epocrates logo
epocrates logo
epocrates logo
  • 0

Diseases

Brachial plexus injury

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

AAFont SizeShareMore Information
Key Highlights
  • Brachial plexus injuries most commonly result from motor vehicle accidents, gunshot or stab wounds, contact sports accidents, or falls.

  • Injury may involve a portion of the plexus (partial injury) or all 5 nerve roots (pan-plexus injury). Partial and pan-plexus brachial plexus injuries both have potential surgical treatment options; however, the prognosis for pan-plexus injuries is limited. More extensive injuries may require multiple major operations, while partial injuries can often be corrected in a single operation.

  • Brachial plexus injuries can be ruptures (roots still connected to the spinal cord) or avulsions (roots detached from the spinal cord). Nerve transfer techniques, which can be successfully applied to both ruptures and avulsions, are often the treatment of choice for microsurgical repair. However, there are situations in which graft repair of brachial plexus injuries is indicated, particularly in pan-plexus injuries where there are limited nerve transfer options.

  • An injury that does not show signs of improvement within 3 months will often require major surgical reconstruction. The speed of nerve regeneration after spontaneous recovery or nerve repair is about 1 mm per day (1 inch per month).

  • Given the time frame to permanent paralysis (about 1-2 years), surgical repair is best carried out by 3-6 months after injury.

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Left brachial plexus

            Left brachial plexus

          • Repair of avulsed spinal nerve

            Repair of avulsed spinal nerve

          Citations

            Key Articles

            • Hill JR, Lanier ST, Brogan DM, et al. Management of adult brachial plexus injuries. J Hand Surg Am. 2021 Sep;46(9):778-88.[Abstract][Full Text]

            • American College of Radiology. ACR appropriateness criteria: plexopathy. 2021 [internet publication].[Full Text]

            • National Institute for Health and Care Excellence. Free-functioning gracilis transfer to restore upper limb function in brachial plexus injury​. Mar 2021 [internet publication].[Full Text]

            Referenced Articles

            • 1. Nath RK, Lyons AB, Bietz G. Physiological and clinical advantages of median nerve fascicle transfer to the musculocutaneous nerve following brachial plexus root avulsion injury. J Neurosurg. 2006;105:1-5.[Abstract]

            • 2. Kaiser R, Waldauf P, Ullas G, et al. Epidemiology, etiology, and types of severe adult brachial plexus injuries requiring surgical repair: systematic review and meta-analysis. Neurosurg Rev. 2020 Apr;43(2):443-52.[Abstract]

            • 3. Moghekar AR, Moghekar AR, Karli N, et al. Brachial plexopathies: etiology, frequency, and electrodiagnostic localization. J Clin Neuromuscul Dis. 2007;9:243-7.[Abstract]

            • 4. Sunderland S. Nerves and nerve injuries, 2nd Edition. London: Churchill Livingstone; 1978.

            • 5. Seddon HJ. Three types of nerve injury. Brain. 1943;66:237-88.

            • 6. Midha R. Epidemiology of brachial plexus injuries in a multitrauma population. Neurosurgery. 1997;40:1182-8.[Abstract]

            • 7. American College of Surgeons. National Trauma Data Bank annual report 2016 [internet publication].[Full Text]

            • 8. Boyle A, Karia C, Wade RG, et al. The epidemiology of traumatic brachial plexus injuries in England and Wales-a 32-year review. JB JS Open Access. 2025 Jan-Mar;10(1):e24.00105.[Abstract][Full Text]

            • 9. Blankson PK, Amoako JKA, Asah-Opoku K, et al. Epidemiology of injuries presenting to the accident centre of Korle-Bu Teaching Hospital, Ghana. BMC Emerg Med. 2019 Jul 20;19(1):39.[Abstract][Full Text]

            • 10. Suroto H, Antoni I, Siyo A, et al. Traumatic brachial plexus injury in Indonesia: an experience from a developing country. J Reconstr Microsurg. 2022 Sep;38(7):511-23.[Abstract][Full Text]

            • 11. Cho ÁB, Guerreiro AC, Ferreira CHV, et al. Epidemiological study of traumatic brachial plexus injuries. Acta Ortop Bras. 2020 Jan-Feb;28(1):16-8.[Abstract][Full Text]

            • 12. Jain DK, Bhardwaj P, Venkataramani H, et al. An epidemiological study of traumatic brachial plexus injury patients treated at an Indian centre. Indian J Plast Surg. 2012 Sep;45(3):498-503.[Abstract][Full Text]

            • 13. Gilbert WH, Nesbitt TS, Danielsen B. Associated factors in 1611 cases of brachial plexus injury. Obstet Gynecol. 1999;93:536-40.[Abstract]

            • 14. Van der Looven R, Le Roy L, Tanghe E, et al. Risk factors for neonatal brachial plexus palsy: a systematic review and meta-analysis. Dev Med Child Neurol. 2020 Jun;62(6):673-83.[Abstract][Full Text]

            • 15. Belviso I, Palermi S, Sacco AM, et al. Brachial plexus injuries in sport medicine: clinical evaluation, diagnostic approaches, treatment options, and rehabilitative interventions. J Funct Morphol Kinesiol. 2020 Mar 30;5(2):22.[Abstract][Full Text]

            • 16. Kim DH, Cho YJ, Tiel RL, et al. Outcomes of surgery in 1019 brachial plexus lesions treated at Louisiana State University Health Sciences Center. J Neurosurg. 2003;98:1005-16.[Abstract]

            • 17. Mullins GM, O'Sullivan SS, Neligan A, et al. Non-traumatic brachial plexopathies, clinical, radiological and neurophysiological findings from a tertiary centre. Clin Neurol Neurosurg. 2007;109:661-6.[Abstract]

            • 18. Bisbinas I, Langkamer VG. Pitfalls and delay in the diagnosis of Pancoast tumour presenting in orthopaedic units. Ann R Coll Surg Engl. 1999;81:291-5.[Abstract][Full Text]

            • 19. Mygland A. Approach to the patient with chronic polyneuropathy. Acta Neurol Scand Suppl. 2007;187:15-21.

            • 20. Johnson EO, Vekris MD, Zoubos AB, et al. Neuroanatomy of the brachial plexus: the missing link in the continuity between the central and peripheral nervous systems. Microsurgery. 2006;26:218-29.[Abstract]

            • 21. Spinner RJ. Outcomes for peripheral nerve entrapment syndromes. Clin Neurosurg. 2006;53:285-94.[Abstract][Full Text]

            • 22. Meiling JB, Boon AJ, Niu Z, et al. Parsonage-Turner syndrome and hereditary brachial plexus neuropathy. Mayo Clin Proc. 2024 Jan;99(1):124-40.[Abstract][Full Text]

            • 23. Smith, SJM. Electrodiagnosis. In: Birch R, Bonney G, Wynn Parry CB, eds. Surgical disorders of the peripheral nerves. London: Churchill-Livingstone; 1998:467-90.

            • 24. Hill JR, Lanier ST, Brogan DM, et al. Management of adult brachial plexus injuries. J Hand Surg Am. 2021 Sep;46(9):778-88.[Abstract][Full Text]

            • 25. Shin AY, Spinner RJ, Steinmann SP, et al. Adult traumatic brachial plexus injuries. J Am Acad Orthop Surg. 2005;13:382-96.[Abstract]

            • 26. Carvalho GA, Nikkhah G, Matthies C, et al. Diagnosis of root avulsions in traumatic brachial plexus injuries: value of computerized tomography myelography and magnetic resonance imaging. J Neurosurg. 1997;86:69-76.[Abstract]

            • 27. American College of Radiology. ACR appropriateness criteria: plexopathy. 2021 [internet publication].[Full Text]

            • 28. Amrami KK, Port JD. Imaging the brachial plexus. Hand Clin. 2005;21:25-37.[Abstract]

            • 29. Baute V, Strakowski JA, Reynolds JW, et al. Neuromuscular ultrasound of the brachial plexus: a standardized approach. Muscle Nerve. 2018 Nov;58(5):618-24.[Abstract]

            • 30. Gonzalez NL, Hobson-Webb LD. Neuromuscular ultrasound in clinical practice: a review. Clin Neurophysiol Pract. 2019 Jul 12;4:148-63.[Abstract][Full Text]

            • 31. Medical Research Council/Guarantors of Brain. Aids to the examination of the peripheral nervous system. London: Ballière Tindall; 1986.

            • 32. Nath RK, Mackinnon SE. Nerve transfers in the upper extremity. Hand Clin. 2000;16:131-9.[Abstract]

            • 33. Leechavengvongs S, Witoonchart K, Uerpairojkit C, et al. Combined nerve transfers for C5 and C6 brachial plexus avulsion injury. J Hand Surg (Am). 2006;31:183-9.[Abstract]

            • 34. Li H, Chen J, Wang J, et al. Review of rehabilitation protocols for brachial plexus injury. Front Neurol. 2023;14:1084223.[Abstract][Full Text]

            • 35. Brito S, White J, Thomacos N, et al. The lived experience following free functioning muscle transfer for management of pan-brachial plexus injury: reflections from a long-term follow-up study. Disabil Rehabil. 2021 Jun;43(11):1517-25.[Abstract]

            • 36. Lovaglio AC, Socolovsky M, Di Masi G, et al. Treatment of neuropathic pain after peripheral nerve and brachial plexus traumatic injury. Neurol India. 2019 Jan-Feb;67(Suppl):S32-7.[Abstract][Full Text]

            • 37. Shekouhi R, Chen X, Taylor J, et al. The safety and efficacy of dorsal root entry zone lesioning for pain management in patients with brachial plexus avulsion: a systematic review and meta-analysis. Neurosurgery. 2024 Aug 1;95(2):259-74.[Abstract]

            • 38. Martin E, Senders JT, DiRisio AC, et al. Timing of surgery in traumatic brachial plexus injury: a systematic review. J Neurosurg. 2018 May 1;1-13.[Abstract][Full Text]

            • 39. Noland SS, Bishop AT, Spinner RJ, et al. Adult traumatic brachial plexus injuries. J Am Acad Orthop Surg. 2019 Oct 1;27(19):705-16.[Abstract][Full Text]

            • 40. Lanier ST, Hill JR, James AS, et al. Approach to the pan-brachial plexus injury: variation in surgical strategies among surgeons. Plast Reconstr Surg Glob Open. 2020 Nov 24;8(11):e3267.[Abstract][Full Text]

            • 41. Garg R, Merrell GA, Hillstrom HJ, et al. Comparison of nerve transfers and nerve grafting for traumatic upper plexus palsy: a systematic review and analysis. J Bone Joint Surg Am. 2011;93:819-29.[Abstract]

            • 42. Wells ME, Gonzalez GA, Childs BR, et al. Radial to axillary nerve transfer outcomes in shoulder abduction: a systematic review. Plast Reconstr Surg Glob Open. 2020 Sep 23;8(9):e3096.[Abstract][Full Text]

            • 43. Schessler MJ, McClellan WT. The role of nerve transfers for C5-C6 brachial plexus injury in adults. W V Med J. 2010 Jan-Feb;106(1):12-7.[Abstract]

            • 44. Gkiatas I, Papadopoulos D, Korompilias A, Vekris M, Beris A, Kostas-Agnantis I. Traumatic upper plexus palsy: is the exploration of brachial plexus necessary? Eur J Orthop Surg Traumatol. 2019 Feb;29(2):255-62.[Abstract]

            • 45. Kakinoki R, Ikeguchi R, Dunkan SF, et al. Comparison between partial ulnar and intercostal nerve transfers for reconstructing elbow flexion in patients with upper brachial plexus injuries. J Brachial Plex Peripher Nerve Inj. 2010;5:4.[Abstract][Full Text]

            • 46. Chammas M, Goubier JN, Coulet B, et al. Glenohumeral arthrodesis in upper and total brachial plexus palsy. A comparison of functional results. J Bone Joint Surg (Br). 2004;86:692-5.[Abstract]

            • 47. Hoang D, Chen VW, Seruya M. Recovery of elbow flexion after nerve reconstruction versus free functional muscle transfer for late, traumatic brachial plexus palsy: a systematic review. Plast Reconstr Surg. 2018 Apr;141(4):949-59.[Abstract]

            • 48. National Institute for Health and Care Excellence. Free-functioning gracilis transfer to restore upper limb function in brachial plexus injury​. Mar 2021 [internet publication].[Full Text]

            • 49. Zelenski NA, Joslyn NA, Lee YH, et al. Factors affecting C5 viability and demographic variability in two brachial plexus centers. Plast Reconstr Surg Glob Open. 2023 Jun;11(6):e5073.[Abstract][Full Text]

            • 50. Merrell GA, Barrie KA, Katz DL, et al. Results of nerve transfer techniques for restoration of shoulder and elbow function in the context of a meta-analysis of the English literature. J Hand Surg (Am). 2001;26:303-14.[Abstract]

            • 51. Doi K, Muramatsu K, Hattori Y, et al. Restoration of prehension with the double free muscle technique following complete avulsion of the brachial plexus. Indications and long-term results. J Bone Joint Surg Am. 2000;82:652-66.[Abstract]

          Have feedback?
          Tell us about your experience
          Scroll to Top
          epocrates logo

          Sign in to access our clinical decision support tools

          Sign inCreate Account
          Download Epocrates from the App StoreDownload Epocrates from the Play Store
          About UsFeaturesBusiness SolutionsHelp & Feedback
          © 2026 epocrates, Inc.   Terms of UsePrivacy PolicyEditorial PolicyDo Not Sell or Share My Information