Vyloy (zolbetuximab-clzb)

Adult Dosing .

Dosage forms:  INJ

Special Note

[formulation clarification]

Info: nonproprietary name = zolbetuximab-clzb

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses, premeds, and dosing incl. toxicity-related dose adjustments

CLDN18.2-positive HER2-negative gastric CA, locally advanced unresectable or metastatic

[800 mg/m^2/dose IV x1, then 600 mg/m^2/dose IV q3wk]

Alt: 800 mg/m^2/dose IV x1, then 400 mg/m^2/dose IV q2wk; Info: for pts w/ gastric or gastroesophageal junction adenocarcinoma; part of multi-drug chemo regimen

renal dosing

[see below]

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

hepatic dosing

[see below]

mild impairment: no adjustment; moderate-severe impairment: not defined

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.