Highlights & Basics
- Metabolic syndrome is a cluster of common abnormalities, including insulin resistance, impaired glucose tolerance, abdominal obesity, reduced high-density lipoprotein (HDL)-cholesterol levels, elevated triglycerides, and hypertension.
- Incidence is increasing in line with the number of people who are overweight or obese, with one quarter of the world population estimated to have the condition.
- Increases risk of cardiovascular disease and diabetes, although there are ethnic variations in the incidence of metabolic syndrome components defined by the same criteria.
- The precise pathogenetic mechanisms unifying all of its components are as yet unknown, although insulin resistance certainly plays a key role.
- Obesity, an atherogenic diet, and physical inactivity are the strongest risk factors for the development of metabolic syndrome.
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Citations
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