Highlights & Basics
- Placental abruption is the separation of the normally located placenta before delivery of the fetus. It may be concealed or overt.
- Frequently presents as vaginal bleeding associated with abdominal pain and contractions in the second half of pregnancy.
- Associated with increased perinatal mortality and morbidity. Also a cause of significant maternal morbidity.
- Risk factors include smoking, trauma, hypertensive disorders, and cocaine use.
- Diagnosis is made clinically. Some ultrasound features may be helpful. Other tests are, for the most part, unreliable.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Types of placental abruption. (A) Revealed placental abruption, where blood tracks between the membranes, and escapes through the vagina and cervix. (B) Concealed placental abruption where blood collects behind the placenta, with no evidence of vaginal bleeding
Ultrasound image of placental abruption: normal placenta is marked "p"; area of abruption depicted by white arrows
Ultrasound image of placental abruption: normal placenta is marked "p"; area of abruption depicted by white arrows
Ultrasound image of placental abruption: normal placenta is marked "p"; area of abruption depicted by white arrows
Ultrasound image of placental abruption: normal placenta is marked "p"; area of abruption depicted by white arrows
Citations
American College of Radiology. ACR appropriateness criteria: second and third trimester bleeding. 2020 [internet publication].[Full Text]
Society for Maternal-Fetal Medicine (SMFM), Gyamfi-Bannerman C. Society for Maternal-Fetal Medicine (SMFM) Consult Series #44: Management of bleeding in the late preterm period. Am J Obstet Gynecol. 2018 Jan;218(1):B2-8.[Abstract][Full Text]
1. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006 Oct;108(4):1005-16.[Abstract]
2. Ananth CV, Lavery JA, Vintzileos AM, et al. Severe placental abruption: clinical definition and associations with maternal complications. Am J Obstet Gynecol. 2016 Feb;214(2):272.e1-272.[Abstract][Full Text]
3. Ananth CV, Keyes KM, Hamilton A, et al. An international contrast of rates of placental abruption: an age-period-cohort analysis. PLoS One. 2015 May 27;10(5):e0125246.[Abstract][Full Text]
4. Tikkanen M. Placental abruption: epidemiology, risk factors and consequences. Acta Obstet Gynecol Scand. 2011 Feb;90(2):140-9.[Abstract]
5. Ventolini G, Samlowski R, Hood DL. Placental findings in low-risk, singleton, term pregnancies after uncomplicated deliveries. Am J Perinatol. 2004 Aug;21(6):325-8.[Abstract]
6. Ananth CV, Oyelese Y, Yeo L, et al. Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol. 2005 Jan;192(1):191-8.[Abstract]
7. Ananth CV, Oyelese Y, Prasad V, et al. Evidence of placental abruption as a chronic process: associations with vaginal bleeding early in pregnancy and placental lesions. Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):15-21.[Abstract]
8. Kurdi W, Campbell S, Aquilina J, et al. The role of color Doppler imaging of the uterine arteries at 20 weeks' gestation in stratifying antenatal care. Ultrasound Obstet Gynecol. 1998 Nov;12(5):339-45.[Abstract]
9. Harrington K, Cooper D, Lees C, et al. Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre-eclampsia, placental abruption or delivery of a small-for-gestational-age baby. Ultrasound Obstet Gynecol. 1996 Mar;7(3):182-8.[Abstract]
10. Dommisse J, Tiltman AJ. Placental bed biopsies in placental abruption. Br J Obstet Gynaecol. 1992 Aug;99(8):651-4.[Abstract]
11. Ananth CV, Peltier MR, Chavez MR, et al. Recurrence of ischemic placental disease. Obstet Gynecol. 2004 Jun 1;103(11):4003-9.[Abstract]
12. Brenner B. Clinical management of thrombophilia-related placental vascular complications. Blood. 2004 Jun 1;103(11):4003-9.[Abstract]
13. ACOG Practice Bulletin No. 197: Inherited Thrombophilias in Pregnancy. Obstet Gynecol. 2018 Jul;132(1):e18-e34.[Abstract]
14. Ananth CV, Smulian JC, Vintzileos AM. Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. Obstet Gynecol.1999 Apr;93(4):622-8.[Abstract]
15. Zetterstrom K, Lindeberg SN, Haglund B, et al. Maternal complications in women with chronic hypertension: a population-based cohort study. Acta Obstet Gynecol Scand. 2005 May;84(5):419-24.[Abstract]
16. Williams MA, Mittendorf R, Monson RR. Chronic hypertension, cigarette smoking, and abruptio placentae. Epidemiology. 1991 Nov;2(6):450-3.[Abstract]
17. Abu-Heija A, al-Chalabi H, el-Iloubani N. Abruptio placentae: risk factors and perinatal outcome. J Obstet Gynaecol Res. 1998 Apr;24(2):141-4.[Abstract]
18. Tikkanen M, Nuutila M, Hiilesmaa V, et al. Clinical presentation and risk factors of placental abruption. Acta Obstet Gynecol Scand. 2006;85(6):700-5.[Abstract]
19. Bhattacharya S, Campbell DM. The incidence of severe complications of preeclampsia. Hypertens Pregnancy. 2005;24(2):181-90.[Abstract]
20. Tikkanen M, Nuutila M, Hiilesmaa V, et al. Prepregnancy risk factors for placental abruption. Acta Obstet Gynecol Scand. 2006;85(1):40-4.[Abstract]
21. Shobeiri F, Masoumi SZ, Jenabi E. The association between maternal smoking and placenta abruption: a meta-analysis. J Matern Fetal Neonatal Med. 2017 Aug;30(16):1963-7.[Abstract]
22. Raymond EG, Mills JL. Placental abruption. Maternal risk factors and associated fetal conditions. Acta Obstet Gynecol Scand. 1993 Nov;72(8):633-9..[Abstract]
23. Landy HJ, Hinson J. Placental abruption associated with cocaine use: case report. Reprod Toxicol. 1987-1988;1(3):203-5.[Abstract]
24. Addis A, Moretti ME, Ahmed Syed F, et al. Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol. 2001 Jul-Aug;15(4):341-69.[Abstract]
25. Handler A, Kistin N, Davis F, et al. Cocaine use during pregnancy: perinatal outcomes. Am J Epidemiol. 1991 Apr 15;133(8):818-25.[Abstract]
26. Lane PL. Traumatic fetal deaths. J Emerg Med. 1989 Sep-Oct;7(5):433-35.[Abstract]
27. Schiff MA, Holt VL. Pregnancy outcomes following hospitalization for motor vehicle crashes in Washington State from 1989 to 2001. Am J Epidemiol. 2005 Mar 15;161(6):503-10.[Abstract][Full Text]
28. El-Kady D, Gilbert WM, Anderson J, et al. Trauma during pregnancy: an analysis of maternal and fetal outcomes in a large population. Am J Obstet Gynecol. 2004 Jun;190(6):1661-8.[Abstract]
29. Getahun D, Oyelese Y, Salihu HM, et al. Previous cesarean delivery and risks of placenta previa and placental abruption. Obstet Gynecol. 2006 Apr;107(4):771-8.[Abstract]
30. Lydon-Rochelle M, Holt VL, Easterling TR, et al. First-birth cesarean and placental abruption or previa at second birth(1). Obstet Gynecol. 2001 May;97(5 Pt 1):765-9.[Abstract]
31. Yang Q, Wen SW, Oppenheimer L, et al. Association of caesarean delivery for first birth with placenta praevia and placental abruption in second pregnancy. BJOG. 2007 May;114(5):609-13.[Abstract]
32. Ananth CV, Oyelese Y, Srinivas N, et al. Preterm premature rupture of membranes, intrauterine infection, and oligohydramnios: risk factors for placental abruption. Obstet Gynecol. 2004 Jul;104(1):71-7.[Abstract]
33. Kramer MS, Usher RH, Pollack R, et al. Etiologic determinants of abruptio placentae. Obstet Gynecol. 1997 Feb;89(2):221-6.[Abstract]
34. Hung TH, Hsieh CC, Hsu JJ, et al. Risk factors for placental abruption in an Asian population. Reprod Sci. 2007 Jan;14(1):59-65.[Abstract]
35. Rasmussen S, Irgens LM, Dalaker K. Outcome of pregnancies subsequent to placental abruption: a risk assessment. Acta Obstet Gynecol Scand. 2000 Jun;79(6):496-501.[Abstract]
36. Rasmussen S, Irgens LM, Albrechtsen S, et al. Women with a history of placental abruption: when in a subsequent pregnancy should special surveillance for a recurrent placental abruption be initiated? Acta Obstet Gynecol Scand. 2001 Aug;80(8):708-12.[Abstract]
37. Toivonen S, Heinonen S, Anttila M, et al. Obstetric prognosis after placental abruption. Fetal Diagn Ther. 2004 Jul-Aug;19(4):336-41.[Abstract]
38. Ruiter L, Ravelli AC, de Graaf IM, et al. Incidence and recurrence rate of placental abruption: a longitudinal linked national cohort study in the Netherlands. Am J Obstet Gynecol. 2015 Oct;213(4):573.e1-8.[Abstract]
39. Salihu HM, Bekan B, Aliyu MH, et al. Perinatal mortality associated with abruptio placenta in singletons and multiples. Am J Obstet Gynecol. 2005 Jul;193(1):198-203.[Abstract]
40. Sheiner E, Bashiri A, Levy A, et al. Obstetric characteristics and perinatal outcome of pregnancies with uterine leiomyomas. J Reprod Med. 2004 Mar;49(3):182-6.[Abstract]
41. Prochazka M, Lubusky M, Slavik L, et al. Frequency of selected thrombophilias in women with placental abruption. Aust N Z J Obstet Gynaecol. 2007 Aug;47(4):297-301.[Abstract]
42. Facchinetti F. Factor V Leiden in pregnancies complicated by placental abruption. BJOG. 2004 Jan;111(1):93.[Abstract]
43. Kinzler WL, Prasad V, Ananth CV, et al. The effect of maternal thrombophilia on placental abruption: Histologic correlates. J Matern Fetal Neonatal Med. 2009 Mar;22(3):243-8.[Abstract]
44. Jaaskelainen E, Keski-Nisula L, Toivonen S, et al. MTHFR C677T polymorphism is not associated with placental abruption or preeclampsia in Finnish women. Hypertens Pregnancy. 2006;25(2):73-80.[Abstract]
45. Dizon-Townson D, Miller C, Sibai B, et al. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus. Obstet Gynecol. 2005 Sep;106(3):517-24.[Abstract]
46. American College of Radiology. ACR appropriateness criteria: second and third trimester bleeding. 2020 [internet publication].[Full Text]
47. Notelovitz M, Bottoms SF, Dase DF, et al. Painless abruptio placentae. Obstet Gynecol. 1979 Feb;53(2):270-2.[Abstract]
48. Ananth CV, Berkowitz GS, Savitz DA, et al. Placental abruption and adverse perinatal outcomes. JAMA. 1999 Nov 3;282(17):1646-51.[Abstract][Full Text]
49. Usui R, Matsubara S, Ohkuchi A, et al. Fetal heart rate pattern reflecting the severity of placental abruption. Arch Gynecol Obstet. 2008 Mar;277(3):249-53.[Abstract]
50. Visser GHA, Thommesen T, Di Renzo GC, et al. FIGO/ICM guidelines for preventing Rhesus disease: a call to action. Int J Gynaecol Obstet. 2021 Feb;152(2):144-7.[Abstract][Full Text]
51. Atkinson A, Santolaya-Forgas J, Matta P, et al. The sensitivity of the Kleihauer-Betke test for placental abruption. J Obstet Gynaecol. 2015 Feb;35(2):139-41.[Abstract]
52. Emery CL, Morway LF, Chung-Park M, et al. The Kleihauer-Betke test. Clinical utility, indication, and correlation in patients with placental abruption and cocaine use. Arch Pathol Lab Med. 1995 Nov;119(11):1032-7.[Abstract]
53. Committee on Practice Bulletins--Obstetrics and the American Institute of Ultrasound in Medicine. Practice Bulletin No. 175: Ultrasound in Pregnancy. Obstet Gynecol. 2016 Dec;128(6):e241-56.[Abstract]
54. Kikutani M, Ishihara K, Araki T. Value of ultrasonography in the diagnosis of placental abruption. J Nippon Med Sch. 2003 Jun;70(3):227-33.[Abstract][Full Text]
55. Yeo L, Ananth C, Vintzileos A. Placental abruption. In: Sciarra J, ed. Gynecology and obstetrics. Hagerstown, MD: Lippincott, Williams & Wilkins; 2004.
56. Glantz C, Purnell L. Clinical utility of sonography in the diagnosis and treatment of placental abruption. J Ultrasound Med. 2002 Aug;21(8):837-40.[Abstract]
57. Shinde GR, Vaswani BP, Patange RP, et al. Diagnostic performance of ultrasonography for detection of abruption and its clinical correlation and maternal and foetal outcome. J Clin Diagn Res. 2016 Aug;10(8):QC04-7.[Abstract][Full Text]
58. Dhanraj D, Lambers D. The incidences of positive Kleihauer-Betke test in low-risk pregnancies and maternal trauma patients. Am J Obstet Gynecol. 2004 May;190(5):1461-3.[Abstract]
59. American College of Obstetricians and Gynecologists. Ultrasound in pregnancy. Dec 2016 [internet publication].[Full Text]
60. Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. Lancet. 2018 Jan 13;391(10116):125-32.[Abstract][Full Text]
61. Society of Obstetricians and Gynaecologists of Canada. Guidelines for the Management of a Pregnant Trauma Patient. Jun 2015 [internet publication].[Full Text]
62. Society for Maternal-Fetal Medicine (SMFM), Gyamfi-Bannerman C. Society for Maternal-Fetal Medicine (SMFM) Consult Series #44: Management of bleeding in the late preterm period. Am J Obstet Gynecol. 2018 Jan;218(1):B2-8.[Abstract][Full Text]
63. Kayani SI, Walkinshaw SA, Preston C. Pregnancy outcome in severe placental abruption. BJOG. 2003 Jul;110(7):679-83.[Abstract]
64. American College of Obstetricians and Gynecologists. Committee opinion no. 713: antenatal corticosteroid therapy for fetal maturation. Aug 2017 [internet publication].[Full Text]
65. American College of Obstetricians and Gynecologists. Committee opinion no. 455: magnesium sulfate before anticipated preterm birth for neuroprotection. Mar 2010 [internet publication].[Full Text]
66. Crowther CA, Brown J, McKinlay CJ, et al. Magnesium sulphate for preventing preterm birth in threatened preterm labour. Cochrane Database Syst Rev. 2014 Aug 15;2014(8):CD001060.[Abstract]
67. Saller DN Jr, Nagey DA, Pupkin MJ, et al. Tocolysis in the management of third trimester bleeding. J Perinatol. 1990 Jun;10(2):125-8.[Abstract]
68. Towers CV, Pircon RA, Heppard M. Is tocolysis safe in the management of third-trimester bleeding? Am J Obstet Gynecol. 1990 Jun;10(2):125-8.[Abstract]
69. Henderson CE, Goldman B, Divon MY. Ritodrine therapy in the presence of chronic abruptio placentae. Obstet Gynecol. 1992 Sep;80(3 Pt 2):510-2.[Abstract]
70. US Food and Drug Administration. FDA drug safety communication: FDA recommends against prolonged use of magnesium sulfate to stop pre-term labor due to bone changes in exposed babies. May 2013 [internet publication].[Full Text]
71. Medicines and Healthcare products Regulatory Agency. Magnesium sulfate: risk of skeletal adverse effects in the neonate following prolonged or repeated use in pregnancy. 2019 May;12(10):3. [Full Text]
72. Ananth CV, Wilcox AJ. Placental abruption and perinatal mortality in the United States. Am J Epidemiol. 2001 Feb 15;153(4):332-7.[Abstract][Full Text]
73. Ananth CV, Vintzileos AM. Medically indicated preterm birth: recognizing the importance of the problem. Clin Perinatol. 2008 Mar;35(1):53-67.[Abstract]
74. Ananth CV, Vintzileos AM. Maternal-fetal conditions necessitating a medical intervention resulting in preterm birth. Am J Obstet Gynecol. 2006 Dec;195(6):1557-63.[Abstract]
75. Gibbs JM, Weindling AM. Neonatal intracranial lesions following placental abruption. Eur J Pediatr. 1994 Mar;153(3):195-7.[Abstract]
76. Pitaphrom A, Sukcharoen N. Pregnancy outcomes in placental abruption. J Med Assoc Thai. 2006 Oct;89(10):1572-8.[Abstract]
77. Rasmussen S, Irgens LM, Dalaker K. The effect on the likelihood of further pregnancy of placental abruption and the rate of its recurrence. Br J Obstet Gynaecol. 1997 Nov;104(11):1292-5.[Abstract]
78. Furuhashi M, Kurauchi O, Suganuma N. Pregnancy following placental abruption. Arch Gynecol Obstet. 2002 Nov;267(1):11-3.[Abstract]
79. Ananth CV, Patrick HS, Ananth S, et al. Maternal cardiovascular and cerebrovascular health after placental abruption: a systematic review and meta-analysis (CHAP-SR). Am J Epidemiol. 2021 Dec 1;190(12):2718-29.[Abstract][Full Text]
80. Lockwood CJ, Toti P, Arcuri F, et al. Mechanisms of abruption-induced premature rupture of the fetal membranes: thrombin-enhanced interleukin-8 expression in term decidua. Am J Pathol. 2005 Nov;167(5):1443-9.[Abstract]
Key Articles
Referenced Articles
Sign in to access our clinical decision support tools