

1 interaction

Caution Advised

donepezil + trihexyphenidyl

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• trimipramine
Aricept (donepezil)

+

trimipramine

1 interaction

Caution Advised

donepezil + trimipramine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• triprolidine
Aricept (donepezil)

+

triprolidine

1 interaction

Caution Advised

donepezil + triprolidine

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• trospium
Aricept (donepezil)

+

trospium

1 interaction

Caution Advised

donepezil + trospium

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• umeclidinium inhaled
Aricept (donepezil)

+

umeclidinium inhaled

1 interaction

Caution Advised

donepezil + umeclidinium inhaled

caution advised: combo may decr. efficacy of both drugs (antagonistic effects)

• valproic acid
Aricept (donepezil)

+

valproic acid

1 interaction

Caution Advised

donepezil + valproic acid

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• vecuronium
Aricept (donepezil)

+

vecuronium

1 interaction

Caution Advised

donepezil + vecuronium

caution advised: combo may decr. non-depolarizing neuromuscular blocker efficacy (antagonistic effects)

• vigabatrin
Aricept (donepezil)

+

vigabatrin

1 interaction

Caution Advised

donepezil + vigabatrin

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• zonisamide
Aricept (donepezil)

+

zonisamide

1 interaction

Caution Advised

donepezil + zonisamide

caution advised: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)