Select a medication above to begin.
Veltassa
patiromer
Adult Dosing .
Dosage forms: PWDR: 1 g per pkt, 8.4 g per pkt, 16.8 g per pkt, 25.2 g per pkt
hyperkalemia
- [individualize dose PO qd]
- Start: 8.4 g PO qd; Max: 25.2 g/day; Info: may adjust dose by 8.4 g/day qwk to target serum potassium levels
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: PWDR: 1 g per pkt, 8.4 g per pkt, 16.8 g per pkt, 25.2 g per pkt
hyperkalemia
- [12 yo and older]
- Dose: individualize dose PO qd; Start: 4 g PO qd; Max: 25.2 g/day; Info: may adjust dose by 4 g/day qwk to target serum potassium levels
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- GI obstruction
- constipation, severe
- fecal impaction
- GI motility disorder
Drug Interactions .
Overview
patiromer
potassium binder
- cation exchange resin/polymer
- hypomagnesemia
- separate admin. from other oral drugs by at least 3h; patiromer may decr. absorption of concomitant oral drugs
- some formulations of patiromer contain sorbitol
sorbitol (in some formulations)
excipient
- colonic mucosal ulceration
- increases gastrointestinal motility
Avoid/Use Alternative
- lamivudine
- sodium polystyrene sulfonate
Monitor/Modify Tx
- amphotericin
- bisoprolol
- bumetanide
- carboplatin
- carvedilol
- cetuximab
- chlorothiazide
- chlorthalidone
- ciprofloxacin
- cisplatin
- cyclosporine
- delafloxacin
- dexlansoprazole
- digoxin
- esomeprazole
- ethacrynic acid
- foscarnet
- furosemide
- gentamicin
- hydrochlorothiazide
- indapamide
- lansoprazole
- levofloxacin
- levothyroxine
- liothyronine
- metformin
- metolazone
- moxifloxacin
- mycophenolate mofetil
- mycophenolic acid
- nebivolol
- necitumumab
- ofloxacin
- omeprazole
- panitumumab
- pantoprazole
- quinidine (antiarrhythmic)
- rabeprazole
- romidepsin
- spironolactone
- tacrolimus
- telmisartan
- thiamine (vitamin B1)
- thyroid
- tobramycin
- torsemide
- vonoprazan
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- hypomagnesemia
- hypokalemia
Common Reactions
- hypomagnesemia
- constipation
- hypokalemia
- diarrhea
- nausea
- abdominal discomfort
- flatulence
Safety/Monitoring .
Monitoring Parameters
K, Mg
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on no systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on no systemic absorption in breastfeeding pts
Pharmacology .
Metabolism: none; CYP450: none; Info: no systemic absorption
Excretion: feces; Half-life: unknown
Subclass: Electrolytes
Mechanism of Action
binds intestinal potassium, lowering serum potassium (cationic polymer)
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.