Vonjo

Adult Dosing .

Dosage forms:  CAP: 100 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing including toxicity-related dose adjustments

myelofibrosis, intermediate or high-risk

[200 mg PO bid]

Info: for patients with primary or secondary disease and Plt <50,000; D/C other kinase inhibitors before tx start; D/C x7 days before elective surgery or invasive procedure; do not open/crush/chew cap

renal dosing

[see below]

eGFR <30: avoid use

HD: avoid use; PD: not defined

hepatic dosing

[adjust dose amount]

Child-Pugh Class C: start 100 mg bid, may incr. dose to 200 mg bid after 12wk if tx ineffective

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.