Highlights & Basics
- Acute appendicitis typically presents as acute abdominal pain starting in the mid-abdomen and later localizing to the right lower quadrant.
- Associated with fever, anorexia, nausea, vomiting, and elevation of the neutrophil count.
- Diagnosis is usually made clinically. If investigation is required, computed tomography scan or ultrasonography may show dilatation of the appendix outer diameter to more than 6 mm.
- Definitive treatment is surgical appendectomy. A nonoperative, antibiotic-only approach may be feasible in select patient populations.
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Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.[Abstract][Full Text]
American College of Radiology. ACR appropriateness criteria: right lower quadrant pain - suspected appendicitis. 2022 [internet publication].[Full Text]
Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017 Jul 10;12:29.[Abstract][Full Text]
1. Fitz RH. Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment. Am J Med Sci. 1886;92:321-46.
2. Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: A Review. JAMA. 2021 Dec 14;326(22):2299-311.[Abstract]
3. Lapsa S, Ozolins A, Strumfa I, et al. Acute appendicitis in the elderly: a literature review on an increasingly frequent surgical problem. Geriatrics (Basel). 2021 Sep 18;6(3):93.[Abstract][Full Text]
4. Antoniou SA, Mavridis D, Kontouli KM, et al. EAES rapid guideline: appendicitis in the elderly. Surg Endosc. 2021 Jul;35(7):3233-43.[Abstract]
5. Fugazzola P, Ceresoli M, Agnoletti V, et al. The SIFIPAC/WSES/SICG/SIMEU guidelines for diagnosis and treatment of acute appendicitis in the elderly (2019 edition). World J Emerg Surg. 2020 Mar 10;15(1):19.[Abstract][Full Text]
6. Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand. 1999;78:758-62.[Abstract]
7. Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg. 2020 Apr 15;15(1):27.[Abstract][Full Text]
8. Davenport M. Acute abdominal pain in children. BMJ. 1996 Feb 24;312(7029):498-501.[Abstract][Full Text]
9. Benabbas R, Hanna M, Shah J, et al. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2017 May;24(5):523-51.[Abstract][Full Text]
10. Ferris M, Quan S, Kaplan BS, et al. The global incidence of appendicitis: a systematic review of population-based studies. Ann Surg. 2017 Aug;266(2):237-41.[Abstract]
11. NHS Digital. Hospital admitted patient care activity, 2021-22. Sep 2022 [internet publication].[Full Text]
12. Snyder MJ, Guthrie M, Cagle S. Acute appendicitis: Efficient diagnosis and management. Am Fam Physician. 2018 Jul 1;98(1):25-33.[Abstract][Full Text]
13. Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc. 2016 Nov;30(11):4668-90.[Abstract][Full Text]
14. Singh JP, Mariadason JG. Role of the faecolith in modern-day appendicitis. Ann R Coll Surg Engl. 2013 Jan;95(1):48-51.[Abstract][Full Text]
15. Ramdass MJ, Young Sing Q, Milne D, et al. Association between the appendix and the fecalith in adults. Can J Surg. 2015 Feb;58(1):10-4.[Abstract][Full Text]
16. Eslahi AV, Olfatifar M, Houshmand E, et al. Parasites in surgically removed appendices as a neglected public health concern: a systematic review and meta-analysis. Pathog Glob Health. 2022 Sep;116(6):341-55.[Abstract][Full Text]
17. Zacarias M, Pizzol D, de Miranda H, et al. Schistosomal appendicitis: Case series and systematic literature review. PLoS Negl Trop Dis. 2021 Jun;15(6):e0009478.[Abstract][Full Text]
18. Di Sebastiano P, Fink T, di Mola FF, et al. Neuroimmune appendicitis. Lancet. 1999 Aug 7;354(9177):461-6.[Abstract]
19. Peisl S, Burckhardt O, Egger B. Neurogenic appendicopathy: an underestimated disease-systematic review of the literature. Int J Colorectal Dis. 2021 Sep;36(9):1995-2005.[Abstract]
20. Soffer D, Zait S, Klausner J, et al. Peritoneal cultures and antibiotic treatment in patients with perforated appendicitis. Eur J Surg. 2001 Mar;167(3):214-6.[Abstract]
21. Brunicardi FC, Andersen DK, Billiar TR, et al, eds. The appendix. In: Schwartz's principles of surgery. 8th ed. New York, NY: McGraw-Hill; 2005:1119-37.
22. Davenport ER, Sanders JG, Song SJ, et al. The human microbiome in evolution. BMC Biol. 2017 Dec 27;15(1):127.[Abstract][Full Text]
23. Elwan TH, Abdennour AEK, Akl U, et al. Unveiling the role of inflammatory mediators and gut microbiome in appendicitis: types and applications in clinical scoring. Adv. Gut Microbiome Res. 2023 Jun 10;2023(1):1-12.[Full Text]
24. Lee MS, Sulit A, Frizelle F, et al. The microbiome in adult acute appendicitis. Gut Microbiome (Camb). 2022;3:e8.[Abstract][Full Text]
25. Blaak EE, Canfora EE, Theis S, et al. Short chain fatty acids in human gut and metabolic health. Benef Microbes. 2020 Sep 1;11(5):411-45.[Abstract][Full Text]
26. Wang Z, Bao L, Wu L, et al. Causal effects of gut microbiota on appendicitis: a two-sample Mendelian randomization study. Front Cell Infect Microbiol. 2023;13:1320992.[Abstract][Full Text]
27. Montgomery SM, Pounder RE, Wakefield AJ. Smoking in adults and passive smoking in children are associated with acute appendicitis. Lancet. 1999 Jan 30;353(9150):379.[Abstract]
28. Oldmeadow C, Wood I, Mengersen K, et al. Investigation of the relationship between smoking and appendicitis in Australian twins. Ann Epidemiol. 2008 Aug;18(8):631-6.[Abstract]
29. Bendeck SE, Nino-Murcia M, Berry GJ, et al. Imaging for suspected appendicitis: negative appendectomy and perforation rates. Radiology. 2002 Oct;225(1):131-6.[Abstract]
30. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986 May;15(5):557-64.[Abstract]
31. Kularatna M, Lauti M, Haran C, et al. Clinical prediction rules for appendicitis in adults: which is best? World J Surg. 2017 Jul;41(7):1769-81.[Abstract]
32. Frountzas M, Stergios K, Kopsini D, et al. Alvarado or RIPASA score for diagnosis of acute appendicitis? A meta-analysis of randomized trials. Int J Surg. 2018 Aug;56:307-14.[Abstract]
33. American College of Radiology. ACR appropriateness criteria: right lower quadrant pain - suspected appendicitis. 2022 [internet publication].[Full Text]
34. Basaran A, Basaran M. Diagnosis of acute appendicitis during pregnancy: a systematic review. Obstet Gynecol Surv. 2009 Jul;64(7):481-8; quiz 499.[Abstract]
35. Baird DLH, Simillis C, Kontovounisios C, et al. Acute appendicitis. BMJ. 2017 Apr 19;357:j1703.[Abstract][Full Text]
36. Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001 May;136(5):556-62.[Abstract][Full Text]
37. Lewis SR, Mahony PJ, Simpson J. Appendicitis. BMJ. 2011 Oct 6;343:d5976.[Abstract]
38. Petroianu A. Diagnosis of acute appendicitis. Int J Surg. 2012;10(3):115-9.[Abstract][Full Text]
39. Brown JJ, Wilson C, Coleman S, Joypaul BV. Appendicitis in pregnancy: an ongoing diagnostic dilemma. Colorectal Dis. 2009 Feb;11(2):116-22.[Abstract]
40. Temple CL, Shirley AH, Temple WJ. The natural history of appendicitis in adults. A prospective study. Ann Surg. 1995 Mar;221(3):278-81.[Abstract][Full Text]
41. Franz MG, Norman J, Fabri PJ. Increased morbidity of appendicitis with advancing age. Am Surg. 1995 Jan;61(1):40-4.[Abstract]
42. Humes DJ, Simpson J. Acute appendicitis. BMJ. 2006 Sep 9;333(7567):530-4.[Abstract][Full Text]
43. Andersson RE. Meta-analysis of the clinical and laboratory diagnosis of acute appendicitis. Br J Surg. 2004 Jan;91(1):28-37.[Abstract]
44. Green R, Bulloch B, Kabani A, et al. Early analgesia for children with acute abdominal pain. Pediatrics. 2005 Oct;116(4):978-83.[Abstract]
45. Manterola C, Vial M, Moraga J, et al. Analgesia in patients with acute abdominal pain. Cochrane Database Syst Rev. 2011 Jan 19;(1):CD005660.[Abstract][Full Text]
46. Carstens AK, Fensby L, Penninga L. Nonoperative treatment of appendicitis during pregnancy in a remote area. AJP Rep. 2018 Jan;8(1):e37-8.[Abstract][Full Text]
47. Bachur RG, Callahan MJ, Monuteaux MC, et al. Integration of ultrasound findings and a clinical score in the diagnostic evaluation of pediatric appendicitis. J Pediatr. 2015 May;166(5):1134-9. [Abstract]
48. Terasawa T, Blackmore CC, Bent S, et al. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 5;141(7):537-46.[Abstract]
49. Dahabreh IJ, Adam GP, Halladay CW, et al. Diagnosis of right lower quadrant pain and suspected acute appendicitis. In: Agency for Healthcare Research and Quality (US). AHRQ Comparative effectiveness reviews report no. 15(16)-EHC025-EF. 2015. Rockville, MD: Agency for Healthcare Research and Quality (US).[Abstract][Full Text]
50. Kumar SS, Collings AT, Lamm R, et al. SAGES guideline for the diagnosis and treatment of appendicitis. Surg Endosc. 2024 Jun;38(6):2974-94.[Abstract]
51. Fu J, Zhou X, Chen L, et al. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis. Front Surg. 2021;8:707160.[Abstract][Full Text]
52. American College of Emergency Physicians Clinical Policies Subcommittee (Writing Committee) on Appendicitis, Diercks DB, Adkins EJ, et al. Clinical policy: critical issues in the evaluation and management of emergency department patients with suspected appendicitis: approved by ACEP Board of Directors February 1, 2023. Ann Emerg Med. 2023 Jun;81(6):e115-52.[Abstract][Full Text]
53. Bonomo RA, Chow AW, Edwards MS, et al. 2024 Clinical practice guideline update by the Infectious Diseases Society of America on complicated intra-abdominal infections: risk assessment, diagnostic imaging, and microbiological evaluation in adults, children, and pregnant people. Clin Infect Dis. 2024 Oct 4;79(supplement_3):S81-7.[Abstract][Full Text]
54. American College of Radiology. ACR Appropriateness Criteria: acute nonlocalized abdominal pain. 2018 [internet publication].[Full Text]
55. Musunuru S, Chen H, Rikkers LF, et al. Computed tomography in the diagnosis of acute appendicitis: definitive or detrimental? J Gastrointest Surg. 2007 Nov;11(11):1417-21; discussion 1421-2.[Abstract]
56. Chiu YH, Chen JD, Wang SH, et al. Whether intravenous contrast is necessary for CT diagnosis of acute appendicitis in adult ED patients? Acad Radiol. 2013 Jan;20(1):73-8.[Abstract][Full Text]
57. Hlibczuk V, Dattaro JA, Jin Z, et al. Diagnostic accuracy of noncontrast computed tomography for appendicitis in adults: a systematic review. Ann Emerg Med. 2010 Jan;55(1):51-9.e1.[Abstract]
58. Arruzza E, Milanese S, Li LSK, et al. Diagnostic accuracy of computed tomography and ultrasound for the diagnosis of acute appendicitis: A systematic review and meta-analysis. Radiography (Lond). 2022 Nov;28(4):1127-41.[Abstract]
59. American College of Radiology. Ten things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2021 [internet publication].[Full Text]
60. D'Souza N, Hicks G, Beable R, et al. Magnetic resonance imaging (MRI) for diagnosis of acute appendicitis. Cochrane Database Syst Rev. 2021 Dec 14;(12):CD012028.[Abstract][Full Text]
61. American College of Radiology. ACR appropriateness criteria: suspected appendicitis - child. 2018 [internet publication].[Abstract][Full Text]
62. American Academy of Pediatrics - Section on Surgery. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].[Full Text]
63. American College of Surgeons. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2021 [internet publication].[Full Text]
64. American Academy of Pediatrics. Ten things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].[Full Text]
65. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38.[Abstract]
66. Eun S, Ho IG, Bae GE, et al. Neutrophil-to-lymphocyte ratio for the diagnosis of pediatric acute appendicitis: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):7097-107.[Abstract][Full Text]
67. Giannis D, Matenoglou E, Moris D. Hyponatremia as a marker of complicated appendicitis: A systematic review. Surgeon. 2020 Oct;18(5):295-304.[Abstract]
68. Zhan W, Deng W, Liu Y, et al. Hyponatremia as a predictor of complicated appendicitis in children: A systematic review and meta-analysis. Asian J Surg. 2022 Oct;45(10):2009-11.[Abstract][Full Text]
69. Anand S, Pakkasjärvi N, Bajpai M, et al. Utility of Pentraxin-3 as a biomarker for diagnosis of acute appendicitis: a systematic review and meta-analysis. Pediatr Surg Int. 2022 Aug;38(8):1105-12.[Abstract][Full Text]
70. Shi W, Wu Y, Zhong L, et al. Diagnostic accuracy of serum amyloid A in acute appendicitis: a systematic review and meta-analysis. Surg Infect (Larchmt). 2022 May;23(4):380-7.[Abstract]
71. Tullavardhana T, Sanguanlosit S, Chartkitchareon A. Role of platelet indices as a biomarker for the diagnosis of acute appendicitis and as a predictor of complicated appendicitis: a meta-analysis. Ann Med Surg (Lond). 2021 Jun;66:102448.[Abstract][Full Text]
72. Shen G, Li S, Shao Z, et al. Platelet indices in patients with acute appendicitis: a systematic review with meta-analysis. Updates Surg. 2021 Aug;73(4):1327-41.[Abstract]
73. Makama JG, Kache SA, Ajah LJ, et al. Intestinal obstruction caused by appendicitis: a systematic review. J West Afr Coll Surg. 2017 Jul-Sep;7(3):94-115.[Abstract][Full Text]
74. Choi D, Park H, Lee YR, et al. The most useful finding for the diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiol. 2003 Nov;44(6):574-82.[Abstract]
75. Eng KA, Abadeh A, Ligocki C, et al. Acute appendicitis: a meta-analysis of the diagnostic accuracy of US, CT, and MRI as second-line imaging tests after an initial US. Radiology. 2018 Sep;288(3):717-27.[Abstract][Full Text]
76. Zhang H, Liao M, Chen J, et al. Ultrasound, computed tomography or magnetic resonance imaging - which is preferred for acute appendicitis in children? A Meta-analysis. Pediatr Radiol. 2017 Feb;47(2):186-96.[Abstract]
77. Hajibandeh S, Hajibandeh S, Hobbs N, et al. Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: a systematic review and meta-analysis. Am J Surg. 2020 Jan;219(1):154-63.[Abstract]
78. Sabiston D. The biliary system. In: Sabiston D, Lyerly HK, eds. Textbook of surgery: the biological basis of modern surgical practice. 15th ed. Philadelphia, PA: W.B. Saunders Company; 1997:1127.
79. Vincelette J, Schirm J, Bogard M, et al. Multicenter evaluation of the fully automated COBAS AMPLICATOR PCR test for detection of Chlamydia trachomatis in urogenital specimens. J Clin Microbiol. 1999 Jan;37(1):74-80.[Abstract][Full Text]
80. Uhe I, Meyer J, Viviano M, et al. Caecal diverticulitis can be misdiagnosed as acute appendicitis: a systematic review of the literature. Colorectal Dis. 2021 Oct;23(10):2515-26.[Abstract][Full Text]
81. Favara G, Maugeri A, Barchitta M, et al. Comparison of RIPASA and ALVARADO scores for risk assessment of acute appendicitis: a systematic review and meta-analysis. PLoS One. 2022;17(9):e0275427.[Abstract][Full Text]
82. Sammalkorpi HE, Mentula P, Savolainen H, et al. The introduction of adult appendicitis score reduced negative appendectomy rate. Scand J Surg. 2017 Sep;106(3):196-201.[Abstract][Full Text]
83. Sammalkorpi HE, Mentula P, Leppäniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014 Jun 26;14:114.[Abstract][Full Text]
84. Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the Alvarado score. World J Surg. 2008 Aug;32(8):1843-9.[Abstract]
85. Chong CF, Adi MI, Thien A, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J. 2010 Mar;51(3):220-5.[Abstract][Full Text]
86. Knaus WA, Draper EA, Wagner DP, et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985 Oct;13(10):818-29.[Abstract]
87. Shapiro NI, Wolfe RE, Moore RB, et al. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003 Mar;31(3):670-5.[Abstract]
88. Knaus WA, Wagner DP, Draper EA, et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest. 1991 Dec;100(6):1619-36.[Abstract]
89. Rivers EP, Nguyen HB, Amponsah D. Sepsis: a landscape from the emergency department to the intensive care unit. Crit Care Med. 2003 Mar;31(3):968-9.[Abstract]
90. Mayumi T, Yoshida M, Tazuma S, et al. The practice guidelines for primary care of acute abdomen 2015. Jpn J Radiol. 2016 Jan;34(1):80-115.[Abstract][Full Text]
91. de Almeida Leite RM, Seo DJ, Gomez-Eslava B, et al. Nonoperative vs operative management of uncomplicated acute appendicitis: a systematic review and meta-analysis. JAMA Surg. 2022 Sep 1;157(9):828-34.[Abstract][Full Text]
92. Salminen P, Tuominen R, Paajanen H, et al. Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA. 2018 Sep 25;320(12):1259-65.[Abstract][Full Text]
93. Sakran JV, Mylonas KS, Gryparis A, et al. Operation versus antibiotics--The "appendicitis conundrum" continues: A meta-analysis. J Trauma Acute Care Surg. 2017 Jun;82(6):1129-37. [Abstract]
94. Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017 Jul 10;12:29.[Abstract][Full Text]
95. Emile SH, Sakr A, Shalaby M, et al. Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses. World J Surg. 2022 May;46(5):1022-38.[Abstract][Full Text]
96. Herrod PJJ, Kwok AT, Lobo DN. Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis. BJS Open. 2022 Jul 7;6(4):zrac100.[Abstract][Full Text]
97. Talan DA, Di Saverio S. Treatment of acute uncomplicated appendicitis. N Engl J Med. 2021 Sep 16;385(12):1116-23.[Abstract]
98. Meier J, Stevens A, Bhat A, et al. Outcomes of nonoperative vs operative management of acute aAppendicitis in Older Adults in the US. JAMA Surg. 2023 Jun 1;158(6):625-32.[Abstract]
99. Georgiou R, Eaton S, Stanton MP, et al. Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics. 2017 Mar;139(3).[Abstract]
100. Gorter RR, The SML, Gorter-Stam MAW, et al. Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis. J Pediatr Surg. 2017 Aug;52(8):1219-27.[Abstract]
101. Podda M, Cillara N, Di Saverio S, et al. Antibiotics-first strategy for uncomplicated acute appendicitis in adults is associated with increased rates of peritonitis at surgery. A systematic review with meta-analysis of randomized controlled trials comparing appendectomy and non-operative management with antibiotics. Surgeon. 2017 Oct;15(5):303-14.[Abstract]
102. Kessler U, Mosbahi S, Walker B, et al. Conservative treatment versus surgery for uncomplicated appendicitis in children: a systematic review and meta-analysis. Arch Dis Child. 2017 Dec;102(12):1118-24.[Abstract]
103. Harnoss JC, Zelienka I, Probst P, et al. Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42015016882). Ann Surg. 2017 May;265(5):889-900.[Abstract]
104. Rollins KE, Varadhan KK, Neal KR, et al. Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg. 2016 Oct;40(10):2305-18.[Abstract]
105. Weston P, Moroz P. Appendicitis in pregnancy; how to manage and whether to deliver. The Obstetrician & Gynaecologist 2015; 17: 105-10.
106. Miller TE, Myles PS. Perioperative fluid therapy for major surgery. Anesthesiology. 2019 May;130(5):825-32.[Abstract][Full Text]
107. Mazuski JE, Tessier JM, May AK, et al. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect (Larchmt). 2017 Jan;18(1):1-76.[Abstract][Full Text]
108. CODA Collaborative., Flum DR, Davidson GH, et al. A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med. 2020 Nov 12;383(20):1907-19.[Abstract][Full Text]
109. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3).[Abstract][Full Text]
110. National Institute for Health and Care Excellence. Intravenous fluid therapy in adults in hospital. May 2017 [internet publication].[Full Text]
111. Mason RJ. Surgery for appendicitis: is it necessary? Surg Infect (Larchmt). 2008 Aug;9(4):481-8.[Abstract]
112. Deakin DE, Ahmed I. Interval appendicectomy after resolution of adult inflammatory appendix mass - is it necessary? Surgeon. 2007 Feb;5(1):45-50.[Abstract]
113. Andersson RE, Petzold MG. Nonsurgical treatment of appendiceal abscess or phlegmon: a systematic review and meta-analysis. Ann Surg. 2007 Nov;246(5):741-8.[Abstract]
114. Rushing A, Bugaev N, Jones C, et al. Management of acute appendicitis in adults: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2019 Jul;87(1):214-24.[Abstract][Full Text]
115. Hayes D, Reiter S, Hagen E, et al. Is interval appendectomy really needed? A closer look at neoplasm rates in adult patients undergoing interval appendectomy after complicated appendicitis. Surg Endosc. 2021 Jul;35(7):3855-60.[Abstract]
116. Mällinen J, Rautio T, Grönroos J, et al. Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging: 1-Year outcomes of the prei-appendicitis acuta randomized clinical trial. JAMA Surg. 2019 Mar 1;154(3):200-7.[Abstract][Full Text]
117. Darwazeh G, Cunningham SC, Kowdley GC. A systematic review of perforated appendicitis and phlegmon: interval appendectomy or wait-and-see? Am Surg. 2016 Jan;82(1):11-5.[Abstract]
118. Peltrini R, Cantoni V, Green R, et al. Risk of appendiceal neoplasm after interval appendectomy for complicated appendicitis: a systematic review and meta-analysis. Surgeon. 2021 Dec;19(6):e549-58.[Abstract]
119. Skendelas JP, Alemany VS, Au V, et al. Appendiceal adenocarcinoma found by surgery for acute appendicitis is associated with older age. BMC Surg. 2021 May 2;21(1):228.[Abstract][Full Text]
120. Lipping E, Saar S, Reinsoo A, et al. Short postoperative intravenous versus oral antibacterial therapy in complicated acute appendicitis: a pilot noninferiority randomized trial. Ann Surg. 2024 Feb 1;279(2):191-5.
121. Kiblawi R, Zoeller C, Zanini A, et al. Laparoscopic versus open pediatric surgery: three decades of comparative studies. Eur J Pediatr Surg. 2022 Feb;32(1):9-25.[Abstract]
122. Neogi S, Banerjee A, Panda SS, et al. Laparoscopic versus open appendicectomy for complicated appendicitis in children: A systematic review and meta-analysis. J Pediatr Surg. 2022 Mar;57(3):394-405.[Abstract]
123. Fugazzola P, Coccolini F, Tomasoni M, et al. Early appendectomy vs. conservative management in complicated acute appendicitis in children: a meta-analysis. J Pediatr Surg. 2019 Nov;54(11):2234-41.[Abstract]
124. Vaos G, Dimopoulou A, Gkioka E, et al. Immediate surgery or conservative treatment for complicated acute appendicitis in children? A meta-analysis. J Pediatr Surg. 2019 Jul;54(7):1365-71.[Abstract]
125. Jaschinski T, Mosch CG, Eikermann M, et al. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2018 Nov 28;(11):CD001546.[Abstract][Full Text]
126. Zhang G, Wu B. Meta-analysis of the clinical efficacy of laparoscopic appendectomy in the treatment of acute appendicitis. World J Emerg Surg. 2022 May 26;17(1):26.[Abstract][Full Text]
127. Wei HB, Huang JL, Zheng ZH, et al. Laparoscopic versus open appendectomy: a prospective randomized comparison. Surg Endosc. 2010 Feb;24(2):266-9. [Abstract]
128. Yau KK, Siu WT, Tang CN, et al. Laparoscopic versus open appendectomy for complicated appendicitis. J Am Coll Surg. 2007 Jul;205(1):60-5.[Abstract]
129. Woodham BL, Cox MR, Eslick GD. Evidence to support the use of laparoscopic over open appendicectomy for obese individuals: a meta-analysis. Surg Endosc. 2012 Sep;26(9):2566-70.[Abstract]
130. Katkhouda N, Mason RJ, Towfigh S, et al. Laparoscopic versus open appendectomy: a prospective randomized double-blind study. Ann Surg. 2005 Sep;242(3):439-48; discussion 448-50.[Abstract][Full Text]
131. Billingham MJ, Basterfield SJ. Pediatric surgical technique: laparoscopic or open approach? A systematic review and meta-analysis. Eur J Pediatr Surg. 2010 Mar;20(2):73-7.[Abstract]
132. Zhang S, Du T, Jiang X, et al. Laparoscopic appendectomy in children with perforated appendicitis: a meta-analysis. Surg Laparosc Endosc Percutan Tech. 2017 Aug;27(4):262-66.[Abstract]
133. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis ?A systematic review and meta-analysis. Int J Surg. 2017 Apr;40:187-97.[Abstract][Full Text]
134. Liew AN, Lim KY, Quach D, et al. Laparoscopic versus open appendicectomy in pregnancy: experience from a single institution and meta-analysis. ANZ J Surg. 2022 May;92(5):1071-8.[Abstract]
135. Zeng Q, Aierken A, Gu SS, et al. Laparoscopic versus open appendectomy for appendicitis in pregnancy: systematic review and meta-analysis. Surg Laparosc Endosc Percutan Tech. 2021 May 3;31(5):637-44.[Abstract]
136. Lee SH, Lee JY, Choi YY, et al. Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis. BMC Surg. 2019 Apr 25;19(1):41.[Abstract][Full Text]
137. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.[Abstract][Full Text]
138. de Wijkerslooth EML, Bakas JM, van Rosmalen J, et al. Same-day discharge after appendectomy for acute appendicitis: a systematic review and meta-analysis. Int J Colorectal Dis. 2021 Jun;36(6):1297-309.[Abstract][Full Text]
139. Trejo-Ávila ME, Romero-Loera S, Cárdenas-Lailson E, et al. Enhanced recovery after surgery protocol allows ambulatory laparoscopic appendectomy in uncomplicated acute appendicitis: a prospective, randomized trial. Surg Endosc. 2019 Feb;33(2):429-36.[Abstract]
140. Lintula H, Kokki H, Vanamo K, et al. Laparoscopy in children with complicated appendicitis. J Pediatr Surg. 2002 Sep;37(9):1317-20.[Abstract]
141. Zhang J, Wang M, Xin Z, et al. Updated evaluation of laparoscopic vs. open appendicectomy during pregnancy: a systematic review and meta-analysis. Front Surg. 2021;8:720351.[Abstract][Full Text]
142. Solomkin J, Evans D, Slepavicius A, et al. Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the investigating gram-negative infections treated with eravacycline (IGNITE 1) trial: a randomized clinical trial. JAMA Surg. 2017 Mar 1;152(3):224-32.[Abstract][Full Text]
143. Zhanel GG, Lawrence CK, Adam H, et al. Imipenem-relebactam and meropenem-vaborbactam: two novel carbapenem-beta-lactamase inhibitor combinations. Drugs. 2018 Jan;78(1):65-98.[Abstract]
144. Collard MK, Christou N, Lakkis Z, et al. Adult appendicitis: Clinical practice guidelines from the French Society of Digestive Surgery and the Society of Abdominal and Digestive Imaging. J Visc Surg. 2021 Jun;158(3):242-52.[Abstract]
145. Starship Child Health. Acute abdominal pain. Mar 2024 [internet publication].[Full Text]
146. Royal College of Surgeons of England. Emergency general surgery - Commissioning guide. Apr 2014 [internet publication].[Full Text]
147. Livingston EH, Woodward WA, Sarosi GA, et al. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg. 2007 Jun;245(6):886-92.[Abstract][Full Text]
148. Busch M, Gutzwiller FS, Aellig S, et al. In-hospital delay increases the risk of perforation in adults with appendicitis. World J Surg. 2011 Jul;35(7):1626-33.[Abstract]
149. Garba ES, Ahmed A. Management of appendiceal mass. Ann Afr Med. 2008 Dec;7(4):200-4.[Abstract]
150. Mentula P, Sammalkorpi H, Leppäniemi A. Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A Randomized Controlled Trial. Ann Surg. 2015 Aug;262(2):237-42.[Abstract]
151. Dimitriou I, Reckmann B, Nephuth O, et al. Single institution's experience in laparoscopic appendectomy as a suitable therapy for complicated appendicitis. Langenbecks Arch Surg. 2013 Jan;398(1):147-52.[Abstract]
152. Liberman MA, Greason KL, Frame S, et al. Single-dose cefotetan or cefoxitin versus multiple-dose cefoxitin as prophylaxis in patients undergoing appendectomy for acute nonperforated appendicitis. J Am Coll Surg. 1995 Jan;180(1):77-80.[Abstract]
153. Salazar MC, Canavan ME, Chilakamarry S, et al. Appendiceal cancer in the National Cancer Database: increasing frequency, decreasing age, and shifting histology. J Am Coll Surg. 2022 Jun 1;234(6):1082-9.[Abstract]
154. Casas MA, Dreifuss NH, Schlottmann F. High-volume center analysis and systematic review of stump appendicitis: solving the pending issue. Eur J Trauma Emerg Surg. 2022 Jun;48(3):1663-72.[Abstract]

