Tyvaso DPI

Adult Dosing .

Dosage forms:  DPI: 16 mcg per cartridge, 32 mcg per cartridge, 48 mcg per cartridge, 64 mcg per cartridge, 80 mcg per cartridge

pulmonary arterial HTN

[48-64 mcg inhaled qid]

Start: 16 mcg inhaled qid, incr. by 16 mcg/dose as tolerated q1-2wk; Info: space doses 4h apart; for dose conversion from treprostinil NEB form, DPI 16 mcg = NEB 30 mcg (5 breaths) or less, DPI 32 mcg = NEB 36-42 mcg (6-7 breaths), DPI 48 mcg = NEB 48-60 mcg (8-10 breaths), DPI 64 mcg = NEB 66-78 mcg (11-13 breaths), DPI 80 mg = NEB 84-90 mcg (14-15 breaths)

pulmonary HTN, interstitial lung dz-associated

[48-64 mcg inhaled qid]

Start: 16 mcg inhaled qid, incr. by 16 mcg/dose as tolerated q1-2wk; Info: space doses 4h apart; for dose conversion from treprostinil NEB form, DPI 16 mcg = NEB 30 mcg (5 breaths) or less, DPI 32 mcg = NEB 36-42 mcg (6-7 breaths), DPI 48 mcg = NEB 48-60 mcg (8-10 breaths), DPI 64 mcg = NEB 66-78 mcg (11-13 breaths), DPI 80 mg = NEB 84-90 mcg (14-15 breaths)

renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

hepatic dosing

[see below]

hepatic impairment: not defined, caution advised; Info: titrate slowly

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.