Adynovate

Adult Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: 10-20 units/kg/dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%

[bleeding episode, moderate]

Dose: 15-30 units/kg/dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding episode, major]

Dose: 30-50 units/kg/dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, minor surgery]

Dose: 30-50 units/kg/dose IV x1 preop; may repeat dose q24h until hemostasis; Start: within 1h before surgery; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, major surgery]

Dose: 40-60 units/kg/dose IV x1 preop, then q8-24h until adequate wound healing; Start: within 1h before surgery; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-120%

[routine bleeding prophylaxis]

Dose: 40-50 units/kg/dose IV 2x/wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[dosing clarification]

Info: 1 unit/kg will incr. factor VIII level approximately 2%; dose, duration varies by site/severity of bleeding, severity of deficiency, and presence of inhibitors

hemophilia A

[bleeding episode, minor]

Dose: 10-20 units/kg/dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 20-40%

[bleeding episode, moderate]

Dose: 15-30 units/kg/dose IV q12-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 30-60%

[bleeding episode, major]

Dose: 30-50 units/kg/dose IV q8-24h until hemostasis; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, minor surgery]

Dose: 30-50 units/kg/dose IV x1 preop; may repeat dose q24h until hemostasis; Start: within 1h before surgery; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 60-100%

[bleeding prophylaxis, major surgery, <12 yo]

Dose: 40-60 units/kg/dose IV x1 preop, then q6-24h until adequate wound healing; Start: within 1h before surgery; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-120%

[bleeding prophylaxis, major surgery, 12 yo and older]

Dose: 40-60 units/kg/dose IV x1 preop, then q8-24h until adequate wound healing; Start: within 1h before surgery; Info: estimated dose (units) = [wt (kg) x desired factor VIII level (%) x 0.5] where desired factor VIII level = 80-120%

[routine bleeding prophylaxis, <12 yo]

Dose: 55 units/kg/dose IV 2x/wk; Max: 70 units/kg/dose

[routine bleeding prophylaxis, 12 yo and older]

Dose: 40-50 units/kg/dose IV 2x/wk

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]