Fruzaqla

Adult Dosing .

Dosage forms:  CAP: 1 mg, 5 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >2wk before major surgery, restart >2wk after major surgery when wound fully healed

colorectal CA, metastatic

[5 mg PO qd on days 1-21 of 28-day cycle]

Info: for patients w/ dz progression after fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemo, anti-VEGF tx, and anti-EGFR tx if RAS wild-type; do not open cap

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

hepatic dosing

[see below]

bilirubin 1.1-1.5x ULN: no adjustment; bilirubin 1.6-3x ULN: not defined; bilirubin >3x ULN: avoid use

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.