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misoprostol
generic
Black Box Warnings .
Pregnancy
use in pregnant pts can cause birth defects, abortion, premature birth, or uterine rupture; uterine rupture reported w/ use to induce labor or abortion; risk of uterine rupture incr. w/ advancing gestational age and prior uterine surgery, incl. cesarean delivery; do not use to decr. NSAID ulcer risk in pregnant pts; advise pts of abortifacient property and warn not to give to others
Pts of Childbearing Potential
do not use to decr. risk of NSAID-induced ulcers in pts of childbearing potential unless high risk of gastric ulcer; in such pts only use if 1) negative serum pregnancy test <2wk prior to start tx, 2) pt capable of complying w/ effective contraception, 3) pt given oral and written warnings of hazards, risk of contraception failure, and danger if taken by other pts of childbearing potential, 4) start med on 2nd or 3rd day of next normal menstrual period
Adult Dosing .
Dosage forms: TAB: 100 mcg, 200 mcg
NSAID GI ulcer prevention
- [100-200 mcg PO qid]
- Info: give w/ meals, last dose at bedtime
constipation, chronic (off-label)
- [600-2400 mcg/day PO divided bid-qid]
- Info: for use in refractory cases; give w/ meals, last dose at bedtime
cervical ripening (off-label)
- [25 mcg PV q3-6h]
- Max: 50 mcg/dose; Info: for use at or near term; wait >4h after last dose before adding oxytocin; for hospital use only
early pregnancy termination (off-label)
- [800 mcg buccally x1]
- Info: pt must be <71 days from 1st day of last menstrual period; use w/in 24-48h of mifepristone per protocol; call Danco Labs 1-877-432-7596 for more info
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.