Olpruva

Adult Dosing .

Dosage forms:  PELLET: 0.5 g per packet, 2 g per packet, 3 g per packet; PELLET (1 g pack): 0.5 g per packet x2; PELLET (4 g pack): 2 g per packet x2; PELLET (5 g pack): 2 g per packet x1 and 3 g per packet x1; PELLET (6 g pack): 3 g per packet x2; PELLET (6.67 g pack): 3 g per packet x1 and 3.67 g per packet x1

chronic hyperammonemia, urea cycle disorder-associated

[9.9-13 g/m^2/day PO/GT divided 3-6x/day]

Max: 20 g/day; Info: for patients with carbamoylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on clinical response and plasma ammonia levels; give with food; separate doses by at least 3h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose

Peds Dosing .

Dosage forms:  PELLET: 0.5 g per packet, 2 g per packet, 3 g per packet; PELLET (1 g pack): 0.5 g per packet x2; PELLET (4 g pack): 2 g per packet x2; PELLET (5 g pack): 2 g per packet x1 and 3 g per packet x1; PELLET (6 g pack): 3 g per packet x2; PELLET (6.67 g pack): 3 g per packet x1 and 3.67 g per packet x1

chronic hyperammonemia, urea cycle disorder-associated

[1 yo and older, 7-19.9 kg]

Dose: 450-600 mg/kg/day PO/GT divided 3-6x/day; Max: 20 g/day; Info: for patients with carbamoylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on clinical response and plasma ammonia levels; give with food; separate doses by at least 3h

[1 yo and older, >20 kg]

Dose: 9.9-13 g/m^2/day PO/GT divided 3-6x/day; Max: 20 g/day; Info: for patients with carbamoylphosphate synthetase, ornithine transcarbamylase, or argininosuccinic acid synthetase deficiency; adjust dose based on clinical response and plasma ammonia levels; give with food; separate doses by at least 3h

renal dosing

[see below]

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

hepatic dosing

[adjust dose amount]

hepatic impairment: use lowest usual start dose