Opfolda

Adult Dosing .

Dosage forms:  CAP: 65 mg

Pompe disease, late-onset

[40-49.9 kg]

Dose: 195 mg PO q2wk; Start: 2wk after last enzyme replacement tx dose; Info: for patients not improving on current enzyme replacement tx; give 1h before cipaglucosidase alfa dose; avoid food/drink for at least 2h before and 2h after admin

[>50 kg]

Dose: 260 mg PO q2wk; Start: 2wk after last enzyme replacement tx dose; Info: for patients not improving on current enzyme replacement tx; give 1h before cipaglucosidase alfa dose; avoid food/drink for at least 2h before and 2h after admin

renal dosing

[40-49.9 kg]

CrCl 15-59: 130 mg q2wk; CrCl <15: not defined

HD/PD: not defined

[>50 kg]

CrCl 15-59: 195 mg q2wk; CrCl <15: not defined

HD/PD: not defined

hepatic dosing

[not defined]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.