Select a medication above to begin.
Rivfloza
nedosiran
Adult Dosing .
Dosage forms: INJ (pre-filled syringe): 128 mg per 0.8 mL, 160 mg per mL; INJ (vial): 80 mg per 0.5 mL
primary hyperoxaluria, type 1
- [<50 kg]
- Dose: 128 mg SC qmo
- [>50 kg]
- Dose: 160 mg SC qmo
renal dosing
- [see below]
- eGFR <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined
Peds Dosing .
- Dosage forms: INJ (pre-filled syringe): 128 mg per 0.8 mL, 160 mg per mL; INJ (vial): 80 mg per 0.5 mL
primary hyperoxaluria, type 1
- [2-11 yo, <39 kg]
- Dose: 3.3 mg/kg/dose SC qmo
- [2-11 yo, 39-49 kg]
- Dose: 128 mg SC qmo
- [2-11 yo, >50 kg]
- Dose: 160 mg SC qmo
- [12 yo and older, <50 kg]
- Dose: 128 mg SC qmo
- [12 yo and older, >50 kg]
- Dose: 160 mg SC qmo
renal dosing
- [see below]
- eGFR <30: avoid use
- HD/PD: not defined
hepatic dosing
- [see below]
- bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN: not defined