Exblifep

Adult Dosing .

Dosage forms:  INJ

Special Note

[strength clarification]

Info: doses expressed as total cefepime + enmetazobactam amt; 2.5 g cefepime/enmetazobactam contains 2 g cefepime + 0.5 g enmetazobactam

UTI, complicated

[2.5 g IV q8h x7 days]

Info: may give up to 14 days if concurrent bacteremia

renal dosing

[see below]

eGFR >130: 2.5 g q8h infused over 4h; eGFR 60-129: 2.5 g q8h infused over 2h; eGFR 30-59: 1.25 g q8h infused over 2h; eGFR 15-29: 1.25 g q12h infused over 2h; eGFR <15: 1.25 g x1, then 0.625 g q24h infused over 2h

HD: 1.25 g x1, then 0.625 g q24h infused over 2h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined

hepatic dosing

[no adjustment]

Peds Dosing .

Peds dosing is currently unavailable or not applicable for this drug.