Tzield (teplizumab-mzwv)

Adult Dosing .

Dosage forms:  INJ

Special Note

[drug name clarification]

Info: nonproprietary name = teplizumab-mzwv

diabetes mellitus prevention, type 1

[65 mcg/m^2/dose IV x1 on day 1, then 125 mcg/m^2/dose IV x1 on day 2, then 250 mcg/m^2/dose IV x1 on day 3, then 500 mcg/m^2/dose IV x1 on day 4, then 1030 mcg/m^2/dose IV qd on days 5-14]

Info: for patients with stage 2 type 1 diabetes mellitus to delay onset of stage 3 disease; premed with antipyretic, antihistamine, and/or antiemetic prior to 1st 5 doses, then as needed

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Dosage forms:  INJ

Special Note

[drug name clarification]

Info: nonproprietary name = teplizumab-mzwv

diabetes mellitus prevention, type 1

[8 yo and older]

Dose: 65 mcg/m^2/dose IV x1 on day 1, then 125 mcg/m^2/dose IV x1 on day 2, then 250 mcg/m^2/dose IV x1 on day 3, then 500 mcg/m^2/dose IV x1 on day 4, then 1030 mcg/m^2/dose IV qd on days 5-14; Info: for patients with stage 2 type 1 diabetes mellitus to delay onset of stage 3 disease; premed with antipyretic, antihistamine, and/or antiemetic prior to 1st 5 doses, then as needed

renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

hepatic dosing

[not defined]