Highlights & Basics
- Degenerative cervical spine disease (cervical spondylosis) is osteoarthritis of the spine, which includes the spontaneous degeneration of either disk or facet joints.
- Patients typically present with axial neck pain. Most commonly the degeneration is asymptomatic, even though cervical radiographs and magnetic resonance imaging (MRI) may show severe, spontaneous degenerative disease. Neurologic complications can occur if the degeneration includes neurologic compression.
- Neurologic complications are common in patients with degenerative cervical spine disease; these include cervical spondylotic radiculopathy, with nerve root compression, and loss of neurologic function from pressure on the spinal cord (degenerative cervical myelopathy). Cervical radiculopathy involves typically only a single nerve root territory, whereas cervical myelopathy can cause more diffuse sensory loss, weakness, and reduction or loss of function in the upper (and sometimes lower) extremities.
- Treatments differ radically depending on patient presentation, specific symptoms, and whether arthritis-related pain or neurologic complications predominate.
- Neurologic complications may respond to surgical decompression if symptoms do not abate after treatment with conservative measures, depending on their longevity and severity.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images

Severe, multilevel degenerative disk disease changes but without significant spinal cord compression (i.e., neither deformation nor intrinsic T2 changes) on cervical MRI (sagittal T2)

Cervical MRI (sagittal T2) with mild degenerative joint disease and disk bulging

Cervical MRI (sagittal T2) with moderate degenerative joint disease but no significant spinal cord compression

Diagram of subsets of cervical spondylosis, including various symptoms possibly arising within the larger field of asymptomatic (radiographic) spondylosis

A single level of spinal cord compression with T2 changes, on cervical sagittal T2 sequence in the presence of symptomatic degenerative cervical myelopathy

Previous spinal cord compression at C3/4 on sagittal T2 MRI, with residual T2 changes, and new compression at C2/3 and C6/7, with T2 changes

Chart showing average dermatome size and location. Radicular pain is usually confined to a single dermatome
Citations
Bono CM, Ghiselli G, Gilbert TJ, et al; North American Spine Society. An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders. Spine J. 2011 Jan;11(1):64-72.[Abstract]
Joint Section on Disorders of the Spine and Peripheral Nerves of the American Association of Neurological Surgeons and Congress of Neurological Surgeons. Guidelines for the surgical management of cervical degenerative disease. 2009 [internet publication].[Full Text]
American College of Radiology. ACR appropriateness criteria: cervical neck pain or cervical radiculopathy. 2024 [internet publication].[Full Text]
Nikolaidis I, Fouyas IP, Sandercock PA, et al. Surgery for cervical radiculopathy or myelopathy. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001466.[Abstract][Full Text]
1. Theodore N. Degenerative cervical spondylosis. N Engl J Med. 2020 Jul 9;383(2):159-68.[Abstract]
2. Matsumoto M, Fujimura Y, Suzuki N, et al. MRI of cervical intervertebral discs in asymptomatic subjects. J Bone Joint Surg Br. 1998 Jan;80(1):19-24.[Abstract][Full Text]
3. Guzman J, Haldeman S, Carroll LJ, et al. Clinical practice implications of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders: from concepts and findings to recommendations. J Manipulative Physiol Ther. 2009 Feb;32(2 suppl):S227-43.[Abstract]
4. Waheed MA, Hasan S, Tan LA, et al. Cervical spine pathology and treatment: a global overview. J Spine Surg. 2020 Mar;6(1):340-50.[Abstract][Full Text]
5. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1789-858.[Abstract][Full Text]
6. Brinjikji W, Luetmer PH, Comstock B, et al. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. AJNR Am J Neuroradiol. 2015 Apr;36(4):811-6.[Abstract][Full Text]
7. Teraguchi M, Yoshimura N, Hashizume H, et al. Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort: the Wakayama Spine Study. Osteoarthritis Cartilage. 2014 Jan;22(1):104-10.[Abstract][Full Text]
8. Buser Z, Ortega B, D'Oro A, et al. Spine degenerative conditions and their treatments: national trends in the United States of America. Global Spine J. 2018 Feb;8(1):57-67.[Abstract][Full Text]
9. Nouri A, Tetreault L, Singh A, et al. Degenerative cervical myelopathy: epidemiology, genetics, and pathogenesis. Spine (Phila Pa 1976). 2015 Jun 15;40(12):E675-93.[Abstract]
10. Badhiwala JH, Ahuja CS, Akbar MA, et al. Degenerative cervical myelopathy - update and future directions. Nat Rev Neurol. 2020 Feb;16(2):108-24.[Abstract]
11. Mansfield M, Smith T, Spahr N, et al. Cervical spine radiculopathy epidemiology: a systematic review. Musculoskeletal Care. 2020 Dec;18(4):555-67.[Abstract]
12. Binder AI. Cervical spondylosis and neck pain. BMJ. 2007 Mar 10;334(7592):527-31.[Abstract]
13. Rao RD, Currier BL, Albert TJ, et al. Degenerative cervical spondylosis: clinical syndromes, pathogenesis and management. J Bone Joint Surg Am. 2007 Jun;89(6):1360-78.[Abstract]
14. Williams FM, Sambrook PN. Neck and back pain and intervertebral disc degeneration: role of occupational factors. Best Pract Res Clin Rheumatol. 2011 Feb;25(1):69-79.[Abstract]
15. Patel AA, Spiker WR, Daubs M, et al. Evidence of an inherited predisposition for cervical spondylotic myelopathy. Spine (Phila Pa 1976). 2012 Jan 1;37(1):26-9.[Abstract][Full Text]
16. Baucher G, Taskovic J, Troude L, et al. Risk factors for the development of degenerative cervical myelopathy: a review of the literature. Neurosurg Rev. 2022 Apr;45(2):1675-89.[Abstract]
17. Rajesh N, Moudgil-Joshi J, Kaliaperumal C. Smoking and degenerative spinal disease: a systematic review. Brain Spine. 2022 Aug 7:2:100916.[Abstract][Full Text]
18. Lambrechts MJ, Maryan K, Whitman W, et al. Comorbidities associated with cervical spine degenerative disc disease. J Orthop. 2021 Jul-Aug;26:98-102.[Abstract][Full Text]
19. Cisler TA. Whiplash as a total-body injury. J Am Osteopath Assoc. 1994 Feb;94(2):145-8.[Abstract]
20. Siivola SM, Levoska S, Tervonen O, et al. MRI changes of cervical spine in asymptomatic and symptomatic young adults. Eur Spine J. 2002 Aug;11(4):358-63.[Abstract]
21. Haldeman S, Carroll L, Cassidy JD. Findings from the bone and joint decade 2000 to 2010 task force on neck pain and its associated disorders. J Occup Environ Med. 2010 Apr;52(4):424-7.[Abstract]
22. Gross AR, Goldsmith C, Hoving JL, et al.; Cervical Overview Group. Conservative management of mechanical neck disorders: a systematic review. J Rheumatol. 2007 May;34(5):1083-102.[Abstract]
23. Hush JM. Prognosis of acute idiopathic neck pain is poor: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2011 May;92(5):824-9.[Abstract]
24. Binder AI. Neck pain. BMJ Clin Evid. 2008 [internet publication].[Abstract][Full Text]
25. Van Zundert J, Huntoon M, Patijn J, et al. 4. Cervical radicular pain. Pain Pract. 2010 Jan-Feb;10(1):1-17.[Abstract]
26. Bono CM, Ghiselli G, Gilbert TJ, et al; North American Spine Society. An evidence-based clinical guideline for the diagnosis and treatment of cervical radiculopathy from degenerative disorders. Spine J. 2011 Jan;11(1):64-72.[Abstract]
27. Rao RD, Gourab K, David KS. Operative treatment of cervical spondylotic myelopathy. J Bone Surg Am. 2006 Jul;88(7):1619-40.[Abstract]
28. Joint Section on Disorders of the Spine and Peripheral Nerves of the American Association of Neurological Surgeons and Congress of Neurological Surgeons. Guidelines for the surgical management of cervical degenerative disease. 2009 [internet publication].[Full Text]
29. Braga-Baiak A, Shah A, Pietrobon R, et al. Intra- and inter-observer reliability of MRI examination of intervertebral disc abnormalities in patients with cervical myelopathy. Eur J Radiol. 2008 Jan;65(1):91-8.[Abstract]
30. Cook CE, Hegedus E, Pietrobon R, et al. A pragmatic neurological screen for patients with suspected cord compressive myelopathy. Phys Ther. 2007 Sep;87(9):1233-42.[Abstract]
31. Cooper G, Bailey B, Bogduk N. Cervical zygapophysial joint pain maps. Pain Med. 2007 May-Jun;8(4):344-53.[Abstract]
32. American College of Radiology. ACR appropriateness criteria: cervical neck pain or cervical radiculopathy. 2024 [internet publication].[Full Text]
33. Nikolaidis I, Fouyas IP, Sandercock PA, et al. Surgery for cervical radiculopathy or myelopathy. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD001466.[Abstract][Full Text]
34. American Association of Neuromuscular & Electrodiagnostic Medicine. Ten things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].[Full Text]
35. Levin JH. Prospective, double-blind, randomized placebo-controlled trials in interventional spine: what the highest quality literature tells us. Spine J. 2009 Aug;9(8):690-703.[Abstract]
36. Matz PG. Does nonoperative management play a role in the treatment of cervical spondylotic myelopathy? Spine J. 2006 Nov-Dec;6(6 suppl):175S-81S.[Abstract]
37. Benatar M. Clinical equipoise and treatment decisions in cervical spondylotic myelopathy. Can J Neurol Sci. 2007 Feb;34(1):47-52.[Abstract]
38. Fehlings MG, Tetreault LA, Riew KD, et al. A clinical practice guideline for the management of patients with degenerative cervical myelopathy: recommendations for patients with mild, moderate, and severe disease and nonmyelopathic patients with evidence of cord compression. Global Spine J. 2017 Sep;7(3 suppl):70S-83S.[Abstract][Full Text]
39. Davies BM, Mowforth OD, Smith EK, et al. Degenerative cervical myelopathy. BMJ. 2018 Feb 22;360:k186.[Abstract][Full Text]
40. Cook CE, Richardson JK, Pietrobon R, et al. Validation of the NHANES ADL scale in a sample of patients with report of cervical pain: factor analysis, item response theory analysis, and line item validity. Disabil Rehabil. 2006 Aug 15;28(15):929-35.[Abstract]
41. White AP, Biswas D, Smart LR, et al. Utility of flexion-extension radiographs in evaluating the degenerative cervical spine. Spine (Phila Pa 1976). 2007 Apr 20;32(9):975-9.[Abstract]
42. Ritchie C, Sterling M. Recovery pathways and prognosis after whiplash injury. J Orthop Sports Phys Ther. 2016 Oct;46(10):851-61.[Abstract][Full Text]
43. Gonzalez-Gay MA. Giant cell arteritis and polymyalgia rheumatica: two different but often overlapping conditions. Semin Arthritis Rheum. 2004 Apr;33(5):289-93.[Abstract]
44. Aho K, Palusuo T, Kurki P. Marker antibodies of rheumatoid arthritis: diagnostic and pathogenetic implications. Semin Arthritis Rheum. 1994 Jun;23(6):379-87.[Abstract]
45. Goldbach-Mansky R, Lee J, McCoy A, et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res. 2000;2(3):236-43.[Abstract][Full Text]
46. Mohan C, Assassi S. Biomarkers in rheumatic diseases: how can they facilitate diagnosis and assessment of disease activity? BMJ. 2015 Nov 26;351:h5079.[Abstract][Full Text]
47. Hegmann KT. Cervical and thoracic spine disorders. In: Occupational medicine practice guidelines: evaluation and management of common health problems and functional recovery in workers. 3rd ed. Elk Grove Village, IL: American College of Occupational and Environmental Medicine (ACOEM); 2011.
48. Evans R, Bronfort G, Nelson B, et al. Two-year follow-up of a randomized clinical trial of spinal manipulation and two types of exercise for patients with chronic neck pain. Spine. 2002 Nov 1;27(21):2383-9.[Abstract]
49. Gross A, Kay TM, Paquin JP, et al. Exercises for mechanical neck disorders. Cochrane Database Syst Rev. 2015 Jan 28;(1):CD004250.[Abstract][Full Text]
50. Pietrobon R, Coeytaux RR, Carey TS, et al. Standard scales for the measurement of functional outcome for cervical pain or dysfunction. Spine. 2002 Mar 1;27(5):515-22.[Abstract]
51. Graham N, Gross A, Goldsmith CH, et al. Mechanical traction for neck pain with or without radiculopathy. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD006408.[Abstract][Full Text]
52. Gross A, Forget M, St George K, et al. Patient education for neck pain. Cochrane Database Systematic Rev. 2012 Mar 14;(3):CD005106.[Abstract][Full Text]
53. Furlan AD, Yazdi F, Tsertsvadze A, et al. A systematic review and meta-analysis of efficacy, cost-effectiveness, and safety of selected complementary and alternative medicine for neck and low-back pain. Evid Based Complement Alternat Med. 2011 Nov 24;2012:953139.[Abstract]
54. Furlan JC, Kalsi-Ryan S, Kailaya-Vasan A, et al. Functional and clinical outcomes following surgical treatment in patients with cervical spondylotic myelopathy: a prospective study of 81 cases. J Neurosurg Spine. 2011 Mar;14(3):348-55.[Abstract]
55. Salt E, Wright C, Kelly S, Dean A. A systematic literature review on the effectiveness of non-invasive therapy for cervicobrachial pain. Man Ther. 2011 Feb;16(1):53-65.[Abstract]
56. Falco FJ, Erhart S, Wargo BW, et al. Systematic review of diagnostic utility and therapeutic effectiveness of cervical facet joint interventions. Pain Physician. 2009 Mar-Apr;12(2):323-44.[Abstract]
57. Mazanec D, Reddy A. Medical management of cervical spondylosis. Neurosurgery. 2007 Jan;60(1 suppl 1):S43-50.[Abstract]
58. Kroeling P, Gross A, Graham N, et al. Electrotherapy for neck pain. Cochrane Database Syst Rev. 2013 Aug 26;(8):CD004251.[Abstract][Full Text]
59. Chow RT, Johnson MI, Lopes-Martins RA, et al. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. Lancet. 2009 Dec 5;374(9705):1897-908.[Abstract]
60. Martimbianco ALC, Porfírio GJ, Pacheco RL, et al. Transcutaneous electrical nerve stimulation (TENS) for chronic neck pain. Cochrane Database Syst Rev. 2019 Dec 12;(12):CD011927.[Abstract][Full Text]
61. Malone D, Baldwin NG, Tomecek FJ, et al. Complications of cervical spine manipulation therapy: 5-year retrospective study in a single-group practice. Neurosurg Focus. 2002 Dec 15;13(6):ecp1.[Abstract][Full Text]
62. Benyamin RM, Singh V, Parr AT, et al. Systematic review of the effectiveness of cervical epidurals in the management of chronic neck pain. Pain Physician. 2009 Jan-Feb;12(1):137-57.[Abstract]
63. Canadian Chiropractic Association; Canadian Federation of Chiropractic Regulatory and Education Boards. Clinical practice guideline for the chiropractic treatment of adults with neck pain. March 2014 [internet publication].
64. Fu LM, Li JT, Wu WS. Randomized controlled trials of acupuncture for neck pain: systematic review and meta-analysis. J Altern Complement Med. 2009 Feb;15(2):133-45.[Abstract]
65. Diwan S, Manchikanti L, Benyamin RM, et al. Effectiveness of cervical epidural injections in the management of chronic neck and upper extremity pain. Pain Physician. 2012 Jul-Aug;15(4):E405-34.[Abstract]
66. Burkus JK, Haid RW, Traynelis VC, et al. Long-term clinical and radiographic outcomes of cervical disc replacement with the Prestige disc: results from a prospective randomized controlled clinical trial. J Neurosurg Spine. 2010 Sep;13(3):308-18.[Abstract]
67. van Middelkoop M, Rubinstein SM, Ostelo R, et al. Surgery versus conservative care for neck pain: a systematic review. Eur Spine J. 2013 Jan;22(1):87-95.[Abstract]
68. Persson LC, Lilja A. Pain, coping, emotional state and physical function in patients with chronic radicular neck pain. Disabil Rehabil. 2001 May 20;23(8):325-35.[Abstract]
69. Borton ZM, Oakley BJ, Clamp JA, et al. Cervical transforaminal epidural steroid injections for radicular pain : a systematic review. Bone Joint J. 2022 May;104-B(5):567-74.[Abstract]
70. Gao F, Mao T, Sun W, et al. An updated meta-analysis comparing artificial cervical disc arthroplasty (CDA) versus anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease (CDDD). Spine (Phila Pa 1976). 2015 Dec;40(23):1816-23.[Abstract]
71. Janssen ME, Zigler JE, Spivak JM, et al. ProDisc-C total disc replacement versus anterior cervical discectomy and fusion for single-level symptomatic cervical disc disease: seven-year follow-up of the prospective randomized US Food and Drug Administration investigational device exemption study. J Bone Joint Surg Am. 2015 Nov 4;97(21):1738-47.[Abstract]
72. Shriver MF, Lubelski D, Sharma AM, et al. Adjacent segment degeneration and disease following cervical arthroplasty: a systematic review and meta-analysis. Spine J. 2016 Feb;16(2):168-81.[Abstract]
73. Fehlings MG, Wilson JR, Kopjar B, et al. Efficacy and safety of surgical decompression in patients with cervical spondylotic myelopathy: results of the AOSpine North America prospective multi-center study. J Bone Joint Surg Am. 2013 Sep 18;95(18):1651-8.[Abstract]
74. Smith-Hammond CA, New K, Pietrobon R, et al. Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical and lumbar procedures. Spine. 2004 Jul 1;29(13):1441-6.[Abstract]
75. Vaccaro A, Beutler W, Peppelman W, et al. Clinical outcomes with selectively constrained SECURE-C cervical disc arthroplasty: two-year results from a prospective, randomized, controlled, multicenter investigational device exemption study. Spine (Phila Pa 1976). 2013 Dec 15;38(26):2227-39.[Abstract]
76. Radcliff K, Davis RJ, Hisey MS, et al. Long-term evaluation of cervical disc arthroplasty with the Mobi-C© cervical disc: a randomized, prospective, multicenter clinical trial with seven-year follow-up. Int J Spine Surg. 2017 Nov 28;11(4):31. [Abstract][Full Text]
77. Wang QL, Tu ZM, Hu P, et al. Long-term results comparing cervical disc arthroplasty to anterior cervical discectomy and fusion: a systematic review and meta-analysis of randomized controlled trials. Orthop Surg. 2020 Feb;12(1):16-30.[Abstract][Full Text]
78. Zhong ZM, Zhu SY, Zhuang JS, et al. Reoperation after cervical disc arthroplasty versus anterior cervical discectomy and fusion: a meta-analysis. Clin Orthop Relat Res. 2016 May;474(5):1307-16.[Abstract][Full Text]
