Select a medication above to begin.
Nexviazyme (avalglucosidase alfa-ngpt)
avalglucosidase alfa
Black Box Warnings .
Hypersensitivity Rxn
life-threatening rxns incl. anaphylaxis have occurred; admin. where appropriate medical support incl. cardiopulmonary resuscitation equip. available; D/C immediately and start appropriate tx if severe rxn occurs; may consider desensitization procedure in pts w/ severe rxn
Infusion Rxns
severe rxns have occurred; consider immediate D/C and start appropriate tx if severe rxn occurs; weigh risk vs. benefit of readministration; acute underlying illness at time of infusion may incr. risk; compromised cardiac and resp. fxn in advanced Pompe dz may incr. risk of severe complications from infusion rxns
Acute Cardiorespiratory Failure Risk in Susceptible Pts
pts w/ compromised cardiac/resp. fxn on fluid restriction, acute underlying resp. illness, or pts susceptible to volume overload may be at risk of serious exacerbation of cardiac/resp. fxn; monitor vital signs more frequently during infusion in these pts
Adult Dosing .
Dosage forms: INJ
Special Note
- [drug name clarification]
- Info: nonproprietary name = avalglucosidase alfa-ngpt
Pompe dz, late-onset
- [20 mg/kg/dose IV q2wk]
- Info: consider premed w/ antipyretic, antihistamine, corticosteroids
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
- Dosage forms: INJ
Special Note
- [drug name clarification]
- Info: nonproprietary name = avalglucosidase alfa-ngpt
Pompe dz, late-onset
- [1 yo and older, <30 kg]
- Dose: 40 mg/kg/dose IV q2wk; Info: consider premed w/ antipyretic, antihistamine, corticosteroids
- [1 yo and older, >30 kg]
- Dose: 20 mg/kg/dose IV q2wk; Info: consider premed w/ antipyretic, antihistamine, corticosteroids
renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [not defined]