Welireg

Adult Dosing .

Dosage forms:  TAB: 40 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

von Hippel-Lindau dz

[120 mg PO qd]

Info: for pts requiring tx but not requiring immediate surgery for associated renal cell carcinoma, CNS hemangioblastoma, or pancreatic neuroendocrine tumor; do not cut/crush/chew tab

renal cell CA, advanced

[120 mg PO qd]

Info: for pts w/ clear cell component who have received prior tx w/ PD-1/PD-L1 inhibitor and VEGF-TKI; do not cut/crush/chew tab

pheochromocytoma or paraganglioma

[120 mg PO qd]

Info: for pts w/ locally advanced, unresectable, or metastatic dz; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined, caution advised

Peds Dosing .

Dosage forms:  TAB: 40 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

pheochromocytoma or paraganglioma

[12 yo and older, <40 kg]

Dose: 80 mg PO qd; Info: for pts w/ locally advanced, unresectable, or metastatic dz; do not cut/crush/chew tab

[12 yo and older, >40 kg]

Dose: 120 mg PO qd; Info: for pts w/ locally advanced, unresectable, or metastatic dz; do not cut/crush/chew tab

renal dosing

[see below]

eGFR >30: no adjustment; eGFR <30: not defined, caution advised

HD/PD: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined, caution advised