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Seizalam
midazolam
Black Box Warnings .
Risks from Concomitant Opioid Use
concomitant benzodiazepine use with opioids may result in profound sedation, respiratory depression, coma, and death; reserve concomitant use for patients with inadequate alternative tx options; limit to minimum required dosage and duration; monitor patients for signs/symptoms of respiratory depression and sedation
Addiction, Abuse, and Misuse
benzodiazepines expose users to risk of abuse, misuse, and addiction, can lead to overdose or death; commonly involves concomitant use with other meds, alcohol, and/or illicit substances, which is associated with incr. frequency of serious adverse outcomes; assess risk for abuse, misuse, and addiction before prescribing and throughout tx
Dependence and Withdrawal Reactions
continuous benzodiazepine use may lead to clinically significant physical dependence; risk of dependence and withdrawal incr. with longer tx duration and higher daily dose; if used more frequently than recommended, use gradual taper to D/C as abrupt D/C or rapid dose reduction may cause acute withdrawal reactions, potentially life-threatening
Adult Dosing .
Dosage forms: INJ
status epilepticus
- [10 mg IM x1]
renal dosing
- [adjust dose amount]
- CrCl <10: decr. usual dose by 50%
- HD/PD: not defined
hepatic dosing
- [see below]
- hepatic impairment: not defined, caution advised
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.