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Nurtec ODT
rimegepant
Adult Dosing .
Dosage forms: ODT: 75 mg
migraine, acute
- [75 mg PO/SL x1]
- Max: 75 mg/24h
migraine prophylaxis, episodic
- [75 mg PO/SL qod]
renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hepatic impairment, Child-Pugh Class C
- caution: HTN
- caution: Raynaud phenomenon
Drug Interactions .
Overview
rimegepant
CGRP antagonist
- CYP3A4 substrate
- P-gp substrate
- hypertensive effects
Avoid/Use Alternative
- adagrasib
- apalutamide
- atazanavir
- atogepant
- bosentan
- butalbital
- carbamazepine
- cenobamate
- ceritinib
- chloramphenicol
- clarithromycin
- cobicistat
- dabrafenib
- efavirenz
- encorafenib
- enzalutamide
- epinephrine inhaled
- eptinezumab
- erenumab
- etravirine
- fexinidazole
- fosphenytoin
- fremanezumab
- furosemide
- galcanezumab
- idelalisib
- itraconazole
- ivosidenib
- ketoconazole
- levoketoconazole
- lonafarnib
- lopinavir/ritonavir
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- midodrine
- mifepristone
- mitapivat
- mitotane
- modafinil
- nafcillin
- nefazodone
- nelfinavir
- netupitant
- pacritinib
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- posaconazole
- primidone
- repotrectinib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rimegepant
- ritonavir
- sotorasib
- St. John's wort
- tipranavir
- tucatinib
- ubrogepant
- voriconazole
- zavegepant
Monitor/Modify Tx
- abiraterone acetate
- acebutolol
- albuterol
- albuterol inhaled
- aliskiren
- almotriptan
- amiloride
- amiodarone
- amlodipine
- amphetamine
- angiotensin II
- aprepitant
- aprocitentan
- arformoterol inhaled
- armodafinil
- asciminib
- atenolol
- atomoxetine
- atropine ophthalmic
- avacopan
- axitinib
- azilsartan medoxomil
- azithromycin
- belumosudil
- benazepril
- benzphetamine
- berotralstat
- betamethasone
- betaxolol
- bevacizumab
- bismuth subsalicylate
- bisoprolol
- brigatinib
- budesonide
- bumetanide
- bupropion
- cabozantinib
- caffeine
- caffeine citrate
- candesartan cilexetil
- cannabidiol
- cannabis
- captopril
- carfilzomib
- carvedilol
- celecoxib
- chlorothiazide
- chlorthalidone
- ciprofloxacin
- clevidipine
- clofazimine
- clonidine
- cocaine
- conivaptan
- copanlisib
- corticotropin
- cortisone
- crizotinib
- cyclosporine
- danazol
- danicopan
- darbepoetin alfa
- darunavir
- deflazacort
- desmopressin
- desvenlafaxine
- dexamethasone
- dexmethylphenidate
- dextroamphetamine
- diclofenac
- diclofenac topical
- diethylpropion
- diflunisal
- dihydroergotamine
- diltiazem
- diosmin
- dobutamine
- dopamine
- doxapram
- doxazosin
- dronabinol
- dronedarone
- droxidopa
- duvelisib
- eletriptan
- enalapril
- enalaprilat
- ephedra
- ephedrine injection
- ephedrine oral
- epinephrine
- eplerenone
- epoetin alfa
- ergotamine
- erythromycin
- esketamine
- esmolol
- estetrol (contraceptive)
- estradiol (contraceptive)
- ethacrynic acid
- ethanol (alcoholic beverage)
- ethinyl estradiol (contraceptive)
- etodolac
- etrasimod
- fedratinib
- felodipine
- fenfluramine
- fenoldopam
- fenoprofen
- fingolimod
- flibanserin
- fluconazole
- fludrocortisone
- flurbiprofen
- formoterol inhaled
- fosamprenavir
- fosinopril
- fostamatinib
- frovatriptan
- fruquintinib
- glecaprevir
- grapefruit
- guanfacine
- hoodia
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroxocobalamin IV
- ibrutinib
- ibuprofen
- imatinib
- indapamide
- indomethacin
- irbesartan
- isavuconazonium
- isradipine
- ketamine
- ketoprofen
- ketorolac
- labetalol
- lanreotide
- lapatinib
- ledipasvir
- lefamulin
- leflunomide
- lenacapavir
- lenvatinib
- letermovir
- levalbuterol inhaled
- levomilnacipran
- licorice
- lisdexamfetamine
- lisinopril
- losartan
- luspatercept
- magnesium salicylate
- mavorixafor
- meclofenamate
- mefenamic acid
- meloxicam
- methamphetamine
- methoxy polyethylene glycol-epoetin beta
- methyldopa
- methylergonovine
- methylphenidate
- methylprednisolone
- methyltestosterone
- metoclopramide
- metolazone
- metoprolol
- milnacipran
- minoxidil
- mirabegron
- moexipril
- nabumetone
- nadolol
- naproxen
- naratriptan
- naxitamab
- nebivolol
- nicardipine
- nifedipine
- nilotinib
- nimodipine
- niraparib
- nirogacestat
- nisoldipine
- norepinephrine
- obinutuzumab
- olmesartan medoxomil
- olodaterol inhaled
- osilodrostat
- oxaprozin
- oxymetazoline nasal
- oxytocin
- ozanimod
- pazopanib
- perindopril
- phendimetrazine
- phenoxybenzamine
- phentermine
- phentolamine
- phenylephrine
- phenylephrine injection
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine rectal
- pibrentasvir
- pindolol
- piroxicam
- ponatinib
- ponesimod
- pralsetinib
- prazosin
- prednisolone
- prednisone
- propafenone
- propranolol
- pseudoephedrine
- quetiapine
- quinapril
- quinidine (antiarrhythmic)
- ramipril
- ramucirumab
- ranolazine
- regorafenib
- rilzabrutinib
- ripretinib
- rizatriptan
- ropinirole
- rotigotine transdermal
- salmeterol inhaled
- salsalate
- selpercatinib
- siponimod
- solriamfetol
- sorafenib
- spironolactone
- sulindac
- sumatriptan
- sunitinib
- tacrolimus
- tagraxofusp
- telmisartan
- tepotinib
- terazosin
- terbutaline
- teriflunomide
- testosterone
- timolol
- tivozanib
- tolmetin
- torsemide
- trametinib
- trandolapril
- triamcinolone
- triamterene
- turmeric
- vadadustat
- valsartan
- vamorolone
- vandetanib
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- vilanterol inhaled
- viloxazine
- vimseltinib
- voclosporin
- voxilaprevir
- yohimbe
- ziv-aflibercept
- zolmitriptan
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction, immediate or delayed
- anaphylaxis
- dyspnea
- rash, severe
- HTN
- Raynaud phenomenon
Common Reactions
- nausea
- abdominal pain
- dyspepsia
Safety/Monitoring .
Monitoring Parameters
BP
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at up to 45x MRHD
Pregnancy Registry
enroll patients or encourage patients to enroll in Migraine Observational Nurtec Pregnancy Registry at 1-877-366-0324 or www.nurtecpregnancyregistry.com or email nurtecpregnancyregistry@ppd.com
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; inadequate human data available, though risk of infant harm not expected based on limited drug excretion into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for rimegepant: unknown; CYP450: 2C9, 3A4 (primary) substrate
Excretion: for rimegepant: feces 78% (42% unchanged), urine 24% (51% unchanged); Half-life: 11h
Subclass: CGRP Inhibitors ; Headache/Migraine
Mechanism of Action
for rimegepant: blocks calcitonin gene-related peptide (CGRP) activity
Formulary .
No Formulary Selected
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