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Auvelity
dextromethorphan/ bupropion hydrochloride
Black Box Warnings .
Suicidality
antidepressants incr. suicidality risk in peds and young adult patients in short-term studies; monitor closely for clinical worsening and suicidality; advise families and caregivers of need for close observation and communication with prescriber; not approved for peds patients
Adult Dosing .
Dosage forms: ER TAB: 30 mg/105 mg, 45 mg/105 mg
major depressive disorder
- [45 mg/105 mg PO bid]
- Start: 45 mg/105 mg PO qam x3 days, then incr. to 45 mg/105 mg PO bid; Max: 90 mg/210 mg/day; Info: in CYP2D6 poor metabolizers, give 45 mg/105 mg PO qam; separate doses by at least 8h; do not cut/crush/chew tab
dementia-associated agitation, patients with Alzheimer disease
- [45 mg/105 mg PO bid]
- Start: 30 mg/105 mg PO qam x7 days, then incr. to 30 mg/105 mg PO bid x7 days, then 45 mg/105 mg PO bid; Max: 90 mg/210 mg/day; Info: in CYP2D6 poor metabolizers, start 30 mg/105 mg PO qam x7 days, then incr. to 45 mg/105 mg PO qam; separate doses by at least 8h; do not cut/crush/chew tab
renal dosing
- [major depressive disorder]
- eGFR 30-59: 45 mg/105 mg qam; eGFR <30: avoid use
- HD/PD: not defined
- [dementia-associated agitation, patients with Alzheimer disease]
- eGFR 30-59: start 30 mg/105 mg qam x7 days, then incr. to 45 mg/105 mg qam; eGFR <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class C: avoid use
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.