Highlights & Basics
- Gilbert syndrome (GS) is a genetic syndrome of mild unconjugated hyperbilirubinemia, by definition <6 mg/dL (rarely exceeding 4 mg/dL). The liver function is otherwise normal.
- Common syndrome affecting approximately 6% of the general population.
- Decreased uridine-diphosphoglucuronate glucuronosyltransferase (UDPGT) activity leads to decreased conjugation of unconjugated bilirubin. In general, the bilirubin clearance is reduced by 60%.
- Presentation usually asymptomatic, with mild icterus (jaundice) seen during times of fasting or physiologic stress.
- No treatment is needed since there is no liver injury or progression to end-stage liver disease.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
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King D, Armstrong MJ. Overview of Gilbert's syndrome. Drug Ther Bull. 2019 Feb;57(2):27-31.[Abstract]
Kwo PY, Cohen SM, Lim JK. ACG clinical guideline: evaluation of abnormal liver chemistries. Am J Gastroenterol. 2017 Jan;112(1):18-35.[Abstract][Full Text]
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