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Aimovig (erenumab-aooe)
erenumab
Adult Dosing .
Dosage forms: INJ (auto-injector): 70 mg, 140 mg; INJ (pre-filled syringe): 70 mg per mL, 140 mg per mL
Special Note
- [drug name clarification]
- Info: nonproprietary name = erenumab-aooe
migraine prophylaxis
- [70-140 mg SC qmo]
renal dosing
- [see below]
- eGFR >30: no adjustment; eGFR <30: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: HTN
- caution: Raynaud phenomenon
Drug Interactions .
Overview
erenumab
CGRP antagonist
- decreases gastrointestinal motility
- hypertensive effects
Avoid/Use Alternative
- atogepant
- benztropine
- clozapine
- eluxadoline
- epinephrine inhaled
- eptinezumab
- fremanezumab
- furosemide
- galcanezumab
- midodrine
- olanzapine
- pramlintide
- rimegepant
- ubrogepant
- zavegepant
Monitor/Modify Tx
- abiraterone acetate
- acebutolol
- albuterol
- albuterol inhaled
- aliskiren
- almotriptan
- amiloride
- amlodipine
- amphetamine
- angiotensin II
- aprocitentan
- arformoterol inhaled
- armodafinil
- asciminib
- atenolol
- atomoxetine
- atropine ophthalmic
- axitinib
- azilsartan medoxomil
- benazepril
- benzphetamine
- betamethasone
- betaxolol
- bevacizumab
- bismuth subsalicylate
- bisoprolol
- brigatinib
- budesonide
- bumetanide
- bupropion
- cabozantinib
- caffeine
- caffeine citrate
- candesartan cilexetil
- cannabis
- captopril
- carfilzomib
- carvedilol
- celecoxib
- chlorothiazide
- chlorthalidone
- clevidipine
- clonidine
- cocaine
- copanlisib
- corticotropin
- cortisone
- cyclosporine
- danazol
- darbepoetin alfa
- deflazacort
- desmopressin
- desvenlafaxine
- dexamethasone
- dexmethylphenidate
- dextroamphetamine
- diclofenac
- diclofenac topical
- diethylpropion
- diflunisal
- dihydroergotamine
- diltiazem
- dobutamine
- dopamine
- doxapram
- doxazosin
- dronabinol
- droxidopa
- eletriptan
- enalapril
- enalaprilat
- ephedra
- ephedrine injection
- ephedrine oral
- epinephrine
- eplerenone
- epoetin alfa
- ergotamine
- esketamine
- esmolol
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethacrynic acid
- ethanol (alcoholic beverage)
- ethinyl estradiol (contraceptive)
- etodolac
- etrasimod
- felodipine
- fenfluramine
- fenoldopam
- fenoprofen
- fingolimod
- fludrocortisone
- flurbiprofen
- formoterol inhaled
- fosinopril
- fostamatinib
- frovatriptan
- fruquintinib
- guanfacine
- hoodia
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroxocobalamin IV
- ibrutinib
- ibuprofen
- indapamide
- indomethacin
- irbesartan
- isradipine
- ketamine
- ketoprofen
- ketorolac
- labetalol
- lanreotide
- leflunomide
- lenvatinib
- levalbuterol inhaled
- levomilnacipran
- licorice
- lisdexamfetamine
- lisinopril
- lorlatinib
- losartan
- lumacaftor/ivacaftor
- luspatercept
- magnesium salicylate
- meclofenamate
- mefenamic acid
- meloxicam
- methamphetamine
- methoxy polyethylene glycol-epoetin beta
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- metolazone
- metoprolol
- milnacipran
- minoxidil
- mirabegron
- modafinil
- moexipril
- nabumetone
- nadolol
- naproxen
- naratriptan
- naxitamab
- nebivolol
- nicardipine
- nifedipine
- nimodipine
- niraparib
- nisoldipine
- norepinephrine
- obinutuzumab
- olmesartan medoxomil
- olodaterol inhaled
- osilodrostat
- oxaprozin
- oxymetazoline nasal
- oxytocin
- ozanimod
- pazopanib
- perindopril
- pexidartinib
- phendimetrazine
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- pindolol
- piroxicam
- ponatinib
- ponesimod
- pralsetinib
- prazosin
- prednisolone
- prednisone
- propranolol
- pseudoephedrine
- quetiapine
- quinapril
- ramipril
- ramucirumab
- regorafenib
- ripretinib
- rizatriptan
- ropinirole
- rotigotine transdermal
- salmeterol inhaled
- salsalate
- selpercatinib
- siponimod
- solriamfetol
- sorafenib
- spironolactone
- sulindac
- sumatriptan
- sunitinib
- tacrolimus
- tagraxofusp
- telmisartan
- terazosin
- terbutaline
- teriflunomide
- testosterone
- timolol
- tivozanib
- tolmetin
- torsemide
- trametinib
- trandolapril
- triamcinolone
- triamterene
- vadadustat
- valsartan
- vamorolone
- vandetanib
- vasopressin
- venlafaxine
- verapamil
- vilanterol inhaled
- viloxazine
- voclosporin
- yohimbe
- ziv-aflibercept
- zolmitriptan
Caution Advised
- aclidinium inhaled
- alfentanil
- alosetron
- amantadine
- amitriptyline
- amoxapine
- atropine
- belladonna alkaloids
- brompheniramine
- buprenorphine
- butorphanol
- carbinoxamine
- chlophedianol
- chlorcyclizine
- chlorpheniramine
- chlorpromazine
- clemastine
- clidinium
- clomipramine
- codeine
- cyclobenzaprine
- cyproheptadine
- darifenacin
- desipramine
- dexbrompheniramine
- dexchlorpheniramine
- dicyclomine
- difenoxin
- dihydrocodeine
- dimenhydrinate
- diphenhydramine
- diphenoxylate
- disopyramide
- doxepin
- doxepin topical
- doxylamine
- fentanyl
- fesoterodine
- flavoxate
- fluphenazine
- glycopyrrolate
- glycopyrrolate inhaled
- glycopyrronium topical
- homatropine
- hydrocodone
- hydromorphone
- hydroxyzine
- hyoscyamine
- imipramine
- ipratropium inhaled
- levorphanol
- loperamide
- loxapine
- meclizine
- meperidine
- methadone
- methscopolamine
- mirtazapine
- molindone
- morphine
- nalbuphine
- nortriptyline
- oliceridine
- opium
- orphenadrine
- oxybutynin
- oxycodone
- oxymorphone
- pentazocine
- perphenazine
- pheniramine
- pimozide
- prochlorperazine
- promethazine
- protriptyline
- pyrilamine
- remifentanil
- revefenacin inhaled
- scopolamine
- sofpironium topical
- solifenacin
- sufentanil
- tapentadol
- thioridazine
- thiothixene
- tiotropium inhaled
- tolterodine
- tramadol
- trifluoperazine
- trihexyphenidyl
- trimipramine
- triprolidine
- trospium
- umeclidinium inhaled
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- constipation, severe
- HTN
- Raynaud phenomenon
Common Reactions
- injection site reaction
- constipation
- cramps
- muscle spasms
Safety/Monitoring .
Monitoring Parameters
BP
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at 20x recommended human dose
Pregnancy Registry
encourage patients to enroll in Genesis Pregnancy Registry at 1-833-244-4083 or www.genesispregnancyregistry.com
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for erenumab: unknown; CYP450: none
Excretion: for erenumab: unknown; Half-life: 28 days
Subclass: CGRP Inhibitors ; Headache/Migraine
Mechanism of Action
for erenumab: blocks calcitonin gene-related peptide (CGRP) activity (monoclonal antibody)
Formulary .
No Formulary Selected
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